Registry-based stroke research in Taiwan: past and future

Cheng-Yang Hsieh,Darren Philbert Wu3,,Sheng-Feng Sung 한국역학회 2018 Epidemiology and Health Vol.40 No.-

Stroke registries are observational databases focusing on the clinical information and outcomes of stroke patients. They play an important role in the cycle of quality improvement. Registry data are collected from real-world experiences of stroke care and are suitable for measuring quality of care. By exposing inadequacies in performance measures of stroke care, research from stroke registries has changed how we manage stroke patients in Taiwan. With the success of various quality improvement campaigns, mortality from stroke and recurrence of stroke have decreased in the past decade. After the implementation of a nationwide stroke registry, researchers have been creatively expanding how they use and collect registry data for research. Through the use of the nationwide stroke registry as a common data model, researchers from many hospitals have built their own stroke registries with extended data elements to meet the needs of research. In collaboration with information technology professionals, stroke registry systems have changed from web-based, manual submission systems to automated fill-in systems in some hospitals. Furthermore, record linkage between stroke registries and administrative claims databases or other existing databases has widened the utility of registry data in research. Using stroke registry data as the reference standard, researchers have validated several algorithms for ascertaining the diagnosis of stroke and its risk factors from claims data, and have also developed a claims-based index to estimate stroke severity. By making better use of registry data, we believe that we will provide better care to patients with stroke.

아시아 횡단철도의 경제적 효과 분석 : 중국 동북 3성을 중심으로

구종순,여희정,동무성 한국관세학회 2009 관세학회지 Vol.10 No.1

The paper explores economic effects of the Trans-Asian Railway North Corridor(TAR-NC) in the Northeast regions of China. The 3 Northeast regions, called Dongbeisan Sheng(3 provinces composed of Liaoning Sheng, Helongjiang Sheng, Jilin Sheng) possess natural resources and form a large regional economic block. In the 2000's the Chinese government has led a development policy of land transport via TAR-NC. Volumes transported by rail from origin/destination stations such as Erlianhaote, Suifenhe, Arasankou, Manzhouli are significantly increasing. Furthermore, by the fact that the Russian government plans to reduce railway tariffs and the Chinese government reforms laws related to container transport to increase competitiveness of the TAR-NC as an international railway route, the TAR-NC will offer a better package of services such as transit times, tariffs to attract shippers and compete against well-established shipping lines. Europe is the second export/import trade partner for the 3 Northeast regions. The reduced transit times and tariffs offered by the railway route for land movements of containers will enhance the competitiveness of products of the regions in the European market.

From an Authoritarian Party-State to a Democratic and Competitive Party System

Wu, Wen Cheng 서강대학교 동아연구소 1988 東亞 硏究 Vol.- No.15

Seroprevalence of Toxoplasma gondii Infection in Police Dogs in Shenyang, Northeastern China

Cheng-Wu Liu,Na Yang,Jian-Bin He,Ming-Yang Mu,Min Yang,Ning Sun,Hong-Kui Li 대한기생충학열대의학회 2013 The Korean Journal of Parasitology Vol.51 No.5

6-Alkylsalicylic Acid Analogues Inhibit In Vitro ATPase Activity of Heat Shock Protein 90

Cheng-Zhu Wu,An Na Moon,Oksik Choi,Sun-Young Kang,Jung Joon Lee,황방연,김영호,Hong-Sub Lee,홍영수,이동호 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.12

The molecular chaperone heat shock protein 90 (Hsp90) is responsible for maintaining the correct folding and stability of many signaling proteins. It is a promising target of cancer therapeutics and several other diseases, including neurodegenerative disease, nerve injuries, inflammation, and infection. In an effort to identify new Hsp90 inhibitors from natural sources using an in vitro ATPase inhibition assay, two 6-alkylsalicylic acid analogues, salaceyin A and B were identified from the culture extract of Streptomyces. Salaceyin A and B exhibited moderate ATPase inhibitory activities with IC50 values of 68.3 and 65.2 μM, respectively. Binding of salaceyins to human Hsp90α was examined by competition binding experiments with ATPSepharose beads. However, the compounds exhibited no degradation activity of Hsp90 client proteins, Her2, c-Raf, or Akt.

A BP Neural Network Based on Improved PSO for Increasing Current Efficiency of Copper Electrowinning

Wu Jing,Cheng Yan-Ming,Liu Cheng,Lee Il-Kyoo,Cha Jae-Sang,Huang Wen-Lin 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.3

In this paper, to improve the current effi ciency in the copper electrowinning process is taken as the research objective. In the traditional production process, sulfate ion concentration, copper ion concentration and current density are carried out according to the empirical value, which cannot ensure the current effi ciency to reach the optimal level. Therefore, fi rstly, this paper proposes a BP neural network model to improve the current effi ciency according to the relationships between sulfate ion concentration, copper ion concentration, current density and the established BP neural network model is trained by using real data from the enterprise. The simulation results indicate that there is a defi nite error between the predicted current effi ciency and corresponding to the current effi ciency measured at the production site. It is proposed that the BP neural network improved by the improved PSO to further improve the prediction accuracy of the BP neural network. Simulation results indicate that the prediction error of the current effi ciency is greatly reduced that meets the accuracy requirements. On the premise of guaranteeing the quality of copper electrowinning, the current density, sulfate ion concentration and copper ion concentration corresponding to the maximum current effi ciency accurately predicted by this method can be respectively adjusted in real-time in the copper electrowinning process, which realizes the optimization of current effi ciency in the process of copper electrowinning under the background of low carbon and environmental protection.

An Optimized Control Method Based on Dual Three-Level Inverters for Open-end Winding Induction Motor Drives

Wu, Di,Su, Liang-Cheng,Wu, Xiao-Jie,Zhao, Guo-Dong The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.2

An optimized space vector pulse width modulation (SVPWM) method with common mode voltage elimination and neutral point potential balancing is proposed for an open-end winding induction motor. The motor is fed from both of the ends with two neutral point clamped (NPC) three-level inverters. In order to eliminate the common mode voltage of the motor ends and balance the neutral point potential of the DC link, only zero common mode voltage vectors are used and a balancing control factor is gained from calculation in the strategy. In order to improve the harmonic characteristics of the output voltages and currents, the balancing control factor is regulated properly and the theoretical analysis is provided. Simulation and experimental results show that by adopting the proposed method, the common mode voltage can be completely eliminated, the neutral point potential can be accurately balanced and the harmonic performance for the output voltages and currents can be effectively improved.

Non-linear FEA of mechanical properties of modular prefabricated steel-concrete composite joints

Wu Cheng Long,Kan Jian Cheng,Liu Ji Ming,Mou Ben 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.40 No.4

This paper study the seismic performance of modular prefabricated SRC column to steel beam composite joint (MPCJ) under static loading. Numerical modeling of MPCJs with three different beam-end connections was carried out in ABAQUS. Results of the numerical calculation were compared with existing quasi-static test results to verify the feasibility of the numerical model. The model was then used to analyze changes in the moment-rotation relation, failure mode, ductility, stiffness, and bolt stress in the joint between the column and joint module. Besides, stress distributions in the joints were analyzed along different stress paths. Under monotonic loading, the mechanical performance of the MPCJ is significantly affected by the beam end connection mode. Failure of the MPCJ mainly occurs at the beam end connection, thus, the aim of keeping the plastic hinge away from the joint core and preventing shear failure is achieved. Furthermore, the maximum story drift ratio is 3.9–5 times greater than the recommended limit, which indicates good ductility and deformation performance. The MPCJ of the three-beam end connection methods is all semi-rigid connections. The beam end structure will have a large influence on the bolt tension and stress distribution. According to the test research results, a nonlinear model with three parameters including joint cover plate cantilever section length, flange connecting plate thickness and flange connecting plate weld length was established. The theoretical calculation results was consistent with the results of the numerical simulation. MPCJs can be designed based on the proposed theoretical calculation formula.

CFD computation of ship motions and added resistance for a high speed trimaran in regular head waves

Wu, Cheng-Sheng,Zhou, De-Cai,Gao, Lei,Miao, Quan-Ming The Society of Naval Architects of Korea 2011 International Journal of Naval Architecture and Oc Vol.3 No.1

Some research work on CFD computation of ship motions and added resistance in waves for a high speed trimaran is carried out in this paper. The governing equations, Reynolds Averaged Navier-Stokes and continuity equations are discretized by finite volume method. Volume of fluid method is adopted to deal with the nonlinear free surface. The incident waves are generated from the inflow boundary by prescribing a velocity profile resembling flexible flap wavemaker motions, and the outgoing waves are dissipated inside an artificial damping zone located at the rear part of the wave tank. In this paper, the computed results of ship motion and added resistance for a high speed trimaran are presented. The results of seakeeping experiment for the high speed trimaran carried out in CSSRC towing tank are also presented in this paper. Rather good agreements are shown between the computational and experimental results. The work in this paper provides a numerical tool for the study of seakeeping performance of high speed trimarans.

Establishment of hybridization breeding of Ganoderma lucidum by protoplast monokaryogenesis method

Wu Jiaojiao,Fu Lizhong,Wu Xueqian,Xu Xiuhong,Li Haibo,Wu Qingqi,Wei Hailong,Cheng Junwen 한국버섯학회 2010 한국버섯학회지 Vol.8 No.4

Four Ganoderma lucidum strains, Chizhi 05, Jingda, Huizhou and Xinzhou, were screened out as hybrid parent in order to establish G. lucidum cross breeding system that based on protoplast monokaryogenesis method. Monokaryotic strains of each parental strains were obtained and mating type of each monokaryotic strains were determined. One to three monokaryotic strains that have different mating types were mated, and hybrids were identified by clamp connection observation and antagonist response. The results showed that the number of monokaryon came from Chizhi 05, Jingda, Huizhou and Xinzhou was 9, 14, 40 and 38, respectively. Only one mating type was obtained from Jingda, and two mating types were obtained from the other three strains, Chizhi 05, Huizhou and Xinzhou, respectively. Chi-square test showed that the ratio of two mating types of the three strains was 1:1. Fourteen monokaryotic strains of different mating types from 4 parental strains were select as a cross- breeding materia, and 17 hybrids were obtained, which were identified by clamp connection observation and antagonist response. This study proclaimed that the practicality of the hybridization breeding of G. lucidum by protoplast monokaryogenesis method.