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Yonghoon Choi,Nayoung Kim,Gi Tark Noh,Ju Yup Lee,Dong Ho Lee 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.1
Background/Aims: The Flos Lonicera extract GCWB104 has been shown to have significant protective effects against gastritis and gastric ulcers in vivo. The aim of this study was to investigate the efficacy and safety of GCWB104 in subjects with functional dyspepsia (FD). Methods: In this single-center, double-blind, randomized clinical trial, 92 subjects diagnosed with FD using the Rome III criteria were allocated to either the test group (300 mg of GCWB104, containing 125 mg of Flos Lonicera extract, twice daily) or the placebo group (300 mg placebo, twice daily). The total score improvement on the Gastrointestinal Symptom Rating Scale (GSRS) for individual symptoms, changes in antioxidant levels, changes in dyspepsia-related quality of life according to the Nepean Dyspepsia Index (NDI), and adverse effects were compared before and after 8 weeks of treatment. Results: The differences in total GSRS scores and score improvements after 8 weeks of treatment were significant between the GCWB104 and control groups (p=0.0452 and p=0.0486, respectively). Thirteen of 15 individual symptoms on the GSRS improved in the GCWB104 group, while six symptoms improved in the control group. In addition, statistically significant changes in rumbling, loose stool, and stool urgency were observed in the GCWB104 group. Blood 8-hydroxy-2’-deoxyguanosine (8-OHdG) levels, known as antioxidants, showed significant reductions after 8 weeks of administration of GCWB104. There were no adverse events related to treatment with GCWB104. Conclusions: GCWB104 safely contributed to improvements in mild to moderate FD and irritable bowel syndrome symptoms. Antioxidant effects of GCWB104 were also suggested (Clinicaltrials.gov number NCT04008901).
Joint Resource Allocation for Parallel Multi-Radio Access in Heterogeneous Wireless Networks
Yonghoon Choi,Hoon Kim,Sang-wook Han,Youngnam Han IEEE 2010 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.9 No.11
<P>Heterogeneous wireless networks where several systems with different bands coexist for multimedia service are currently in service and will be widely adopted to support various traffic demand. Under heterogeneous networks, a mobile station can transmit over multiple and simultaneous radio access technologies (RATs) such as WLAN, HSPA, and WCDMA LTE. Also, cognitive radio for the efficient use of underutilized/unused frequency band is successfully implemented in some networks. In this letter, we address such operational issues as air interface and band selection for a mobile and power allocation to the chosen links. An optimal solution is sought and analyzed and a distributed joint allocation algorithm is proposed to maximize total system capacity. We investigate the benefit of multiple transmissions by multiple RATs over a single transmission by a single RAT at a time, which can be interpreted as network diversity. Numerical results validate the performance enhancement of our proposed algorithm.</P>
Choi Yonghoon,Kim Nayoung,Yoon Hyuk,Shin Cheol Min,Park Young Soo,Lee Dong Ho,Park Young Suk,Ahn Sang-Hoon,Suh Yun-Suhk,Park Do Joong,Kim Hyung Ho 거트앤리버 소화기연관학회협의회 2022 Gut and Liver Vol.16 No.3
Background/Aims: Less invasive surgical treatment is performed in East Asia to preserve postoperative digestive function and reduce complications such as postgastrectomy syndromes, but there is an issue of metachronous gastric cancer (GC) in the remaining stomach. This study aimed to analyze the incidence of metachronous GC and its risk factors in patients who had undergone partial gastrectomy. Methods: A total of 3,045 GC patients who had undergone curative gastric partial resection at Seoul National University Bundang Hospital were enrolled and analyzed retrospectively for risk factors, including age, sex, smoking, alcohol, Helicobacter pylori status, family history of GC, histological type, and surgical method. Results: Metachronous GC in the remaining stomach occurred in 35 of the 3,045 patients (1.1%): 23 in the distal gastrectomy group (18 with Billroth-I anastomosis, five with Billroth-II anastomosis), seven in the proximal gastrectomy (PG) group, and five in the pylorus-preserving gastrectomy (PPG) group. Univariate and multivariate Cox regression analyses showed that age ≥60 years (p=0.005) and surgical method used (PG or PPG, p<0.001) were related risk factors for metachronous GC, while male sex and intestinal type histology were potential risk factors. Conclusions: Metachronous GC was shown to be related to older age and the surgical method used (PG or PPG). Regular and careful follow-up with endoscopy should be performed in the case of gastric partial resection, especially in patients with male sex and intestinal type histology as well as those aged ≥60 years undergoing the PG or PPG surgical method.
Atelectasis caused by post-PEG pneumoperitoneum
( Yonghoon Choi ),( Jaeil Chung ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
PEG (Percutaneous Endoscopic Gastrostomy) has become the most preferred procedure for long-term enteral feeding, since it is proven to be safe and cost effective. Pneumoperitoneum is reported to be common after PEG procedure, but the frequency of serious complications is extremely low, so conservative management is suggested. We report a case of PEG-related pneumoperitoneum and right lung atelectasis, which was not improved after 24 hours and caused respiratory distress. A 76-year-old male received PEG procedure for long-term enteral feeding. Chest X-ray taken after the procedure showed pneumoperitoneum and right lung atelectasis. Since the patient was in a stable state, we decided to observe and wait for spontaneuos resolution. But 1 day after procedure, respiratory distress and desaturation were observed, so mechanical ventilation was started. Needle aspiration of free air and intraabdominal catheter insertion were performed, and atelectasis was resolved after decompression. In our case, only right lung atelectasis was observed, so we waited for self resolution, but pneumoperitoneum and atelectasis were persisted. We decided to perform air aspiration and catheter insertion for decompression since the patient was hemodynamically unstable and his condition was deteriorating rapidly. Pneumoperitoneum may cause lung atelectasis in severe cases, and may have resulted in respiratory distress. If the possibility of respiratory distress is suspected, invasive managements including air aspiration or catheter placement should be considered.
Yonghoon Choi,Changhoon Choi,Joonwon Bae,Jongnam Park,Kyusoon Shin 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
Group III–Ⅴ quantum dots (QDs) are preferred over Group Ⅱ–Ⅵmaterials because of their relatively mildtoxicity. In this study, a facile synthetic method to obtain gallium phosphide (GaP) QDs with color conversionperformance is reported. Colloidal GaP QDs were produced via a hot-injection method using anoptimized combination of precursors. The products showed controllable emissions from 400 to 520 nm,depending on the band gap. High photoluminescence (PL) quantum yields of 35–40% with a full width athalf maximum (FWHM) of 75 nm were achieved in the green emission region. In addition, the greenemissionGaP QDs were applied as a color-conversion material for optical devices with UV and blueLED chips. An average color conversion efficiency of 15% was achieved. This study demonstrates the possibilityof using GaP QDs as a competitive color-conversion material.
Yonghoon Choi 대한상부위장관ㆍ헬리코박터학회 2024 Korean Journal of Helicobacter Upper Gastrointesti Vol.24 No.1
Gastric adenocarcinoma with enteroblastic differentiation (GAED) is rare and its clinicopathological characteristics are not well documented. However, reports indicate that it exhibits more aggressive characteristics, including lymph node metastasis or liver metastasis, than a conventional gastric adenocarcinoma. Herein, we report a case of GAED with rapid recurrence and disease progression. A 55-year-old male, diagnosed with gastric cancer (GC), demonstrated initial endoscopic findings suggestive of advanced GC. He underwent curative resection since there was no evidence of lymph node or distant metastases. The disease was reported as an early GC that was confined to the submucosal layer, without evidence of lymph node metastasis in the final pathological results. However, six months after surgery, multiple hepatic metastases were found during abdominal computed tomography; the pathological results were consistent with metastasis from the GC. Immunohistochemistry of the primary carcinoma pathological specimens showed positive results for alpha-fetoprotein and sal-like protein 4, suggesting enteroblastic differentiation, which is thought to be associated with rapid recurrence and disease progression.
Liver abscess occurred in patient with ectopic opening of ampulla of Vater
( Yonghoon Choi ),( Gyuwon Kim ),( Chansup Shim ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
The ampulla of Vater is normally located in the posteromedial wall of the second portion of the duodenum. But it may be ectopic and located in uncommon sites such as the other parts of the duodenum and the stomach. The most common location of ectopic biliary drainage into the stomach is the body of the stomach followed by the antrum and cardia; the pylorus is very rare. An ectopic opening of the CBD is reported to be associated with biliary tract diseases or peptic ulcer diseases; In literature, duodenal ulcers are the most common complication, and gastric ulcers are the least common. However, liver abscesses are not mentioned as a complication of ectopic opening of the CBD. A 56-year-old male was admitted to our hospital with the diagnosis of liver abscess. Pneumobilia and dilatation of the CBD were seen on computed tomography scan. ERCP was performed. But no area suggestingthe presence of the papilla of Vater was found within the second duodenal portion, and finally the major papilla was located in the pylorus. The CBD which should be located parallel to the portal vein and the pancreatic duct was not seen on EUS. MRCP showed narrowing and tapering of distal end of the CBD (hook-shaped). We suggest that the ectopic ampulla of Vater could be associated with liver abscess, since the most common cause of pyogenic liver abscess is known to ascending infection of biliary tract and the patient was healthy without any predisposing factor. Cautious evaluation about accompanying biliary tract anomalies may be needed in patients with liver abscess.