Molecular and Clinicopathological Features of Gastrointestinal Stromal Tumors in Vietnamese Patients

Quoc Dat Ngo,Quoc Thang Pham,Dang Anh Thu Phan,Anh Vu Hoang,Thi Ngoc Ha Hua,Sao Trung Nguyen 대한병리학회 2019 Journal of Pathology and Translational Medicine Vol.53 No.6

Background: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. Management of GIST patients is currently based on clinicopathological features and associated genetic changes. However, the detailed characteristics and molecular genetic features of GISTs have not yet been described in the Vietnamese population. Methods: We first identified 155 patients with primary GIST who underwent surgery with primary curative intent between 2011 and 2014 at University Medical Center at Ho Chi Minh City, Vietnam. We evaluated the clinicopathological features and immunohistochemical reactivity to p53 and Ki-67 in these patients. Additionally, KIT genotyping was performed in 100 cases. Results: The largest proportion of GISTs was classified as high-risk (43.2%). Of the 155 GISTs, 52 (33.5%) were positive for Ki-67, and 58 (37.4%) were positive for p53. The expression of Ki-67 and p53 were correlated with mitotic rate, tumor size, risk assessment, and tumor stage. Out of 100 GIST cases, KIT mutation was found in 68%, of which 62 (91.2%) were found in exon 11, two (2.9%) in exon 9, and four (5.8%) in exon 17. No mutation in exon 13 was identified. Additionally, KIT mutations did not correlate with any clinicopathological features. Conclusions: The expression of Ki-67 and p53 were associated with high-risk tumors. Mutations in exon 11 were the most commonly found, followed by exon 17 and exon 9. Additionally, KIT mutation status was not correlated with any recognized clinicopathological features.

Study Design for the 2016 Baseline Survey of a Health System Strengthening Project in Quoc Oai District, Hanoi, Vietnam

Van Minh Hoang,오주환,Bao Ngoc Nguyen,Le Minh Dat,이종구,Thi Giang Huong Tran,Van Huy Nguyen,이승표,방경숙,조영태,김선영,이화영,Quang Cuong Le,Narshil Choi,Thai Son Dinh,Ngoc Hoat Luu 대한의학회 2019 Journal of Korean medical science Vol.34 No.5

Background: In order to provide essential scientific evidence on the population's health status and social health determinants as well as the current capacity of the health care system in Vietnam to health policy makers and managers, Vietnam Ministry of Health, Hanoi University of Public Health, Hanoi Medical University, and Ho Chi Minh University of Medicine and Pharmacy collaborated with Seoul National University (Korea) and conducted a health system survey in the Quoc Oai district (of Hanoi capital) that represented northern rural Vietnam. Methods: The study design was a cross-sectional study. The survey covered different topics (more than 200 questions) and was administered in three separate questionnaires: 1) Basic information of all household members; 2) Household characteristics; and 3) Individual characteristics. Socio-demographic characteristics among the households and individuals were collected from 2,400 households sampled by multi-stage cluster sampling method: more than 200 questions. Results: The household size of Quoc Oai was larger than the national average and there was no significant difference in gender composition. In addition, the proportions of pre-elderly, age 55–64, and elderly group (65 years old and over) were higher than the national population statistics. In this context, demographic transition has begun in Quoc Oai. Conclusion: This study design description provides the basic information about a baseline survey of a future prospective cohort (as a part of a collaborative project on strengthening the health system in Vietnam) to the prospective data user of this survey.

The distribution channel, strategic factor and firm performance: Evidence from FDI enterprises

Lan Thi Hoang BUI,Dat Ngoc NGUYEN 한국유통과학회 2021 유통과학연구 Vol.19 No.10

Purpose: Research on the development of distribution channels and the strategy will help businesses develop competitiveness in the market. At the same time, the excellent effect of distribution channels and the outstanding implementation of business strategies will help optimize firm performance. Therefore, this study helps to evaluate the influence of distribution channels, and strategy factors on the performance of FDI enterprises in Vietnam. Research design, data, and methodology: Research using quantitative method with PLS-SEM model based on 210 samples using Smart-PLS3. software. The survey subjects are corporate managers who understand the strategies, distribution channels, and performance in Vietnamese FDI enterprises. Results: The analysis results show that strategy factors have a positive effect on firm performance, and distribution channel also has a positive impact on firm performance. This result also indicates that distribution channels activity as an intermediary between strategy and firm performance. Conclusion: The study also gives some policy implications on strategy and distribution channels to improve firm performance. The strategic implementation of finance, human resources, risk, innovation, and diversification of distribution channels are implications for improving firm performance in FDI enterprises. In addition, the research has contributed to the relationship between the distribution channels and firm performance.

The Determinants of Listed Commercial Banks’ Profitability in Vietnam

Hai Thanh PHAN,Tien Ngoc HOANG,Linh Viet DINH,Dat Ngoc HOANG 한국유통과학회 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.11

The study investigates the factors affecting the profitability of listed commercial banks in Vietnam. Survey data for this research were collected from 10 Vietnamese listed commercial banks for the period from 2008 to 2018. In the study, we have built a model of econometric regression with the dependent variable being listed commercial banks’ profitability results measured through ROA. The research methods used include descriptive statistics, IV regression and OLS regression analysis, and the authors carried out the model verification with Stata 14 software. The results showed that operating efficiency, loans size, retail loans ratio, state ownership, inflation rate, and GDP growth are factors that have a positive impact on profitability On the other hand, variables such as capital size, credit risk, liquidity risk, bank size, and revenue diversification are statistically insignificant; hence, these variables are not statistically adequate to indicate the influence of those independent variables to banks’ profitability. The findings of this study suggest that the quality of assets should be considered in the context that bad debt risks come from lending heavily to the real estate sector. Meeting Basel II’s capital compliance requirements is relatively difficult for small listed commercial banks compared to bigger listed commercial banks in Vietnam.

Safety of Balloon Kyphoplasty in the Treatment of Thoracic Osteoporotic Vertebral Compression Fractures in Vietnamese Patients

Nguyen Dinh HOA,Vu Duc-Dat,Doan Thi-Ngoc-Ha,Vo Hoang-Long 대한정형외과학회 2020 Clinics in Orthopedic Surgery Vol.12 No.2

Background: The evidence for the efficacy and safety of balloon kyphoplasty (BKP) in treating the Vietnamese patients is sparse. There is no convincing evidence regarding BKP’s efficacy in Vietnamese patients, especially in the patients with thoracic osteoporotic vertebral compression fractures (VCFs). This article aims to evaluate the outcomes of restoring the body height of the compressed thoracic vertebrae in patients undergoing BKP. Methods: We prospectively enrolled 65 consecutive patients with thoracic VCFs (73 vertebrae) due to osteoporosis who were treated with BKP between June 2018 and May 2019. Results: A trocar was inserted through the pedicle in 84.9% (62/73) and beside the pedicle in 15.1% (11/73). The mean amount of mixed cement injected was 4.1 ± 1.1 mL (range, 1.5–7 mL). Cement leakage was radiographically confirmed in 30.8% of 65 patients. Among patients with complications caused by cement extravasation, the leakage was through the anterior margin of the vertebrae in 15.4%, through the vertebral disc in 12.3%, and through the posterior margin of the vertebrae in 3.1%. In the last 3.1% of patients, there was no clinically notable lesions of the nerve roots or spinal cord. The mean visual analog scale score decreased significantly from 7.3 ± 1.1 preoperatively to 3.3 ± 0.6 at 24 hours after surgery, and then to 1.2 ± 1.1 at 3 months after surgery (p < 0.01). The mean reduction in Cobb angle measured on standing radiographs after treatment was 3.7°, showing statistical significance (p < 0.01). Conclusions: BKP is a minimally invasive treatment effective for immediate pain relief, early motor rehabilitation, and humpback correction. The present study provided convincing evidence to support the use of BKP by spine surgeons and clinical specialists in treating osteoporotic thoracic VCFs in Vietnamese patients.

Factors Affecting Enterprise's Satisfaction toward Social Security's Online Public Service: The Case of Thanh Hoa Province, Vietnam

NGO, Chi Thanh,NGUYEN, Thi Ngoc Mai,NGUYEN, Duy Dat,LE, Hoang Ba Huyen,LE, Van Cuong,LE, Thi Binh Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9

The study aims to investigate factors affecting enterprise's satisfaction and loyalty toward the Social Security's online public services, looking at the case of Thanh Hoa province, Vietnam. This study employs samples with 216 enterprises that use online public system of Thanh Hoa province's Social Security. The research model is closely linked to the SERVQUAL model developed by Parasuraman, Zeithaml and Berry (1988). We propose 23 scales that constitute the quality of service, three scales that constitute Customer Satisfaction and three components that constitute Customer Loyalty. This study use the tool of Exploratory Factor Analysis (EFA), Cronbach's Alpha test, Confirm Factor Analysis (CFA) and Structural Equation Modeling (SEM) in order to address the question of satisfaction and loyalty. The result shows that the factor with the most impact is Reliability, next is Capacity of staffs, Tangibles, Attitude of staffs, and the least impacting factor is Empathy; moreover, the results also show that Satisfaction has a strong impact on Customer Loyalty. The findings of this study suggest that Thanh Hoa province's Social Security should: (i) strengthen the reliability of online service system; (ii) build capacity for staffs; (iii) develop the responsiveness of electronic transactions systems; and (iv) improve the empathy of staffs.

Using sulfate-functionalized Hf-based metal–organic frameworks as a heterogeneous catalyst for solvent-free synthesis of pyrimido[1,2-a] benzimidazoles via one-pot three-component reaction

Minh-Huy Dinh Dang,Linh Ho Thuy Nguyen,Trang Thi Thu Nguyen,Ngoc Xuan Dat Mai,Phuong Hoang Tran,Tan Le Hoang Doan 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.103 No.-

Functionalized metal–organic frameworks have recently received significant attention in heterogeneouscatalysis applications due to their high catalytic activity. In this work, a sulfate-functionalized Hf-clusterbasedmetal–organic framework was prepared via sulfation of a Hf-MOF, named Hf-BTC, constructed byHf6 clusters and 1,3,5-tricarboxylate linkers. The Hf-BTC-SO4 material was consequently demonstrated tobe an efficiently reusable superacid catalyst for a one-pot three-component reaction of pyrimido[1,2-a]benzimidazoles synthesis. The reaction catalyzed by the sulfated Hf-BTC could be carried out under mildand solvent-free conditions and give superior performance in a wide range of substrates. According todetailed investigation, the good catalytic performance of the sulfated-functionalized MOF likely originatesfrom the high-porosity framework and the high active sites of the functionalized clusters. Importantly, the catalyst could be easy to recover and reuse the functionalized framework several timeswith minor changes in catalytic efficiency.

An effective combination of reusable Pd@MOF catalyst and deep eutectic solvents for high-performance C–C coupling reaction

Minh-Huy Dinh Dang,Trang Thi Thu Nguyen,Bao Quang Gia Le,Linh Ho Thuy Nguyen,Ngoc Xuan Dat Mai,My Van Nguyen,Phuong Hoang Tran,Tan Le Hoang Doan 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-

Pd-incorporated Zr-based metal–organic framework containing sulfone groups, named Pd(II)BUT-11, wassuccessfully prepared by dispersing the sulfone-functionalized MOF in Pd(OAc)2 solution. X-ray diffraction,scanning electron microscopy, N2 isotherm sorption, X-ray photoelectron spectroscopy, and thermogravimetricanalysis were applied to determine the features of the Pd-incorporated MOF. In the catalyticstudies, Pd(II)@BUT-11 was shown to be an efficient heterogeneous catalyst for synthesizing various stilbenederivatives via the cross-coupling Heck reaction with DABCO-derived deep eutectic solvent (DES) asa green solvent. Notably, the catalyst and the solvent could be recovered and reused, with their activityand structure remaining stable throughout several trials. The method provides an alternative solution tothe conventional catalysts and solvents, resulting in a green and efficient stilbene synthesis process. Furthermore, the stilbenes were separated by extraction with ethyl acetate due to the low solubility ofDES with this solvent.