Consensus recommendations for patient-centered therapy in mild-to-moderate ulcerative colitis: the i Support Therapy-Access to Rapid Treatment (iSTART) approach

( Silvio Danese ),( Rupa Banerjee ),( Jr Fraser Cummings ),( Iris Dotan ),( Paulo G Kotze ),( Rupert Wing Loong Leong ),( Kristine Paridaens ),( Laurent Peyrin-biroulet ),( Glyn Scott ),( Gert Van Ass 대한장연구학회 2018 Intestinal Research Vol.16 No.4

Symptomatic ulcerative colitis (UC) can be a chronic, disabling condition. Flares in disease activity are associated with many of the negative impacts of mild-to-moderate UC. Rapid resolution of flares can provide benefits to patients and healthcare systems. i Support Therapy-Access to Rapid Treatment (iSTART) introduces patient-centered care for mild-to-moderate UC. iSTART provides patients with the ability to self-assess symptomology and self-start a short course of second-line treatment when necessary. An international panel of experts produced consensus statements and recommendations. These were informed by evidence from systematic reviews on the epidemiology, mesalazine (5-ASA) treatment, and patient use criteria for second-line therapy in UC. Optimized 5-ASA is the first-line treatment in all clinical guidelines, but may not be sufficient to induce remission in all patients. Corticosteroids should be prescribed as second-line therapy when needed, with budesonide MMX^® being a preferred steroid option. Active involvement of suitable patients in management of UC flares has the potential to improve therapy, with patients able to show good accuracy for flare self-assessment using validated tools. There is a place in the UC treatment pathway for an approach such as iSTART, which has the potential to provide patient, clinical and economic benefits. (Intest Res 2018;16:522-528)

The Effects of the Somatic Cell Count on Yield, Composition and Coagulating Properties of Mediterranean Buffalo Milk

Tripaldi, C.,Terramoccia, S.,Bartocci, S.,Angelucci, M.,Danese, V. Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.5

The monitoring was carried out for one year on 20 farms of Mediterranean buffalo situated in central Italy. The milk yield, the somatic cell count, the coagulating properties and some components were determined. The average value of somatic cells was $21.28n{\times}10^3/ml$. Milk production decreased when somatic cell numbers increased. The rennet clotting time increased significantly when somatic cells were higher than $300.00n{\times}10^3/ml$, the curd firming time was significantly higher when somatic cells were more than $1,000.00n{\times}10^3/ml$ and the curd firmness increased up to $200.00n{\times}10^3$/ml, then gradually decreased. Protein and casein decreased when somatic cells increased and the same trend was shown by casein/protein ratio. Both for these components and the coagulating properties the threshold limit of somatic cells to obtain better results was $200.00n{\times}10^3/ml$. The somatic cell number did not show a trend which was strictly influenced by the lactation stage, contrary to what happened in the other species.

Influence of a Regular, Standardized Meal on Clinical Chemistry Analytes

Gabriel Lima-Oliveira,Gian Luca Salvagno,Giuseppe Lippi,Matteo Gelati,Martina Montagnana,Elisa Danese,Geraldo Picheth,Gian Cesare Guidi 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.4

Background: Preanalytical variability, including biological variability and patient preparation, is an important source of variability in laboratory testing. In this study, we assessed whether a regular light meal might bias the results of routine clinical chemistry testing. Methods: We studied 17 healthy volunteers who consumed light meals containing a standardized amount of carbohydrates, proteins, and lipids. We collected blood for routine clinical chemistry tests before the meal and 1, 2, and 4 hr thereafter. Results: One hour after the meal, triglycerides (TG), albumin (ALB), uric acid (UA), alkaline phosphatase (ALP), Ca, Fe, and Na levels significantly increased, whereas blood urea nitrogen (BUN) and P levels decreased. TG, ALB, Ca, Na, P, and total protein (TP) levels varied significantly. Two hours after the meal, TG, ALB, Ca, Fe, and Na levels remained significantly high, whereas BUN, P, UA, and total bilirubin (BT) levels decreased. Clinically significant variations were recorded for TG, ALB, ALT, Ca, Fe, Na, P, BT, and direct bilirubin (BD) levels. Four hours after the meal, TG, ALB, Ca, Fe, Na, lactate dehydrogenase (LDH), P, Mg, and K levels significantly increased, whereas UA and BT levels decreased. Clinically significant variations were observed for TG, ALB, ALT, Ca, Na, Mg, K, C-reactive protein (CRP), AST, UA, and BT levels. Conclusions: A significant variation in the clinical chemistry parameters after a regular meal shows that fasting time needs to be carefully considered when performing tests to prevent spurious results and reduce laboratory errors, especially in an emergency setting. Background: Preanalytical variability, including biological variability and patient preparation, is an important source of variability in laboratory testing. In this study, we assessed whether a regular light meal might bias the results of routine clinical chemistry testing. Methods: We studied 17 healthy volunteers who consumed light meals containing a standardized amount of carbohydrates, proteins, and lipids. We collected blood for routine clinical chemistry tests before the meal and 1, 2, and 4 hr thereafter. Results: One hour after the meal, triglycerides (TG), albumin (ALB), uric acid (UA), alkaline phosphatase (ALP), Ca, Fe, and Na levels significantly increased, whereas blood urea nitrogen (BUN) and P levels decreased. TG, ALB, Ca, Na, P, and total protein (TP) levels varied significantly. Two hours after the meal, TG, ALB, Ca, Fe, and Na levels remained significantly high, whereas BUN, P, UA, and total bilirubin (BT) levels decreased. Clinically significant variations were recorded for TG, ALB, ALT, Ca, Fe, Na, P, BT, and direct bilirubin (BD) levels. Four hours after the meal, TG, ALB, Ca, Fe, Na, lactate dehydrogenase (LDH), P, Mg, and K levels significantly increased, whereas UA and BT levels decreased. Clinically significant variations were observed for TG, ALB, ALT, Ca, Na, Mg, K, C-reactive protein (CRP), AST, UA, and BT levels. Conclusions: A significant variation in the clinical chemistry parameters after a regular meal shows that fasting time needs to be carefully considered when performing tests to prevent spurious results and reduce laboratory errors, especially in an emergency setting.

CSR POLICY AND PRACTICES: AN EMPIRICAL STUDY OF HIGH-END FASHION RETAIL

Virginia Fani,Alessandro Da Giau,Laura Macchion,Romeo Bandinelli,Federico Caniato,Maria Caridi,Pamela Danese,Rinaldo Rinaldi,Andrea Vinelli 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06

This paper aims to investigate the alignment between fashion companies’ CSR policy, as communicated through company website, and CSR retail practices customers can actually observe or get information about when visiting company’s retail stores. The case study analysis is carried out using the Mystery Shopping technique. The sample is made up of companies belonging to the top of the fashion luxury pyramid, whilst the visited stores are located in Italy. The purpose of this paper is to provide a classification of companies’ behaviours in deploying CRS policy at the retail level, and to highlight different levels of fit between companies’ CSR policy and CSR practices communicated at the retail-store level. Our results reveal that several companies show a mismatch between their CSR policy and CRS practices communicated in stores to customers.

Low-Dose Acetazolamide in the Treatment of Premenstrual Dysphoric Disorder: A Case Series

Gabriele Sani,Georgios D. Kotzalidis,Isabella Panaccione,Alessio Simonetti,Lavinia De Chiara,Antonio Del Casale,Elisa Ambrosi,Flavia Napoletano,Delfina Janiri,Emanuela Danese,Nicoletta Girardi,Chiara 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.1

The treatment of premenstrual dysphoric disorder (PMDD) is far from satisfactory, as there is a high proportion of patients who do notrespond to conventional treatment. The antidiuretic sulfonamide, acetazolamide, inhibits carbonic anhydrase and potentiates GABAergictransmission; the latter is putatively involved in PMDD. We therefore tried acetazolamide in a series of women with intractable PMDD. Here, we describe a series of eight women diagnosed with DSM-IV-TR PMDD, five of whom had comorbidity with a mood disorder andone with an anxiety disorder, who were resistant to treatment and responded with symptom disappearance after being added-on 125mg/day acetazolamide for 7-10 days prior to menses each month. Patients were free from premenstrual symptoms at the 12-month follow-up. We suggest that acetazolamide may be used to improve symptoms of PMDD in cases not responding to other treatments. GABAergicmechanisms may be involved in counteracting PMDD symptoms.

Knowledge Sharing Behavior in Indonesia: An Application of Planned Behaviour Theory

NEGARA, Danes Jaya,FERDINAND, Ferdinand,MEITIANA, Meitiana,ASTUTI, Maria Haryulin,ANDEN, Trecy,SARLAWA6, Rita,MAHRITA, Ani Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3

The objective of this research is to empirically study public servant knowledge sharing intention by implementing the Theory of Planned Behavior (TPB) of the Sustainable Development Goals (SDGs). The researcher proposes an extended TPB combined with a perceived environmental concern variable as a determinant of behavioral intention. A total of 150 questionnaires were distributed among civil society and the public sector at the district level in the Central Kalimantan Province of Indonesia. Collectively, 126 inquiries were received. A Partial Least Squares (PLS) analysis was applied to analyze and test the research model and hypothesis. The results show that all of the components of the TPB significantly influenced perceived SDG realization. The findings also partially show that knowledge sharing intention mediated the effect of attitude, perceived behavioral control, and perceived environmental concern on SDG realization. This study confirms that perspectives that affect knowledge sharing intention among public sectors could be approached based on the offered model. Hence, the local government can implement the suggestion offered in this research. The originality of this paper lies in the fact that this study discloses factors affecting knowledge sharing among public servants.

Resilience Perceived by Korean International Student/Scholar Families in the United States: Family Demands, Capabilities, and Adaptation

Lee, Jinhee,Danes, Sharon M. The Korean Home Economics Association 2015 International Journal of Human Ecology Vol.16 No.1

Although Korean international students/scholars are among the largest groups of international students/scholars on most campuses in the United States, little is known about what types of demands their families face and how they adapt successfully in the face of demands. The purpose of this study was to explore family resilience, which consists of family demands, capabilities, and adaptation, perceived by Korean international student/scholar families, being theoretically guided by the Family Adjustment and Adaptation Response (FAAR) model. Data were collected through face-to-face interviews with couple informants. Following procedures of theory-based content analysis, data were analyzed using key FAAR concepts. Findings showed that most informants reported normative types of family demands such as hardships due to childcare; primary family capabilities were "maintaining social integration," "affective and instrumental communication," and "family cohesiveness," and "nurturance, education, and socialization" was the primary family adaptation mode. New categories under family capabilities, "religious commitment" and "transnational family support" were developed. The results suggest that there is a unique set of family capabilities that contribute to the successful adaptation of Korean international student/scholar families. Implications and limitations are discussed.

Family Studies : Original Article ; Resilience Perceived by Korean International Student/ Scholar Families in the United States: Family Demands, Capabilities, and Adaptation

( Jinhee Lee ),( Sharon M Danes ) 대한가정학회 2015 International Journal of Human Ecology Vol.16 No.1

Although Korean international students/scholars are among the largest groups of international students/scholars on most campuses in the United States, little is known about what types of demands their families face and how they adapt successfully in the face of demands. The purpose of this study was to explore family resilience, which consists of family demands, capabilities, and adaptation, perceived by Korean international student/ scholar families, being theoretically guided by the Family Adjustment and Adaptation Response (FAAR) model. Data were collected through face-to-face interviews with couple informants. Following procedures of theorybased content analysis, data were analyzed using key FAAR concepts. Findings showed that most informants reported normative types of family demands such as hardships due to childcare; primary family capabilities were “maintaining social integration,” “affective and instrumental communication,” and “family cohesiveness,” and “nurturance, education, and socialization” was the primary family adaptation mode. New categories under family capabilities, “religious commitment” and “transnational family support” were developed. The results suggest that there is a unique set of family capabilities that contribute to the successful adaptation of Korean international student/scholar families. Implications and limitations are discussed.

Dual targeting of EphA2 and FAK in ovarian carcinoma.

Shahzad, Mian M K,Lu, Chunhua,Lee, Jeong-Won,Stone, Rebecca L,Mitra, Rahul,Mangala, Lingegowda S,Lu, Yiling,Baggerly, Keith A,Danes, Christopher G,Nick, Alpa M,Halder, Jyotsnabaran,Kim, Hye-Sun,Vivas- Landes Bioscience 2009 Cancer Biology & Therapy Vol.8 No.11

<P>EphA2 gene silencing has been shown to result in antitumor efficacy. Here we considered whether silencing additional targets downstream of EphA2 would further enhance the therapeutic effect. EphA2 targeted siRNA was tested in combination with either FAK or Src targeted siRNA using DOPC nanoliposomes in orthotopic models of ovarian carcinoma. The effects of therapy were determined by changes in tumor weight, proliferation (Ki-67), and microvessel density (CD31). In our initial in vivo study, EphA2 plus FAK silencing resulted in the greatest reduction in tumor growth (by 73%, p < 0.005) as compared to control siRNA alone. In the SKOV3ip1 and HeyA8 ovarian cancer models, EphA2 siRNA-DOPC treatment resulted in a 50-67% decrease in tumor growth (p < 0.02, for both), and FAK siRNA-DOPC resulted in a 61-62% decrease in tumor growth (p < 0.009, p < 0.05, respectively). EphA2 plus FAK siRNA-DOPC treatment resulted in a significant reduction (SKOV3ip1: 76%, p < 0.007, HeyA8: 90%, p < 0.003) in tumor growth compared to control siRNA-DOPC. Combination treatment with EphA2 + FAK siRNA-DOPC resulted in significant decreases in tumor cell proliferation (p < 0.001) and microvessel density compared to control siRNA-DOPC (80%; p < 0.001), or the monotherapy groups (p values <0.001). These data suggest that the antitumor efficacy of in vivo EphA2 targeting is enhanced in combination with FAK silencing. Dual targeting of EphA2 and FAK may have therapeutic implications for ovarian cancer management.</P>