Potential Therapeutic Efficacy of Curcumin in Liver Cancer

Dai, Xin-Zheng,Yin, Hai-Tao,Sun, Ling-Fei,Hu, Xiang,Zhou, Chong,Zhou, Yun,Zhang, Wei,Huang, Xin-En,Li, Xiang-Cheng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Purpose: Liver cancer, one of the most common cancers in China, is reported to feature relatively high morbidity and mortality. Curcumin (Cum) is considered as a drug possessing anti-angiogenic, anti-inflammation and anti-oxidation effect. Previous research has demonstrated antitumor effects in a series of cancers. Materials and Methods: In this study the in vitro cytotoxicity of Cum was measured by MTT assay and pro-apoptotic effects were assessed by DAPI staining and measurement of caspase-3 activity. In vivo anti-hepatoma efficacy of Cum was assessed with HepG2 xenografts. Results: It is found that Cum dose-dependently inhibited cell growth in HepG2 cells with activation of apoptosis. Moreover, Cum delayed the growth of liver cancer in a dose-dependent manner in nude mice. Conclusions: Cum might be a promising phytomedicine in cancer therapy and further efforts are needed to explore this therapeutic strategy.

A simple rat model of in situ reversible obstructive jaundice in situ reversible obstructive jaundice model

Xin Huang,Chong-Hui Li,Ai-Qun Zhang,Zhe Kong,Wan-Qing Gu,Jia-Hong Dong 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.6

Purpose: To develop a simple and reliable rat model of in situ reversible obstructive jaundice with low morbidity and mortality rates. Methods: Rats were divided into 4 groups with 8 rats each: the sham-operated (SH) group only underwent laparotomy, the control internal drainage (ID-C) group underwent choledochoduodenostomy, the new internal drainage (ID-N) group and the long-term internal drainage (ID-L) group underwent choledochocholedochostomy. Common bile duct ligation was performed in all the drainage groups 7 days before reversal procedures. All rats were sacrificed for samples 7 days after the last operation except rats of the ID-L group that survived 28 days before sacrifice. Body weight, liver function, histopathological changes, morbidity and mortality were assessed. Results: One rat died and 2 rats had complications with tube blockage in the ID-C group. No death or complications occurred in the ID-N and ID-L groups. The drainage tube remained patent in the long-term observation ID-L group. Body weight showed no significant difference between the ID-C and ID-N groups after 7 days drainage. Liver function was not fully recovered in the ID-C and ID-N groups after 7 days drainage, but statistical differences were only observed in the ID-C group compared with the SH and ID-L groups. Periportal inflammation and bile duct proliferation showed severer in the ID-C group than in the ID-N group. Conclusion: The present study provided an efficient, simple, and reliable rat model that is especially suitable for long-term or consecutive studies of reversible obstructive jaundice.

Opportunistic Scheduling: An Illustration of Cross Layer Design

Xin Liu,Ness B. Shroff,Edwin K. P. Chong 에스케이텔레콤 (주) 2004 Telecommunications Review Vol.14 No.6

地方师范型院校应用型人才培养的实践研究

李冲(Chong Li),赵欣(Xin Zhao) 아시아사회과학학회 2023 International Science Research Vol.3 No.3

本文以食品生物化学实验教学为例,探讨了高校应用型人才培养的实践研究。通过对传统实验教学的分析和评价,提出了一系列改革措施,包括实验内容的优化、实验教学方式多元化以及建立综合性评价体系。通过实践研究,我们发现这些改革措施能够有效提高学生的实践能力和创新能力,促进学生的综合素质提升,为高校应用型人才的培养提供了有益的借鉴和参考。 This article takes the experimental teaching of food biochemistry as an example to explore the practical research of cultivating applied talents in universities. Through the analysis and evaluation of traditional experimental teaching, a series of reform measures have been proposed, including optimizing experimental content, diversifying experimental teaching methods, and establishing a comprehensive evaluation system. Through practical research, we have found that these reform measures can effectively improve students' practical and innovative abilities, promote the improvement of students' comprehensive quality, and provide useful reference and reference for the cultivation of applied talents in universities.

Realization of a magneto-optical near-zero index medium by an unpaired Dirac point

Zhou, Xin,Leykam, Daniel,Chattopadhyay, Udvas,Khanikaev, A. B.,Chong, Y. D. American Physical Society 2018 Physical review. B Vol.98 No.20

Comparative Study on Single Pulse and Dual Pulses Variable Width Control Strategies for High-Speed PM BLDC Motor Drive

Jian-Xin Shen,Xue-Fei Qin,Wei-Zhong Fei,Yun-Chong Wang 한국자기학회 2019 Journal of Magnetics Vol.24 No.2

Pulse width modulation (PWM) of voltage source inverter (VSI) is common for speed regulation of permanent magnet (PM) brushless direct-current (BLDC) motor drives. However, when the motor runs at high speed, the conventional PWM technique may become unfeasible due to the low carrier ratio of inverter, which makes the motor current distorted and the motor core loss increased significantly. In this paper, two control strategies, namely single pulse variable width (SPVW) and dual pulses variable width (DPVW), are introduced for the high-speed PM BLDC motor drives, and are comprehensively investigated. Finite element method (FEM) is employed to evaluate and compare the drive system performance when using the conventional PWM, and the proposed SPVW and DPVW, respectively. Influence of the control techniques, especially on the loss distribution, is revealed.

Remarkable impact of amino acids on ginsenoside transformation from fresh ginseng to red ginseng

Zhi Liu,Xin Wen,Chong-Zhi Wang,Wei Li,Wei-Hua Huang,Juan Xia,Chang-Chun Ruan,Chun-Su Yuan 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.3

Background: Amino acids are one of the major constituents in Panax ginseng, including neutral aminoacid, acidic amino acid, and basic amino acid. However, whether these amino acids play a role in ginsenosideconversion during the steaming process has not yet been elucidated. Methods: In the present study, to elucidate the role of amino acids in ginsenoside transformation fromfresh ginseng to red ginseng, an amino acids impregnation pretreatment was applied during thesteaming process at 120 C. Acidic glutamic acid and basic arginine were used for the acid impregnationtreatment during the root steaming. The ginsenosides contents, pH, browning intensity, and free aminoacids contents in untreated and amino acidetreated P. ginseng samples were determined. Results: After 2 h of steaming, the concentration of less polar ginsenosides in glutamic acidetreatedP. ginseng was significantly higher than that in untreated P. ginseng during the steaming process. However,the less polar ginsenosides in arginine-treated P. ginseng increased slightly. Meanwhile, free aminoacids contents in fresh P. ginseng, glutamic acid-treated P. ginseng, and arginine-treated P. ginsengsignificantly decreased during steaming from 0 to 2h. The pH also decreased in P. ginseng samples at hightemperatures. The pH decrease in red ginseng was closely related to the decrease in basic amino acidslevels during the steaming process. Conclusion: Amino acids can remarkably affect the acidity of P. ginseng sample by altering the pH value. Theywere the main influential factors for the ginsenoside transformation. These results are useful in elucidatingwhy andhowsteaming induces the structural change of ginsenoside in P. ginseng and also provides an effectiveand green approach to regulate the ginsenoside conversion using amino acids during the steaming process.

Effects of dietary protein level on growth performance and nitrogen excretion of dairy heifers

Bin Zhang,Chong Wang,He Liu,Jian-Xin Liu,Hongyun Liu 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.3

Objective: Protein supplementation is costly and can result in excess nitrogen (N) excretion. The objective of this study was to evaluate the effects of feeding different levels of dietary protein on average daily gain, body size, rumen fermentation, and nitrogen excretion of 8 to 10 month-old Holstein heifers. Methods: Thirty-six Holstein heifers were divided into 12 blocks according to age (273±6.2 d) and were randomly assigned to diets containing a low (10.2% dry matter [DM]), medium (11.9% DM), or high (13.5% DM) level of dietary crude protein (CP). All diets contained approximately 70% roughage and 30% concentrate with similar dietary metabolizable energy (ME) content (2.47 Mcal/kg). Results: Dry matter intake did not differ among the treatments, and average daily gain increased with the increasing dietary protein, 0.79, 0.95, 0.97 kg/d for low, medium, and high group, respectively. Body height increased linearly with increasing dietary CP but no other significant differences in body dimensions were found among the treatments. The increased ratios of dietary CP improved the rate of rear teat length growth remarkably (p<0.05). There was no difference in rumen pH or ruminal major volatile fatty acid (acetate, propionate, and butyrate) concentration among the 3 diets, but rumen ammonia-N concentration increased with the higher dietary CP (p<0.05). Increasing N intake led to increased total N excretion; urinary N excretion was significantly increased (p<0.05) but fecal N excretion was similar among the treatments. Conclusion: These data suggest that the diet containing 11.9% CP (ME 2.47 Mcal/kg) could meet the maintenance and growth requirements of 9 to 11 month-old Holstein heifers gaining approximately 0.9 kg/d.

Body constitution and dysmenorrhea: a study on university students in Malaysia

Teek Foh Chong,Xin Ee Ser,Lay Khuan Ooi,Ling Shing Wong 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.4

Dysmenorrhea is a common gynecologic condition among women. The relation between the menstrual pain and the Chinese medicine body constitution had never being studied in Malaysia, especially among students in higher education institute. In this study, a survey was carried out to analyze the relationship between the occurrence of dysmenorrhea among female students and the Chinese medicine body constitution. A cross-sectional descriptive was conducted on 201 female students. The information were obtained via questionnaires. The result analysis indicated 80% of the respondents experienced dysmenorrhea, with 79.6% of them had biased constitutions. The top three biased constitutions in the dysmenorrhea group were qi deficiency constitution, qi stagnation constitution, and yin deficiency constitution. Through this study, the relation between dysmenorrhea and the biased Chinese medicine body constitution was confirmed.

A Robust H∞ Control Approach for a Class of Networked Control Systems with Sampling Jitter and Packet-dropout

Chang-chun Hua,Shao-Chong Yu,Xin-Ping Guan 제어·로봇·시스템학회 2014 International Journal of Control, Automation, and Vol.12 No.4

This paper is concerned with the robust H∞ control problem for a class of networked control systems (NCSs) with sampling jitter, short time-varying delays and packet-dropouts. By considering state feedback controller, the close-loop NCS is described as a discrete-time linear switched system model with uncertainties. Based on the linear matrix inequality (LMI) approach, a robust H∞ condition is proposed to solve the H∞ stability and stabilization problems for the considered NCS. An illustrative example is provided to demonstrate the effectiveness of the proposed theoretical results.