Preparation of Thermo-Responsive and Injectable Hydrogels Based on Hyaluronic Acid and Poly(N-isopropylacrylamide) and Their Drug Release Behaviors

Ha Dong In,Lee Sang Bong,Chong Moo Sang,Lee Young Moo,Kim So Yeon,Park Young Hoon The Polymer Society of Korea 2006 Macromolecular Research Vol.14 No.1

Copolymers composed of hyaluronic acid (HA) and poly(N-isopropylacrylamide) (PNIPAAm) were prepared to create temperature-sensitive injectable gels for use in controlled drug delivery applications. Semi-telechelic PNIPAAm, with amino groups at the end of each main chain, was synthesized by radical polymerization using 2-aminoethanethiol hydrochloride (AESH) as the chain transfer agent, and was then grafted onto the carboxyl groups of HA using carbodiimide chemistry. The result of the thermo-optical analysis revealed that the phase transition of the PNIPAAm-grafted HA solution occurred at around 30$\∼$33$^{circ}C$. As the graft yield of PNIPAAm onto the HA backbone increased, the HA-g-PNIPAAm copolymer solution exhibited sharper phase transition. The short chain PNIPAAm-grafted HA ($M_{w}$=6,100) showed a narrower temperature range for optical turbidity changes than the long chain PNIPAAm-grafted HA ($M_{w}$=13,100). PNIPAAm-grafted HA exhibited an increase in viscosity above 35$^{circ}C$, thus allowing the gels to maintain their shape for 24 h after in vivo administration. From the in vitro riboflavin release study, the HA-g-PNIPAAm gel showed a more sustained release behavior when the grafting yield of PNIPAAm onto the HA backbone was increased. In addition, BSA released from the PNIPAAm-g-HA gels showed a maximum concentration in the blood 12 h after being injected into the dorsal surface of a rabbit, followed by a sustained release profile after 60 h.

유구치 와동형성이 아말감 파절에 미치는 영향에 관한 연구

하대송,김종관,이종갑 大韓小兒齒科學會 1984 大韓小兒齒科學會誌 Vol.11 No.1

In this experiments, the fracture loads were measured and analysed by using of Instron universal testing machine (Model 1132). With 80 upper and lower deciduous molars that were free of dental caries. Isthmus of teeth were prepared to 1/3 and 1/4 of intercuspal width, and internal line angles with round and sharp shape, and then amalgam restoration were performed. The results of this study were as follows; 1. Resistance to fracture loads were greater with isthmus of 1/3 intercuspal width than of 1/4 intercuspal width, especially, statistically significant difference on upper and lower second deciduous molars. 2. Resistance to fracture loads were greater with rounded internal line angle than sharp internal line angle. The above results were as follows, the fracture loads had greater resistance on isthmus of 1/3 intercuspal width, and rounded internal line angle, but normal physiological occlusal forces could permit isthmus of 1/4 intercuspal width and rounded internal line angle.

Sezary증후군과 병발된 용혈성 빈혈 1예

유광하,진춘조,김홍승,이종인,심영학,정순희,이창훈 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.- No.7

養鷄 主飼料인 옥수수 代置飼料로서 小麥利用에 關한 硏究 : 第 1報 옥수수 代置飼料로서 小麥의 利用水準 Ⅰ. Utilization Level of Wheat as a Substitute Feed for Corn

河正基,李炳五,郭鍾瀅,安炳弘 慶尙大學校 1972 論文集 Vol.11 No.-

初生雛 育成飼料의 主飼料인 옥수수의 代置飼料로서 밀을 이용한 代置水準을 究明하고저 本 實驗을 實施하였던 바 그 結果는 다음과 같다. 1. 增體量은 옥수수와 밀을 各各 50%씩 使用한 區와 밀보다 옥수수를 많이 使用한 區가 밀 만을 使用한 區에 비해서 增體量이 좋았다. 2. 飼料攝取量은 옥수수를 제일많이 使用한 區가 제일 적었고, 반대로 밀을 많이 사용한 區 일수록 높았다. 3. 飼料效率은 옥수수와 밀을 50%씩 使用한 區가 옥수수와 밀의 單用區 보다는 좋았다. 4. kg增體에 所要된 飼料費는 옥수수와 밀을 50%씩 사용한 區가 제일 낮아 本 試驗에 의하면 養鷄配合飼料의 穀類 60%中 밀을 30%程度 使用할 수 있다고 하겠다. To investigate the substitute level of wheat for corn used as major ration of laying hen, was carried out. The results obtained were as follows: 1. Body weight gain was higher in the treatment of Corn 50% : Wheat 50% and in used more corn than wheat in contrast with the treatment used only wheat. 2. Diet intake was least in the treatment used only corn and on the other hand, the only wheat was higher than other treatment used corn in the diet intake. 3. Feed efficiency was more improved in the treatment used 50% of wheat and corn, respectively than in the treatment used only wheat. 4. Feed cost required per kg body gain was lowest in the treatment used 50% of wheat and corn. Therefore, according to the present experiment it may be to say that s0% of wheat will be substituted for corn in the formulated ration of laying hen using 60% cereals.

호텔 從事員 敎育에 關한 硏究

河宗明 진주여자전문대학 1991 論文集 Vol.14 No.-

The hotel business has become a part of the third industry influencing the development of the tourism industry. As the toursim growing as one of the important industries, the employees of tourism generally being given service education, but it is generally pointed out that such education is still far from adequate. The goal of this treatise is to provide materials for the devices on the development of our national toursim hotel and The researcher some suggestions to improve the guality of employees in the future. The suggestions are as follows : 1) on the educational system : it is urgent to establish the national professional school of tourism hotel and to cultivate professors and specialists. 2) We should try harder to operate the educational-industrial complex more effectively. 3) A more effective enlightment is needed to improve the nation-wide recognition for the field of the tourism hotel.

初生雛의 體重 및 臟器重量에 關한 硏究

河正基,金鍾涉,朴重錫 慶尙大學校 1980 論文集 Vol.19 No.1

本 試驗은 實用鷄인 Hisex와 Hybro의 種卵을 孵化시켜 發生直後의 初生雛에 대하여 體重, 腦, 眼球, 肺, 心腸, 腎臟, 胃, 卵黃?, 盲腸, 小腸, 結腸과 直腸의 重量을 測定하고, 各 項目의 平均과 標準誤差를 求하는 同時에 各項目間의 相關關係 및 回歸直線方程式을 調査하였든 바 그 結果는 다음과 같다. 1) Hisex의 調査項目中 體重은 35.312±0.324g, 腦의 重量은 0.873±0.009g, 眼球의 重量은 0.866±0.019g, 肺의 重量은 0.348±0.013g, 肝의 重量은 1.108g±0.015g, 心腸의 重量은 0.415g±0.010g, 腎臟의 重量은 0.292g±0.007g, 胃의 重量은 2.502g±0.045g, 卵黃?의 重量은 3.562g±0.186g, 盲腸의 重量은 0.294g±0.018g, 小腸의 重量은 1.200g±0.026g, 結腸과 直腸의 重量은 0.169g±0.009g이였다. 2)Hybro의 調査項目中 體重은 36.569±0.295g, 腦의 重量은 0.912±0.009g, 眼球의 重量은 0.920±0.019g, 肺의 重量은 0.386±0.011g, 肝의 重量은 1.140±0.051g, 心腸의 重量은 0.401±0.013g, 腎臟의 重量은 0.280±0.010g, 胃의 重量은 2.723±0.045g, 卵黃?의 重量은 3.464±0.158g, 盲腸의 重量은 0.446g±0.028g, 小腸의 重量은 1.414±0.040g, 結腸과 直腸의 重量은 0.203g±0.016g이였다. 3) Hisex와 HYbro의 各 測定成績間에서 相關關係를 調査한 結果 正과 負의 相關이 있었다. This study was carried out to measure the weight and correlation between body weight and each visceral organs in commercial day old chicks(Hisex and Hybro). Names of the visceral organs measured are brain, eyeball, llung, liver heart, kidney, stomach, yolk sac, cecum, small intestine and colon and rectum. The results obtained are summarized as follows: 1. Average weight of body, brain, eye-ball, lung, liver, heart, kidney, stomach, yolk sac, cecum, small intestine and colon and rectum of the Hybre chicks(Meat type)and standard error to the items measured were 36.569±0.324g, 0.873±0.009g, 0.860±0.019g, 0.348±0.013g, 1.108±0.015g, 0.415±0.010g, 0.292±0.07g, 2.502±0.045g, 3.562±0.186g,0.294±0.018g, 1.200±0.026g and 0.167±0.009g, respectively. 2. Average weight of body, brain, eye-ball, lung, liver, heart, kidney, stomach, yolk sac, cecum, small intestine and colon and rectum of the Hybre chicks(Meat type) and standard error to the items measured were 36.569±0.295g, 0.912±0.109g, 0.920±0.019g, 0.386±0.011g, 1.140±0.051g, 0.401±0.013g, 0.280±0.010g, 2.723±0.045g, 3.464±0.158g, 0.446±0.028g, 1.414±0.040g and 0.203±0.016g, respectively. 3. Positive correlation and inverse correlation between items investigated in Hybro and Hisex were found.

NGO 운동을 통한 민족 공동체0 건설 모색 : 새마을 운동을 중심으로 Based on Sae Ma Ul movement

정하성 평택대학교 1999 論文集 Vol.12 No.-

통일의 당위성 속에 제기되고 있는 민족 동질성 회복을 위한 사회적 노력은 시급하다. NGO차원에서 남·북한 교류를 통하여 신뢰성과 동일성의 회복을 접근시키는 방법이 제기되고 있다. 교류를 활성화하여 공통점과 상이점을 발견하고 상호 이해를 증진시켜 가야 한다. 먼저 물자와 재원을 지원하여 북한주민이 감사한 긍정적인 마음을 갖도록 해 준다. 다음 단계로 남·북한의 공통된 전통문화체험을 통하여 상호간 필요하고 소중한 존재임을 인식하도록 한다. 생태체험관광을 통하여 국토와 문화의 동질성과 공유성을 자각시킨다. 상호교류와 협력에 의하여 생활 양태를 변화시켜 가고 생활환경을 개선시켜가도록 한다. 그런 후에 자조적인 지역연계 공동체의 실현성을 인식하고 남·북한의 개성 있고 다양성 있는 선한공동체를 단계적으로 구축하여 민족공동체 건설의 기반을 조성해 간다. 30년 동안 추진되어 온 남한의 새마을운동 원리와 경험을 바탕으로 북한지역에 적용할 수 있는 대안을 제시하였다. 추진과정은 북한주민을 자극하여 참여동기를 부여하고 조직화하여 주민사회 교육을 시켜서 다양한 지역사회 개발사업을 추진하여 선한공동체를 건설하고 상호 공존의 행복을 창조해 가도록 한다. 추진방법은 지역사회 개발원리를 도입하여 15년 동안 단계별 사업을 추진해 간다.

생태관광의 교육활용 프로개발

정하성 평택대학교 1998 論文集 Vol.11 No.-

생쥐 중이와 상기도 점막의 섬모세포운동

정하원,오승하,유원석,이강수,모지훈,전상준,김인상,김종선 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.9

현대사회의 청소년 문제 실태와 대안 모색

정하성 평택대학교 1997 論文集 Vol.9 No.1