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( Daniel H. Cox ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.10
Due to its high external and low internal concentration the Ca2+ ion is used ubiquitously as an intracellular signaling molecule, and a great many Ca2+-sensing proteins have evolved to receive and propagate Ca2+ signals. Among them are ion channel proteins, whose Ca2+ sensitivity allows internal Ca2+ to influence the electrical activity of cell membranes and to feedback-inhibit further Ca2+ entry into the cytoplasm. In this review I will describe what is understood about the Ca2+ sensing mechanisms of the three best studied classes of Ca2+-sensitive ion channels: Large-conductance Ca2+-activated K+ channels, small-conductance Ca2+-activated K+ channels, and voltage- gated Ca2+ channels. Great strides in mechanistic understanding have be made for each of these channel types in just the past few years. [BMB reports 2011; 44(10): 635-646]
육상의 직립구조물에 미치는 지진 해일에 의한 수평 파력 및 파압에 대한 수리모형실험
박형수,Daniel Cox,신성원 한국해안,해양공학회 2017 한국해안해양공학회 논문집 Vol.29 No.6
지진해일은 그 파랑이 연안 도시로 범람하여 육상 구조물에 피해를 주게 된다. 육상 구조물에 미치는 파압 및 파력에 대한 연구는 육상 구조물의 안정성 설계의 중요한 요인 중 하나이다. 본 연구에서는 단순화한 박스구조물에 미치는 지진 해일의 수평 파력 및 파압에 대한 2차원 단면 수리모형실험을 수행하였다. 시간에 따른 수평 파압의 수직 분포와 파력을 파압계와 파력계를 사용하여 계측하여 상호 비교하였다. 또한, 쇄파의 형태도 다양하게 고려하여 계측하였다. 쇄파된 파랑이 입사하는 경우 구조물에 미치는 수평 파력이 최대가 되는 순간에는 수평 파압이 수직적으로 균일하였고, 그 외의 경우에는 육상 저면에 가까울수록 수평 파압이 커지는 분포를 보였다. 최대 수평 파력을 다양한 입사파랑 조건에 대한 함수로 표현하기 위해 쇄파상사계수를 사용하여 수평 파력과의 관계식을 산출하였다. 그 결과 무차원화한 수평 파력은 쇄파상사계수가 증가함에 따라 지수적으로 감소하는 경향을 있음을 보였다. The tsunami flood the coastal cities and damage the land structures. The study on wave pressure and force on land structures is one of the important factors in designing the stability of inland structures. In this study, two - dimensional wave flume tests on the horizontal wave force and pressure of tsunamis on a simplified box-type structure was conducted. Vertical distribution and wave power of horizontal wave pressure over time were measured by pressure sensors and force transducer. Also, those were measured from the different wave breaking types. The vertical distribution of horizontal wave pressure was uniform at the moment when the horizontal wave force to the structure was maximum under the breaking wave condition. A surf similarity parameter was employed in order to figure out the relationship between the maximum horizontal wave force on the structure as a function of various incident wave conditions. As a result, the non - dimensionalized horizontal wave force tends to decrease exponentially as the surf similarity parameter increases.
Application of the Goda Pressure Formulae for Horizontal Wave Loads on Elevated Structures
Dane M. Wiebe,박형수,Daniel T. Cox 대한토목학회 2014 KSCE JOURNAL OF CIVIL ENGINEERING Vol.18 No.6
Small-scale physical experiments were conducted to investigate the application of the Goda wave pressure formulae modified to predictthe horizontal wave loads on elevated structures considering non-breaking, broken, and impulsive breaking waves. The air gap defined asthe vertical distance from the still water level to the base of the structure played a key role in the reduction of wave impact forces. Physicalmodel results using random waves confirmed that the modified application of the Goda wave pressure formulae provided a good estimateof the horizontal forces on elevated structures for both broken and impulsive breaking waves. As the air gap was increased, the resultingforces decreased, and the estimated values became increasingly conservative. When the ratio of the air gap to water depth, a/h', increasedfrom -1.0 to 1.5, the reduction in force was approximately 75% when the wave height to breaking water depth ratio, H/hb, was equal to unity.