GLOBAL ATTRACTOR FOR A SEMILINEAR PSEUDOPARABOLIC EQUATION WITH INFINITE DELAY

Thanh, Dang Thi Phuong Korean Mathematical Society 2017 대한수학회논문집 Vol.32 No.3

In this paper we consider a semilinear pseudoparabolic equation with polynomial nonlinearity and infinite delay. We first prove the existence and uniqueness of weak solutions by using the Galerkin method. Then, we prove the existence of a compact global attractor for the continuous semigroup associated to the equation. The existence and exponential stability of weak stationary solutions are also investigated.

An Empirical Study of Commodity Market Patterns in Ethnic Minorities and Mountainous Areas: Evidence from Vietnam

Trinh Thi Thanh THUY,Nguyen Thi BINH,Trinh Thi Thu HUONG,Nguyen Thu THUY,Dang Thanh PHUONG,Tran Thi Bao KHANH,Nguyen Thi YEN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.11

The development of the ethnic minorities and mountainous areas (EMMA) is currently receiving the attention of countries around the world. This is demonstrated through a large number of studies, in many respects, in many different countries. The objective of the study is to find out the current situation of the commodity market in the ethnic minorities and mountainous areas (EMMA) of Vietnam. In particular, the authors will study whether there is a link between the ability to access governmental policies and the characteristics of this commodity market. To achieve the goal, the authors employed the secondary data collection method to gather the relevant information on government policies for EMMA and conducted an interview of seventy (70) enterprises in the Northern midlands and mountainous regions and the Central Coast to clarify the characteristics of commodity market. By Levene’s test, the results showed that the accessibility to governmental policies has a certain influence on the development of the commodity market patterns in the EMMA in terms of diversification of distribution forms and sales method of the business. These findings brought some basic solutions to further enhance the role of the government in developing commodity markets in the EMMA of Vietnam.

HER2 Status and Its Heterogeneity in Gastric Carcinoma of Vietnamese Patient

Dang Anh Thu Phan,Vu Thien Nguyen,Thi Ngoc Ha Hua,Quoc Dat Ngo,Thi Phuong Thao Doan,Sao Trung Nguyen,Anh Tu Thai,Van Thanh Nguyen 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.4

Background: Human epidermal growth factor receptor 2 (HER2) is related to the pathogenesis and poor outcome of numerous types of carcinomas, including gastric carcinoma. Gastric cancer patients with HER2 positivity have become potential candidates for targeted therapy with trastuzumab. Methods: We investigated 208 gastric cancer specimens using immunohistochemistry (IHC), fluorescence in situ hybridization and dual in situ hybridization (ISH). We also investigated the concordance between IHC and ISH. The correlation between HER2 status and various clinicopathological findings was also investigated. Results: In total, 15.9% (33/208) and 24.5% (51/208) of gastric cancers showed HER2 gene amplification and protein overexpression, respectively. A high level of concordance between ISH and IHC analyses (91.3%, κ = 0.76) was found. A significant correlation between HER2 status and intestinal-type (p < .05) and differentiated carcinomas (p < .05) was also noted. The HER2 heterogeneity was high in gastric cancers; we found 68.8% phenotypic heterogeneity and 57.6% genotypic heterogeneity. Heterogeneity in HER2 protein expression and gene amplification showed a close association with diffuse histologic type and IHC 2+. Conclusions: HER2 protein overexpression and gene amplification were detected in 24.5% and 15.9% of gastric cancer specimens, respectively. Intestinal-type showed a higher level of HER2 protein overexpression and gene amplification than diffuse type. HER2 status also showed a significant relationship with well- and moderately-differentiated carcinomas. The ratio of phenotypic and genotypic heterogeneity of HER2 was high in gastric carcinomas and was associated with HER2 IHC 2+ and diffuse histologic type.

The Impact of Consumer Ethnocentrism on Purchase Intention: An Empirical Study from Vietnam

Thanh Ngoc Dan NGUYEN,Phuong Nhu DANG,Phu Hoang TRAN,Trang Thi Thuy NGUYEN 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.2

Ethnocentrism in users plays an important role in predicting user behavior when deciding between imported and domestic goods. The purpose of this study is to look into the influence of ethnocentrism in customer behavior on brand image, perceived value, perceived quality, brand trust, and brand buy intention. Vietnamese customers prefer homegrown brands. The moderate role of consumer ethnocentrism in the conceptual framework emphasizes the country origin of the product is the most important factor. It also demonstrates how the intention of Vietnamese consumers to buy domestic brands is substantially influenced. To test the hypothesis, this article used a quantitative technique utilizing PLS-SEM software. With 917 samples, the study used the quota sampling approach to collect data from students at 10 universities in Ho Chi Minh City. The data suggest that all players have a positive association and that consumer ethnocentrism has a moderate impact in the Vietnamese brand context. Following that, suggestions are made to help Vietnamese firms create and retain their brands in the face of severe competition from global brands in the domestic market. To increase consumer intent in purchasing behavior, the Vietnamese local company needs to establish a strong brand.

Design, synthesis and evaluation of novel <i>N</i>-hydroxybenzamides/<i>N</i>-hydroxypropenamides incorporating quinazolin-4(3<i>H</i>)-ones as histone deacetylase inhibitors and antitumor agents

Hieu, Doan Thanh,Anh, Duong Tien,Tuan, Nguyen Minh,Hai, Pham-The,Huong, Le-Thi-Thu,Kim, Jisung,Kang, Jong Soon,Vu, Tran Khac,Dung, Phan Thi Phuong,Han, Sang-Bae,Nam, Nguyen-Hai,Hoa, Nguyen-Dang Elsevier 2018 Bioorganic chemistry Vol.76 No.-

<P><B>Abstract</B></P> <P>In our search for novel small molecules targeting histone deacetylases, we have designed and synthesized several series of novel <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides incorporating quinazolin-4(3<I>H</I>)-ones (<B>4a-h</B>, <B>8a-d, 10a-d)</B>. Biological evaluation showed that these hydroxamic acids were generally cytotoxic against three human cancer cell lines (SW620, colon; <I>PC</I>-3, prostate; NCI-H23, lung cancer). It was found that the <I>N</I>-hydroxypropenamides (<B>10a-d)</B> were the most potent, both in term of HDAC inhibition and cytotoxicity. Several compounds, e.g. <B>4e</B>, <B>8b-c</B>, and <B>10a-c</B>, displayed up to 4-fold more potent than SAHA (suberoylanilide hydroxamic acid, vorinostat) in term of cytotoxicity. These compounds also comparably inhibited HDACs with IC<SUB>50</SUB> values in sub-micromolar range. Docking experiments on HDAC2 isozyme revealed some important features contributing to the inhibitory activity of synthesized compounds, especially for propenamide analogues. Importantly, the free binding energy computed was found to have high quantitative correlation (<I>R</I> <SUP>2</SUP> ∼ 95%) with experimental results.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel quinazolin-4(3H)-one-based <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides were synthesized. </LI> <LI> The <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides exhibited potent HDAC inhibition. </LI> <LI> The <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides exhibited good cytotoxicity. </LI> <LI> Docking studies and ADMET estimation were carried out. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Two series of novel, simple <I>N</I>-hydroxybenzamides/<I>N</I>-hydroxypropenamides incorporating quinolin-4(3H)-one (<B>4a-h</B>, <B>8a-d, 10a-d</B>) were designed and synthesized. Biological evaluation showed that these benzamides/propenamides potently inhibited HDAC with IC<SUB>50</SUB> values in sub-micromolar range. A number of compounds also exhibited cytotoxicity up to 4-fold more potent than SAHA, a positive control.</P> <P>[DISPLAY OMISSION]</P>

Chitosan Oligomer as a Hopeful Adjuvant for H5n1 Influenza Vaccine

( Le Van Hiep ),( Mai Thi Thanh ),( Dang Thi Hong Van ),( Vo Thi Phuong Khanh ),( Nguyen Anh Dzung ) 한국키틴키토산학회 2008 한국키틴키토산학회지 Vol.13 No.1

Effect of Chitosan oligomer (dp = 8-16) and other adjuvant such as: Aluminum phosphate (AlPO4) and Freund on immune response of H5N1 influenza vaccine in Swiss mice has been investigated. The Swiss mice were twice vaccinated alternative 20 days with dose 0.1 ml/mouse. After 10, 20 and 30 days, the immune response of Swiss mice with H5N1 vaccine was detected. The result showed that after 20 days of the first vaccination, immune response of chitosan oligomer test and Freund was 100%, but Freund test reduced 80% after 30days of vaccination. Meanwhile, immune response of the control and AlPO4 test was very low, only 40%. The Effect of chitosan oligomer and the others on antibody titer has been also investigated. The result showed that the antibody titer of chitosan oligomer test was 60 HIU (Hemagglutination units), 70 HIUs after 10 and 20 days of the first vaccination, and increased up to 112 HIUs after 10 days of the second vaccination and the antibody titer of the chitosan oligomer test was higher than the others. Therefore, chitosan oligomer is a hopeful adjuvant for H5N1 influenza vaccine.

One-Pot Preparation of Antibacterial Electrospun Polycaprolactone Membrane Embedded with Gamma Irradiation-Induced Silver Nanoparticles

Chien Minh Tran,Ngoc Thi‑Thanh Nguyen,Minh Hieu Ho,Vinh Khanh Doan,Khanh Loan Ly,Nhi Ngoc‑Thao Dang,Nam Minh‑Phuong Tran,Hoai Thi‑Thu Nguyen,Long Phuoc Truong,Thai Minh Do,Quyen Ngoc Tran,Hien Quoc Ng 한국섬유공학회 2023 Fibers and polymers Vol.24 No.1

In this study, we proposed a straightforward electrospun polycaprolactone (PCL) loaded with silver nanoparticles (SNPs)membrane fabrication process, in which SNPs were directly synthesized from silver nitrate (AgNO3) in PCL–acetone mixtureby gamma irradiation. The insolubility of AgNO3in PCL solution was solved using an auxiliary dimethyl sulfoxide solvent. As a physical approach, gamma rays readily converted silver ions into SNPs without the addition of harmful reductionagents, which reduced the cytotoxicity of the synthesized material. By avoiding some processes such as purification, solventremoval, or redispersion of SNPs, this method was more time-saving compared to other related studies. SNPs formation wasconfirmed by both UV–Visible spectrum (UV–Vis) and X-ray diffraction analysis. Scanning electron microscopy (SEM)revealed that the addition of SNPs significantly reduced the fiber diameter of PCL–Ag membranes compared to that of rawPCL. Uniform spherical-shaped SNPs incorporated in PCL fibers were observed under transmission electron microscopy(TEM). The tensile test showed that the electrospun PCL–Ag membranes exhibited good mechanical characteristics. Moistureeasily penetrated the porous microstructure of PCL–Ag, facilitating wound humidity regulation. Inductively coupledplasma-mass spectroscopy (ICP-MS) was employed to study the release profiles of SNPs at different time intervals. Overall,the PCL–Ag 500 ppm sample exerted excellent antibacterial activity against Pseudomonas aeruginosa and Staphylococcusaureus strains and low in vitro cytotoxicity.

The Impact of Corporate Social Responsibility on Brand Value and Financial Performance: Evidence from Bancassurance Service Providers in Vietnam

NGUYEN, Xuan Hung,DANG, Thuy Quynh,DINH, Thi Thao Quyen,DO, Phuong Thanh,PHAM, Thu Uyen,MAI, Duc Duong Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.6

The objective of this article is to assess the impact of corporate social responsibility (CSR) implementation on Corporate Brand Value (CBV) and Corporate Financial Performance (CFP). At the same time, the article examines the mediated role of CBV on the relationship between CSR implementation and CFP. In-depth interviews and observation techniques were used in this article on 4 experts to collect qualitative information. Quantitative analysis was based on primary data obtained from 454 employees working at enterprises providing Bancassurance services. The article uses various models of Cronbach's Alpha coefficient, Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and Structural Equation Analysis (SEM) using SPSS 22.0 and AMOS 20.0 software. In addition, a 5-point Likert scale is used to measure observed variables. Research results show that CBV plays an intermediate role in the relationship between CSR implementation and CFP. At the same time, the implementation of CSR toward communities, customers, and workers directly impacts CBV and CFP. The article draws a new conclusion; there is no relationship found between the implementation of CSR and CFP. The result proposes implications for the state and Bancassurance service providers to develop and implement CSR-related policies and activities to enhance their brand value and financial performance.

EXISTENCE AND LONG-TIME BEHAVIOR OF SOLUTIONS TO NAVIER-STOKES-VOIGT EQUATIONS WITH INFINITE DELAY

Anh, Cung The,Thanh, Dang Thi Phuong Korean Mathematical Society 2018 대한수학회보 Vol.55 No.2

In this paper we study the first initial boundary value problem for the 3D Navier-Stokes-Voigt equations with infinite delay. First, we prove the existence and uniqueness of weak solutions to the problem by combining the Galerkin method and the energy method. Then we prove the existence of a compact global attractor for the continuous semigroup associated to the problem. Finally, we study the existence and exponential stability of stationary solutions.

Existence and long-time behavior of solutions to Navier-Stokes-Voigt equations with infinite delay

Cung The Anh,Dang Thi Phuong Thanh 대한수학회 2018 대한수학회보 Vol.55 No.2

In this paper we study the first initial boundary value problem for the 3D Navier-Stokes-Voigt equations with infinite delay. First, we prove the existence and uniqueness of weak solutions to the problem by combining the Galerkin method and the energy method. Then we prove the existence of a compact global attractor for the continuous semigroup associated to the problem. Finally, we study the existence and exponential stability of stationary solutions.