Analysis of cutaneous malignant tumors - 10 years single center study

( Daeyoung Oh ),( Dae Won Koo ),( Kyung Eun Jung ),( Joong Sun Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Occurrence of cutaneous malignant tumors has been increasing worldwide due to changes in various environmental factors. However, there are little statistical studies in Korea. Objectives: The purpose of this study was to analyze the clinical characteristics in single center patients with cutaneous malignant tumors, according to the sex, age, duration, size, anatomic site, treatments and accompanying diseases. Methods: We retrospectively reviewed the medical records, clinical photographs of 327 patients diagnosed as cutaneous malignant tumors (squamous cell carcinoma, basal cell carcinoma, melanoma, angiosarcoma, Kaposi sarcoma, lymphoma, dermatofibrosarcoma protuberans, metastatic cancer, Paget disease) and 107 patients diagnosed as premalignant tumor (Bowen’s disease). Results: We retrospectively reviewed the medical records, clinical photographs of 327 patients diagnosed as cutaneous malignant tumors (squamous cell carcinoma, basal cell carcinoma, melanoma, angiosarcoma, Kaposi sarcoma, lymphoma, dermatofibrosarcoma protuberans, metastatic cancer, Paget disease) and 107 patients diagnosed as premalignant tumor (Bowen’s disease). Conclusion: Our study is overall review about the cutaneous malignant tumors. On the basis of this data, additional risk factors or prognostic factors of the tumors can be found later in further studies.

Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

Oh, Daeyoung,Han, Seungnam,Seo, Jinsoo,Lee, Jae-Ran,Choi, Jeonghoon,Groffen, John,Kim, Karam,Cho, Yi Sul,Choi, Han-Saem,Shin, Hyewon,Woo, Jooyeon,Won, Hyejung,Park, Soon Kwon,Kim, Soo-Young,Jo, Jihoon The Society 2010 The Journal of neuroscience Vol.30 No.42

<P>Rho family small GTPases are important regulators of neuronal development. Defective Rho regulation causes nervous system dysfunctions including mental retardation and Alzheimer's disease. Rac1, a member of the Rho family, regulates dendritic spines and excitatory synapses, but relatively little is known about how synaptic Rac1 is negatively regulated. Breakpoint cluster region (BCR) is a Rac GTPase-activating protein known to form a fusion protein with the c-Abl tyrosine kinase in Philadelphia chromosome-positive chronic myelogenous leukemia. Despite the fact that BCR mRNAs are abundantly expressed in the brain, the neural functions of BCR protein have remained obscure. We report here that BCR and its close relative active BCR-related (ABR) localize at excitatory synapses and directly interact with PSD-95, an abundant postsynaptic scaffolding protein. Mice deficient for BCR or ABR show enhanced basal Rac1 activity but only a small increase in spine density. Importantly, mice lacking BCR or ABR exhibit a marked decrease in the maintenance, but not induction, of long-term potentiation, and show impaired spatial and object recognition memory. These results suggest that BCR and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive Rac1 activity negatively affects synaptic and cognitive functions.</P>

An association between the reduced levels of SLC1A2 and GAD1 in the dorsolateral prefrontal cortex in major depressive disorder: possible involvement of an attenuated RAF/MEK/ERK signaling pathway.

Oh, Dong Hoon,Oh, Daeyoung,Son, Hyeon,Webster, Maree J,Weickert, Cyndi S,Kim, Seok Hyeon Springer 2014 JOURNAL OF NEURAL TRANSMISSION Vol.121 No.7

<P>Previous human postmortem studies have shown that expression of glutamate transporters (SLC1A2 and SLC1A3) and gamma-aminobutyric acid-synthesizing enzyme [glutamic acid decarboxylase 1 (GAD1)] are reduced in the dorsolateral prefrontal cortex (dlPFC) in subjects with major depressive disorder (MDD). However, no studies have explored the association between these two molecules and its related biological processes in MDD because of limited postmortem sample availability. Data sharing using the Stanley neuropathology consortium integrative database (SNCID), a web-based tool that integrates datasets from the same postmortem brain samples, allowed us to reanalyze existing postmortem data efficiently. We found two datasets where the mRNA levels of GAD1 and SLC1A2 in subregions of the dlPFC were significantly and marginally lower in subjects with MDD (n = 15) than in controls (n = 15) (p = 0.045 and 0.057, respectively). In addition, there was a positive correlation between these two molecules (n = 30, p < 0.05). Spearman's rank correlation analysis using all available datasets revealed that the expression levels of both GAD1 and SLC1A2 mRNAs were commonly correlated with the expression levels of several neuropathological markers in the dlPFC in all of the SNCID subjects (n = 60, p < 0.001). Most of these markers are known to be involved in the RAF/MEK/ERK signal transduction pathway. This exploratory study provides an initial step for future studies to investigate an association between the reductions in SLC1A2 and GAD1 mRNA expression and their relation to the attenuation of the RAF/MEK/ERK signaling pathway in the dlPFC in MDD. The integration of the existing archival data may shed light on one important aspect of the pathophysiology of MDD.</P>

Fluoxetine-induced regulation of heat shock protein 90 and 14-3-3&epsis; in human embryonic carcinoma cells

Oh, Daeyoung,Choi, Mi Ran,Han, Dal Mu Ri,Chai, Young Gyu,Choi, Joonho Wolters Kluwer Health | Lippincott Williams Wilkin 2014 NEUROREPORT - Vol.25 No.17

Fluoxetine, a serotonin-selective reuptake inhibitor, exerts antidepressant and antianxiety effects on major depressive and anxiety disorders. Previous studies suggest that treatment with fluoxetine influences the expression of various proteins that are involved in proliferation, differentiation, and apoptosis in the neuronal cells of the brain. However, many aspects of the molecular pathways that modulate antidepressant action are not well understood. Here, with the aim of identifying proteins involved in antidepressant action, we examined the protein expression profile of human embryonic carcinoma (NCCIT) cells in response to fluoxetine treatment using proteomic techniques such as two-dimensional gel electrophoresis and matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS). We found several upregulated and downregulated proteins in fluoxetine-treated NCCIT cells, and then biochemically confirmed the increased expression of heat shock protein 90 and 14-3-3&epsis;, which play an essential role in many cellular mechanisms including cell cycle control and other signaling pathways. Our data suggest that the regulated expression of heat shock protein 90, 14-3-3&epsis;, and other identified proteins may be associated with the therapeutic action of fluoxetine.

Eye Movement Desensitization and Reprocessing for Posttraumatic Stress Disorder in Bipolar Disorder

Daeyoung Oh,Daeho Kim 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.3

지능형 스마트 TV 응용을 위한 BGOLAM 기반의 성별분류

오대영(Oh, Daeyoung),최지원(Choi, Jiwon),김창익(Kim, Changick) 한국방송·미디어공학회 2011 한국방송공학회 학술발표대회 논문집 Vol.2011 No.7

최근 스마트폰, 태블릿 PC와 같은 모바일 스마트 디바이스(mobile smart devices)와 더불어 스마트 TV에 대한 관심이 크게 증가하면서 사용자들의 컨텐츠와 기능에 대한 요구 또한 다양해지고 있다. 스마트 TV가 컨텐츠와 기능적 측면에서 사용자의 편의와 재미, 그리고 유익함을 동시에 만족시키기 위해서는 더욱 지능화된 기능을 탑재할 필요가 있다. 일반적으로 남녀에 따라 TV를 시청하는 경향이 다르기 때문에 현재 TV를 시청하는 사용자의 성별분류(gender classification)를 통해 성별에 따른 따른 채널이나 광고, 응용 프로그램을 달리 제공하는 성별 기반의 스마트 TV 응용을 개발할 수 있게 된다. 본 논문에서는 스마트 TV 응용에 적합한 BGOLAM 기반의 성별분류 방법에 대해 제안하고, 실험을 통해 제안하는 방법의 적절성을 보인다

Fabrication of Silicon Pyramid-Nanocolumn Structures with Lowest Reflectance by Reactive Ion Etching Method

Kong, DaeYoung,Oh, JungHwa,Pyo, Daeseung,Kim, Bonghwan,Cho, ChanSeob,Lee, JongHyun IOP Publishing 2013 Japanese journal of applied physics Vol.52 No.6

소규모 학교 통폐합에 따른 교육과정 만족도 비교 : 울산 A초등학교를 대상으로

오세희 ( Oh Sehee ),김대영 ( Kim Daeyoung ) 안암교육학회 2017 한국교육학연구 Vol.23 No.2

본 연구는 농산어촌 소규모 통폐합학교의 교육과정 만족도를 비교하여 현재 지속적으로 추진되고 있는 통폐합 학교의 교육과정 편성 · 운영 방안을 제안하는데 그 목적이 있다. 이를 위해 국내 최초로 3개의 학교가 통합되어 2016년 개교한 A초등학교를 대상으로 통폐합 과정에 주도적으로 참여하였던 교사들의 인터뷰를 통해 통폐합 과정에서 야기된 이슈들을 점검해 보았으며, 설문조사를 통해 A초등학교 구성원인 학생, 학부모, 교사를 대상으로 교육과정 만족도를 확인해 보았다. 통폐합 과정의 주요 쟁점은 인센티브나 폐교 활용 방안으로 실제적으로 교육과정에 대한 논의는 별로 진행되지 않았음을 확인할 수 있었다. 설문분석 결과는 전반적으로 통폐합 이후 A초등학교의 교육활동에 만족한다고 조사되었지만, 실제적으로 그 만족도는 교육과정에서 기인하기 보다는 교과외 활동(방과후 수업, 학교 특색사업)의 효과로 해석될 여지가 높게 나타났다. 이는 학교 통폐합 효과의 지속 가능성 측면에서 한계를 가질 수 있기에 본 연구에서는 이를 극복할 수 있는 방안을 제안하고 있다. This study was to examine the curriculum satisfaction of small-sized school consolidation to suggest school curricular for school consolidation by collecting and analyzing the qualitative and quantitative data on elementary school curriculum. For the study, focus group interview (FGI) was performed to gather information from the persons in charge of small-sized school consolidation of A elementary school in Ulsan province. Based on the results of FGI, the survey instrument was developed and distributed to students, parents and teachers in A elementary school. The results showed that all of students, parents and teachers satisfied the activities of A elementary school. However, long-term plans are needed for the small-sized school consolidation by developing school curricular. In this study, therefore, curriculum-reorganization of teachers in the level of instruction and school are suggested.

시냅스 접착 단백질과 구조 단백질의 정신과적 의의

오대영,Oh, Daeyoung 대한생물정신의학회 2010 생물정신의학 Vol.17 No.3

Synaptic adhesion molecules mediate synapse formation, maturation and maintenance. These proteins are localized at synaptic sites in neuronal axons and dendrites. These proteins function as a bridge of synaptic cleft via interaction with another synaptic adhesion molecules in the opposite side. They can interact with scaffold proteins via intracellular domain and recruit many synaptic proteins, signaling proteins and synaptic vesicles. Scaffold proteins function as a platform in dendritic spines or axonal terminals. Recently, many genetic studies have revealed that synaptic adhesion molecules and scaffold proteins are important in neurodevelopmental disorders, psychotic disorders, mood disorders and anxiety disorders. In this review, fundamental mechanisms of synapse formation and maturation related with synaptic adhesion molecules and scaffold proteins are introduced and their psychiatric implications addressed.

Starin gage를 이용한 Seat 구동용 Leadnut의 성능평가

김대영(Daeyoung Kim),이경태(Kyungtae Lee),이상배(Sangbae Lee),전용두(Yongdu Jeon),오범석(Bumsuk Oh) 한국자동차공학회 2011 한국자동차공학회 지부 학술대회 논문집 Vol.2011 No.5

In this experimental study, a strain gage system is used to evaluate leadnut performance for driving car seats. The tensile strain is measured at the leadnut which deforms the hole shape of leadnut from circle to ellipse. Therefore the driving force of leadscrew decreases by the deformed hole shape of leadnut. It could be concluded from this result that this experimental procedures are useful to find out the responsible mechanism that affects power seat leadnut performance.