광중합 광원의 종류와 조사시간에 따른 치면열구전색제의 미반응 모노머 용출

오유향,박윤경,이난영,이창섭,이상호 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.3

본 연구에서는 기존의 할로겐 광과 보다 강한 강도와 짧은 조사시간을 갖는 아르곤 레이저와 플라즈마 광의 광중합도를 평가하기 위해 많은 양의 TEGDMA를 용출하는 치면열구전색제를 실험재료로 이용하여 각각의 중합시간과 용출시간에 따른 미반응 TEGDMA의 양을측정, 비교 분석하여 중합도를 평가하였다. 광원에 따른 중합시간 당 각각 10개의 시편을 제작하여 3차 증류수에 넣은 후 바로 용출시킨 액을 0시간으로 하고 37℃ 항온기에서 10분, 1시간, 12시간, 24시간 동안 용출시켰다. 각 용출액의 20 μl를 역상 크로마토그래피(RP-HPLC)에 적용시켜 미반응 모노머의 시간경과에 따른 용출양을 측정하였다. 이상의 실험을 통해 얻은 결과는 다음과 같다. 1. 할로겐 광은 중합시간이 증가할수록 TEGDMA의 초기 용출량 감소를 보였다(p>0.05). 2. 플라즈마 광은 6초, 9초로 중합한 군에서는 TEGDMA의 용출량의 차이를 보이지 않았으나, 3초 중합 군에서는 6초와 9초 중합 군보다 초기 용출량이 크게 나타났다(p<0.05). 3. 아르곤 레이저는 전반적으로 할로겐 광과 플라즈마 광보다 TEGDMA의 초기 용출량이 컸으며 조사시간이 증가할수록 용출량은 감소되었다 (p<0.05). 4. 광원의 제조회사에서 권장하는 최소 중합시간인 할로겐 광 20초, 플라즈마 광 3초, 아르곤 레이저 5초로 조사시 TEGDMA의 용출량은 할로겐 광. 플라즈마 광, 아르곤 레이저 순으로 용출량이 적었다(p>0.05). 5. 제조회사의 권장 중합시간인 할로겐 광 40초, 플라즈마 광 6초, 아르곤 레이저 10초 조사시 할로겐 광 40초와 플라즈마광의 6초의 TEGDMA의 용출량은 아르곤 레이저 보다 낮게 나타났다(p>0.05). 6. 권장시간 이상인 할로겐 광 60초와 플라즈마 광 9초, 아르곤 레이저 20초 중합시 나타나는 TEGDMA의 용출량 간에는 유의할만한 차이가 없었다(p>0.05). The purpose of this study was to measure and compare the amount of unreacted TEGDMA from pit and fissure sealants cured with three different light sources ; conventional halogen light curing unit, plasma arc light curing unit and argon laser The specimens were eluted in distilled water for different time intervals. The time-related release of TEGDMA were analyzed by reverse-phase high performance liquid chromatography(HPLC). The result of present study can be summarized as follows: 1. The time-related release of TEGDMA decreased with increasing curing time in conventional halogen light, however, that not statistically significant difference(p>0.05). 2. The elution from the specimens cured for 6 and 9 seconds with plasma arc light was similar results corresponding with the time-related TEGDMA release, and was significantly lower than that cured for 3 seconds(p<0.05). 3. The elution of TEGDMA from the specimens cured with argon laser was significantly higher than that cured with halogen and plasma arc light(p<0.05). 4. The elution of TEGBMA from under recommended time of three different light sources were showed to be no statistically significant difference(p>0.05). 5. In time-related release of TEGDMA from recommended time of each light sources, the results correspond to 40 seconds of halogen light and 6 seconds of plasma arc light were similar(p>0.05). 6. The elution of TECDMA from over recommended time of three different light sources were showed to be no statistically significant difference (p>0.05). In this study, I suggest that curing time of plasma arc light is 6 and/or 9 seconds in the field of clinical pediatric dentistry claiming its effectiveness in optimal polymerization and reduced chair time.

Interarm Blood Pressure Difference is Associated with Early Neurological Deterioration, Poor Short-Term Functional Outcome, and Mortality in Noncardioembolic Stroke Patients

Chang, Yoonkyung,Kim, Jinkwon,Kim, Min-Ho,Kim, Yong-Jae,Song, Tae-Jin 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.4

<P><B>Background and Purpose</B></P><P>Interarm differences in the systolic and diastolic blood pressures (IASBD and IADBD, respectively) are found in various populations, including stroke patients, but their significance for stroke outcomes has rarely been reported. We aimed to determine the associations of IASBD and IADBD with early neurological deterioration (END), functional outcome, and mortality.</P><P><B>Methods</B></P><P>This study included 1,008 consecutive noncardioembolic cerebral infarction patients who were admitted within 24 hours of onset and had automatic measurements of blood pressures in the bilateral arms. END was assessed within 72 hours of stroke onset according to predefined criteria. A poor functional outcome was defined as a score on the modified Rankin Scale ≥3 at 3 months after the index stroke. All-cause mortality was also investigated during a median follow-up of 24 months. The absolute difference of blood pressure measurements in both arms were used to define IASBD and IADBD.</P><P><B>Results</B></P><P>END occurred in 15.3% (155/1,008) of the patients. A multivariate analysis including sex, age, and variables for which the <I>p</I> value was <0.1 in a univariate analysis revealed that IASBD ≥10 mm Hg was significantly associated with END [odds ratio (OR)=1.75, 95% CI=1.02–3.01]. IADBD ≥10 mm Hg was also related to END (OR=3.11, 95% CI=1.61–5.99). Moreover, having both IASBD ≥10 mm Hg and IADBD ≥10 mm Hg was related to a poor functional outcome (OR=2.67, 95% CI=1.36–5.35) and mortality (hazard ratio=7.67, 95% CI=3.76–12.83) even after adjusting for END.</P><P><B>Conclusions</B></P><P>This study suggests that an interarm blood pressure difference of ≥10 mm Hg could be a useful indicator for the risks of END, poor functional outcome, and mortality.</P>

Rescue Stenting for Failed Mechanical Thrombectomy in Acute Ischemic Stroke : A Multicenter Experience

Chang, Yoonkyung,Kim, Byung Moon,Bang, Oh Young,Baek, Jang-Hyun,Heo, Ji Hoe,Nam, Hyo Suk,Kim, Young Dae,Yoo, Joonsang,Kim, Dong Joon,Jeon, Pyoung,Baik, Seung Kug,Suh, Sang Hyun,Lee, Kyung-Yul,Kwak, Hy Ovid Technologies Wolters Kluwer -American Heart A 2018 Stroke Vol.49 No.4

<P>Conclusions-RS was independently associated with good outcomes without increasing symptomatic intracranial hemorrhage or mortality. RS seemed considered in MT-failed internal carotid artery or middle cerebral artery M1 occlusion.</P>

Perioperative outcomes of sinusoidal obstruction syndrome underwent liver resection for colorectal metastases after neoadjuvant chemotherapy

Yoonkyung WOO,Yoonyoung CHOI,Haneol PARK,Chang Ho SEO,Sung Eun PARK,Joseph AHN,Ho Joong CHOI,Tae Ho HONG,Young Kyoung YOU 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

국회의원 STAFF에 관한 연구

장은경,박선영,이윤경,장혜영 이화여자대학교 법정대학 비서학과 1993 비서학연구 Vol.- No.13

18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

Alleviation of Murine Osteoarthritis by Cartilage-Specific Deletion of IκBζ

Choi, Moon-Chang,MaruYama, Takashi,Chun, Churl-Hong,Park, Yoonkyung Wiley Blackwell (John WileySons) 2018 Arthritis & rheumatology Vol.70 No.9

Pse-T2, an Antimicrobial Peptide with High-Level, Broad-Spectrum Antimicrobial Potency and Skin Biocompatibility against Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Infection

Kang, Hee Kyoung,Seo, Chang Ho,Luchian, Tudor,Park, Yoonkyung American Society for Microbiology 2018 Antimicrobial agents and chemotherapy Vol.62 No.12

<P>Pseudin-2, isolated from the frog <I>Pseudis paradoxa</I>, exhibits potent antibacterial activity but also cytotoxicity. In an effort to develop clinically applicable antimicrobial peptides (AMPs), we designed pseudin-2 analogs with Lys substitutions, resulting in elevated amphipathic α-helical structure and cationicity.</P><P>Pseudin-2, isolated from the frog <I>Pseudis paradoxa</I>, exhibits potent antibacterial activity but also cytotoxicity. In an effort to develop clinically applicable antimicrobial peptides (AMPs), we designed pseudin-2 analogs with Lys substitutions, resulting in elevated amphipathic α-helical structure and cationicity. In addition, truncated analogs of pseudin-2 and Lys-substituted peptides were synthesized to produce linear 18-residue amphipathic α-helices, which were further investigated for their mechanism and functions. These truncated analogs exhibited higher antimicrobial activity and lower cytotoxicity than pseudin-2. In particular, Pse-T2 showed marked pore formation, permeabilization of the outer/inner bacterial membranes, and DNA binding. Fluorescence spectroscopy and scanning electron microscopy showed that Pse-T2 kills bacterial cells by disrupting membrane integrity. <I>In vivo</I>, wounds infected with multidrug-resistant (MDR) <I>Pseudomonas aeruginosa</I> healed significantly faster when treated with Pse-T2 than did untreated wounds or wounds treated with ciprofloxacin. Moreover, Pse-T2 facilitated infected-wound closure by reducing inflammation through suppression of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor alpha (TNF-α). These data suggest that the small antimicrobial peptide Pse-T2 could be useful for future development of therapeutic agents effective against MDR bacterial strains.</P>

The Effects of Marine Carbohydrates and Glycosylated Compounds on Human Health

Kang, Hee-Kyoung,Seo, Chang Ho,Park, Yoonkyung MDPI 2015 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.16 No.3

<P>Marine organisms have been recognized as a valuable source of bioactive compounds with industrial and nutraceutical potential. Recently, marine-derived carbohydrates, including polysaccharides and low molecular weight glycosylated oligosaccharides, have attracted much attention because of their numerous health benefits. Moreover, several studies have reported that marine carbohydrates exhibit various biological activities, including antioxidant, anti-infection, anticoagulant, anti-inflammatory, and anti-diabetic effects. The present review discusses the potential industrial applications of bioactive marine carbohydrates for health maintenance and disease prevention. Furthermore, the use of marine carbohydrates in food, cosmetics, agriculture, and environmental protection is discussed.</P>

Antimicrobial Effects of Ocotillone Isolated from Stem Bark of Ailanthus altisshima

LEE, DONG GUN,CHANG, YOUNG-SU,PARK, YOONKYUNG,HAHM, KYUNG-SOO,WOO, EUN-RHAN 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.5

Bioassay-directed chromatographic fractionation of a methylene chloride extract of Ailanthus altisshima indicated the presence of 20(S), 24(R), epoxy-25-hydroxydammarance-3-one (compound 1, ocotillone) which was isolated from this plant, for the first time. Antimicrobial activity of compound 1 was measured by inhibition of bacterial and fungal cells growth and by a hemolytic assay with human erythrocytes, respectively. The results revealed that compound 1 had potent antibacterial activity against Gram-negative bacteria, P. aeruginosa and S. typhimurium, that were without hemolytic activity, whereas it had weak antimicrobial activity against Gram-positive bacteria and fungi. These result demonstrated that the compound 1 has more antibacterial activity against Gram-negative bacteria, which have no hemolytic activity, than Gram-positive bacteria and fungi. This is the first report on the biological activities of the compound 1.