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DNA delivery using low molecular water-soluble chitosan nanocomplex as a biomedical device
Choi, Changyong,Kim, Dong-Gon,Jang, Min-Ja,Kim, Tae-Hyeong,Jang, Mi-Kyeong,Nah, Jae-Woon Wiley Subscription Services, Inc., A Wiley Company 2006 Journal of applied polymer science Vol.102 No.4
<P>We investigate the potential of low molecular water-soluble chitosan (LMWSC), LMWSC–methoxy polyethylene glycol (MPEG) [LCP], and LMWSC–MPEG–cholesterol (LCP–Ch) as a gene carrier. LMWSC with free-amine group was formed at the low weight ratio, above a 1:2 weight ratio of plasmid DNA:LMWSC. LCP and LCP–Ch achieved complex formation of above 1:8 and 1:24 by reacting with MPEG and cholesterol (Ch) on the amine-group, respectively. Particle sizes at the pH 6.5 and 7.0 were about 100–120 nm and 120–160 nm, respectively. The surface charge of the complex also depended on the pH. At pH 6.5, the surface charge of the complex was higher than that at pH 7.0. The zeta potential of the LCP modified with MPEG or of the LCP-Ch modified with cholesterol has lower positive value than that of LMWSC because of the decrease of the positive charge. The morphologies of the complexes by transmission electron microscope were of spherelike shape with the average diameters of about 100–150 nm. Among the three gene carriers, LCP–Ch/plasmid DNA showed the highest gene expression owing to the hydrophobic interaction between cell surface and cholesterol. No cytotoxicity was observed in the gene carriers investigated in this study at various concentrations. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 3545–3551, 2006</P>
Choi, Changyong,Kim, Tae-Hyeong,Chae, Su Young,Kim, Dong-Gon,Kwon, Joong-Kuen,Nah, Jae-Woon 한국공업화학회 2004 응용화학 Vol.8 No.2
To prepare nanoparticles, which are thermosensitive, biocompatible, and biodegradable, the well-defined PNIPAAm-PCL and PEG-PCL block copolymers were synthesized by ring-opening polymerization of c-caprolactone using mPEG-OH and PNIPAAm-OH and characterized by ¹H-NMR and GPC. Thermosensitive nanaparticles according to various ratios of PNIPAAm-PCL and PEG-PCL were prepared by a solvent evaporation method. The nanoparticles showed composition dependent physicochemical properties such as lower critical solution temperature, particle size, and critical aggregation concentration. Then, the nanoparticles were introduced into drug delivery systems using hydrophobic model drug of clonazepam. The drug release behaviors from nanoparticles were investigated.
Choi, Changyong,Kim, Tae-Hyoung,Chae, Su Young,Choi, Hey Young,Kim, Dong-Gon,Kwon, Joong-Kuen,Nah, Jae-Woon 한국공업화학회 2004 응용화학 Vol.8 No.1
Thermosensitive nanoparticles were prepared by self-assembly of two different poly(ε-caprolactone)(PCL) based amphiphilic block copolymers of PEG-PCL and poly(N-isopropylacrylamide)-PCL (PNIPAAm-PCL). The nanoparticles, prepared by dialysis method with different PNIPAAm-PCL contents, showed different physicochemical properties such as lower critical solution temperature (LCST), particle size, and critical aggregation concentration (cac), measured by ¹H NMR, DSC, dynamic light scattering (DLS), and fluorescence spectroscopy.
Dyeability of Polygoum Tinctoria against Fabrics according to Various Dyeing Conditions
Choi, Changyong,Yang, Suk-Hyang,Nah, Jae-Woon 한국공업화학회 2004 응용화학 Vol.8 No.1
The natural dye substances largely consist of plant, animal and mineral materials, which we can easily and naturally be obtained all around us. It has been widely used all around the world for numerous years. Indigo, as a blue pigment, has been known as one of the oldest natural dyes. Generally, natural dyes have moderate colors and are environmentally friendly, while harmful mordants must be used for fixing them and obtaining a full color range on fabrics and it is very hard to improve K/S of the dyeing and mordanting. In this study, physicochemical characterization of polygoum tinctoria dye substance was investigated, and polygoum tinctoria dyeing was carried out various fabrics according to the various dyeing conditions - fermentation temperature, dyeing temperature, dyeing time, and kinds and amounts of alkali. And then the values of K/S according to dyeing conditions were investigated by colorimeter. Also we investigated to dyefastness against the light, washing, perspiration and friction by KS(Korea Industrial Standard).
최창용(Choi, Changyong),이주연(Lee, Juyeon),신유미(Shin, Yumi) 한국청소년정책연구원 2015 한국청소년연구 Vol.26 No.3
또래관계와 자아존중감은 청소년기의 대표적인 발달 산물로서, 이론적으로 두 변인은 서로 영향을 주고받는 것으로 설명되어 왔다. 그러나 또래관계와 자아존중감을 다룬 다수의 기존 연구들은 두 변인 간의 상호관계를 동시에 고려하지 못하고 일방향적인 관계만을 확인해왔다는 한계가 있다. 본 연구는 또래소외감과 자아존중감 간의 종단적인 상호관계를 검증하기 위해 한국청소년정책연구원이 수행한 한국아동청소년패널조사(KCYPS) 중학교 1학년 코호트의 1차년도와 3차년도 자료를 활용하여 실증 분석을 실시하였다. 구체적으로는 또래소외감과 이원적 자아존중감을 구성하는 자기가치 및 자기비하 간의 자기회귀교차지연모형을 설정함으로써, 보다 풍부한 이론적, 실천적 함의를 제시하고자 하였다. 분석 결과, 중학교 1학년 시기의 또래소외감, 자기가치, 자기비하는 중학교 3학년 시기의 각 변인과 모두 유의한 관계가 있었다. 또한 또래소외감과 자아존중감 간의 교차지연 효과를 살펴보면, 또래소외감은 이후의 자기비하에 유의한 영향을 미치는 반면, 자기가치와 자기비하는 이후의 또래소외감에 유의한 영향을 미치지 않는 것으로 나타났다. 한편, 자아존중감의 하위 요인인 자기가치 및 자기비하 간의 교차지연 효과 분석 결과, 자기가치가 이후의 자기비하에 미치는 영향만이 유의하게 나타났다. 분석 결과를 바탕으로 이론적 함의와 함께 우리나라 청소년의 또래소외감을 감소 및 예방하고 자아존중감을 향상시키기 위한 실천적 함의를 논하였다. In theory terms at least, peer relationships and self-esteem, the two most important developmental outcomes in adolescence, have a reciprocal relationship. However, most previous research has failed to examine the bidirectional influence between these variables. The present study aimed to examine the longitudinal effects of each on the other, using the 7th grade cohort’s data (n=2259) of the 2010 and 2012 Korean Children and Youth Panel Survey. Specifically, this study examined the auto-regressive and cross-lagged effects of peer alienation and two dimensions of self-esteem, self-worth and self-deprecation, between the first and third year of middle school. The auto-regressive results showed that the levels of peer alienation, self-worth, and self-deprecation in the first year was positively related with the levels of each variable in the third year. The results of cross-lagged effects suggested that peer alienation positively influenced the later self-deprecation, while neither self-worth nor self-deprecation affected peer alienation over time. Additionally, self-worth was found to influence the later self-deprecation. Based on these results, the theoretical and practical implications are also discussed.
아토피 피부염 청소년의 삶의 만족도에 영향을 미치는 요인
최창용(Choi, Changyong) 한국청소년정책연구원 2015 한국청소년연구 Vol.26 No.1
본 연구는 적응유연성 모형을 통해서 아토피 피부염 청소년 간의 삶의 만족도 차이를 설명할 수 있는 위험요인과 보호요인을 확인하는데 목적을 두고 수행되었다. 본 연구를 통하여 아토피 피부염 청소년 집단 내부의 삶의 만족도 변량을 설명할 수 있는 요인을 확인함으로써 그들에 대한 구체적인 지원방안을 모색하고자 한다. 이를 위해 청소년정책연구원의 한국아동청소년패널(KYCPS) 중1코호트 1차년도 조사자료 중 아토피 피부염이 있다고 응답한 337명의 자료를 대상으로 분석을 실시하였다. 위계적 다중회귀분석을 통하여 질병 관련 위험요인(질병으로 인한 일상생활 지장여부, 건강상태에 대한 부정적 인식)의 주효과와 개인적, 가족적, 사회적 차원 보호요인(자아존중감, 부모의 애정적 양육태도, 또래애착)의 주효과, 위험요인과 보호요인 간의 상호작용효과를 검증하였다. 연구 결과, 질병으로 인한 일상생활 지장여부와 건강상태에 대한 부정적 인식은 아토피 피부염 청소년의 삶의 만족도에 대한 위험요인으로 확인되었으며, 자아존중감과 부모의 애정적 양육태도는 보호요인으로 확인되었다. 특히, 보호요인 중 자아존중감은 건강상태에 대한 부정적 인식의 부적 영향에 대한 조절효과를 가지는 것으로 확인되었다. 본 연구 결과를 바탕으로 아토피 피부염 청소년의 삶의 만족도를 향상하기 위한 실천적 함의를 논의하였다. Atopic dermatitis(AD) is one of the representative chronic disease of modern society, and it is an affliction which creates difficulties in the bio-psychosocial development of young people in particular. By means of a resilience model, this study aims at identifying both the risk factors and protective factors which can affect the life satisfaction of adolescents suffering from AD. This study was undertaken using the national representative 1st year data of the ‘Korean Child and Youth Panel Survey(KCYPS, 2010)’. This study used data from those of the 7th grade cohort (n=337)who responded that they have suffered from AD. The results of the analysis showed that there is a strong negative association between AD related risk factors and life satisfaction. Those whose daily lives are interfered with by AD have lower life satisfaction than who suffer no such interferance. The level of life satisfaction decreases as the perception of subjective health worsens. Self-esteem and affectionate parenting attitudes are shown to be positively associated with life satisfaction. Moreover, self-esteem moderates the effect of self-rated negative perceptions of health on life satisfaction. These results enable us to suggest a number of possible interventions for adolescents suffering from AD and their families.