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Cordycepsmilitaris polysaccharide triggers apoptosis and G0/G1 cell arrest in cancer cells
Cheng Chen,Mei-LinWang,Chao Jin,Huijuan Chen,Shao-Hui Li,Shu-Ying Li,Xing-Fan Dou,Jun-Qiang Jia,Zhong-Zheng Gui 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.3
Although many studies have shown the antitumor properties of Cordyceps militaris (artificial cultivated from Bombyx mori pupa) polysaccharides, little is known regarding the mechanism of its effects. This study was conducted to determine the mechanism of antitumor effects of C. militaris polysaccharide extract by evaluating apoptosis rate and cell cycle progression status in human liver cancer cell SMMC-7721, stomach cancer cell BGC-823 and breast cancer cell MCF-7. Results showed that C. militaris polysaccharides inhibited proliferation of SMMC-7721, BGC-823 and MCF-7 cells with an IC50 of 192 ± 23.2 μg/mL, 237 ± 12.7 μg/mL and 165 ± 16.3 μg/mL, respectively. We also found that C. militaris polysaccharides at increasing concentrations induced apoptosis dose dependently in those cancer cells: apoptosis rates were 48.3%, 59.4% and 70.9% for SMMC-7721, 41.3% and 57.0%, 72.2% for BGC-823 and 61.3%, 66.9% and 80.6% for MCF-7 at 110, 156 and 323 mg/mL of C. militaris polysaccharides, respectively. C. militaris polysaccharides arrested SMMC-7721, BGC-823 and MCF-7 cells at G0/G1 and G2/M phases with corresponding decrease in S-phase. This study suggests that C. militaris polysaccharides may exert its antitumor effects in those cancer cells by suppressing its growth, arresting the G0/G1-phase, reducing DNA synthesis and inducing apoptosis.
Ying Li,Wan-Chao Qiu,Zhuo-Cheng Ou,Zhuo-Ping Duan,Feng-Lei Huang 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.6
The strain rate effects on the interaction between a Mode I matrix crack and an inclined elliptic matrix-inclusion interface under dynamic tensile loadings were investigated numerically, and the results are in agreement with previous experimental data. It is found, for a given material system, that there are the first and the second critical strain rates, by which three kinds of the subsequent crack growth patterns can be classified in turn with the increasing strain rate, namely, the crack deflection, the double crack mode and the perpendicular crack penetration. Moreover, such a crack deflection/penetration behavior is found to be dependent on the relative interfacial strength, the inclined angle and the inclusion size. In addition, it is shown that the so-called strain rate effect on the dynamic strength of granule composites can be induced directly from the structural dynamic response of materials, not be entirely an intrinsic material property.
Li, Ying,Qiu, Wan-Chao,Ou, Zhuo-Cheng,Duan, Zhuo-Ping,Huang, Feng-Lei Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.6
The strain rate effects on the interaction between a Mode I matrix crack and an inclined elliptic matrix-inclusion interface under dynamic tensile loadings were investigated numerically, and the results are in agreement with previous experimental data. It is found, for a given material system, that there are the first and the second critical strain rates, by which three kinds of the subsequent crack growth patterns can be classified in turn with the increasing strain rate, namely, the crack deflection, the double crack mode and the perpendicular crack penetration. Moreover, such a crack deflection/penetration behavior is found to be dependent on the relative interfacial strength, the inclined angle and the inclusion size. In addition, it is shown that the so-called strain rate effect on the dynamic strength of granule composites can be induced directly from the structural dynamic response of materials, not be entirely an intrinsic material property.
Graphite-based selectorless RRAM: improvable intrinsic nonlinearity for array applications
Chen, Ying-Chen,Hu, Szu-Tung,Lin, Chih-Yang,Fowler, Burt,Huang, Hui-Chun,Lin, Chao-Cheng,Kim, Sungjun,Chang, Yao-Feng,Lee, Jack C. The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.33
<P>Selectorless graphite-based resistive random-access memory (RRAM) has been demonstrated by utilizing the intrinsic nonlinear resistive switching (RS) characteristics, without an additional selector or transistor for low-power RRAM array application. The low effective dielectric constant value (<I>k</I>) layer of graphite or graphite oxide is utilized, which is beneficial in suppressing sneak-path currents in the crossbar RRAM array. The tail-bits with low nonlinearity can be manipulated by the positive voltage pulse, which in turn can alleviate variability and reliability issues. Our results provide additional insights for built-in nonlinearity in 1<I>R</I>-only selectorless RRAMs, which are applicable to the low-power memory array, ultrahigh density storage, and in-memory neuromorphic computational configurations.</P>
The back contact modification in high-efficiency Cu₂ZnSn(S,Se)₄ solar cells by a thin MoO₃ layer
Septia KHOLIMATUSSADIAH,Cheng-Ying CHEN,Wei-Chao CHEN,Yi-Rung LIN,Shao-Hung LU,Meng-Chia HSIEH,Jan-Kai CHANG,Chih-I WU,Ruei-San CHEN,Kuei-Hsien CHEN,Li-Chyong CHEN 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8
Genome-wide association study for intramuscular fat content in Chinese Lulai black pigs
Yanping Wang,Chao Ning,Cheng Wang,Jianfeng Guo,Jiying Wang,Ying Wu 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.5
Objective: Intramuscular fat (IMF) content plays an important role in meat quality. Identification of single nucleotide polymorphisms (SNPs) and genes related to pig IMF, especially using pig populations with high IMF content variation, can help to establish novel molecular breeding tools for optimizing IMF in pork and unveil the mechanisms that underlie fat metabolism. Methods: We collected muscle samples of 453 Chinese Lulai black pigs, measured IMF content by Soxhlet petroleum-ether extraction method, and genotyped genome-wide SNPs using GeneSeek Genomic Profiler Porcine HD BeadChip. Then a genome-wide association study was performed using a linear mixed model implemented in the GEMMA software. Results: A total of 43 SNPs were identified to be significantly associated with IMF content by the cutoff p<0.001. Among these significant SNPs, the greatest number of SNPs (n = 19) were detected on Chr.9, and two linkage disequilibrium blocks were formed among them. Additionally, 17 significant SNPs are mapped to previously reported quantitative trait loci (QTLs) of IMF and confirmed previous QTLs studies. Forty-two annotated genes centering these significant SNPs were obtained from Ensembl database. Overrepresentation test of pathways and gene ontology (GO) terms revealed some enriched reactome pathways and GO terms, which mainly involved regulation of basic material transport, energy metabolic process and signaling pathway. Conclusion: These findings improve our understanding of the genetic architecture of IMF content in pork and facilitate the follow-up study of fine-mapping genes that influence fat deposition in muscle.
MUTYH Association with Esophageal Adenocarcinoma in a Han Chinese Population
Kong, Feng,Han, Xue-Ying,Luan, Yun,Qi, Tong-Gang,Sun, Chao,Wang, Jue,Hou, Hua-Ying,Jiang, Yu-Hua,Zhao, Jing-Jie,Cheng, Guang-Hui Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic and environmental factors. Much evidence has shown that the MutY glycosylase homologue (MUTYH) plays a key role in the pathogenesis of many cancers. However, there have been no reports on influence on AE in the Han Chinese population. The objective of this study was to investigate this issue. A gene-based association study was conducted using three single nucleotide polymorphisms(SNPs) reported in previous studies. The three SNPs (rs3219463, rs3219472, rs3219489) were genotyped in 207 unrelated AE patients and 249 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results revealed that the genotype distribution of rs3219472 differed between the case and control groups (OR=1.66,95%CI=1.11-2.48, P=0.012), indicating that an association may exist between MUTYH and AE. These findings support a signifcant role for MUTYH in AE pathogenesis in the Han Chinese population.
An Empirical Analysis of Sino-Russia Foreign Trade Turnover Time Series: Based on EMD-LSTM Model
GUO, Jian,WU, Kai Kun,YE, Lyu,CHENG, Shi Chao,LIU, Wen Jing,YANG, Jing Ying Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.10
The time series of foreign trade turnover is complex and variable and contains linear and nonlinear information. This paper proposes preprocessing the dataset by the EMD algorithm and combining the linear prediction advantage of the SARIMA model with the nonlinear prediction advantage of the EMD-LSTM model to construct the SARIMA-EMD-LSTM hybrid model by the weight assignment method. The forecast performance of the single models is compared with that of the hybrid models by using MAPE and RMSE metrics. Furthermore, it is confirmed that the weight assignment approach can benefit from the hybrid models. The results show that the SARIMA model can capture the fluctuation pattern of the time series, but it cannot effectively predict the sudden drop in foreign trade turnover caused by special reasons and has the lowest accuracy in long-term forecasting. The EMD-LSTM model successfully resolves the hysteresis phenomenon and has the highest forecast accuracy of all models, with a MAPE of 7.4304%. Therefore, it can be effectively used to forecast the Sino-Russia foreign trade turnover time series post-epidemic. Hybrid models cannot take advantage of SARIMA linear and LSTM nonlinear forecasting, so weight assignment is not the best method to construct hybrid models.
Paleogene lacustrine dolomitization, Xingou region, southern Qianjiang Depression, China
Junjun Shen,Bo Chen,Fangfang Chen,Chao Cheng,Yangfan Li,Ying Tian 한국지질과학협의회 2016 Geosciences Journal Vol.20 No.2
The lacustrine dolomicrites of Unit II of the lower Xingouzui Formation deposited in the southern part of the Qianjiang Depression provide a good “tight carbonate” hydrocarbon reservoir. The dolomicrites are typically interbedded with and sourced from organic-rich argillite, which together form a source-reservoir assemblage characterized by thin single-layer thicknesses, far lateral extent and continuous lateral distribution. Systematic sedimentological and geochemical studies indicate that the depositional environment and organic matter evolution of the dark argillites (with TOC of 0.5–2%) are favorable for formation of the dolomicrites. The dolomicrite was mainly formed in a shallow-water evaporative environment; crystals are anhedral under SEM, in non-surface contact, and include a number of honeycomb intergranular micropores associated with replacement. The dolomicrite shows orange-orangered light by cathodoluminescence, indicative of association with minor terrigenous debris; X-ray diffraction results indicate that the dolomicrite is characterized by high calcium content (CaCO3 molar contents of 52.28–52.28%), low degree of orders of 0.2–0.4), and high content of Fe. The dolomicrite has δ18O values of 2.47–2.47‰ PDB, more positive than micrite, and δ13C values as moderately negative as 9.4–4.21‰ PDB, similar to micrite. Both values indicate the dolomicrite formed in a low-temperature genetic zone. Together, these characteristics indicate that the dolomicrite in the study area was formed in a high-salinity, confined lake basin, characterized by low temperature, shallow burial, and rapid nucleation and crystallization. The dolomicrite experienced a contemporaneous period with formation of dark mudstone, shale and calcite, and a penecontemporaneous period with formation of dolomicrite via seepage-reflux and a diagenetic period when ferrodolomite was formed via burial.