干支와 遅氣에 關한 硏究

尹暢烈,朴賛国 慶熙大學校韓醫科大學韓醫學硏究所 1987 慶熙韓醫大論文集 Vol.10 No.-

Ⅲ급 부정교합자의 양악 수술과 하악 편악 수술 시 연조직 변화에 관한 비교 연구

박영국,장인희,이영준 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.1

악교정 수술 시행 시 연조직 변화에 대한 대부분의 연구는 Ⅱ급 부정교합을 대상으로 하였다. 또한 수술 방법에 따른 연조직 변화에 대한 비교 연구가 부족하였다. 따라서 이 연구는 골격성 Ⅲ급 부정교합자에서 상악골 전진술과 하악골 후퇴술을 동시에 시행한 양악 수술과 하악골 편악 수술 시행 시, 경조직과 연조직 측모 및 연조직 두께의 변화를 관찰하고, 수술 전후 변화의 상관성을 산출하며, 경조직 변화에 수반하는 연조직 변화의 비율을 산출하여 교정-악교정 수술 복합 치료 계획 수립과 결과의 예측에 이용하고자 시행되었다. 경희대학교 치과병원 교정과에 내원하여 골격성 Ⅲ급 부정교합자로 진단받은 환자 52명을 대상으로 하여, Le Fort I osteotomy를 이용한 상악골 전방이동술과 시상분할골절단술을 이용한 하악골 후퇴술을 시행한 양악 수술군 26명과 하악골 후퇴술만을 시행한 편악 수술군 26명으로 구분하여, 수술 전후 측모두부방사선규격사진을 계측, 분석하여 다음과 같은 결과를 얻었다. 양악 수술군은 골격 변화량의 72.4% 비율로 상순 부위 연조직의 전방 이동을 보였으며, 편악 수술군은 통계적으로 유의한 변화를 보이지 않았다. 비순각은 양악 수술군에서 편약 수술군에 비해 더 크게 증가하였다. 이순각은 편악수술군에서 더 크게 감소하였다. 하악골의 후방 이동에 따른 연조직 pogonion의 후방 이동은 양악 수술군에서 98%, 편악 수술군에서 109%로 편악 수술군에서 더 크게 나타났다. 양악 수술군에서는 편악 수술군에 비하여 경조직의 변화에 수반하는 상순에서의 큰 변화가 나타났다. 편악 수술군에서는 상순의 변화는 미약하엿으며, 하순 및 이부의 변화가 양악 수술군에 비해 두드러지게 나타났다. Numbers of postulations lie on the difference of integumental changes with two major surgical remedies of one jaw vs. two jaw surgery in skeletal Class Ⅲ malocclusion. Accordingly it was the aim of the study to elucidate the skeletal profile changes with an accompanying disposition of soft tissues, consequently to yield the correlation and ratio of soft tissue changes with two types of surgical procedures, which in turn make it possible to predict the soft tissue outcomes by means of assembled regression equations. Cephalometric headfilms of fifry two adult skeletal Class Ⅲ comprised of 26 maxillary advancement by Le Fort I osteotomy and mandibular setback by sagittal split ramus osteotomy simultaneously (double jaw surgery, group A), 26 mandibular setback alone (one jaw surgery, group B) were statistically analyzed. Group A manifested 72.4% soft tissue advancement to skeletal changes in the upper lip area, while group B appeared to have no statistically significant changes. The nasolabial angle showed more increment in group A than in group B, whereas the mentolabial angle illustrated more reduction in group B. The backward movement of soft tissue pogonion to skeletal change revealed 98% in group A, and 109% in group B. The double jaw surgery group characteristically revealed remarkable integ umental change in the upper lip area, while the one jaw surgery had major effects in the lower lip and soft tissue pogonion areas.

A study on the dynamic behavior of the Korean next-generation high-speed train

Jeon, Chang-Sung,Kim, Young-Guk,Park, Joon-Hyuk,Kim, Seog-Won,Park, Tae-Won Professional Engineering Publishing Ltd 2016 Proceedings of the Institution of Mechanical Engin Vol. No.

<P>This study describes the dynamic behavior of the HEMU-430X, the Korean next-generation high-speed train. The HEMU-430X was initially analyzed using VAMPIRE, a computer program that is used to examine the dynamics of railway vehicles, based on which it was expected to sway strongly at its tail end. This hunting motion was expected to disappear when the position of the yaw damper was changed. The dynamic behavior of the HEMU-430X was assessed in an on-track test performed using the protocols in the EN14363 standard and measuring the carbody, bogie and axle accelerations; the HEMU-430X was found to satisfy the safety criterion. The hunting motion appeared at speeds of 150, 350 and 387km/h, and countermeasures such as changing the position of the yaw damper, installing carbody dampers, and increasing the damping coefficient of the yaw damper installed on the motor car containing the driver's cab were taken in order to reduce the vibrations. Ultimately, the highest test speed achieved was 421.4km/h. Subsequently, it was found that the critical speed tended to decrease with mileage. This was attributed to excessive lateral damping and a revised design was proposed to solve this problem.</P>

Ethylnitrosourea가 치배 및 치주조직에 미치는 영향에 관한 실험적 연구

오창근,조한국 慶熙大學校 齒科大學 1994 慶熙齒大論文集 Vol.16 No.1

The purpose of this study was to evaluate the effect of ethylnitrosourea(N-ethyl-N-nitrosourea ; ENU, Sigma Co.) on the tooth germs and its surrounding tissues. Forty male Wistar rats; one month of age and 100-130gm in body weight, were used in this experiment, which were devided into 3 experimental groups and 2 control groups. Ten animals of experimental group 1 were given local injection of 1% ENU solution which were dissolved in physiologic saline into the region of incisor tooth germ of the right mandible every other day for 19 days (a total of 10 times). Ten animals of experimental group 2 received ENU injections as the same manner as group 1 and were given mechanical injuries on the same regions at 2nd, 8th and 15th days after beginning of experiment. And fifteen animals of experimental group 3 received mechanical injuries as well as ENU injections as the same manner of group 2, and were given 4% ethanol as drinking water and subcutaneous injections of 2.5mg prednisolone acetate at 2 times per week. Three animals a control group 4 were treated as the same manner with experimental group 3, but received injections of physiologic saline instead of ENU, and two animals of control group 5 were not treated. All animals were sacrificed at the end of the sixth month, and the mandibles were removed, fixed in 10% N-fornialin, decalcified with electrolytic decalcification method, embedded in paraffin, sectioned in 4-6/tm thickness, and stained with Hematoxylin and eosin, and Masson's trichrome. The results were as follows ; 1. Various polycystic structures with fibrous connective tissue wall and neoplasm-like proliferation were revealed at the ENU-injected areas of the tooth germs, the periodontal ligaments and the salivary glands. 2. The epithelium of the tooth germ revealed irregular epithelial hyperplasia and disturbance of dentinogenesis. 3. The stratum intermedium of the tooth germ revealed severe adenomatous proliferations, therefore suggesting a potential of odontogenic tumors. 4. Malassez's epithelial rests in the periodontal membrane of the posterior teeth revealed mild hyperplastic proliferation. 5. Gingival hyperplasia at the posterior teeth and the formation of epithelial islands resembling with enamel organ at the affected interdental papillae were observed. 6. The ductal epithelium of the intercalated ducts and the secretory ducts of the accessory salivary glands revealed basal cell adenomatous proliferations, 7. Group 2 and 3 revealed more prominent histopathological changes than group 1, therefore it suggested that these changes would develop to odontogenic tumors.

癎疾性 치매 1例

梁昌國,張煥一,申榮宇 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.3

The authors experienced and reported a 21-years-old female patient who was severely deteriorated following uncontrolled grand mal seizures lasting for more than 10 years. At first petit mal seizure was developed at the age of 7 and then the pattern of seizure was changed to grand mal type. She had achieved normal physical and mental developments till the appearance of grand mal seizure, but she has become deteriorated gradually with repeated seizures of 7-8 times a day. Deteriorations have been progressed markedly and finally she became a severely deteriorated dementic, like a 1-2 years old baby since the age of 19. She could not walk and speak a word except "mamma" when she was brought to emergency room. Diffuse scattering of slow waves and spikes were noticed on the E.E.G. and moderate degree of cerebral atrophy on computerized tomography of the brain. With the beginning of anticonvulsant therapy, the seizure was controlled almost completely and hence her mental and physical states have become improved steadily during 9 months of follow-up treatment. And at the end of follow-up period, she became to be able to speak freely with others and carry out usual life activities with minimal limitations. In this case, we can presume that her severe deterioration have been resulted primarily from long-standing hypoxia of the brain due to repeated clinical and subclinical seizures. But the possibilities that the other factors such as adverse effects of anticonvulsants, folate deficiency and social factors could play a role in part can not be excluded entirely. And also we call attention to the fact that epileptic deterioration can be prevented through adequate control of seizures and support of epileptic individuals by various means.

Characterization of changes in global gene expression in the brain of neuron-specific enolase/human Tau23 transgenic mice in response to overexpression of Tau protein.

Woo, Jong-Min,Park, So Jung,Kang, Ho Il,Kim, Byoung Guk,Shim, Sun Bo,Jee, Seung Wan,Lee, Su Hae,Sin, Ji Soon,Bae, Chang Joon,Jang, Mee Kyung,Cho, Chunghee,Hwang, Dae Youn,Kim, Chuel Kyu D.A. Spandidos 2010 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.25 No.5

<P>Tau is a neuronal phosphoprotein responsible for the formation of the neurofibrillary tangles in Alzheimer's disease. To characterize the changes in global gene expression in the brain of transgenic mice that overexpress human Tau23 protein in response to the increase of Tau23 phosphorylation, total RNA extracted from the hippocampus of 12-month-old transgenic and wild-type mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide microarrays. The microarray results were confirmed by real-time RT-PCR and Western blotting method. It was determined that 43 genes were up-regulated and 8 genes were down-regulated by Tau23 in transgenic mice compared to controls, based on the arbitrary difference in the 2-fold change. Among the up-regulated transcripts, those encoding for transporter and oxidoreductase were dramatically over-represented, followed by those related to regulatory molecule, cytoskeletal protein, signaling molecule, and extracellular matrix protein. Genes encoding for transcription factor, regulatory molecule, miscellaneous function, and chaperone were significantly reduced in the down-regulated group. The major genes in the up-regulated categories included Ecrg4, Folr1, Defb11, Aqp1 and Soctdc1. The major genes in the down-regulated categories were Ncor1, Gpm6a, and Hspd1. These results indicate that the microarray analysis identifies several gene functional groups and individual genes that respond to a sustained increase in Tau23 phosphorylation levels in the brain of transgenic mice. In addition, the results suggest the microarray test is a useful tool for increased understanding of the role of Tau23 protein in regulating neurodegenerative disorders.</P>

갑상선암에 의한 림프절 전이의 CT 진단

주지선,김형진,조영국,임명관,서창해,Ju, Ji-Seon,Kim, Hyeong-Jin,Jo, Yeong-Guk,Im, Myeong-Gwan,Seo, Chang-Hae 대한영상의학회 2001 대한영상의학회지 Vol.45 No.6

목적: 갑상선암의 일차 및 이차 림프절 전이에 대한 CT의 진단적 가치를 평가하고, 갑상선암에 의한 림프절 전이의 다양한 CT 소견을 알아보고자 하였다. 대상과 방법: 갑상선암으로 갑상선절제술 및 경부청소술이 시행된 환자 중 수술 전 CT를 시행한 59명을 대상으로 하였다. 59명 모두에서 일차 림프절 (Level VI)을 제거하는 중앙부청소술이 시행되었고, 21명에서는 총 136 level의 이차 림프절 (Level II-V)을 제거하는 측부청소술이 병행되었다. CT상 기준치 이상의 크기, 균질하고 높은 조영증강, 석회화, 낭성 또는 괴사성변화를 보이는 경우 림프절 전이가 있는 것으로 판정하였다. 이와 같이 분석한 CT 소견을 조직학적 소견과 비교하여 일차 및 이차 림프절 전이에 있어서 CT의 진단능을 평가하였고, 림프절 전이의 진단에 유용한 CT 소견을 알아보았다. 결과: 59명의 갑상선암 환자 중 조직학적으로 경부 림프절 전이는 31명 (53%)에서 진단되었으며 이 중 일차 림프절은 59명 중 30명, 이차 림프절은 136 level 중 44 level에서 전이가 관찰되었다. 일차와 이차 림프절 전이에 대한 CT의 민감도, 특이도, 양성예측도, 음성예측도 및 정확도는 각각 27%와 93%, 100%와 93%, 100%와 87%, 57%와 97%, 그리고 63%와 93%이었다. CT상 기준치 이상의 크기 (n=19), 낭성 또는 괴사성 변화 (n=14), 석회화 (n=8)의 소견 중 한 개 이상의 소견을 보이는 이차 림프절에서는 조직검사상 모두 전이가 발견되었으나, CT상 조영증강만을 보인 25 level의 이차 림프절 중 6 level (24%)에서는 조직학적 전이소견 없이 반응성 림프절로 진단되었다. 결론: 갑상선암의 경부 림프절 전이의 평가에 있어서 CT의 민감도는 일차 림프절에서는 매우 낮았으나 이차 림프절에서는 비교적 높았다. 기준치 이상의 크기, 석회화 및 낭성변화는 갑상선암의 림프절 전이를 예측하는데 매우 유용한 지표로 생각된다. Purpose: To determine the usefulness of CT for diagnosing metastases to primary and secondary echelon lymph nodes (LNs) and to investigate various CT findings of metastatic LNs in thyroid carcinomas. Materials and Methods: We retrospectively reviewed the CT and histologic findings in 59 patients with thyroid carcinomas who had undergone thyroidectomy and neck dissection. Primary echelon LNs (Level VI) were removed by central neck dissection in all patients, and in 21, a total of 136 levels of secondary echelon LNs (Level II-V) were excised away by lateral neck dissection. CT criteria of metastatic LNs included large size, significant homogeneous enhancement, calcification, and cystic change. We evaluated the ability of CT to detect primary and secondary echelon LN metastasis and tried to determine which CT features were useful for the diagnosis of LN metastasis. Results: Histologically, LN metastasis was found in 31 (53%) of 59 patients, including 30 with metastasis to primary echelon LNs. Of the 136 levels of secondary echelon LNs resected in 21 patients, 44 were found at histology to harbor metastatic foci. The sensitivities, specificities, positive and negative predictive values, and accuracies of CT in the diagnosis of metastasis to primary and secondary echelon LNs, respectively, were 27% and 93%, 100% and 93%, 100% and 87%, 57% and 97%, and 63% and 93%. While all secondary echelon LNs with at least one of the following CT criteria-large size (n=19), cystic or necrotic change (n=14), or calcifications(n=8)-were histologically proven to be metastatic, six (24%) of 25 such LNs with a sole sign of significant enhancement at CT were found to be due to reactive lymphadenopathy. Conclusion: Although CT was unable to detect metastasis to primary echelon LNs, it was useful in the detection of secondary echelon LN involvement. Large size, cystic change, and calcification are considered highly reliable signs of metastatic LNs.

디스크 시스템의 설계를 위한 모의 실험에 대한 연구

장윤석,김홍일,김국보 대진대학교 1994 大眞論叢 Vol.2 No.-

I/O subsystems, especially, disk systems are the most important aspect at computer system performance for recent high-performance computer systems. But development of new d s k system consumes very high costs, it performed by simulation, in general. This paper researches accurate disk modeling techniques for basis of accurate simulation, and implements the disk model, and proves the modelled disk can be executed with small deviation, compares with real disk system, by trace-driven simulation The simulation program can widely be used for basic tool to develope new disk systems.

飮毒 自殺企圖者에 대한 社會精神醫學的 硏究

梁昌國,張煥一 慶熙大學校 醫科大學 1982 慶熙 醫大 論文集 Vol.7 No.1

몽타주 자동 작성을 위한 퍼지 의사 결정 시스템의 설계

김국보,김홍일,장윤석 대진대학교 1994 大眞論叢 Vol.2 No.-

It is well known that search method for multimedia information is very difficult problem. In this paper, the implementation of a automatic montage generator using fuzzy decision making system is described and proposed an effective fuzzy inference system based on description data. In addition, some techniques which can improve the retrieval efficiency of a image information are also suggested.