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- 저자 : Chuan Peng (검색결과 51 건)
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Chuan Peng,Jae Kyung Pan 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
Channel characteristics of an indoor wireless optical communication system is provided here. A channel impulse response includes the power ratio and time delay due to bounce times. Based on the scenario of the indoor structure, we obtained and discussed the received power distribution according to six configurations in Table 1, which vary with respect to transmitter and receiver positions and reflection coefficients. We used the input Gaussian pulse, Rectangular pulse, and Practical pulse, which are applied to pulse position modulation (PPM) and OOK, based on the impulse response of indoor channels in Configuration D. We evluated the BER with respect to the signal-to-noise ratio per bit for various input pulses in lineof-sight (LOS) and diffuse channels.
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Hepatocyte organoids and cell transplantation: What the future holds
Peng Weng Chuan,Kraaier Lianne J.,Kluiver Thomas A. 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Historically, primary hepatocytes have been difficult to expand or maintain in vitro. In this review, we will focus on recent advances in establishing hepatocyte organoids and their potential applications in regenerative medicine. First, we provide a background on the renewal of hepatocytes in the homeostatic as well as the injured liver. Next, we describe strategies for establishing primary hepatocyte organoids derived from either adult or fetal liver based on insights from signaling pathways regulating hepatocyte renewal in vivo. The characteristics of these organoids will be described herein. Notably, hepatocyte organoids can adopt either a proliferative or a metabolic state, depending on the culture conditions. Furthermore, the metabolic gene expression profile can be modulated based on the principles that govern liver zonation. Finally, we discuss the suitability of cell replacement therapy to treat different types of liver diseases and the current state of cell transplantation of in vitro-expanded hepatocytes in mouse models. In addition, we provide insights into how the regenerative microenvironment in the injured host liver may facilitate donor hepatocyte repopulation. In summary, transplantation of in vitro-expanded hepatocytes holds great potential for large-scale clinical application to treat liver diseases.
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Chuan Peng(팽천),Zan Wang(왕잔),Ji Do Kim(김지도),Jae Kyung Pan(반재경) 한국통신학회 2008 韓國通信學會論文誌 Vol.33 No.2A
In this paper, we consider the diffuse type of indoor wireless optical communication (WOC) system. To find the channel characteristics of indoor wireless infrared communication system, we investigate the simulation process to get the impulse response of diffuse type and analyze the scenario of the indoor structure which we have built. The simulation results of the impulse response include power ratio and time delay due to bounce times. We get and discuss the receiving power distribution according to six configurations which have different transmitter and receiver positions and reflection coefficients of the indoor structure assumed. The results of this paper are useful to design the indoor wireless optical communication systems.
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Inhibitory Effects of Syk Transfection on Lung Cancer Cell Invasion
Peng, Chuan-Liang,Zhang, Ying,Sun, Qi-Feng,Zhao, Yun-Peng,Hao, Ying-Tao,Zhao, Xiao-Gang,Cong, Bo Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Objective: Spleen tyrosine kinase (Syk) is closely related to tumor invasion and metastasis, and has been shown to have potential inhibitory effects in tumors. In this study, we constructed a eukaryotic expression vector for Syk and analyzed its effects on invasive ability of the A549 non-small cell lung cancer cell line in vitro. Methods: A fragment of Syk was obtained by RT-PCR from human lung cancer cells and cloned into the expression vector pLNCXSyk. After restriction endonuclease digestion, PCR and DNA sequencing confirmation, the recombinant Syk expression plasmid was transfected into A549 human lung cancer cells using lipofectamine protocols. After selection, the cells stably expressed Syk. Detection of Syk expression of the cells by RT-PCR, and invasive ability were examined. Results: The eukaryotic expression plamid pLNCXSyk was constructed and expressed stably in the A549 human lung cancer cells. The RT-PCR results showed that Syk mRNA expression was upregulated significantly (P<0.05). Lower invasion through a basal membrane were apparent after transfection (P<0.05). Conclusions: A eukaryotic expression plasmid to cause Syk expression in lung cancer cells can obviously inhibit their invasive ability in vitro.
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Zhang, Chuan-Peng,Liu, Tie,Yuan, Jinghua,Sanhueza, Patricio,Traficante, Alessio,Li, Guang-Xing,Li, Di,Tatematsu, Ken’ichi,Wang, Ke,Lee, Chang Won,Samal, Manash R.,Eden, David,Marston, Anthony,Liu, Xia American Astronomical Society 2018 The Astrophysical journal Supplement series Vol.236 No.2
<P>In order to understand the initial conditions and early evolution of star formation in a wide range of Galactic environments, we carried out an investigation of 64 Planck Galactic cold clumps (PGCCs) in the second quadrant of the Milky Way. Using the (CO)-C-13 and (CO)-O-18 J = 1-0 lines and 850 mu m continuum observations, we investigated cloud fragmentation and evolution associated with star formation. We extracted 468 clumps and 117 cores from the (CO)-C-13 line and 850 mu m continuum maps, respectively. We made use of the Bayesian distance calculator and derived the distances of all 64 PGCCs. We found that in general, the mass-size plane follows a relation of m similar to r(1.67). At a given scale, the masses of our objects are around 1/10 of that of typical Galactic massive star-forming regions. Analysis of the clump and core masses, virial parameters, densities, and mass-size relation suggests that the PGCCs in our sample have a low core formation efficiency (similar to 3.0%), and most PGCCs are likely low-mass star-forming candidates. Statistical study indicates that the 850 mu m cores are more turbulent, more optically thick, and denser than the (CO)-C-13 clumps for star formation candidates, suggesting that the 850 mu m cores are likely more appropriate future star formation candidates than the (CO)-C-13 clumps.</P>
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Peng Liu,Chuan-xiang Xiong,Fu-quan Chen 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.3
Rigid piles have been widely used to reinforce soft subgrade. However, some studies do not consider the bending failure of piles and wedge sliding surfaces, which may lead to an overestimation of stability. In this study, a stability calculation method for a multi-section linear sliding surface is first derived and then simplified to three-part wedge method based on the numerical modeling of the failure evolution process. The real safety factor is replaced by the average value of the upper and lower bound solutions of the embankment stability safety factor. Through calculations, then the average value or the approximate solution of the real value, of both the upper and lower bound solutions can be obtained. The accuracy of the approximate solution can be verified through an analysis of the relative error of the average and true values. Finally, the proposed method was verified by a three-dimensional numerical simulation method and compared with the traditional limit equilibrium method and the equivalent shear strength parameter method. The results indicate that the support contributionof rigid piles to the embankment can be effectively reflected by considering wedge sliding surfaces, and a more reasonable stability safety factor can be obtained through the proposed method.
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Chuan-Jin Zhang,Rui-Peng Wei,Yi Tang,Ke Wang 전력전자학회 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.5
A novel space vector modulation strategy in the non-orthogonal three-dimensional coordinate system for multi-level three-phase four-wire inverters is proposed in this paper. This new non-orthogonal three-dimensional space vector modulation converts original trigonometric functions in the orthogonal three-dimensional space coordinate into simple algebraic operations, which greatly reduces the algorithm complexity of three-dimensional space vector modulation and preserves the independent control of the zero-sequence component. Experimental results have verified the correctness and effectiveness of the proposed three-dimensional space vector modulation in the new non-orthogonal three-dimensional coordinate system.
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Peng Zhou,Zi-Han Zheng,Tao Wan,Jie Wu,Chuan-Wen Liao,Xue-Jun Sun 대한위암학회 2021 Journal of gastric cancer Vol.21 No.4
Purpose: Gastric cancer (GC) has high morbidity and mortality and is a serious threat to public health. The flavonoid compound vitexin is known to exhibit anti-tumor activity. In this study, we explored the therapeutic potential of vitexin in GC and its underlying mechanism. Materials and Methods: The viability, migration, and invasion of GC cells were determined using MTT, scratch wound healing, and transwell assays, respectively. Target molecule expression was determined by western blotting. Tumor growth and liver metastasis were evaluated in vivo using nude mice. Protein expression in the tumor tissues was examined by immunohistochemistry. Results: Vitexin inhibited GC cell viability, migration, invasion, and epithelial-mesenchymal transition (EMT) in a dose-dependent manner. Vitexin treatment led to the inactivation of phosphatidylinositol-3-kinase (PI3K)/AKT/hypoxia-inducible factor-1α (HIF-1α) pathway by repressing HMGB1 expression. Vitexin-mediated inhibition in proliferation, migration, invasion and EMT of GC cells were counteracted by hyper-activation of PI3K/AKT/HIF-1α pathway or HMGB1 overexpression. Finally, vitexin inhibited the xenograft tumor growth and liver metastasis in vivo by suppressing HMGB1 expression. Conclusions: Vitexin inhibited the malignant progression of GC in vitro and in vivo by suppressing HMGB1-mediated activation of PI3K/Akt/HIF-1α signaling pathway. Thus, vitexin may serve as a promising therapeutic agent for the treatment of GC.
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Xu, Chuan,Huang, Xin-En,Wang, Shu-Xiang,Lv, Peng-Hua,Sun, Ling,Wang, Fu-An Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6
Purpose: Percutaneous transhepatic biliary drainage (PTBD) is a form of palliative care for patients with malignant obstructive jaundice. We here compared the infection incidence between internal-external and external drainage for patients with malignant obstructive jaundice. Methods: Patients with malignant obstructive jaundice without infection before surgery receiving internal-external or external drainage from January 2008 to July 2014 were recruited. According to percutaneous transhepatic cholangiography (PTC), if the guide wire could pass through the occlusion and enter the duodenum, we recommended internal-external drainage, and external drainage biliary drainage was set up if the occlusion was not crossed. All patients with infection after procedure received a cultivation of blood and a bile bacteriological test. Results: Among 110 patients with malignant obstructive jaundice, 22 (52.4%) were diagnosed with infection after the procedure in the internal-external drainage group, whereas 19 (27.9%) patients were so affected in the external drainage group, the difference being significant (p<0.05). In 8 patients (36.3%) in the internal-external group infection was controlled, as compared to 12 (63.1%) in the external group (p< 0.05). The mortality rate for patients with infection not controlled in internal-external group in one month was 42.8%, while this rate in external group was 28.6% (p< 0.05). Conclusion: External drainage is a good choice, which could significantly reduce the chance of biliary infection caused by bacteria, and decrease the mortality rate at one month and improve the long-term prognosis.
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