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이원영,조근호,박천호 한국화훼연구회 2001 화훼연구 Vol.9 No.1
This study focuses on changes in the kinds of flowers, colors, shapes of bridal bouquet in Korea for 50 years from 1950's to 1990's. The results show that two to three kinds of flowers were used in 1960's and 1970's, but various materials were used in 1980's and 1990's. White chrysanthemums rank first in 1950's and 1960's, carnations in 1970's, but roses and cymbidiums in 1980's, and use of cymbidiums, roses, and denphalae increased in 1990's. When it comes to foliage, camellia leaf used most frequently until 1960's and Asparagus in 1970's, but use of various tropical foliage such as scindapsu, ivy, Rumora fern increased in 1980's. In colors, white was most preferred in 1950's and 1960'sl pink was added in 1970's, but both white and pink were used in bouquet and boutonniere in 1990's. In shape, large arm bouquet was most preferred in 1950's. Round bridal bouquet with long asparagus stem was most favorite style in 1960's and 1970's, cascade shape and empire bouquet in 1980's, and various bridal bouquet such as cascade, round, triangular and free style in 1990's. In boutonniere they used triangular most frequently.
신경망 확산망을 이용한 항만물류 연속 음성인식시스템에 관한 연구
이창민,장종칠,이춘근 東義大學校産業技術開發硏究所 2003 産業技術硏究誌 Vol.17 No.-
항만 물류 시스템의 인간공학적인 설계가 요구되고 있다. 특히 물류(컨테이너)의 선, 하적시 컨트롤 문제는 인간에게 과부하를 주고 있어 시스템의 음성화가 요구되고 있다. 본 연구에서는 연속음에서 음성구간을 추출하여 각 음성을 확산필터뱅크를 통해 특징을 추출하고 신경망 인식기에서 인식하여 인식결과를 항만물류 음성인식시스템에 사원번호 인식에 사용하였으며 사원번호 입력화면에서 숫자로 디스플레이 되도록 설계하였다. 인식결과는 각 숫자음과 "확인", "삭제" 등으로 나타내었다. 전체적으로 인식률은 96%을 보이고 있으며 100% 인식결과를 나타내는 음도 있었지만 숫자 "사"의 경우 인식률 80%로 약간 낮은 결과을 나타내었다. 추후에는 패턴의 다양화와 전 처리에서의 개선 등으로 문제점을 보완 하여야 할 것이다.
이성환,김준식,박근수,김명성,권태찬,김천수,이상락 啓明大學校 醫科大學 1996 계명의대학술지 Vol.15 No.1
A Clinical assessment of the 25 patients with dilated cardiomyopathy who were admitted to the Department of Pediatrics, Keimyung University Dong San Hospital from January, 1982 to June, 1993 was performed. The result were as follows: 1) Among 25 patients with dilated cardiomyopathy. 8(32%) were younger than 1 year of age at the time of admission. 2) Adriamycin toxicity was the only encountered etiologic factor in 1 patient. 3) On admission, hepatomegaly and tachycardia were noted in almost all patients. 4) The Chest X-rays showed cardiomegalies in all 25 patients, pulmonary vein congestions in 15(60%) and pleural effusion in 2(8%). 5) The electrocardiography showed left ventricular hypertrophy in 72% and supraventricular tachycardia in 32%. 6) The echocardiographic examination showed left ventricular dilatations in all patients and left atrial dilatations in 20(80%). 7) Of 18 patients who had followed mean period of 2.9 years, 10 patients died within 9 months after the diagnosis.
Clinical and histological significance of atypical glandular cells on cervical cytology(초)
최홍준 ( Hong Jun Choi ),( Woo Chul Kim ),( Ho Soap Hahn ),( Seok Geun Yoon ),( Yong Soon Kwon ),( In Ho Lee ),( Kyung Taek Lim ),( Ki Heon Lee ),( Jae UK Shim ),( Jung Eun Mok ),( Yi Kyeong Chun2 ),( Ta 대한산부인과학회 2009 대한산부인과학회 학술대회 Vol.95 No.-
토당귀 종자의 형태적 특성과 발아와 입모율에 대한 저장방법,생장조절제 및 프라이밍 처리 효과
안희정,안복주,·김도현,·안영섭,·김영국,박춘근,이상원,·박충범·차선우,·송범헌, 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.1
This study was conducted to have basic and applied informations to establish the cultivation method and to improve the cultivation techniques of Angelica gigas Nakai through investigating the rates of germination and seedling establishment with treatment of plant growth regulator and seed priming. The germination rates of round shape seed were about 0.3~12% higher than those of parallel shape. The germination rates with different storage durations were increased at the level of 25oC and 4oC with the storage days, while they were clearly higher at -20oC compared to those at 4oC and 25oC without the storage durations. With the results of germination rates with treating of plant growth regulator and seed priming, their rates with the round shape seeds were comparatively higher about 6% than those with parallel shape seed and they were increased with increasing of the storage durations. The germination rates were generally appeared higher with GA3 than did those with seed priming. The highest germination rate was appeared at 50 ppm GA3 of plant growth regulator and at -0.5 MPa PEG6000 of seed priming. The germination rates?ㅤ ?ㅤ of Angelica gigas were different with different temperature, storage durations and the treatments of plant growth regulator and seed priming. These results could be used according to different cultivating conditions.
새로운 주름개선 소재: 3,9-diferuloyl-6-oxopterocarpen (Tensolin-F<sup>®</sup>)의 개발과 화장품 응용
이범천 ( Bum-chun Lee ),이정재 ( Jeong-jae Lee ),박성민 ( Sung-min Park ),김철배 ( Chul-bae Kim ),심관섭 ( Gwan-sub Sim ),김진화 ( Jin-hwa Kim ),이근수 ( Geun-soo Lee ),이천일 ( Chun-il Lee ),표형배 ( Hyeong-bae Pyo ) 대한화장품학회 2004 대한화장품학회지 Vol.30 No.1
3,9-Dihydro-6-oxopterocarpen과 ferulic acid의 에스테르 반응을 통해 페룰산 유도체인 3,9-diferuloyl-6-oxopterocarpen (Tensolin-F<sup>®</sup>)를 합성하여 이를 함유한 주름개선 화장품을 개발하였다. Tensolin-F<sup>®</sup>는 농도 의존적으로 DPPH와 superoxide radical에 대한 소거효과를 나타냈으며, 각각 0.8 mM에서 78%, 0.053 mM에서 92.9%로 DPPH와 superoxide radical을 소거하여 우수한 항산화 효과를 나타내었다. MMP-1 효소 활성 저해 효과도 0.16 mM에서 74%를 저해하였다. HDF에서 UVA에 의해 발현이 증가되는 MMP-1의 발현 저해 효과는 Tensolin-F<sup>®</sup> 0.8 uM에서 85.5%로 단백질 수준에서 모두 농도 의존적으로 발현 저해효과가 나타났다. Tensolin-F<sup>®</sup>를 함유한 제품의 피부 주름개선 효과 평가 결과, Tensolin-F<sup>®</sup>를 함유한 화장품을 약 8주 간 도포한 경우 유의한 주름개선 효과가 있음을 확인 할 수 있었다. 본 연구를 통하여 Tensolin-F<sup>®</sup>는 항산화 효과와 MMP-1활성 저해 효과 및 UVA에 의한 MMP-1의 발현을 저해하는 효과가 나타났으며 새로운 주름개선 기능성 화장품으로 이용될 수 있을 것이다. As a novel anti-wrinkle agent, 3,9-diferuloyl-6-oxopterocarpen (Tensolin-F<sup>®</sup>) has been synthesized and its anti-aging effects have been investigated. In the present study, to investigate the relationship between aging and Tensolin-F<sup>®</sup>, we examined its effect on scavenging activities of radicals and reactive oxygen species (ROS), in vitro inhibition activity of matrix-metalloproteinase (MMP) and expression of UVA-induced MMPs in human dermal fibroblasts (HDF). Tensolin-F<sup>®</sup> was found to show activities of scavenging radicals and ROS with the IC<sub>50</sub> values of 0.2 mM and 0.95 mM against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and superoxide radicals, respectively, in the xanthine/xanthine oxidase system. Fluorometric assays for the proteolytic activities of MMP-l (collagenase) were performed using fluorescent collagen substrates. Tensolin-F<sup>®</sup> inhibited the activities of MMP-l in a dose-dependent manner and the IC<sub>50</sub> values calculated from semi-log plots were 0.025 mM. Also, UVA induced MMP-1 expression was reduced 85% by treatment with Tensolin-F<sup>®</sup> at 0.8 uM, which was reduced dose-dependent manner. The results of clinical study showed that 4.8 mM Tensolin-F<sup>®</sup> treated group reduced wrinkle significantly compared with placebo treated group (P<0.05). Taken together, these result suggest that Tensolin-F<sup>®</sup> act as an anti-wrinkle agent by taking effects to antioxidation and reducing UVA-induced MMP-l production.-l production.
Lee Soo Yeon,Park Soo-Yeon,Lee Seunghyun,Kim Hyunsik,Kwon Jae-Hwan,Yoo Jung-Yoon,Kim Kyunggon,Park Moo Suk,Lee Chun-Geun,Elias Jack A.,Sohn Myung Hyun,Shim Hyo Sup,Yoon Ho-Geun 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Idiopathic pulmonary fibrosis (IPF) is a chronic, fatal, fibrotic, interstitial lung disease of unknown cause. Despite extensive studies, the underlying mechanisms of IPF development remain unknown. Here, we found that p300 was upregulated in multiple epithelial cells in lung samples from patients with IPF and mouse models of lung fibrosis. Lung fibrosis was significantly diminished by the alveolar type II (ATII) cell–specific deletion of the p300 gene. Moreover, we found that ubiquitin C-terminal hydrolase L3 (UCHL3)-mediated deubiquitination of p300 led to the transcriptional activation of the chemokines Ccl2, Ccl7, and Ccl12 through the cooperative action of p300 and C/EBPβ, which consequently promoted M2 macrophage polarization. Selective blockade of p300 activity in ATII cells resulted in the reprogramming of M2 macrophages into antifibrotic macrophages. These findings demonstrate a pivotal role for p300 in the development of lung fibrosis and suggest that p300 could serve as a promising target for IPF treatment.
Delftia acidovorans Isolated from the Drainage in an Immunocompetent Patient with Empyema
Chun, Jaeyoung,Lee, Jaechun,Bae, Jaeseok,Kim, Miyeon,Lee, Jae-Geun,Shin, Sang-Yop,Kim, Young Ree,Lee, Keun-Hwa The Korean Academy of Tuberculosis and Respiratory 2009 Tuberculosis and Respiratory Diseases Vol.67 No.3
Delftia acidovorans is a gram-negative motile rod found ubiquitously in soil and in water. Confirmed isolation from clinical infections is rare, and has been documented mostly in immunocompromised patients or those with indwelling catheters. A 53-year-old man was referred for the evaluation of a huge mass-like lesion found incidentally by chest X-ray. The lesion occupied more than half of the right lung and was diagnosed as a large loculated pleural effusion by CT scan. Bloody pus was drained through a percutaneous catheter, and D. acidovorans, identified by the Vitek GN card and confirmed by amplification of 16S ribosomal RNA and sequencing analysis, was isolated repeatedly from the drained pus. The patient was treated with imipenem/cilastatin to which the organism was sensitive. This is a rare report of chronic empyema associated with D. acidovorans in the respiratory system of an immunocompetent patient.
Lee, Kwang Jae,Kim, Jin Il,Park, Ju Sang,Moon, Byung Sik,Kim, Sang-Gyun,Chun, Jae Hee,Jung, Hoon-Yong,Choi, Chang Hwan,Chun, Seong Woo,Song, Geun Am,Choi, Myung Gyu,Chun, Hoon Jai The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.12
<P>The objective of the study was to document practice pattern of gastroenterologists for the management of gastroesophageal reflux disease (GERD) under the minimal influence of the insurance reimbursement guideline. Data on management for 1,197 consecutive patients with typical GERD symptoms were prospectively collected during 16 weeks. In order to minimize the influence of reimbursement guideline on the use of proton pump inhibitors (PPIs), rabeprazole was used for the PPI treatment. A total of 861 patients (72%) underwent endoscopy before the start of treatment. PPIs were most commonly prescribed (87%). At the start of treatment, rabeprazole 20 mg daily was prescribed to 94% of the patients who received PPI treatment and 10 mg daily to the remaining 6%. At the third visits, rabeprazole 20 mg daily was prescribed to 70% of those who were followed and 10 mg daily for the remaining 30%. Continuous PPI treatment during the 16-week period was performed in 63% of the study patients. In conclusion, a full-dose PPI is preferred for the initial and maintenance treatment of GERD under the minimal influence of the insurance reimbursement guideline, which may reflect a high proportion of GERD patients requiring a long-term treatment of a full-dose PPI.</P>