Methylmethacrylate Monomer의 가토 신장기능에 미치는 영향 : Effects of Methylmethacrylate Monomer on the Renal Function in Rabbits

김민형,장석종 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2

Relating to toxicity of methylmethacrylate monomer, there are many evidences of pathological changes, ie. parenchymal degeneration in pulmonary, hepatic, and renal tissue of animal with high dosage. But the reports about the effects of methylmethacrylate monomer on renal function are rare. Therefore the author intended to investigate the effects of methylmethacrylate monomer on parameters of renal function. Experimental dosages of methylmethacrylate monomer were 0.1㎕/min and 0.25㎕/min, of which didn't cause the arterial hypotension. The infusion was perfermed at a rate of 30 ml/hr for 1 hour. During the one hour periods of administration of methylmethacrylate and recovery proces blood and urine samples were collected and analyzed. Plasma clearances of substances various were obtained by the measuring the plasma and urine concentrations of inulin, PAH, osmolarlty sodium and potassium. The results were summarized as follows. 1. Glomerular filtration rate and renal plasma flow were not affected at a dose of but tended to decrease at a dose of 0.25ul/min of methylmethacrylate monomer. 2. Urine flow was reduced significantly (p<0.05) by methylmethacrylate monomer. 3. Urine osmolarity was increased significantly (p<0.05) by methylmethacrylate monomer. 4. Negative free water clearance was increased significantly (p<0.05) by methylmethacrylate monomer. 5. Osrnolar clearance and sodium and potassium reabsorption rate were not affected significantly by methylmethacrylate monomer. From the above results, it was suggests that methylmethacrylate monomer caused the reduction of urine flow through enhancement of tubular free water reabsorption and partially affecting the GFR and RPF.

측면 방사선 촬영 자세의 표준화를 위한 정상 척추의 시상면 정렬의 분석

김민석(Min-Seok Kim),정석원(Seok-Won Chung),황창주(Changju Hwang),이춘기(Choon-Ki Lee),장봉순(Bong-Soon Chang) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.7

목적: 양팔의 자세 변화에 따르는 척추의 시상면 정렬의 차이를 분석하고, 환자에게서 가장 기능적인 시상면 정렬을 재현 할 수 있는 측면 기립 방사선 촬영 자세를 제시하고자 하였다. 대상 및 방법: 정상 성인 남자 30명에 대해 제7 경추와 제1 천추의 피부 표면에 표식자를 부착시킨 후 전 척추측면 기립 방사선 촬영을 시행하였다. 팔을 내리고 서있는 자세(자세 A), 견관절을 각각 30°, 90° 굴곡한 자세(자세 B, C), 양팔을 끌어안은 자세(cross-arm position) (자세 D), 견관절을 90° 굴곡시킨 후 팔을 수평봉에 얹은 자세(자세 E)를 취하게 하여, 자세 변화에 따른 시상 수직축(sagittal vertical axis), 흉추 후만각, 요추 전만각, 천추 전경각의 차이에 대해 분석하였다. 결과: 자세 A에서 E의 평균 시상 수직축은 각각 +1.47±2.06 cm, -0.58±2.96 cm, -2.11±2.67 cm, +0.16±2.38 cm, -0.51±2.70 cm으로 일차원 분산분석(one-way ANOVA)을 시행한 결과 그룹간의 유의한 차이를 보였고(p<0.001), Duncan의 사후검증결과 자세 A와 D는 차이가 없는 것으로 판단되어 자세 D가 자세 A에 대해 가장 유사한 자세로 나타났다. 흉추 후만각, 요추 전만각, 천추 전경각은 자세간의 유의한 차이를 보이지 않았다. 결론: 양팔을 끌어안은 자세(crosss-arm position)는 평상시 서있는 자세와 가장 유사한 기능적인 시상면 정렬을 구현할 수 있는 자세로 생각된다. Purpose: To analyze the difference in sagittal balance based on different positions of both arms and to promote the proper lateral spine view which can reconstruct the most functional posture of sagittal balance. Materials and Methods: We applied X-rays to thirty healthy male adults with no spinal diseases after application of marks on the skin surface at the location of the C7 and S1 vertebrae with the following five postures, standing lateral position with both arms neutral (posture A) with both shoulders flexed thirty degrees and ninety degrees (postures B and C) with both arms crossed (posture D) with both shoulders flexed ninety degrees and with both arms on a parallel bar (posture E). We analyzed the differences of the sagittal vertical axis, thoracic kyphotic angle, lumbar lordotic angle, and sacral inclination angle after the postural changes. Results: The average sagittal vertical axis value from posture A to E was 1.47±2.06 cm, -0.58±2.96 cm, -2.11±2.67 cm, 0.16±2.38 cm, and -0.51±2.70 cm. We discovered that five postures were statistically different (one-way ANOVA, p<0.001) and that posture D was the closest to posture A (Duncan's multiple comparison test). However we did not observe any statistical differences among the thoracic kyphotic angle, the lumbar lordotic angle, and sacral inclination angle postures. Conclusion: We can reconstruct the functional sagittal alignment in the cross-arm position, which is the closest to the normal standing position.

국내외 수용가 맞춤형 수력발전시스템 현대화개발 및 실증

오민환(Min-Hwan Oh),신기석(Ki-Seok Shin),임재황(Jae-Hwang Lim),윤여창(Yeo-Chang Yun),김현아(Hyun-Ah Kim),강석원(Seok-Won Kang),백종명(Jong-Myung Paik),이준용(Jun-Yong Lee) 대한전기학회 2017 대한전기학회 학술대회 논문집 Vol.2017 No.10

기후변화가 축산업에 미치는 경제효과

공현석(Hyeon Seok Gong),정경수(Kyeong Soo Jeong),김민경(Min Kyoung Kim),장재봉(Jae Bong Chang) 한국농식품정책학회 2020 농업경영정책연구 Vol.47 No.2

Adopting the Ricardian approach, this study investigates the economic effects of climate changes such as average temperature and rainfalls on Korean livestock farm revenue. The explanatory variables of empirical model were selected based on the previous literature. The pseudo-panel analysis is employed to resolve the imperfectness of the panel data. The results indicate that the control variables such as farming experience, household size, employment, ownership of heavy machinery, technology use, full-time farming and male owner affect the livestock farm revenue positively, and the age does negatively. The impact of summer average temperature on farm revenue was significant and negative, while that of winter was significant and positive. The marginal change of the summer temperature decrease farm revenue per head by 2.48%. This paper suggests that the livestock farm’s revenue responds sensitively to changes in summer and winter average temperature, and so we need to establish the long-term countermeasures against rapid climate change.

Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice

Yoon, Hye Eun,Kim, Eun Nim,Kim, Min Young,Lim, Ji Hee,Jang, In-Ae,Ban, Tae Hyun,Shin, Seok Joon,Park, Cheol Whee,Chang, Yoon Sik,Choi, Bum Soon Hindawi Publishing Corporation 2016 Oxidative medicine and cellular longevity Vol.2016 No.-

<P><I>Background</I>. This study evaluated whether the change in the renin-angiotensin system (RAS) is associated with arterial aging in mice.<I> Methods</I>. Histologic changes and expressions of transforming growth factor-<I>β</I> (TGF-<I>β</I>), collagen IV,<I> fibronectin</I>, angiotensin II (Ang II), angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), prorenin receptor (PRR), Mas receptor (MasR), endothelial nitric oxide synthase (eNOS), NADPH oxidase 2 and oxidase 4 (Nox2 and Nox4), 8-hydroxy-2′-deoxyguanosine (8-OHdG),<I> 3-nitrotyrosine</I>, and superoxide dismutase 1 and dismutase 2 (SOD1 and SOD2) were measured in the thoracic aortas from 2-month-old, 12-month-old, and 24-month-old C57/BL6 mice.<I> Results</I>. Twenty-four-month-old mice showed significantly increased aortic media thickness and expressions of TGF-<I>β</I>, collagen IV, and fibronectin, compared to 2-month-old and 12-month-old mice. The expressions of PRR, ACE, and Ang II, and AT1R-positive area significantly increased, whereas expressions of ACE2 and MasR and AT2R-positive area decreased with age. The expressions of phosphorylated serine<SUP>1177</SUP>-eNOS, SOD1, and SOD2 decreased, and the 8-OHdG-positive area and the 3-nitrotyrosine-positive area increased with age. The expression of Nox2 significantly increased with age, but that of Nox4 did not change.<I> Conclusions</I>. The enhanced PRR-ACE-Ang II-AT1R axis and reduced ACE2-MasR axis were associated with arterial aging in mice. </P>

철도 부하의 이동성을 반영한 변전소 정태부하모델링 수립에 대한 연구

창상훈(Sang-Hoon Chang),윤석민(Seok-Min Youn),김정훈(Jung-Hoon Kim) 대한전기학회 2015 전기학회논문지 Vol.64 No.2

Nowadays, it is expected that mobility loads such as electric railways and electric vehicles will be penetrated gradually and affect on the power system stability by their load characteristics. Various researches have been carried out about electric vehicles for the recent decade though the load of electric railway could be forecasted because of the specified path and timetable, is a field with a long historic background. Some precise 5th polynomial equations are required to analyze the power system stability considering mobility load to be increased in the immediate future while the electric railway dispatching simulator uses load models with constant power and constant impedance for the system analysis. In this paper, seasonal urban railway load models are established as the form of 5th polynomial equations and substation load modeling methods are proposed merging railway station load models and general load models. Additionally, load management effects by the load modeling are confirmed through the case studies, in which seasonal load models are developed for Seoul Subway Line No. 2, Gyeongui Line and Airport Railroad and the substation load change is analyzed according to the railway load change.

Bone Marrow T Cells are Superior to Splenic T Cells to Induce Chimeric Conversion After Non-Myeloablative Bone Marrow Transplantation

( Hyun Sil Park ),( Seok Goo Cho ),( Min Jung Park ),( So Youn Min ),( Hong Seok Chang ),( Hee Je Kim ),( Seok Lee ),( Chang Ki Min ),( Jong Wook Lee ),( Woo Sung Min ),( Chun Choo Kim ),( Ho Youn Kim 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.3

Background/Aims: The bone marrow functions not only as the primary B-lymphocyte-producing organ but also as a secondary lymphoid organ for CD4 and CD8 cell responses and a site of preferential homing and persistence for memory T cells. Bone marrow T (BM-T) cells are distinguished from peripheral blood T cells by surface phenotype, cytokine secretion profile, and immune functions. In this study, we evaluated the alloreactive potential of donor lymphocyte infusion (DLI) using BM-T cells in mixed chimerism compared to that using spleen T (SP-T) cells. Methods: Cells were prepared using established procedures. BM-T cells were obtained as a by-product of T-cell depletion in BM grafting and then cryopreserved for subsequent DLI. We performed DLI using BM-T cells in allogeneic mixed chimera mice on post-BMT day 21. Results: When the same dose of T cells, 5-10×105 (Thy1.2+), fractionated from BM and spleen were administered into mixed chimeras, the BM-T group showed complete chimeric conversion, with self-limited graftversus-host disease (GVHD) and no pathological changes. However, the SP-T group showed persistent mixed chimerism, with pathological signs of GVHD in the liver and intestine. Conclusions: Our results suggest that DLI using BM-T cells, even in small numbers, is more potent at inducing chimeric conversion in mixed chimerism than DLI using SP-T cells. Further study is needed to determine whether cryopreserved BM-T cells are an effective cell source for DLI to consolidate donor-dominant chimerism in clinical practice without concerns about GVHD. (Korean J Intern Med 2009;24:252-262)

연구보문 : 자연과학 ; 황산처리에 의한 불투수성 황근 종자의 발아촉진에 관한 연구

서상흠 ( Sang Heum Seo ),박민우 ( Min Woo Park ),장미하 ( Mi Ha Chang ),장일웅 ( Il Ung Jang ),심상인 ( Sang In Shim ),나영왕 ( Young Wang Na ),김수영 ( Soo Young Kim ),김석현 ( Seok Hyeon Kim ) 한국국제농업개발학회 2012 韓國國際農業開發學會誌 Vol.24 No.3

The reason of poor germination rate of hamabo mallow seed was speculated using TZ test to determine the viability of seed. Seeds showed high viability via TZ test were not germinated well. The quiescent seeds did not imbibed properly due to the hard seed coat and did not show further processes required for germination. Several well-known treatments for seed coat loosening and water uptake into seed were applied and compared for their efficiency. Stratification, hot water treatment, seed coat scarification, wet-cold treatment were revealed as less effective for improving germination although those treatments were common method for breaking dormant seed. Chemical scarification with sulfuric acid, however, effectively increased germinability and promptness index of hamabo mallow seeds. Optimal time for sulfuric acid treatment was 20 min. Seeds treated for 20 min showed improved germination percentage, germination speed, and promptness index of 80%, 13, and 1969 at 30 days after imbibition, respectively, in petri dish experiment. The values were greater than control seeds showed low values (12%, 1, and 183, respectively). The similar tendency was observed in the pot experiment that sulfuric acid treated seed were sown in artificially mixed soil (loamy soil:peatmoss:sand:compost = 5:2:2:1) and placed in greenhouse. Ultrastructure analysis of chemically scarified seed with sulfuric acid for 20 min by scanning electron microscopy did not show any noticeable changes in seed coat hardness and water uptake via hilum. But the only change after sulfuric acid treatment was removal of hilum cap that close the hilum and hider imbibition. Therefore, subsequent experiment was conducted to know the relationship between removal of hilum cap and facilitated imbibition by sulfuric acid treatment and whether the hilum cap removal directly influenced to the opening of micropyle. Water uptake velocity of seed treated for 20 min in concentrated sulfuric acid for was greater than control seed. This result implies that the crucial effect of sulfuric acid treatment is the removal of hilum cap that increase water uptake via micropyle in hamabo mallow.

스마트팜 환경 관리를 위한 계측 시스템

이동형(Dong-Hyung Lee),백창대(Chang-Dae Back),윤현성(Hyeon-Seong Yun),손형민(Hyeong-Min Son),차현석(Hyun-Seok Cha),김남호(Nam-Ho Kim) 한국정보통신학회 2021 한국정보통신학회 종합학술대회 논문집 Vol.25 No.2

정보통신기술이 점차 발전함에 따라 기존의 생산 시스템에 네트워크 및 컴퓨팅 기술을 적용하여 효율적인 생산 환경을 유지하는 연구가 많이 진행되고 있다. 고전적인 제어 시스템과 달리 이러한 스마트 생산 시스템은 생산 환경에 대한 데이터를 실시간으로 수집하여 통계화하고, 그 변화에 따라 유동적으로 작동할 필요가 있다. 본 논문에서는 네트워크 기반의 센서를 통해 실시간으로 데이터를 수집하고, 환경 변화에 효과적으로 대응할 수 있는 계측 시스템을 제시한다. 또한 이를 스마트팜에 적용하여 외부의 환경 변화에 대처하고 효과적인 생산 환경을 유지할 수 있음을 확인하였다. As information and communication technologies develop, many studies are being conducted to maintain an efficient production environment by applying network and computing technologies to existing production systems. Unlike classical control systems, these smart production systems need to collect data about the production environment in real time, and operate fluidly as it changes. In this paper, we present a measurement system that can collect data in real time through network-based sensors and respond effectively to environmental changes. We also proved this smart system can cope with external environmental changes and maintain an effective production environment.

자바리, Epinephelus bruneus의 난 발생과 부화에 미치는 수온의 영향

양문호,최영웅,정민민,구학동,오봉세,문태석,이창훈,김경민,한석중,Yang, Moon-Ho,Choi, Young-Ung,Jung, Min-Min,Ku, Hag-Dong,Oh, Bong-Sae,Moon, Tae-Seok,Lee, Chang-Hoon,Kim, Kyong-Min,Han, Seock-Jung 한국발생생물학회 2007 발생과 생식 Vol.11 No.2

This study examined temperature effect in egg development and hatching of longtooth grouper, Epinephelus bruneus. Fertilized embryos was not growth after morula stage at $15^{\circ}C$, at 18, 21, 24 and $27^{\circ}C$, the required time from fertilized embryos to hatching were 70 h. 30 min., 44 h. 10 min., 29 h. 10 min. and 24 h. 30 min., respectively. The hatching rates at $24^{\circ}C$ were higher than the other conditions and the hatching was not occurred at $15^{\circ}C$. These results suggest that the water temperature range of egg development and hatching was $18{\sim}27^{\circ}C$. 이 연구는 실내 사육수조에서 자연산란 후 수정된 난을 대상으로 수온에 따른 난 발생속도와 부화율을 조사하였다. 부화에 이르기까지 각 수온조건에서 소요된 시간은 $15^{\circ}C$에서 상실기 이후 발생이 진행되지 않았고, 18, 21, 24, $27^{\circ}C$에서 각각 70시간 30분, 44시간 10분, 29시간 10분 그리고 24시간 30분이 소요되었다. 부화율은 $15^{\circ}C$에서 0%였고, 18, 21, 24 그리고 $27^{\circ}C$에서 각각 $8.3{\pm}1.2%$, $18.0{\pm}6.2%$, $24.0{\pm}4.0%$ 그리고 $17.0{\pm}7.2%$로 뚜렷한 차이 없이 $24^{\circ}C$에서 다소 높았고 21와 $27^{\circ}C$에서 비슷한 경향이었으며 $18^{\circ}C$에서 가장 낮게 나타났다. 이러한 결과에서 자바리의 난발생 수온범위는 $18{\sim}27^{\circ}C$로 제안된다.