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RISS 인기검색어
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- 저자 : Chuan-Yuan Hsu (검색결과 2 건)
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Chuan-Yuan Hsu,Jongsun Kim,Ping Chang,Steven F. DiMarco 한국해양과학기술원 2022 Ocean science journal Vol.57 No.1
This study investigates the resonated diurnal impact of the surface wind forcing from several atmospheric wind products, including CCMP (Cross-Calibrated Multi-Platform), ERA Interim, NCEP-2 (NCEP-DOE AMIP-II Reanalysis), MERRA (Modern-Era Retrospective analysis for Research and Application), NARR (Northern American Regional Reanalysis) and NAM (North American Mesoscale Forecast System), on the wind-driven near-inertial ocean motions in the northern Gulf of Mexico by numerical simulation, and in comparison, with NDBC buoy surface observed winds. Our analyses show that the near-inertial wind power input, which can affect vertical mixing in the water column, is closely associated with the variability of land-sea breeze by various wind products. In comparison with buoy observations in the northern Gulf of Mexico, the MERRA has the worst land-sea breeze representation, while the NCEP2 and CCMP, which are chosen to represent the coarsest and medium–high horizontal resolution, have the best performance. We further show that by comparison of the buoy data, that the near-inertial wind power input derived from all the wind products is underestimated by 30–50% approximately.
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Chih-Jen Yang,Yu-Jung Huang,Cheng-Yuan Wang,Chuan-Sheng Wang,Pei-Hui Wang,Jen-Yu Hung,Tung-Heng Wang,Hseng-Kuang Hsu,Hurng-Wern Huang,S.P. Anand Kumar,Ming-Shyan Huang,Ching-Feng Weng 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
Toona sinensis is a traditional Chinese herb, and the extracts of T. sinensis leaf possess a variety of biological functions. This study attempted to test the antiproliferative effect of TSL-1 (a bioactive fraction of T. sinensis) in H441 cells (lung adenocarcinoma). The data showed that the antiproliferative effect of TSL-1 on H441 cells is prominent using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. TSL-1-induced apoptosis was confirmed by cell morphology, sub-G1 peak accumulation, cleavage of poly(ADP)-ribose polymerase, and propidium iodide-annexin V double staining. Furthermore, decreased Bcl-2 accompanied by increased Bax (in western blotting) was found with TSL-1 treatment of H441 cells. TSL-1 treatment-induced G1 arrest was concurrent with the down-regulation of protein levels of cyclin D1 and cyclin-dependent kinase 4 in H441 cells. Peroral and intraperitoneal administrations of TSL-1 were performed to evaluate the therapeutic efficacy, and peroral administration of TSL-1 was also used to elucidate the therapeutic efficacy in the H441 cell xenograft model in vivo. The data revealed that TSL-1 treatment inhibited H441 tumor growth in both therapeutic and preventive experiments. Taken together, these results demonstrate that TSL-1 possesses the capability of preventing and alleviating lung cancer proliferation in vitro and in vivo with proven nephrological and hepatic safety and has the potential to be developed as an anti–lung cancer drug.
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