Early Intervention with High-Dose Steroid Pulse Therapy Prolongs Disease-Free Interval of Severe Alopecia Areata: A Retrospective Study

( Chao Chun Yang ),( Chun Te Lee ),( Chao Kai Hsu ),( Yi Pei Lee ),( Tak Wah Wong ),( Sheau Chiou Chao ),( Julia Yu Yun Lee ),( Hamm Ming Sheu ),( Wenchieh Chen ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.4

Background: Spontaneous recovery of severe alopecia areata is rare and the condition is difficult to treat. Objective: The aim of this study is to investigate and compare the effects and safety of steroid pulse therapy between oral and intravenous administrations between 1999 and 2010 at the Department of Dermatology, National Cheng Kung University Hospital. Methods: Data were retrospectively retrieved. A satisfactory response was defined as more than 75% hair regrowth in the balding area. Results: A total of 85 patients with more than 50% hair loss were identified and treated, with an overall satisfactory response rate of 51.8%. The mean follow-up time was 37.6 months, with a relapse rate of 22.7%. Patients with alopecia areata (hereafter, AA) of recent onset within one year showed higher response rates (p< 0.001) and lower relapse rates compared to patients with AA persisting for more than 1 year. Further, even in patients with alopecia totalis, alopecia universalis or ophiasis type, early treatment resulted in a satisfactory response rate of 47% among the treated patients. In general, oral therapy was as effective and well-tolerated as intravenous therapy. Conclusion: The response rate is determined by disease severity and time of intervention, not by the administration form of steroid pulse therapy. Oral steroid pulse therapy can be considered as the first-line treatment for patients with severe AA of recent onset within one year. (Ann Dermatol 25(4) 471∼474, 2013)

Monitoring Analysis and Numerical Simulation of the Land Subsidence in Linear Engineering Areas

Chao Jia,Xiao Yang,Jing Wu,Pengpeng Ding,Chao Bian 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.7

Non-uniform land subsidence can cause subgrade deformation and threaten the safety of linear projects such as high-speed railways. The Lunan high-speed railway is taken as the research background. Combined with the hydrogeological and engineering geological conditions, the regional land subsidence is analyzed by the combined method of the differential interferometric synthetic aperture radar (D-InSAR) and small baseline subset interferometric synthetic aperture radar (SBAS-InSAR), which is verified by using precise leveling and GPS monitoring data. The accurate land subsidence analysis of large-scale linear engineering is realized. The distribution situation and change laws of land subsidence in linear engineering areas are revealed. Then, a three-dimensional coupled numerical model of land subsidence along a large-scale linear project is established by using the finite difference method. The spatial distribution characteristics of land subsidence in the linear engineering area are quantitatively analyzed and predicted. The main factors affecting land subsidence and the degree of land subsidence are discussed while keeping the pumping rate constant. The results show that: 1) The combined method of D-InSAR and SBAS-InSAR has high accuracy in the land subsidence monitoring of linear engineering. 2) There are five non-uniform settlement funnels along the Lunan high-speed railway. The groundwater over-extraction and coal mining are the main reasons for the land subsidence. 3) Realizing water source conversion and reduce groundwater exploitation are the main factors in linear engineering areas as soon as possible.

25th the Fall of Berlin Wall

Chao Yang 한국콘텐츠학회 2015 ICCC International Digital Design Invitation Exhib Vol.2015 No.5

The IC Design of A High Speed RSA Processor

Yang, Ching Chao,Jen, Chein Wei,Chang, Tian Sheuan 대한전자공학회 1996 APCCAS:Asia Pacific Conference on Circuits And Sys Vol.1 No.1

In this paper, we proposed a new algorithm based on Montgomery's algorithm[I] to calculate modular multiplication that is the core arithmetic operation in RSA cryptosystem. Since the critical path delay in modular multiplication operation is reduced, the new design yields a very fast implementation. We have implemented a 512-bit single chip RSA processor based on our modified algorithm with Compass 0.6㎛ SPDM cell library. By our modified modular exponentiation algorithm, it takes about 1.5n² clock cycles to finish one n-bit RSA modular exponentiation operation in our architecture. The simulation results show that we can operate up to 125Mhz, therefore the baud rate of our 512-bit RSA processor is about 164k bits/sec.

CacheSCDefender: VMM-based Comprehensive Framework against Cache-based Side-channel Attacks

( Chao Yang ),( Yunfei Guo ),( Hongchao Hu ),( Wenyan Liu ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.12

Cache-based side-channel attacks have achieved more attention along with the development of cloud computing technologies. However, current host-based mitigation methods either provide bad compatibility with current cloud infrastructure, or turn out too application-specific. Besides, they are defending blindly without any knowledge of on-going attacks. In this work, we present CacheSCDefender, a framework that provides a (Virtual Machine Monitor) VMM-based comprehensive defense framework against all levels of cache attacks. In designing CacheSCDefender, we make three key contributions: (1) an attack-aware framework combining our novel dynamic remapping and traditional cache cleansing, which provides a comprehensive defense against all three cases of cache attacks that we identify in this paper; (2) a new defense method called dynamic remapping which is a developed version of random permutation and is able to deal with two cases of cache attacks; (3) formalization and quantification of security improvement and performance overhead of our defense, which can be applicable to other defense methods. We show that CacheSCDefender is practical for deployment in normal virtualized environment, while providing favorable security guarantee for virtual machines.

Study on Waterborne Polyurethanes Based on Poly(dimethyl siloxane) and Perfluorinated Polyether

Yang Du,Chao Zhou,Zhihui Yang 한국고분자학회 2015 Macromolecular Research Vol.23 No.9

Methylsiloxane and fluorinated segments were introduced into the polymer backbone of polyurethane by direct reaction of isocyanate with dialcohol terminated perfluoropolyether (E10-H) and poly(dimethyl siloxane) (PDMS). The polyurethane structure was revealed by Fourier transform infrared spectrometer in ATR mode and Xray photoelectron spectroscope. It was found that the silicon and fluorine moieties easily migrated to the surface of material in film-forming process due to their lower energy, so the water contact angle on membrane surface was greatly enhanced (maximum 100.1º), and the hydrophobic property of material was improved. Different degree of phase separation was observed by scanning electron microscope. Increment of PDMS or E10-H content caused the phase separation obviously, but section of PDMS and E10-H modified polyurethane showed that phase separation reduced. The linear dynamic viscoelastic measurements indicated that the dynamic storage modulus of all samples increased with the increment of frequency, and PDMS modified WPU’s grew fastest. The slope of G' vs. G'' showed a decrement, so each sample had a shear thinning behavior. The perfluoropolyether oil was to reduce viscosity of the system.

Elastodynamic modeling of spatial parallel manipulators contain subclosed loops

Chao Yang,Yang Wang,Junbin Lou,Wei Ye,Fengli Huang 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.3

In this work, the delta parallel manipulator (PM) was considered as a case study to present a system elastodynamic modeling of spatial PMs contain subclosed loops. The mechanism consisted of major substructures including proximal, short, and distal links. Each link was divided into elements to establish the body-to-body and body-to-ground constraint equations. The global independent generalized displacement coordinates (IGDC) of the mechanism were extracted with the theory of multi-point constraint elements. Besides, the global IGDC and substructure synthesis approach was used to obtain the complete elastodynamic modeling of the mechanism without supplementing constraint equations. The resulting configuration-dependent elastodynamic modeling had fewer degrees of freedom, different from thousands used in finite element model (FEM). The natural frequencies could be predicted at any configuration of the mechanism, and were compared against the values of FEM to assess the correctness of the modeling. The proposed modeling could predict the distribution of natural frequencies of the mechanism in the workspace with computational efficiency. Therefore, it could be used as a numerical twin to simulate the elastodynamic performance of PMs in the pre-design stage.

Elastostatic Stiffness Analysis of a 2PUR-PSR Overconstrained Parallel Mechanism

Chao Yang,Qiaohong Chen,Junhua Tong,Qinchuan Li 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.4

The elastostatic stiffness performance of a 2PUR-PSR (S: spherical joint; U: universal joint; R: revolute joint; P: prismatic pair) overconstrained parallel mechanism with two rotational and one translational (2R1T) degrees of freedom was studied based on screw theory and strain energy. First, the actuator and constraint wrenches of the mechanism were obtained based on screw theory. Second, by considering the space composite elastic deformation of the rod (including axial tension, and shear, torsional and bending deformation), compact limb stiffness matrixes were obtained in terms of strain energy and Castigliano’s second theorem. Finally, analytic expressions for the overall stiffness matrix of the mechanism and the amplitudes of the actuator and constrained wrenches were obtained based on the virtual-work principle and the balance equation for a moving platform. The relative error between results from the analytical model and the Workbench finite element model is approximately 1.3%, which validates the effectiveness of the proposed elastostatic stiffness model. Unlike traditional stiffness evaluation index, a regional stiffness index was proposed to measure the mechanism’s stiffness performance at various working heights. Using the index, it is possible to determine the optimum stiffness region of a moving platform with known external wrenches.

Transfer matrix for rotor coupler with parallel misalignmen

Chao-Yang Tsai,Shyh-Chin Huang 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.5

A transfer matrix for shafts coupler with parallel misalignment (offset) was derived. The responses of a rotor system composed of flexible shafts, unbalanced disks, elastic supports and shafts coupler with misalignment were then investigated. Through the derivation, the boundary shears induced by a rotating shaft were first discovered to be coupled in two perpendicular directions. These coupling shears might reduce the first critical speed up to 50% in the free-free case. The studies showed that the shafts coupler altered the rotor’s critical speeds and the misalignment played as an external load resulting through the whole driven shaft. The combined effects of disk unbalance and shaft misalignment showed that the misalignment predominated the response in most of the rotation speeds, but the unbalance could become significant at high speed. The whirling orbits before and after the misalignment were illustrated as well, and numerical results showed that the two ends of the misalignment whirled asynchronously as the rotation fell into some regions.

The finite-time ruin probability in two non-standard renewal risk models with constant interest rate and dependent subexponential claims

Yang Yang,Jinguan Lin,Chao Huang,Xin Ma 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.2

This paper considers an ordinary renewal risk model and a compound renewal risk model with constant interest rate, subexponential claims and a general premium process. We derive some asymptotic results on the finite-time ruin probabilities.