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      • KCI등재

        Contact Tracking Development Trend Using Bibliometric Analysis

        Chaoqun Li,Zhigang Chen,Tongrui Yu,Xinxia Song 한국정보처리학회 2022 Journal of information processing systems Vol.18 No.3

        The new crown pneumonia (COVID-19) has become a global epidemic. The disease has spread to mostcountries and poses a challenge to the healthcare system. Contact tracing technology is an effective way forpublic health to deal with diseases. Many experts have studied traditional contact tracing and developed digitalcontact tracking. In order to better understand the field of contact tracking, it is necessary to analyze thedevelopment of contact tracking in the field of computer science by bibliometrics. The purpose of this researchis to use literature statistics and topic analysis to characterize the research literature of contact tracking in thefield of computer science, to gain an in-depth understanding of the literature development status of contacttracking and the trend of hot topics over the past decade. In order to achieve the aforementioned goals, weconducted a bibliometric study in this paper. The study uses data collected from the Scopus database. Whichcontains more than 10,000 articles, including more than 2,000 in the field of computer science. For populartrends, we use VOSviewer for visual analysis. The number of contact tracking documents published annuallyin the computer field is increasing. At present, there are 200 to 300 papers published in the field of computerscience each year, and the number of uncited papers is relatively small. Through the visual analysis of the paper,we found that the hot topic of contact tracking has changed from the past “mathematical model,” “biologicalmodel,” and “algorithm” to the current “digital contact tracking,” “privacy,” and “mobile application” and othertopics. Contact tracking is currently a hot research topic. By selecting the most cited papers, we can displayhigh-quality literature in contact tracking and characterize the development trend of the entire field throughtopic analysis. This is useful for students and researchers new to field of contact tracking ai well as forpresenting our results to other subjects. Especially when comprehensive research cannot be conducted due totime constraints or lack of precise research questions, our research analysis can provide value for it.

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        Insights into interfacial stability of Li6PS5Cl solid electrolytes with buffer layers

        Bingbing Chen,Chaoqun Xu,Han Wang,Jianqiu Zhou 한국물리학회 2019 Current Applied Physics Vol.19 No.2

        The large interfacial resistance seriously restricts the development of all-solid-state lithium batteries (ASSLBs). In our work, first-principles calculations are employed to investigate the interfacial properties on lithium (Li) metal anode/Li6PS5Cl solid electrolyte (LPSCl) interface system as well as buffer layers (Li2S) effects. The stable interface structures, Li/LPSCl, L2S/LPSCl and Li/L2S, are established at atomic level. We find that PS4 tetrahedral structure has been seriously destroyed in Li/LPSCl interface, whereas the presence of Li2S buffer layers may smooth the interface without PS4 tetrahedral damage occurred. In addition, the electronic structure of interface indicates that solid electrolyte interphases are not easy to form on LPSCl surfaces considering buffer layers effects, which may improve the stability of anode/solid electrode interface. Moreover, the calculated energies of exchange ions between Li metal and solid electrolyte with buffer layers suggest that the Li2S interposition can suppress the atoms diffusion in LPSCl layers, and provide a smooth interface structure, which may promote the stability of Li/LPSCl interface. This work on the atomic scale will offer a useful perspective for designing high performance of solid electrolytes to enhance good cyclability in ASSLBs.

      • SCISCIESCOPUS

        Two-dimensional metal organic framework for effective gas absorption

        Cheng, Kaiwu,Li, Yaojia,Gao, Zhiguo,Chen, Fanghui,You, Chaoqun,Sun, Baiwang Elsevier 2019 Inorganic Chemistry Communications Vol.101 No.-

        <P><B>Abstract</B></P> <P>Herein, crystalline metal organic framework (MOF) nanosheets have been fabricated through using a modified soft physical exfoliation method from bulk crystals of a layered MOF, [Cd(4,4′‑bpy)<SUB>2</SUB>(H<SUB>2</SUB>O)<SUB>2</SUB>](ClO<SUB>4</SUB>)<SUB>2</SUB>·(2,4′‑bpy)<SUB>2</SUB>·H<SUB>2</SUB>O (MOF-1), and fully characterized via transmission electron microscope (TEM), scanning electron microscopy (SEM), and atomic force microscope (AFM). The delaminated MOF-1 nanosheets with porous structure showed good growth potential in selective gas adsorption.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Using a modified soft physical exfoliation method from bulk crystals, we firstly synthesized a layered MOF nanosheets. </LI> <LI> The MOF-2 nanosheets revealed a superior absorption performance. </LI> <LI> The delaminated MOF nanosheets with porous structure showed good growth potential in selective gas adsorption. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

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        Activation of Tyrosine Metabolism in CD13+ Cancer Stem Cells Drives Relapse in Hepatocellular Carcinoma

        Li Sun,Lin Zhang,Jun Chen,Chaoqun Li,Hongqin Sun,Jiangrong Wang,Hong Xiao 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

        Purpose Cancer stem cells (CSCs) are naturally resistant to chemotherapy, explaining why tumor relapse frequently occurs after initial regression upon administration of chemotherapeutic agents in most cases. A CSC population characterized by CD13 expression has been identified in hepatocellular carcinoma (HCC). In the current study, we aimed to clarify the molecular mechanism by which it escapes conventional therapies. Materials and Methods Here, we used flow cytometry to examine the percentage of CD13+ CSCs in HepG2 and HuH7 cells after chemotherapy. Using in vitro isotope labeling technique, we compared metabolic pathways between CD13+ and CD13– subpopulations. Using co-immunoprecipitation and western blotting, we determined the target expressions in protein levels under different conditions. We also performed immunohistochemistry to detect the target proteins under different conditions. Animal models were constructed to verify the potential role of tyrosine metabolism in post-chemotherapeutic relapse in vivo. Results We observed that quiescent CD13+ CSCs are enriched after chemotherapy in HCCs, and serve as a reservoir for recurrence. Mechanistically, CD13+ CSCs were dependent on aerobic metabolism of tyrosine rather than glucose as energy source. Tyrosine metabolism also generated nuclear acetyl-CoA to acetylate and stabilize Foxd3, thereby allowing CD13+ CSCs cells to sustain quiescence and resistance to chemotherapeutic agents. Conclusion These findings encourage further exploration of eliminating CD13+ cells by targeting specific metabolic pathways to prevent recurrence in HCCs.

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