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( Daseul Hwang ),( Hyung Won Ryu ),( Ji-won Park ),( Jung-hee Kim ),( Doo-young Kim ),( Jae-hoon Oh ),( Ok-kyoung Kwon ),( Sang-bae Han ),( Kyung-seop Ahn ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.1
Peucedanum japonicum Thunberg (PJT) has been used in traditional medicine to treat colds, coughs, fevers, and other inflammatory diseases. The goal of this study was to investigate whether 3′-isovaleryl-4′-senecioylkhellactone (IVSK) from PJT has anti-inflammatory effects on lung epithelial cells. The anti-inflammatory effects of IVSK were evaluated using phorbol 12-myristate 13-acetate (PMA)-stimulated A549 cells and regular human lung epithelial cells as a reference. IVSK reduced the secretion of the inflammatory mediators interleukin (IL)-8 and monocyte chemoattractant protein-1 (MCP-1), and the mRNA expression of IL-6, IL-8, MCP-1, and IL-1β. Additionally, it inhibited the phosphorylation of IκB kinase (IKK), p65, Iκ-Bα, and mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK in A549 cells stimulated with PMA. Moreover, the binding affinity of activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) was significantly reduced in the luciferase assay, while nuclear translocation was markedly inhibited by IVSK in the immunocytochemistry. These findings indicate that IVSK can protect against inflammation through the AP-1 and NF-κB pathway and could possibly be used as a lead compound for the treatment of inflammatory lung diseases.
Generation of Charged SiC Nanoparticles During HWCVD Process
Daseul Kim,Du Yun Kim,Ji Hye Kwon,Kun‑Su Kim,Nong‑Moon Hwang 대한금속·재료학회 2020 ELECTRONIC MATERIALS LETTERS Vol.16 No.5
Charged nanoparticles have been shown to be spontaneously generated in the gas phase in various chemical vapor deposition(CVD). Furthermore, it has been shown that these charged nanoparticles can contribute to the growth of thin films,nanowires, nanotetrapods and so on. Here, the generation of charged silicon carbide (SiC) nanoparticles in the gas phaseduring a hot wire CVD process was studied by capturing nanoparticles with a different delay time on a silicon monoxidemembrane of the copper mesh grid for transmission electron microscope. The average size of SiC nanoparticles capturedfor 30 s increased from 2.9 to 6.1 nm with increasing delay time from 0 to 60 min. The deposition behavior of SiC filmswas affected by the applied bias on a substrate holder. A homo-epitaxial SiC film as thick as ~ 200 nm was grown under thesubstrate bias of − 200 V, whereas polycrystalline SiC films were grown under 0 V and + 15 V. It indicates that nanoparticlesgenerated in the gas phase should be charged.
정국모 ( Kuk Mo Jung ),황다슬 ( Daseul Hwang ) 한국경제학회 2022 經濟學硏究 Vol.70 No.2
대부분의 국내 기후변화 영향 연구는 기후변화가 일부 산업 등에 미치는 개별 효과 추정을 중심으로 한정되어 있고, 통합기후모형을 통한 기후변화의 종합적인 경제 피해 비용, 또는 탄소의 사회적 비용 추정은 아직 미미한 상태이다. 본 연구는 최신 통합기후모형인 Golosov, Hassler, Krusell, and Tsyvinski(2014)를 통하여 제주도에서의 탄소의 사회적 비용을 국내 최초로 추정하였다. 본 연구의 분석에 따르면 2019년 기준으로 제주도에서 탄소 배출로 인한 연평균 총 사회적 비용은 약 205~365억 원 정도로 추정되었다. 탄소의 사회적 비용을 1톤당 비용으로 전환했을 때 제주도에서의 비용은 약 16,000원~29,000원 사이로 추정 되었다. In Korea, most research on the economic effects of climate change is limited to partial analyses of climate change on individual industries and sectors. Estimates on aggregate costs of externality caused by climate change a.k.a. the social cost of carbon through a lens of the Integrated Assessment Model (IAM) are rare. Based on recent IAM proposed by Golosov, Hassler, Krusell, and Tsyvinski (2014) this study estimates the social cost of carbon in Jeju Island for the first time in Korea. We find that social cost of carbon in Jeju Island based on year 2019 are estimated between ₩20.5 and ₩36.5 billion. These results amount to the social cost of carbon of a range from ₩16,000 to ₩29,000 per ton carbon in Jeju Island.