Matched Comparison of Fusion Rates between Hydroxyapatite Demineralized Bone Matrix and Autograft in Lumbar Interbody Fusion

Kim, Dae Hwan,Lee, Nam,Shin, Dong Ah,Yi, Seong,Kim, Keung Nyun,Ha, Yoon The Korean Neurosurgical Society 2016 Journal of Korean neurosurgical society Vol.59 No.4

Objective : To compare the fusion rate of a hydroxyapatite demineralized bone matrix (DBM) with post-laminectomy acquired autograft in lumbar interbody fusion surgery and to evaluate the correlation between fusion rate and clinical outcome. Methods : From January 2013 to April 2014, 98 patients underwent lumbar interbody fusion surgery with hydroxyapatite DBM (HA-DBM group) in our institute. Of those patients, 65 received complete CT scans for 12 months postoperatively in order to evaluate fusion status. For comparison with autograft, we selected another 65 patients who underwent lumbar interbody fusion surgery with post-laminectomy acquired autograft (Autograft group) during the same period. Both fusion material groups were matched in terms of age, sex, body mass index (BMI), and bone mineral density (BMD). To evaluate the clinical outcomes, we analyzed the results of visual analogue scale (VAS), Oswestry Disability Index (ODI), and Short Form Health Survey (SF-36). Results : We reviewed the CT scans of 149 fusion levels in 130 patients (HA-DBM group, 75 levels/65 patients; Autograft group, 74 levels/65 patients). Age, sex, BMI, and BMD were not significantly different between the groups (p=0.528, p=0.848, p=0.527, and p=0.610, respectively). The HA-DBM group showed 39 of 75 fused levels (52%), and the Autograft group showed 46 of 74 fused levels (62.2%). This difference was not statistically significant (p=0.21). In the HA-DBM group, older age and low BMD were significantly associated with non-fusion (61.24 vs. 66.68, p=0.027; -1.63 vs. -2.29, p=0.015, respectively). VAS and ODI showed significant improvement after surgery when fusion was successfully achieved in both groups (p=0.004, p=0.002, HA-DBM group; p=0.012, p=0.03, Autograft group). Conclusion : The fusion rates of the hydroxyapatite DBM and Autograft groups were not significantly different. In addition, clinical outcomes were similar between the groups. However, older age and low BMD are risk factors that might induce non-union after surgery with hydroxyapatite DBM.

2010 해남, 평창, 원주지역 갈대 등 야초류의 이용실태와 사료가치 평가

서성(Sung Seo),한대덕(Dae Duk Han),장선식(Sun Sik Jang),김원호(Won Ho Kim),정민웅(Min Woong Jung),최진혁(Jin Hyuck Choi),김진숙(Jin Sook Kim),김하영(Ha Young Kim),이종경(Joung Kyong Lee) 한국초지조사료학회 2012 한국초지조사료학회지 Vol.32 No.1

본 연구는 부존 조사료자원 이용으로 수입사료를 줄이고 사료비를 절감하고자 2010년도에 전남 해남(간척지), 강원 평창(강변), 원주(섬강변), 전남 영광(와탄강변) 등 4개 지역에서 갈대와 억새 등 야초 자생지를 탐색하고, 수확·이용실태 조사와 함께 사료가치를 분석하였다. 전남 해남 해남목장 내 갈대(Phragmites communis) 위주의 야초 자생지는 300 ha로 예년에는 2회 곤포작업하여 연간 사일리지로 2,300~2,500톤(ha당 8톤)을 생산하였으나 2010년도는 1회 곤포조제로 사일리지 2,000톤(ha당 7톤)을 생산하였다. 유통가격은 롤 당 53천원으로 ㎏당 110원이었다. 곤포는 전량 자가소비하며, 외부 작업단에 롤 당 26천원의 작업비를 지불하였다. 연간 조수입은 2억 2,260만원이며, 소득은 1억원 수준(345천원/ha)이었다. 초장 150 ㎝의 갈대는 조단백질 8.4%, 상대사료가치 71.9 (건초 5등급), 건물 소화율 60.1%로 사료가치는 볏짚에 비해 약간 나은 것으로 평가되었다. 갈대 사일리지의 사료가치와 유기산 함량은 동일 지역에서 동일한 재료로 사일리지를 조제하더라도 수확시기에 따라 차이가 컸으며(CP 4.7~6.4%, RFV 62.2~78.9, 건물 소화율 41.9~53.9%), 갈대 사일리지의 품질은 수단그라스에 비해 불량하였다. 강원 평창 강변 자생갈대의 사료가치는 초장이 79, 117, 121, 142㎝로 생육이 진행됨에 따라 낮아져, 조단백질은 각각 13.9%에서 7.6%로, 상대사료가치는 90.7 (건초 3등급)에서 76.1 (건초 4등급)로, 건물 소화율은 72.9%에서 54.7%로 감소하였다. 원주 섬강 주변 야초류는 곤포수확 작업에 어려움이 있었으며, 초장 130 cm의 갈대는 조단백질 8.5%, 상대사료가치 82.3 (건초 4등급), 건물 소화율 70.2%로 사료가치는 높았으며, 220㎝의 성숙한 갈대는 조단백질 10.2%, 상대사료가치 65.1 (건초 5등급), 건물 소화율 48.9%로 볏짚 대비 조금 나은 것으로 평가되었다. 전남영광지역에서는 와탄천 주변에 자생하는 갈대를 수거 이용하고자 시도하였으나 경제성이 없어 중단하였다. 이상의 결과를 종합하여볼 때, 갈대, 억새 등 야초류는 현 상태에서 최대한 수거·이용하되, 사료가치를 유지하고 가축 기호성이 양호한 시기에 수확하는 것이 중요하며, 최소한 볏짚과 비슷하거나 그 이상의 사료가치를 기대하기 위해서는 7월 중순 이전(늦어도 7월까지)에 수확·이용하는 것이 권장된다. This study was carried out in 2010 to investigate the utilization and forage quality of native grasses, such as Phragmites communis which might reduce the cost of feeding domestic cattle. The regions surveyed were the Haenam ranch in Haenam, Pyeongchang, Wonju, and Yeonggwang. In Haenam, yearly silage production harvested from 300 ha was 2,000 MT (7 MT/ha). All of those round bale silages were self-consumed in that region, and marketing price was 50,000 55,000 won per roll (110 won/㎏). Phragmites communis of 150 ㎝ in length contained 8.4% crude protein (CP) with relative feed value (RFV) 71.9 and 60.1% in vitro dry matter digestibility (IVDMD), which was somewhat more favorable than forage quality of rice straw. The silage quality of Phragmites communis varied greatly by the time of harvest (CP 4.7 6.4%, RFV 62.2 78.9, and IVDMD 41.9 53.9%), even with the same district and of the same original forage materials. Generally, the quality of Phragmites communis silage of was poorer than that of sorghum * sudangrass hybrid. In Pyeongchang, forage quality of Phragmites communis was decreased from 13.9% to 7.6% in CP, 90.7 to 76.1 in RFV, and 72.9% to 54.7% in IVDMD, as plant was getting mature, from 79 ㎝ to 117 ㎝, 121 ㎝ or to 142 ㎝ in length. In Wonju, the quality values of Phragmites communis of 130 ㎝ in length were 8.5% CP, 82.3 RFV and 70.2% IVDMD, while those of matured grasses of 220 ㎝ in length were lower (10.2% CP, 65.1 RFV and 48.9% IVDMD), but this was a little more favorable than quality of rice straw. In Yeonggwang, feeding Phragmites communis was tried in a Hanwoo feed, but stopped due to low profitability. In conclusion, the overall quality of most native grasses including Phragmites communis in this survey was poor. Therefore, we recommend that Phragmites communis and native grasses should be harvested on June or July to obtain richer forage quality in forage values than rice straw.

돈분뇨 액비 시용이 양파의 생육, 양분흡수량 및 토양 화학성에 미치는 영향

이종태(Jong Tae Lee),하인종(In Jong Ha),김희대(Hee Dae Kim),문진성(Jin Seong Moon),김우일(Woo Il Kim),송원두(Won Doo Song) 한국원예학회 2006 원예과학기술지 Vol.24 No.2

벼와 양파 2모작 논토양에서 효율적인 돈분뇨 액비 시용을 위하여 액비 시용에 따른 양파의 생육, 양분흡수량 변화와 토양의 이화학적 특성을 조사하였다. 사용된 액비의 질소, 인산 및 칼륨 함량은 각각 4.2, 0.34, 1.2g kg⁻¹ 등이었다. 추비용 액비는 시용 10일 전에 물로 2배 희석하여 월 2회씩 4회와 6회로 나누어 시용하였다. 기비는 질소표준시비량 기준으로 19,280kg ha⁻¹로 시용하였으며 추비에 사용된 액비량은 101,910kg ha⁻¹이었다. 양파의 초장은 정식 136일 후부터 186일까지 급격히 증가하였으며 화학비료구, 액비기비+화학비료 추비구 및 액비기비+액비 4회 추비구 간에는 차이가 없었으나 무비구와 액비전량 기비구는 양분부족으로 생육이 저조하였다. 구 비대초기의 구경은 무비구에서 가장 컸으나 그 이후 화학비료구와 액비시용구에서 크게 증가하였다. 엽 생체중의 변화는 초장과 유사한 경향을 보인 반면 구 생체중은 구경과 비슷한 경향을 나타내었다. 초장과 엽중은 화학비료구와 액비전량 기비구 및 액비기비+액비 6회 추비구간 다소 작았으나 구경, 구중 및 엽수는 처리간 차이가 뚜렷하지 않았다. 양파 구와 잎의 양분흡수량은 전 생육기간에 시그모이드 형을 나타내었으며 잎과 구의 양분흡수량은 각각 잎과 구의 생육이 진전됨에 따라 증가하는 경향이었다. 화학비료구와 액비기비+화학비료 추비구 및 액비 4회 추비구간에 양분흡수량의 차이는 없었고 액비전량 기비구에서 잎의 질소와 칼륨흡수량이, 구의 질소흡수량이 화학비료구보다 적었다. 무비구는 질소, 칼륨 및 마그네슘 흡수량이 다른 처리구보다 적었다. 액비기비+액비 4회 추비구에서 질소와 인산이용률이 각각 23.5%, 13.2%로 가장 높았으나 액비기비+액비 4회 추비구에서 칼륨이용률이 높았고 상품 수량도 55.0Mg ha⁻¹로 가장 많았다. 구의 질소, 인산 및 칼륨함량은 생육이 진전됨에 감소하는 경향이었고 잎의 질소함량은 생육초기에 가장 많은 반면 칼륨함량은 구비대 초기에 가장 많았다. 수확 후 토양 pH, 질산태 질소, 교환성 칼륨 및 EC 농도는 화학비료구보다 액비시용구에서 약간 증가하였다. 본 연구 결과를 종합해 볼 때 돈분뇨 액비를 기비로 시용하고 3배 희석한 액비를 2월과 3월에 4회 추비하면 균형적인 양분공급이 가능하고 적정 수량도 확보할 수있었다. This study was carried out to evaluate the effect of liquid pig manure (LPM) on the nutrient uptake, yield of onion and soil properties. The LPM applied to onion field contained 4.2 g kg⁻¹ N, 0.34 g kg⁻¹ P, 1.2 g kg⁻¹ K and it was diluted with water by 1:2 for top-dressing, which was applied separately 4 or 6 times from February to April. The LPM application rate for basal fertilization was 19,280 kg ha⁻¹ which included 80 kg N, 6.6 kg P, and 22 kg K. The application rate for top-dressing was 101,910 kg ha⁻¹ which included 160 kg N, 13 kg P, and 53 kg K. The plant height was not almost different among treatments until 136 days after planting. Thereafter, it enlarged abruptly until 186 days, on May 4. The significant difference among CF and LPM + top-dressing by CF or LPM I was not shown, but no fertilizer and LPM only (it was applied totally as basal fertilization) made plant height of onion lessen at the maximum growth stage because of insufficient nutrients. The plant diameter increased after 136 days, and there was a significant difference between CF or LPM and no fertilizer from 186 days after planting. The leaf weight was similar tendency to plant height while bulb weight was similar to plant diameter. The amount of nutrient uptake in leaf coincided with leaf growth and the nutrient uptake in bulb swelled simultaneously with bulb growth. The difference between CF and LPM + top-dressing by CF or LPM I was not significant in nutrient uptake of onion leaf and bulb. But LPM only decreased in nitrogen and potassium of leaf and in nitrogen of bulb. And no fertilizer made a remarkable difference to others in nitrogen, potassium and magnesium of leaf and bulb. The utilization of nitrogen and phosphorus in LPM + top-dressing by CF were 23.5%, 13.2% respectively, more than the others. The LPM + top-dressing by LPM I was most available with potassium, and it leaded the most abundant marketable yield by 55.0 t ha⁻¹ as well. The nitrogen, phosphorus, and potassium contents in bulb were inclined to decrease with progress of onion growth. The nitrogen contents in leaf maximized at the initial growth stage while potassium contents increased at the initial bulbing stage. The LPM application increased pH, nitrate nitrogen, potassium and EC in soil more than chemical fertilizer (CF) did.

비글개에서 신원방우황청심원의 급성 및 아급성독성시험

성하정,권오경,방명주,곽형일,이진영,신대희,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with sinlge dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 ㎎/㎏/day (low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NSCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NSCH in beagle dogs is considered to be safe.

비글개에서 신우황청심원의 급성 및 아급성독성시험

권오경,성하정,곽형일,방명주,신대희,이진영,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New Woohwangchungsimwon (NWCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NWCH, 160 ㎎/㎏/day(low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NWCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NWCH in beagle dogs is considered to be safe.

텍스트 종류와 Cattell-Horn-Carroll(CHC) 인지요인과의 관계

김수연 ( Su Yhen Kim ),하대현 ( Dae Hyun Ha ) 한국독서학회 2006 독서연구 Vol.0 No.16

초등학교 아동을 대상으로 연구한 보고들을 살펴보면 이야기 텍스트 이해를 설명적 텍스트 이해보다 더 쉬워한다. 이런 차이는 주로 배경지식에 의한 것으로 해석되나 텍스트 이해는 개인의 인지 능력의 영향을 받으며, 인지적 능력의 부족이 이해 능력에 어려움을 가져온다. 본 연구에서는 텍스트의 종류에 따라 어떤 인지적 요인들이 관여하는지를 새로운 지능이론의 관점으로 알아보고자 한다. 본 연구에서 사용된 지능 검사는 현대의 지능이론으로 새로이 제안되는CHC(Cattell-Horn-Carroll) 지능 이론에 따르며 본 연구에서 사용된CHC 지능검사의 신뢰도는 .60-.79이며, 타당도 검증을 위한 탐색적 요인분석과 확인적 요인분석을 실시하여 타당도를 확인하였다. 개인내의 이야기 텍스트를 설명적 텍스트보다 더 이해하기 쉬워한다는 것을 통계적으로 확인하였다. 개인 간 차이로 이야기 텍스트를 더 잘 이해하는 집단과 설명적 텍스트를 더 잘 이해하는 집단 간의 인지적 차이를 살펴보았다. 이야기 텍스트 이해를 잘하는 집단이 Gc(결정지능)와 Ga(청각처리)는 p<.05에서 의미 있는 차이가 있었으며 Gsm(단기기억)은p<.01에서 의미 있게 높은 점수를 보여주었다. 이런 결과는 어려서의 읽기 경험은인지적 요인에 영향을 미치며, 이야기 텍스트를 어려서부터 접하고 경험한 아동의 Gc, Ga, Gsm이 높아질 수 있다는 것을 시사하여 준다. The present study was to explore the relationship between the narrative/expository texts and CHC cognitive ability in 4,5,6 grade elementary school. They were easier to understand the narrative texts than the expository, because of they had not only prior knowledge but also cognitive ability related text comprehension. On the view of recent CHC cognitive ability, this study investigated two types(narrative/ expository) of texts related cognition. The measures of CHC had high reliability and good validity - exploratory, confirmatory factor analysis. The subjects of this study were divided to two groups. The first group was more comprehensible to understand narrative text than expository text. The second group was more comprehensible to understand expository text than narrative text. Between two groups was verified from t-test. The results of this study clearly indicated that the first group was more significant to effect on Gc(comprehension knowledge), Ga(auditory processing) and Gsm (short-term memory) play an important role than the second group.

복어의 건조와 냉동에 의한 근육조직의 변화

하수용,하진환,송대진 濟州大學校 工科大學 産業技術硏究所 1991 産業技術硏究報告 Vol.2 No.-

The observations on the histological changes of muscular tissue during the processes, such as drying, freezing and thawing were carried out to get basic data for processes and storage of puffer, Fugu xanthopterus. The results are as follows : Epidermal part is tough and thick. That is connected with muscular tissue by soft and tough connective tissue . The muscular tissue structures of puffer are epidermis, corium and partially dark muscle, without hypodermic fat. According to the respective muscular parts, there exist crossed muscle fibers like abalone. The connective tissues of intercellular materials and myocommata were found abundantly. During the couresc of drying, the dehydration of muscular tissue occured on connective tissue in the early stage ; thus caused widening between muscle bundles respectively. In the late stage of drying, contraction of myocommata and the widening between muscle bundles were appeared. After frozen storage for a month, distributions of ice crystal were affected deeply by freezing temperature, that is. those were observed mainly on the intracellular sites when frozen at -35℃. while on the extracellular sites when frozen at -10℃. but the ice crystals formed in both temperatures caused the condensation of muscle fibers. Thawing fter frozen storage for a month, a recovery of muscle fibers and figuration were observed in muscular tissue stored at -35℃, while insufficien recovery of muscle fibers and disfiguration by dehydration at -10℃. In the observation of uscle figbers when the tissue was homogenated with 1% cold formali. the fresh tissue was fragmented to myofibril level and intermixed like thred, while the frozen tissue for a month became rigid due to disfiguration, contraction, the loss of elasticity and water holding capacity.

MIN-MAX SOFM과 객체 분석을 이용한 얼굴 검출 알고리즘 개발

하성욱,강대성,권기항 東亞大學校 附設 情報通信硏究所 1998 情報通信硏究所論文誌 Vol.6 No.1

This paper proposes a face region detecting algorithm in stream images. The main limitation of current face detection researches is the front face detection. But, the face detection in stream images needs to extract features in various angles. Current algorithms also are not enough to be applied to the real world from the several limited arguments as uniform luminous intensity, simple background, etc. This reserch suggests a detection algorithm of stream face images which is regardless of these limit arguments. The firs stage supports a proposition of MIN-MAX SOFM(self organizing feature maps) by applied MIN-MAX theory in SOFM which is independent on luminous intensity. After the first stage, the small regioin removing algorithin is processed for loss regions in SOFM output mode. We propose a histogram object analysis method which selects speedy recognized regions and a frame based moving detection method by moving real images.

정서지능의 지능성: 그 이해와 오해

하대현 인제대학교 아동ㆍ가족복지연구소 1996 아동ㆍ가족복지연구 Vol.1 No.-

본 논문의 주요 목적은 새로운 지능 개념으로서의 정서 지능(EI)를 이해하고, 그 개념의 타당성과 한계를 규명하고자 하는 것이다. 이외에 본 논문의 또 다른 목적은 현재 EI 개념에 대해 일반인들이 오해하고 있는 내용과 그 원인을 밝히고자 하는 것이다. 이런 목적하에 본문의 체제는 크게 세 부분으로 구성된다. 첫 번째 부분에서는 EI 개념을 현대 지능이론과 연구의 맥락 안에서 이해하기 위해서 먼저 Salovey와 Mayer의 EI 개념의 일반적인 성격을 개관하고, 그 특징적 내용을 지능의 본질, 측정, 훈련의 세 관점에서 분석한다. 두 번째 부분에서는 현대 지능이론가들의 EI 개념에 대한 비판점을 중심으로 새로운 지능 개념으로서의 EI의 타당성과 한계를 논의한다. 끝으로 세 번째 부분에서는 EI 개념의 어떤 내용이 왜 일반인들에게 오해되고 있는지를 밝히고, 아울러 EI에 대한 향후 연구 과제들을 제시한다. The purpose of this paper is to understand the intelligence of emotional intelligence(EI) and to examine its validity and limitations as a new concept of intelligence. In addition, another purpose is to show what and why laypersons have misunderstandings about EI. Under these purposes, the main body of this paper is largely divided into three parts. In the first part, in order to understand EI in the context to contemporary theories and research traditions of intelligence, first of all, the general nature of the EI proposed by P. Salovey and J. Mayer in both 1990 and 1997 is reviewed and then some important features of EI are clarified in terms of three perspectives such as the basic nature, the meausrement or assessment, and the training of intelligence. In the second part, some degree and/or kind of the validity and limitation of EI are discussed on the basis of some of modern theorists' criticisms of it. In the final and third part, what contents of EI make laypersons misunderstood and why they have them do are discussed. And the paper concludes with some suggestions for future research on EI.

MMSOFM과 블록 매칭을 이용한 얼굴 추출 방법에 관한 연구

하성욱,강대성 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.1

It had be shown that features can be characterized in various background images, and that this methods can be overcome for numerous limited vectors. Possible applications of such techniques could be, in fact, found in few different fields, ranging from machine vision to video compression. In this paper an algorithm, based on MMSOFM(Min-Max self organizing feature map), block matching and moving perception, for moving stream images of frame, and features based face shape is described. The perpomance of the proposed algorithm, with considerable reduction in computation. The number of face extraction improves as the trained vectors alapted on MMSOFM and block matching.