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알칼리환원수 음용이 급성 염증성장질환 생쥐 모델에 미치는 영향
김단,김동희,등영건,최주봉,이규재 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.2
알칼리환원수 (Alkaline Reduced Water: ARW)는 아시아를 비롯한 여러 나라에서 음용수로 사용되고 있으며 항산화효과와 장내이상발효 개선효과 등을 중심으로 안전성과 유효성의 검증이 이루어지고 있다. 본 연구에서는 알칼리환원수가 급성 염증성대장질환 (Inflammatory Bowel Disease: IBD) 동물모델에 미치는 영향을 알아보기 위해, ARW를 2주 동안 급이 시킨 후 4% DDS로 염증성 대장염을 유발시키고 대장의 길이와 조직병리학적 변화를 관찰하였다. 그 결과 대장의 길이와 육안적, 현미경적 질환점수의 수치가 대조군과 비교하여 유의한 차이를 나타내지 않았다. 이 결과는 DSS로 유도된 급성 염증성장질환 모델에서는 2주 동안의 ARW 급이가 개선효과를 나타내지 않았음을 말해준다. 그러나 ARW 가 장내환경을 개선시키고 위장관의 질환을 개선시키는 효과가 있음을 고려해볼 때 급성 IBD 동물모델이 ARW의 효과를 증명하기에 적합하지 않았거나 MARW의 급이기간이 장내환경을 개선할 만큼 충분히 길지 않았을 가능성을 추측해 볼 수 있다. 알칼리환원수의 장내이상발효 개선효과는 확인되고 있으나 그 기전은 아직까지 구체적으로 확인되어지지 않고 있다. 이번 연구결과에 의하면 인위적으로 유발시킨 급성 염증성 동물모델에서 ARW가 유의한 영향을 미치지 않았지만, 다른 장질환 모델을 이용한 효과 검증과 ARW의 장기 급이에 따른 효과, 그리고 ARW 가 장내환경에 미치는 작용기전에 대한 연구가 더 깊이 있게 이루어져야 할 것으로 사료된다. Alkaline reduced water (ARW) has been used for drinking widely in several countries of Asia. The safety and clinical effects of ARW has been reported including anti-oxidative effect and intestinal abnormal fermentation. To confirm the effect of ARW on DSS-induced acute inflammatory bowel disease (IBD) mouse model, we observed the length of total large intestine and the histopathological changes after supplying mineral induced-ARW (MARW) for 2 weeks and oral administration of 4% DSS (dextran sulfate sodium). As the result, the length of total large intestine and the disease scores by macro and microscopical access in the ARWsupplied group showed no significant differences compared with those in the control group. This result suggests that the supply of ARW for 2 weeks exerted no effect on amelioration in the DSS-induced acute IBD model. However, in consideration of the effect of ARW on the improvement of intestinal environment and gastrointestinal disease, this result seems that acute IBD animal model is not suitable or the period of ARW supply is not enough to prove the effect of ARW. The ameliorative effect of ARW on the intestinal abnormal fermentation has been confirmed by some researchers, but the precise mechanism also remain unclear. In conclusion, although MARW had no effect on the DSS-induced acute experimental colitis model, further studies on the verification of the effects of ARW by using other intestinal disease model and by long-term supply of ARW will be required. Also, It needs to clear the mechanism of ARW on the intestinal environment.
산국 (Chrysanthemum boreale) 휘발성 추출액의 항균 및 항진균활성
차정단,김태영,우원홍,정규용,김강주,길봉섭 원광대학교 생체재료·매식연구소 1999 원광생체재료·매식 Vol.8 No.1
To investigate the antimicrobial and antifungal activity of Chrysanthemum boreale(C. boreale) essential oil, the growth inhibition against Aspergillus nidulans, Fusarium oxysporum, Alternaria mali, Staphylococcus aureus, Streotococcus pyogenes, Streptococcus mutans and Escherichia coli in the presence of the essental oil was monitored by agar dilution method. The antifungal effect of C. boreale on Aspergillus nidulans, Fusarium oxysporum and Alternaria mali as affected at the concentration of 400 ppm. The antibacterial effect of C. boreale on staphylococcus aureus, streptococcus pyogenes and Streptococcus mutans was affected at the concentration of 0.4 μl, while growth of E. coli was not inhibited at the concentration of essential oil. The results of this experiment on microorganisms indicated that naturally occuring chemical substances from C. boreale might have biologically toxic activities, that is, allelopathic potentials to the microorganisms.
( Dan Kyu Yoon ),( Hyo Jeong Ban ),( Young Jin Kim ),( Eun Jin Kim ),( Hyung Cheol Kim ),( Bok Ghee Han ),( Jung Won Park ),( Soo Jong Hong ),( Sang Heon Cho ),( Kie Jung Park ),( Joo Shil Lee ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.5
Allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis are heterogeneous diseases characterized by multiple symptoms and phenotypes. Recent advancements in genetic study enabled us to identify disease associated genetic factors. Numerous genome-wide association studies (GWAS) have revealed multiple associated loci for allergic diseases. However, the majority of previous studies have been conducted in populations of European ancestry. Moreover, the associations of single nucleotide polymorphisms (SNPs) with allergic diseases have not been studied amongst the large-scale general Korean population. Herein, we performed the replication study to validate the previous variants, known to be associated with allergic diseases, in the Korean population. In this study, we categorized three allergic related phenotypes, one allergy and two asthma related phenotypes, based on self-reports of physician diagnosis and their symptoms from 8,842 samples. As a result, we found nominally significant associations of 6 SNPs with at least one allergic related phenotype in the Korean population. [BMB reports 2012; 45(5): 305-310]
Effect of Mineral-induced Alkaline Reduced Water on Sprague-Dawley Rats Fed on High-fat Diet
Jin Dan,Park Seung-Kyu,Lee Young-Mi,Yoon Yang-Suk,Kim Dong-Heui,Deung Young-Kun,Lee Kyu-Jae The Korean Society for Biomedical Laboratory Scien 2006 Journal of biomedical laboratory sciences Vol.12 No.1
Mineral-induced alkaline-reduced water (MRW) is generated by the chemical reaction of water with alkaline earth metals and characterized by high pH and low oxidation-reduction potential. As ROS are believed to have a role in the pathogenesis of obesity, we attempted to determine the effect of MRW on obesity in Sprague-Dawley (SD) rats fed on a high-fat diet. The body weight of the MRW group was significantly lower than that of the control group in most periods of the examination (P<0.05). Serum level of triglycerides (p<0.05) and fat deposition in the livers of the MRW group were found to have been significantly reduced. This suggests that MRW down-regulates lipid metabolism, thereby suppressing obesity. Possible mechanisms of MRW related to reactive oxygen species were also discussed. Our results suggest that MRW is effective in the alleviation of obesity in SD rats fed on high-fat diet.
( Kyu Bong Yoo ),( Jong Soo Kim ),( Jin Wan Park ),( Yun Dan Kang ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: The major reason of preterm premature rupture of the amniotic membrane (pPROM)is an inflamed amniotic membrane barrier due to infection. The inflammation is related with a disturbance in the tight and adhesion junctions. However, the relationship between pPROM and the profile of tight and adhesion junctions is unclear. We investigated the profile of protein expression between tight junction and adhesion molecules on the fetal membranes of patients with pPROM. 방법: We collected pPROM samples under approval by the institutional review board of Dankook University. The fetal membranes were subjected to immunocytochemistry for the qualitative pattern and to Western blot for quantitative expression of tight junction and adhesion proteins 결과: We found significant changes in the properties of occludin as a tight junction for pPROM. Base on the immunohistochemistry, occludin showed a loss of polarization on the fetal membranes of patients with pPROM. But ZO-1 and claudin were not different between normal and pPROM membranes. Western blot data also showed that ZO-1 and occludin had no relationship with pPROM symptoms, whereas occludin showed decreased expression pattern compared with that of normal membranes. Interestingly, integrin beta1 expression decreased significantly in pPROM samples compared with that in normal samples. Therefore, inflammation may be correlated with adhesion signaling thought the integrin receptor of the extracellular matrix. 결론: The results suggest that claudin may be involved as a major factor in pPROM in humans. Occludin showed a loss of polarity on the membranes of patients with pPROM and a decreased expression ratio compared with that of normal membranes. Additionally, integrin beta1 was involved as an adhesion factor in pPROM processing of the amniotic membrane. We found a dramatic decrease in the integrin beta1 receptor on the fetal membrane of patients with pPROM. More study is needed to determine how adhesion signaling is related to pPROM.