http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3
Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)
Cho, Cheong Ho,Choi, Jun Yong,Han, Sang Hoon,Lee, Han Sung,Choi, Suk Hoon,Chin, Bum Sik,Choi, Hee Kyoung,Jeoung, Su Jin,Kim, Myung Soo,Kim, Chang Oh,Kim, Chang Ki,Yong, Dongeun,Song, Young Goo,Lee, Ky 대한감염학회 2008 감염과 화학요법 Vol.40 No.2
목적 : 동물 모델을 이용하여 GISA에 의한 심내막염에서 teicoplain과 arbekacin 병용 요법의 치료 효과를 알아보고자 하였다. 재료 및 방법 : 토끼 심내막염 모델을 이용하여 GISA 에 의한 심내막염에서 teicoplanin과 arbekacin 병용 요법의 효과를 단독 요법의 효과와 비교하였다. GISA 균주는 Mu50 균주를 사용하였고, 기존 문헌과 동일한 방법으로 토끼를 이용하여 동맥판 심내막염 모델을 사용하였다. 항생제 치료는 균을 주사한지 20시간 이후에 시작하였다. Teicoplanin은 40 mg/kg를 1회 근육 주사한 후에 20 mg/kg의 용량을 12시간 마다 4일간 투여하였다. Arbekadn은 5 mg/kg를 12시간 마다 4일간 근육 주사하였다. 마지막 항균제 투여 20시간 이후에 토끼 대동맥판의 증식(vegetation)을 채취하였다. 항균제를 투여하지 않은 대조군, teicoplanin 단독 치료군, arbekacin 단독 치료군, teicoplanin과 arbekacin 병용치료 군간의 증식의 무게(gram) 당 log_10)CFU의 차이를 비교하였다. 결과 : Teicoulanin과 arbekacin 병용 치료군에서 teicoplanin단독 치료군, 혹은 arbekacin 단독 치료군에 비해 증식의 무게(gram)당 log_10)CFU 값이 유의하게 낮았다(P<0.05). 결론 : 동물 모델에서 GISA에 의한 심내막염에 대한 teicoplanin과 arbekacin 병용 치료의 효과가 teicoplanin이나 arbekacin 단독 치료에 비해 우월하였다. Background : There have been no reports to evaluate the usefulness of combination therapy with glycopeptide and arbekacin in endocarditis by in vivo model. Materials and Methods : We investigated the efficacy of the arbekacin and teicoplanin combination on glycopeptide intermediate Staphylococcus aureus (GISA) in rabbit model of endocardits. GISA Mu50 strain was used for the experiment. The rabbit model of aortic valve endocarditis as described previously was used. Treatment was started 20h later inoculation with teicoplanin alone (at 20 mg/kg of body weight intramuscularly every 12 hours for 4 days after loading dose of 40 mg/kg of body weight intramuscularly), arbekacin alone (5 mg/kg of body weight intramuscularly every 12h for 4 days), or teicoplanin plus arbekacin. Results : The results of therapy for experimental endocarditis due to Mu50 showed that teicoplanin and arbekacin combination was more effective than the administration of both drugs alone in reducing the log_10)CFU/g of aortic vegetation (P<0.05). Conclusion : The combination of teicoplanin and arbekacin was more effective against GISA (Mu50) than both drugs alone in vivo endocarditis model.
Antioxidant and Antiobesity Activity of Solvent Fractions from Red Garlic
Cho Rong Hwang(황초롱),Jung Hae Shin(신정혜),Min Jung Kang(강민정),Soo Jung Lee(이수정),Nak Ju Sung(성낙주) 한국생명과학회 2012 생명과학회지 Vol.22 No.7
열처리를 통한 새로운 마늘 가공품의 개발 및 그 생리활성 규명을 위한 연구의 일환으로 새로이 개발된 홍마늘의 용매별 계통 분획물을 제조하고, 항산화 활성과 항비만 활성을 중심으로 한 생리활성을 비교 분석하였다. 홍마늘 계통 분획물 중 갈변물질의 함량은 chloroform 분획물에서 가장 높았고, 총 페놀 화합물과 플라보노이드 함량은 hexane 분획물에서 가장 높은 함량이었고, 다음으로 chloroform 분획물의 순이었다. DPPH와 ABTS 라디칼소거능 및 FRAP법에 의한 항산화능도 chloroform 분획물이 타 분획물에 비해 유의적으로 높은 활성을 나타내었다. 항산화 활성은 갈변물질의 함량이 높고, 총 페놀 화합물 및 플라보노이드의 함량이 높은 hexane 및 chloroform 화합물에서 활성이 높아 홍마늘 분획물의 항산화능은 이들 물질의 상호작용에 의한 결과로 추정된다. Pancreatic lipase 저해활성은 500 μg/ml 미만의 농도에서는 농도 증가와 더불어 유의적으로 활성이 증가하였으며, 가장 활성이 높았던 chloroform 분획물에서 40% 이상의 활성을 나타내었다. 항산화 활성 분석의 결과에서 활성이 높았던 hexane 및 chloroform 분획물의 지방세포 분화와 지방 축적 억제 활성은 여타 분획물에 비해 상대적으로 낮았다. 항산화 활성과 항비만 활성이 일치하는 경향을 나타내지 않았는데, 이는 홍마늘 중의 항산화 활성물질은 주로 비극성이며, 지방 축적 억제 활성이 있는 물질은 주로 극성에 대한 용해성이 더 높기 때문으로 추정되며, 이와 관련하여서는 향후 더 많은 연구가 진행되어야 할 것으로 생각된다. Development of garlic processing products by thermal treatment and researched biological activity of a new product, red garlic. Red garlic MeOH extract was graduated by solvents, such as hexane, chloroform, ethyl acetate, butanol, and water, in order. Each solvent fraction was dried by a rotary evaporator and then resolved in water for analysis of its antioxidant and antiobesity activity. Browning compounds of red garlic fractions were the highest in the chloroform fraction. Total phenolic compounds and flavonoid content were highest in the hexane fraction. The chloroform fraction showed significantly higher activity in DPPH, ABTS radical scavenging activity, and antioxidant activity by FRAP. We propose that the antioxidant activity of the solvent fractions from red garlic was revealed interaction of browning compounds, total phenolic compounds, and flavonoids. Due to the higher activity of the shown fraction, the hexane and the chloroform fractions were have high contents of these compounds. Below 500 μg/ml, pancreatic lipase inhibition activity was significantly increased by sample concentration. And chloroform fraction, have the highest inhibition activity was shown over the 40%. In 3T3-L1 cells, the lipid accumulation inhibition activity was lower in the hexane and in the chloroform fraction than in the other fractions.
Cho, Oyeon,Chun, Mison,Park, Sung Ho,Oh, Young-Taek,Kim, Mi-Hwa,Park, Hae-Jin,Nam, Sang Soo,Heo, Jaesung,Noh, O Kyu The Korean Society for Radiation Oncology 2013 Radiation Oncology Journal Vol.31 No.1
Purpose: Parotid gland can be considered as a risk organ in whole brain radiotherapy (WBRT). The purpose of this study is to evaluate the parotid gland sparing effect of computed tomography (CT)-based WBRT compared to 2-dimensional plan with conventional field margin. Materials and Methods: From January 2008 to April 2011, 53 patients underwent WBRT using CT-based simulation. Bilateral two-field arrangement was used and the prescribed dose was 30 Gy in 10 fractions. We compared the parotid dose between 2 radiotherapy plans using different lower field margins: conventional field to the lower level of the atlas (CF) and modified field fitted to the brain tissue (MF). Results: Averages of mean parotid dose of the 2 protocols with CF and MF were 17.4 Gy and 8.7 Gy, respectively (p < 0.001). Mean parotid dose of both glands ${\geq}20$ Gy were observed in 15 (28.3%) for CF and in 0 (0.0%) for MF. The whole brain percentage volumes receiving >98% of prescribed dose were 99.7% for CF and 99.5% for MF. Conclusion: Compared to WBRT with CF, CT-based lower field margin modification is a simple and effective technique for sparing the parotid gland, while providing similar dose coverage of the whole brain.
Cho, Myung Hyun,Yoo, Ha Yeong,Kwak, Byung Ok,Park, Hye Won,Chung, Sochung,Kim, Soo Nyung,Son, Jae Sung,Kim, Kyo sun Korean Society of Pediatric Nephrology 2015 Childhood kidney diseases Vol.19 No.2
Purpose: The aim of this study was to establish a simple formula to predict renal length in children using a Technesium-99m dimercaptosuccinic acid (DMSA) scan data, and to compare it with the formula derived from ultrasonography, which is widely accepted. Methods: Children who underwent a DMSA scan and ultrasonography were reviewed retrospectively, and those who had anatomical urinary tract abnormalities or urinary tract infections were excluded. Results: A total of 230 children (84 males and 146 females; age, 1 month to 16 years; mean age, $16.8{\pm}27.4$ months). Mean renal length measured by DMSA scan was longer than that by ultrasonography ($6.38{\pm}1.16$ vs. $6.02{\pm}1.14cm$; P < 0.001). Renal length was correlated with age, weight, height, and body surface area on the DMSA scan and ultrasonography, and showed the strongest positive correlation with height. The following formulae were established to predict renal length: mean renal length (cm) = 5.433 ${\times}$ height (m) + 2.330 (R2, 0.833) using the DMSA scan data, and mean renal length (cm) = 5.367 ${\times}$ height (m) + 2.027 (R2, 0.853) using ultrasonography data. Conclusion: We propose a simple height-based formula to predict renal length in children using a DMSA scan data, and validate it by comparing with ultrasonography formula.