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가로쓰기 한글의 글자꼴과 글줄이 인지속도에 미치는 영향
이병근,이진호,심효섭 東西大學校 1997 동서논문집 Vol.3 No.1
This study investigated the effect of character form and the Numbers of characters per line on Readability of Hangul characters and words horizontal printing. The results were as follows. In canceling tests. (1) the speeds of character canceling were faster in the order of elongated form condensed form and original form conditions, and (2) the speeds of word canceling were in the order of elongated, original and condensed form conditions. But in a reading task, (3) the order of the Readability were [40>35>30] in number of characters per line condition and [original>elongated>condensed] in character form conditions. The above indicates that original form with 40 characters per line is the best combination for horzontal Haugul printing.
박사영,이나영,이효진,이선영,최진혁,이순남,심강섭,성순희,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3
Multiple primary cancer means that more that two cancers occur independently in an individual. Recently, the incidence of multiple primary cancer has increased with lengthened survival, of cancer patients, development of new diagnostic technique and increased clinical evaluation. We report a patient who had adenocarcinoma of stomach combined with squamous cell carcinoma of esophagus simultaneously.
Molecular portraits of intratumoral heterogeneity in human ovarian cancer
Choi, Yoon Pyo,Shim, Hyo Sup,Gao, Ming-Qing,Kang, Suki,Cho, Nam Hoon Elsevier 2011 Cancer letters Vol.307 No.1
<P><B>Abstract</B></P> <P>One of the most common characteristic profiles of cancer is intratumoral heterogeneity (ITH). We aimed to clarify the molecular profiles and biological significance of ITH with relation to cancer stem cell (CSC). We analyzed five primary cultured clones generated from different spatial zones, front and rear zone, of a fresh-frozen ovarian tumor tissue, performing ATP-CRA, conventional RT-PCR, side population (SP) analysis, flow cytometry immunophenotyping, and cell proliferation assays. We also carried out array CGH and Ingenuity Pathways Analysis (IPA) between SP and non-SP (NSP) cells. Clones from tumor front zone showed phenotypically and genetically distinct subpopulations with relatively higher SP proportions, CD24<SUP>+</SUP> and CD117<SUP>+</SUP> expression, and chemotherapeutic resistance. We demonstrate that phenotype of SP cells in heterogeneous clones of human ovarian cancer was closely related to CD24<SUP>+</SUP>, CD117<SUP>+</SUP>, and combined CD117<SUP>+</SUP>/CD24<SUP>+</SUP> fractions. Chromosomal alterations in SP cells relative to NSP cells were closely related to the novel core networks of cancer stem cell-like cells (CSCs), such as cycle checkpoint regulation, notch, PTEN, wnt/β-catenin, PI3K/AKT, integrin, and cytokine and chemokine signaling. ITH could arise from clonal diversity closely related to CSC-like molecules, as evidenced by accumulated genetic, transcriptional and gene products alterations in SP.</P>
Shim, Hyo Sup,Yoon, Bo Sung,Cho, Nam Hoon Elsevier 2009 Human pathology Vol.40 No.5
<P><B>Summary</B></P><P>This study was designed to investigate the prognostic significance of the expression of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma. The expression of epithelial cell adhesion molecule and E-cadherin was examined immunohistochemically on a tissue microarray of formalin-fixed paraffin-embedded tissue specimens from 72 consecutive patients. The overexpression of epithelial cell adhesion molecule was correlated with poor survival (<I>P</I> = .036). In contrast, the reduced expression of E-cadherin was correlated with poor survival (<I>P</I> = .034). When patients were subclassified into 4 groups according to positivity and negativity of epithelial cell adhesion molecule and E-cadherin expression, the epithelial cell adhesion molecule-positive E-cadherin–negative group showed the worst survival rate (<I>P</I> = .002, compared with the epithelial cell adhesion molecule-negative E-cadherin–positive group). These data suggest that the overexpression of epithelial cell adhesion molecule and reduced expression of E-cadherin in combination is more significant than a single marker for predicting poor survival.</P>
Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung
Shim, Hyo Sup,Kenudson, Mari-,Zheng, Zongli,Liebers, Matthew,Cha, Yoon Jin,Hoang Ho, Quan,Onozato, Maristela,Phi Le, Long,Heist, Rebecca S.,Iafrate, A. John Elsevier 2015 JOURNAL OF THORACIC ONCOLOGY Vol.10 No.8
Shim, Hyo Sup,Chung, Jin-Haeng,Kim, Lucia,Chang, Sunhee,Kim, Wan-Seop,Lee, Geon Kook,Jung, Soon-Hee,Jang, Se Jin The Korean Society of Pathologists and The Korean 2013 KOREAN JOURNAL OF PATHOLOGY - Vol.47 No.2
<P>Mutations of the epidermal growth factor receptor (<I>EGFR</I>) are the strongest predictive factor for response to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. EGFR TKIs are approved in Korea as a first-line treatment for lung cancer patients with mutated <I>EGFR</I>. Rapid and accurate <I>EGFR</I> mutation testing is essential for patient selection and establishing targeted therapies with EGFR TKIs. Thus, a standard set of guideline recommendations for <I>EGFR</I> mutation testing suitable for the Korean medical community is necessary. In this article, we propose a set of guideline recommendations for <I>EGFR</I> mutation testing that was discussed and approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.</P>