Huang-Lin Error Correcting Code and the circuit

Bingshan Lin,Yuanshan Huang,Zhongquan Ren 대한전자공학회 1995 International Conference on Electronics, Informati Vol.1995 No.8

A retrospective analysis of 20-year data of the surgical management of ulcerative colitis patients in Taiwan: a study of Taiwan Society of Inflammatory Bowel Disease

( Chun-chi Lin ),( Shu-chen Wei ),( Been-ren Lin ),( Wen-sy-tsai ),( Jinn-shiun Chen ),( Tzu-chi Hsu ),( Wei-chen Lin ),( Tien-yu Huang ),( Te-hsin Chao ),( Hung-hsin Lin ),( Jau-min Wong ),( Jen-kou 대한장연구학회 2016 Intestinal Research Vol.14 No.3

Background/Aims: With the recent progress in medical treatment, surgery still plays a necessary and important role in treating ulcerative colitis (UC) patients. In this study, we analyzed the surgical results and outcomes of UC in Taiwan in the recent 20 years, via a multi-center study through the collaboration of Taiwan Society of IBD. Methods: A retrospective analysis of surgery data of UC patients from January 1, 1995, through December 31, 2014, in 6 Taiwan major medical centers was conducted. The patients’ demographic data, indications for surgery, and outcome details were recorded and analyzed. Results: The data of 87 UC patients who received surgical treatment were recorded. The median post-operative follow-up duration was 51.1 months and ranged from 0.4 to 300 months. The mean age at UC diagnosis was 45.3±16.0 years and that at operation was 48.5±15.2 years. The 3 leading indications for surgical intervention were uncontrolled bleeding (16.1%), perforation (13.8%), and intractability (12.6%). In total, 27.6% of surgeries were performed in an emergency setting. Total or subtotal colectomy with rectal preservation (41.4%) was the most common operation. There were 6 mortalities, all due to sepsis. Emergency operation and low pre-operative albumin level were significantly associated with poor survival (P =0.013 and 0.034, respectively). Conclusions: In the past 20 years, there was no significant change in the indications for surgery in UC patients. Emergency surgeries and low pre-operative albumin level were associated with poor survival. Therefore, an optimal timing of elective surgery for people with poorly controlled UC is paramount.

Implementation of an Interleaved AC/DC Converter with a High Power Factor

Lin, Bor-Ren,Lin, Li-An The Korean Institute of Power Electronics 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.3

An interleaved bridgeless buck-boost AC/DC converter is presented in this paper to achieve the characteristics of low conduction loss, a high power factor and low harmonic and ripple currents. There are only two power semiconductors in the line current path instead of the three power semiconductors in a conventional boost AC/DC converter. A buck-boost converter operated in the boundary conduction mode (BCM) is adopted to control the active switches to achieve the following characteristics: no diode reverse recovery problem, zero current switching (ZCS) turn-off of the rectifier diodes, ZCS turn-on of the power switches, and a low DC bus voltage to reduce the voltage stress of the MOSFETs in the second DC/DC converter. Interleaved pulse-width modulation (PWM) is used to control the switches such that the input and output ripple currents are reduced such that the output capacitance can be reduced. The voltage doubler topology is adopted to double the output voltage in order to extend the useable energy of the capacitor when the line voltage is off. The circuit configuration, principle operation, system analysis, and a design example are discussed and presented in detail. Finally, experiments on a 500W prototype are provided to demonstrate the performance of the proposed converter.

Hybrid ZVS Converter with a Wide ZVS Range and a Low Circulating Current

Lin, Bor-Ren,Chen, Jia-Sheng The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.3

This paper presents a new hybrid soft switching dc-dc converter with a low circulating current and high circuit efficiency. The proposed hybrid converter includes two sub-converters sharing two power switches. One is a three-level PWM converter and the other is a LLC converter. The LLC converter and the three-level converter share the lagging-leg switches and extend the zero-voltage switching (ZVS) range of the lagging-leg switches from nearly zero to full load since the LLC converter can be operated at f_sw (switching frequency) $\approx$ f_r (series resonant frequency). A passive snubber is used on the secondary side of the three-level converter to decrease the circulating current on the primary side, especially at high input voltage and full load conditions. Thus, the conduction losses due to the circulating current are reduced. The output sides of the two converters are connected in series. Energy can be transferred from the input voltage to the output load within the whole switching period. Finally, the effectiveness of the proposed converter is verified by experiments with a 1.44kW prototype circuit.

Huang-Lin Error Correcting Code and the Circuit

Bing Shan Lin,Yuan Shan Huang,Zheng Quan Ren 대한전자공학회 1995 ICEIC:International Conference on Electronics, Inf Vol.1 No.1

Interleaved DC-DC Converters with Partial Ripple Current Cancellation

Lin, Bor-Ren,Chiang, Huann-Keng,Cheng, Chih-Yuan The Korean Institute of Power Electronics 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.2

An interleaved PWM converter is proposed to implement the features of zero voltage switching (ZVS), load current sharing and ripple current reduction. The proposed converter includes two ZVS converters with a common clamp capacitor. With the shared capacitor, the charge balance of the two interleaved parts is automatically regulated under input voltage and load variations. The active-clamping circuit is used to realize the ZVS turn-on so that the switching losses on the power switches are reduced. The ZVS turn-on of all of the switching devices is achieved during the transition interval. The interleaved pulse-width modulation (PWM) operation will reduce the ripple current and the size of the input and output capacitors. The current double rectifier (CDR) is adopted in the secondary side to reduce output ripple current so that the sizes of the output chokes and capacitor are reduced. The circuit configuration, operation principles and design considerations are presented. Finally experimental results based on a 408W (24V/17A) prototype are provided to verify the effectiveness of the proposed converter.

miR-29 family inhibited the proliferation and migration of lung cancer cells by targeting SREBP-1

Lin Lin,Bao Yongxia,Tian Miao,Ren Qiu,Zhang Wei 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.2

Backgrounds Lipid metabolism dysregulation is an important characteristic of tumor cells. Increased lipid metabolism provides a vital material and energy source for tumor growth, thereby promoting tumor invasion and metastasis. Objectives In the current work, we carried out a series of in vivo and in vitro studies to explore the relationship between miR-29 and lung cancer. Results The results showed that miR-29 was down-regulated in lung cancer, and overexpression of miR-29 inhibited the proliferation and migration of lung cancer cells (in vitro). Anti-lung cancer effect of miR-29 in vivo was evaluated, and results indicated that transfection of miR-29b/c markedly inhibited lung tumor growth (in vivo). We further explored the potential mechanism by which miR-29 could inhibit the cell proliferation of lung cancer. It is well known that lipid metabolism dysregulation is an important characteristic of tumor cells. Increased lipid metabolism provides a vital material and energy source for tumor growth, thereby promoting tumor invasion and metastasis, and sterol regulatory element-binding protein 1 (SREBP) is involved in liposome metabolism. Therefore, we analyzed the interaction between miR-29C and SREBP-1 in lung cancer cells. Bioinformatics analysis showed that the miR-29 has the potential binding site on SCAP and SREBP mRNA, and Luciferase reporter gene assays revealed the interaction between 3′UTR of SREBP-1 mRNA and miR-29c. Further study showed that miR-29 suppressed (SREBP-1) expression by interacting with 3′UTR of SREBP-1. Further work indicated that miR-29 transfection strongly inhibited lung cancer cell proliferation, which was rescued by the overexpression of SREBP-1. Conclusion These fi ndings demonstrate that transfection of miR-29 suppressed lung cancer proliferation via inhibiting SREBP-1 expression. The current study provides a basis for exploring the targeted agents against lung cancer.

DC-DC converter implementation with wide output voltage operation

Lin, Bor-Ren The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.2

A direct current (DC) to DC converter with soft switching and high efficiency is developed for industry power units with a wide range of output voltage applications. A series resonant converter is the main circuit on the primary side to accomplish the soft switching characteristics for the active devices and rectifier diodes without switching loss or reverse recovery current loss. To overcome the drawback of the limited operation input or output voltage range in conventional LLC converters, a hybrid resonant converter including a half-bridge circuit and a full-bridge circuit with auxiliary windings is developed to achieve 8:1 (V_o,max=8V_o,min) output voltage characteristics for a wide range of output voltage applications. To achieve this function, two AC power switches are used in the developed circuit. Since a single-stage hybrid resonant converter is presented instead of a two-stage converter to realize wide voltage range operation, the developed circuit has better efficiency when compared to conventional LLC converters and two-stage DC-DC converters. To confirm the circuit analysis and effectiveness, a prototype with a 400 W rated power was built and tested.

Analysis of an Interleaved Resonant Converter for High Voltage and High Current Applications

Lin, Bor-Ren,Chen, Chih-Chieh The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.5

This paper presents an interleaved resonant converter to reduce the voltage stress of power MOSFETs and achieve high circuit efficiency. Two half-bridge converters are connected in series at high voltage side to limit MOSFETs at $V_{in}/2$ voltage stress. Flying capacitor is used between two series half-bridge converters to balance two input capacitor voltages in each switching cycle. Variable switching frequency scheme is used to control the output voltage. The resonant circuit is operated at the inductive load. Thus, the input current of the resonant circuit is lagging to the fundamental input voltage. Power MOSFETs can be turn on under zero voltage switching. Two resonant circuits are connected in parallel to reduce the current stress of transformer windings and rectifier diodes at low voltage side. Interleaved pulse-width modulation is adopted to decrease the output ripple current. Finally, experiments are presented to demonstrate the performance of the proposed converter.

Interleaved ZVS DC/DC Converter with Balanced Input Capacitor Voltages for High-voltage Applications

Lin, Bor-Ren,Chiang, Huann-Keng,Wang, Shang-Lun The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.4

A new DC/DC converter with zero voltage switching is proposed for applications with high input voltage and high load current. The proposed converter has two circuit modules that share load current and power rating. Interleaved pulse-width modulation (PWM) is adopted to generate switch control signals. Thus, ripple currents are reduced at the input and output sides. For high-voltage applications, each circuit module includes two half-bridge legs that are connected in series to reduce switch voltage rating to $V_{in}/2$. These legs are controlled with the use of asymmetric PWM. To reduce the current rating of rectifier diodes and share load current for high-load-current applications, two center-tapped rectifiers are adopted in each circuit module. The primary windings of two transformers are connected in series at the high voltage side to balance output inductor currents. Two series capacitors are adopted at the AC terminals of the two half-bridge legs to balance the two input capacitor voltages. The resonant behavior of the inductance and capacitance at the transition interval enable MOSFETs to be switched on under zero voltage switching. The circuit configuration, system characteristics, and design are discussed in detail. Experiments based on a laboratory prototype are conducted to verify the effectiveness of the proposed converter.