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Poster Session : PS 0633 ; Respiratory Medicine ; COPD and Percutaneous Coronary Intervention
( Pavel Alexei Chisholm Sanchez ),( Javier De Miguel Diez ),( Diego Jose Castrillon Rodriguez ),( Rodrigo Jimenez Garcia ),( Valentin Hernandez Barrera ),( Pilar Carrasco Garrido ),( Ana Lopez De Andr 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To compare trends in the use and outcomes of PCI in patients COPD and non COPD patients in Spain from 2001 to 2011. Methods: We identifi ed all patients who had undergone PCI, using national hospital discharge data. Discharges were divided, according to history of COPD, in 2 groups: COPD and non COPD. The incidence of discharges attributed to percutaneous coronary intervention were calculated and stratifi ed by COPD status. We calculated comorbidity Charlson Comorbidity Index (CCI), length of stay (LOS) and in-hospital mortality (IHM). Results: From 2001 to 2011, 434,108 PCI´s were performed. The incidence of use of PCI increased over time in both groups (p<0.05), COPD and non COPD, from 4.94 per 100,000 inhabitants in 2001 to 11.76 in 2011 in COPD, and from 87.74 to 177.56 in non COPD. Comorbidity increased signifi cantly in both groups (p<0.05). The average LOS decreased signifi cantly over time, from 9 (IQR 10) days in 2001 to 6 (IQR 6) days in COPD patients, and from 6 (IQR 9) days in 2001 to 5 (IQR 6) days in patients without COPD. IHM changed signifi cantly over the entire study period among patients with COPD (from 2.65% in 2001 to 2.66% in 2011, p<0,05, x2 linear trend analysis) and non COPD (from 1.92% in 2001 to 1.85% in 2011, p<0,05, x2 linear trend analysis). Conclusions: The incidence of use of PCI procedures increased over time in COPD and non COPD patients. Increasing comorbidity can be associated with a higher use of PCI procedures. LOS and IHM were higher in patients with COPD than in those without this disease.
북한의 대미 사회-정치 인식 변화: 1960-1991년의 『조선중앙년감』을 중심으로
WARD ROBERT PETER CHISHOLM 한국세계문화사학회 2019 세계 역사와 문화 연구 Vol.0 No.53
North Korean official perception of the US society and politics is very important given what an significant role anti-Americanism plays in North Korean state identity. Yet it has largely remained neglected as a topic of research both in South Korea and elsewhere. Up to now, most research on North Korean official discourse on the United States has focused on other issues like the social reproduction of anti-Americanism inside North Korea, the portrayal of the United States as an actor on the Korean peninsula, and the view of the United States as an imperial. The North Korean view of US society and politics within its broader ideology of anti-Americanism has remained largely unstudied. This article seeks to fill this gap in the literature by focusing on how US society and politics are depicted in a particular official North Korean source: The Korean Central Yearbook. This source is published yearly by the state's wire agency, which makes longitudinal, qualitative analysis easier to do systematically. The period under analysis here is 1960-91, and this period was chosen because this is when Kim Il-sung, having faced Soviet and Chinese intervention in North Korean internal affairs, sought to distance the country from its erstwhile backers. North Korean discourse in this period with respect to US politics and society are quite consistent, with little change noticeable change in how ruling US elites are depicted. Conversely, in North Korean discourse, perceptions of US society become less positive, with less hope put in revolutionary/progressive forces, and more emphasis on the 'diseased and rotten' nature of US society as the period goes on. The latter may speak to loss of hope in 'progressive' social forces in the United States on the part of the North Korean elite. 반미주의를 국가 정체성의 기본적 요소로 삼은 북한에게 있어 미국 정치 및 사회에 대한 인식은 중요하다. 그렇지만 지금까지 국내외에서 진행된 연구에서는 반미주의의 사회적 재생산, 역사적 배경, 주한미군 그리고 소위 미제국주의 등 북한 공식 담론의 다른 요소에 초점을 맞추었다. 북한 공식 담론에 있어서 반미주의를 구성하고 재생산하는 대미 인식에서의 미국 사회 및 정치에 대한 인식을 다루지 않고 있다. 본 연구는 기존 연구에서 거의 다루어지지 않아 온 북한 담론의 미국 사회 및 정치에 대한 담론에 대한 분석을 중심으로 한다. 담론의 실체 및 변화를 주기적으로 파악하는 데에는 북한 관영통신사인 조선중앙통신에서 매년 출간하는『조선중앙년감』을 기초자료로 활용한다. 1960년대에 접어드는 시점, 즉 북한이 독자적 외교노선을 취하게 될 때로부터 1990년까지의 북한 대미 정치-사회 인식을 주된 분석 대상으로 삼아, 김일성 시대의 대미 인식 변화를 밝히고자 한다. 이 시기 동안, 북한 담론에서의 미국 정치에 대한 논의는 일정한 일관성을 지니며 미국 지도층에 대한 비난의 논조 및 내용에서의 변화는 관찰되지 않는다. 반면에 미국 사회에 대한 인식은 시기별로 변화가 보이는데, 이는 미국 사회의 진보세력에 대한 북한의 희망이 감퇴되어 가는 현상 및 북한의 사상 변화로 해석된다.
강택진,( Carly Fleagle Chisholm ),( Axel Lehrer ),( Theodore W. Randolph ) 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
Proteins of pathogens whether prepared as inactivated viruses/bacteria or recombinantly produced can potentially act as vaccines. However, a recombinant protein alone is usually not immunogenic enough to evoke meaningful antibody production in human bodies, which leads to the formulation with a proper adjuvant. Currently, either aluminum hydroxide or aluminum phosphate is used in the most of adjuvanted vaccines in the market. Considering that the both aluminum salts are prone to aggregation upon freeze in the cold chain, the vaccine formulations with aluminum salts can be greatly stabilized in the absence of water. Since proteins in general become more stable upon heat shocks as well when they are in a solid state drying approaches in vaccine formulation can also be justified. As a part of continued efforts to prove the concept, here we report the stabilization and characterization of Ebola glycoprotein adjuvanted with aluminum hydroxide by lyophilization.
신성훈,David Hui,Gary Chisholm,강정훈,Julio Allo,Janet Williams,Eduardo Bruera 대한암학회 2015 Cancer Research and Treatment Vol.47 No.3
Purpose The response to haloperidol as a first-line neuroleptic and the pattern of neuroleptic rotation after haloperidol failure have not been well defined in palliative care. The purpose of this study was to determine the efficacy of haloperidol as a first-line neuroleptic and the predictors associated with the need to rotate to a second neuroleptic. Materials and Methods We conducted a retrospective review of the charts of advanced cancer patients admitted to our acute palliative care unit between January 2012 and March 2013. Inclusion criteria were a diagnosis of delirium and first-line treatment with haloperidol. Results Among 167 patients with delirium, 128 (77%) received only haloperidol and 39 (23%) received a second neuroleptic. Ninety-one patients (71%) who received haloperidol alone improved and were discharged alive. The median initial haloperidol dose was 5 mg (interquartile ranges [IQR], 3 to 7 mg) and the median duration was 5 days (IQR, 3 to 7 days). The median final haloperidol dose was 6 mg (IQR, 5 to 7 mg). A lack of treatment efficacy was the most common reason for neuroleptic rotation (87%). Significant factors associated with neuroleptic rotation were inpatient mortality (59% vs. 29%, p=0.001), and being Caucasian (87% vs. 62%, p=0.014). Chlorpromazine was administered to 37 patients (95%) who were not treated successfully by haloperidol. The median initial chlorpromazine dose was 150 mg (IQR, 100 to 150 mg) and the median duration was 3 days (IQR, 2 to 6 days). Thirteen patients (33%) showed reduced symptoms after the second neuroleptic. Conclusion Neuroleptic rotation from haloperidol was only required in 23% of patients with delirium and was associated with inpatient mortality and white race.