아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향

최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4

연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.

Causes and Predictive Factors Associated with “Diagnosis Changed” Outcomes in Patients Notified as Tuberculosis Cases in a Private Tertiary Hospital

( Byung Ju Kang ),( Kyung Wook Jo ),( Tai Sun Park ),( Jung Wan Yoo ),( Sei Won Lee ),( Chang Min Choi ),( Yeon Mok Oh ),( Sang Do Lee ),( Woo Sung Kim ),( Dong Soon Kim ),( Tae Sun Shim ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.6

Background: The aim of our study was to evaluate the “diagnosis changed” rate in patients notified as tuberculosis (TB) on the Korean TB surveillance system (KTBS). Methods: A total of 1,273 patients notified as TB cases on the KTBS in one private tertiary hospital in 2011 were enrolled in the present study. Patients were classified into three groups: “diagnosis maintained”, “diagnosis changed” (initially notified as TB, but ultimately diagnosed as non-TB), and “administrative error” (notified as TB due to administrative errors). Results: Excluding 17 patients in the “administrative error” group, the “diagnosis maintained” and “diagnosis changed” groups included 1,097 (87.3%) and 159 patients (12.7%), respectively. Common causes of “diagnosis changed” were nontuberculous mycobacterial (NTM) disease (51.7%, 61/118), and pneumonia (17.8%) in cases notified as pulmonary TB, and meningitis (19.5%, 8/41) and Crohn`s disease (12.2%) in cases notified as extrapulmonary TB. Being older than 35 years of age (odds ratio [OR], 2.18) and a positive acid-fast bacilli stain (OR, 1.58) were positive predictors and a TB-related radiological finding (OR, 0.42) was a negative predictor for a “diagnosis changed” result via multivariate logistic regression analysis in pulmonary TB cases. Conclusion: Because of a high “diagnosis changed” rate in TB notifications to the KTBS, the TB incidence rate measured by the KTBS may be overestimated. Considering the worldwide trend toward increased NTM disease, the “diagnosis changed” rate may increase over time. Thus, when reporting the annual TB notification rate in Korea, the exclusion of “diagnosis changed” cases is desirable.

Causes and Predictive Factors Associated with "Diagnosis Changed" Outcomes in Patients Notified as Tuberculosis Cases in a Private Tertiary Hospital

Kang, Byung Ju,Jo, Kyung-Wook,Park, Tai Sun,Yoo, Jung-Wan,Lee, Sei Won,Choi, Chang-Min,Oh, Yeon-Mok,Lee, Sang-Do,Kim, Woo Sung,Kim, Dong Soon,Shim, Tae Sun The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.6

Background: The aim of our study was to evaluate the "diagnosis changed" rate in patients notified as tuberculosis (TB) on the Korean TB surveillance system (KTBS). Methods: A total of 1,273 patients notified as TB cases on the KTBS in one private tertiary hospital in 2011 were enrolled in the present study. Patients were classified into three groups: "diagnosis maintained", "diagnosis changed" (initially notified as TB, but ultimately diagnosed as non-TB), and "administrative error" (notified as TB due to administrative errors). Results: Excluding 17 patients in the "administrative error" group, the "diagnosis maintained" and "diagnosis changed" groups included 1,097 (87.3%) and 159 patients (12.7%), respectively. Common causes of "diagnosis changed" were nontuberculous mycobacterial (NTM) disease (51.7%, 61/118), and pneumonia (17.8%) in cases notified as pulmonary TB, and meningitis (19.5%, 8/41) and Crohn's disease (12.2%) in cases notified as extrapulmonary TB. Being older than 35 years of age (odds ratio [OR], 2.18) and a positive acid-fast bacilli stain (OR, 1.58) were positive predictors and a TB-related radiological finding (OR, 0.42) was a negative predictor for a "diagnosis changed" result via multivariate logistic regression analysis in pulmonary TB cases. Conclusion: Because of a high "diagnosis changed" rate in TB notifications to the KTBS, the TB incidence rate measured by the KTBS may be overestimated. Considering the worldwide trend toward increased NTM disease, the "diagnosis changed" rate may increase over time. Thus, when reporting the annual TB notification rate in Korea, the exclusion of "diagnosis changed" cases is desirable.

Protective effect of chorioamnionitis on the development of bronchopulmonary dysplasia triggered by postnatal systemic inflammation in neonatal rats

Choi, Chang Won,Lee, Juyoung,Oh, Joo Youn,Lee, Seung Hyun,Lee, Hyun Ju,Kim, Beyong Il Nature Publishing Group 2016 Pediatric research Vol.79 No.2

<P><B>Background:</B></P><P>Prenatal or postnatal systemic inflammation can contribute to the development of bronchopulmonary dysplasia (BPD). We investigated whether prenatal intra-amniotic (i.a.) inflammation or early postnatal systemic inflammation can induce BPD in a rat model.</P><P><B>Methods:</B></P><P>One microgram of lipopolysaccharide (LPS) or vehicle was injected into the amniotic sacs 2 d before delivery (E20). After birth, 0.25 mg/kg of LPS or vehicle was injected into the peritoneum of pups on postnatal day (P)1, P3, and P5. On P7 and P14, peripheral blood (PB), bronchoalveolar lavage fluid (BALF), and lung tissue were obtained and analyzed.</P><P><B>Results:</B></P><P>Postnatal i.p. injections of LPS significantly increased neutrophil counts in PB and BALF on P7 and P14. Similarly, proinflammatory cytokine and angiogenic factor transcript levels were increased in the lung by i.p. LPS on P7. Alveolar and pulmonary vascular development was markedly disrupted by i.p. LPS on P14. However, pretreatment with i.a. LPS significantly negated the detrimental effects of postnatal i.p. LPS on PB and BALF neutrophil counts and on lung proinflammatory cytokine expression and histopathological changes.</P><P><B>Conclusion:</B></P><P>Exposure to early postnatal systemic LPS induces BPD, an arrest in alveolarization, in neonatal rats. Preceding exposure to i.a. LPS protects the lungs against BPD triggered by postnatal systemic inflammation.</P>

년령 증가에 따른 췌장도 내분비세포 분포에 관한 조직학적 연구

최창근,이원복,라봉진 중앙대학교 의과대학 의과학연구소 1983 中央醫大誌 Vol.8 No.1

It is well known that the islet changes of pancreas could be induced by various factors, for example, obesity, hormones, pregnancy, age, etc. For the observation of the effect of age and sex, the size of the pancreatic islets and endocrine cells composing them were calculated. As an experimental animal the albino rats of Wistar strain were used. During breeding for fifty weeks, the rats were sacrificed with the interval of ten weeks and the pancreatic tissues were fixed in Bouin's solution and stained with hematoxylin and eosin, and aldehyde fuchsin and trichrome. The results were as follows : 1. At the age of fifty weeks of the male, the islets showed marked hypertrophy with peri-and intra-insular fibrosis. 2. The changes of the islets are found more earlier and severe in the male than in the female. 3. The frequency of appearance of pancreatic endocrine cells seemed not to change greatly during the increase of age.

A Rare Solitary Fibrous Tumor of the Pleura with Extensive Cystic Change

Chang Woo Choi,Chang Woo Choi,Soon Won 순천향의학연구소 2013 Journal of Soonchunhyang Medical Science Vol.19 No.2

A right pleural mass was detected incidentally in a 52-year-old woman and chest computed tomography showed lobulated pleural mass. Thoracoscopic excision was performed. Histology showed solitary fibrous tumor with extensive cystic change. Solitary fibrous tumor with extensive cystic change is very rare and we treated this tumor successfully with video-assisted thoracic surgery.

Cerebral vascular burden on hippocampal subfields in first-onset drug-naïve subjects with late-onset depression

Choi, Woo Hee,Jung, Won Sang,Um, Yoo Hyun,Lee, Chang Uk,Park, Young Ha,Lim, Hyun Kook Elsevier 2017 Journal of affective disorders Vol.208 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Although there is substantial evidence of associations between frontal-striatal circuits and cerebral vascular burden in late-onset depression (LOD), relationships between vascular burden and hippocampal subfields are not clear. The purpose of this study was to investigate relationships between cerebral vascular burden and hippocampal subfield volume in LOD patients.</P> <P><B>Methods</B></P> <P>Fifty subjects with LOD and 50 group-matched healthy control subjects underwent magnetic resonance imaging scanning. Hippocampal subfields volumes were measured and compared between the groups. In addition, association patterns between white matter hyperintensity (WMH) volumes, clinical measures and hippocampal subfield volumes were investigated in the LOD group.</P> <P><B>Results</B></P> <P>Subjects with LOD exhibited significant hippocampal volume reductions in the total hippocampus, cornu ammonis (CA) 1 and 3 and dentate gyrus (DG) areas compared with healthy subjects. Total WMH volume was negatively correlated with left total hippocampal volume and CA1 in the LOD group. In addition, depression severity was negatively associated with left and right CA3 volumes in the LOD group.</P> <P><B>Limitation</B></P> <P>Our findings of distinctive relationships between WMH and hippocampal subfields demonstrate a simple correlation, but do not prove causation</P> <P><B>Conclusion</B></P> <P>This study is the first to elaborate distinctive association patterns between hippocampal subfield volumes and cerebral vascular burden in LOD. These structural changes in the hippocampal CA1, CA3 and DG areas might be at the core of the underlying neurobiological mechanisms of hippocampal dysfunction in LOD. However, longitudinal studies will be needed to identify the mechanisms of these structural changes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This study is the first to elaborate distinctive association patterns between hippocampal subfield volumes and cerebral vascular burden in LOD. </LI> <LI> White matter hyperintensity was negatively correlated with left total hippocampal volume and CA1 in the LOD group. </LI> <LI> In addition, depression severity was negatively associated with left and right CA3 volumes in the LOD group. </LI> </UL> </P>

化卉의 消費形態에 관한 硏究

崔圭晧,裵相源,金昶佑 全北大學校 1995 論文集 Vol.39 No.-

The purpose of this survey is to investigate and analize the status of flower consumption by city households so that it can provide basic materials for the development of horticulture industry. For this purpose, one thousand housewives were questioned living in six large cities : Seoul, Pusan, Taegu, Inchon, Kwangju and Taejon. The results of the analysis are as follows; 1. The most favorite cut flowers by season were rose, carnation and freesias in spring: roses and gypsophila paniculate in summer : chrysanthermum in autumn : gypsophila paniculate, roses chrysanthemums and lilies in winter. 2. The uses of cut flowers was mostly for gifts(58.4%), and that of pot flowers was mostly for home decoration. 3. flower shops were the most popular place for buying cut flowers(59.5%), followed by wholesale markets(22.5%) and street stalls(16.2%). In the case of pot flower, wholesale markets were the most favorite place(32.4%), street stalls(27.9%), flower shops(24.8%), and farm houses(11.9%). The survey showed that consumers frequent a shopping place because of 'easy accessibility', and 'various varieties in stock' in the case of cut flowers and, in that of pot flowers, 'easy accessibility' and 'low price' were the main resons in the case of pot flowers. 4. The purchase frequency rate by seson for cut flowers was that 'regardless of season' was 58.1% and 'spring', 28.9%. For pot flowers, 'spring' 58.9% and 'regardless of season' 33.6%. For the day of the week cut flowers were bought most open, Saturday came first with 34.2%, Monday and Sunday followed with 27.0% and 15.5% respectively. On the other hand, Sunday came first with 42.3%, Saturday(32.5%) and Monday(8.3%) took the second and third place respectively for pot flowers When it came to the purchase time of the day for cut flowers, 31.8% of the respondents bought then between ten and noon and 21.8% between four and six in the afternoon. 5. concerning the average amount of money spent at one time for cut flowers, 33.3% of the respondents said 3,000won to 5,000won and 23.2% replied 5,000won to 10,000won. While 36.8% answered that they paid 5,000won to 10,000won and 23.5% said 3,000won to 5,000won for a pot flowers. 6. Relating to the demand of flower stores, 28.8% wanted 'low price' : 27.9%. requested 'clear markings of the prices' : and 26.4%, wanted 'abundant commodities'

계획 신도시 물 사용량 및 이용 패턴 추정

송창근 ( Chang Geun Song ),조형근 ( Hyoung Geun Jo ),최진탁 ( Jin Tak Choi ),김주원 ( Joo Won Kim ) 한국수처리학회 2015 한국수처리학회지 Vol.23 No.1

Recently, due to the water shortage by urbanization, industrialization, and climate change, the importance of efficient water resources management is increasing. In particular, when it comes to a planned new town whose development is in progress, the researches on the estimation of the water demand and the water usage patterns are essential for the risk assessment of regional water shortage. In this study, targeting an Youngjong Island, which is in lack of internal water resource owing to the high reliance on external water supply through subbed pipeline and the island characteristics, the amount of water consumption and the water usage pattern in every five years from 2015 to 2030 were estimated in terms of seasonal and hourly basis. At the final objective year 2030, the daily maximum demand of water for living was about 57,000 m3/day, which was approximately 7.4 times higher than that of 2015. Despite of the decrease of the estimated water demand in lpcd (liter per capita day) in 2030, the population increases corresponding to 7.7 times compared with 2015 mainly influenced the increment. The analysis by time-series data at Incheon Airport Region revealed that the water consumption in summer was highest while that of spring was lowest. This was closely related with variation of the number of visitor according to the season change. In addition, the estimation of the water usage pattern in Haneul City, in which most of the population in Youngjong Island is expected to reside, showed that the seasonal water consumption ranked in order of summer, spring, fall, and winter. Further studies are planned to provide the facility invest model that can ensure sustainable and economic water supply under higher water consumption demand.

전남 신안지역어의 어휘 연구

최창원 ( Choi Chang-won ) 한민족문화학회 2018 한민족문화연구 Vol.63 No.-

이 연구는 전남 신안지역어의 어휘 연구를 목적으로 한다. 구체적으로 그들 어휘를 표준어와 비교하여 어원적으로 차이를 보이는 어휘, 어간이 확장되거나 축소된 어휘, 음운변화와 관련된 어휘로 나누어 논의하였다.먼저 표준어와 어원적으로 차이를 보이는 어휘들은 ① 표준어에서 한자어인 경우 신안 지역어에서는 고유어로, ② 표준어의 고유어가 지역어에서는 한자어로, ③ 표준어의 고유어가 지역어에서는 다른 고유어로 나타나는 경우가 많이 있었고, 그 외에도 ④ 비유적인 표현에서 온 것, ⑤ 의성어에서 온 것 등이 있었다.다음으로 어간이 확장된 어휘들로는 ① 어간에 ‘으’가 첨가된 것, ② ‘ㅂ-변칙동사의 어간’의 이형태 ‘Xㅂ-’와 ‘X우-’가 ‘X우-’로 단일화되는 과정에서 ‘Xㅂ-’가 ‘X웁-’으로 확장된 것, ③ 접미사가 통합되어 파생된 어간 등이 있었다. 한편 ④ 어간이 축소된 어휘들로는 동화나 탈락에 의한 것이 있었다.끝으로 음운 변화와 관련된 어휘들로는 ① ‘ㅸ’의 변화, ② ‘ㅿ’의 변화, ③ 체언 어간말 ‘ㅊ’와 ‘ㅌ’의 변화, ④ 원순모음화, ⑤ 체언 어간말 ‘Vy’의 변화에 의한 것들이 있었다. This article’s purpose is to study Sinan regional vocabulary in Korean. It discussed the differences between Standard Korean language to Sinan regional vocabulary, such as etymological difference, stem extension/reduction, and euphonic changes.Firstly, there are the etymological differences between Standard Korean langage and Sinan regional vocabulary: ① Sino-Korean words in Korean Standard Language vs. Native words in Sinan regional vocabulary, ② Native words in Standard Korean Language vs. Sino-Korean words in Sinan regional vocabulary, ③ Native words in Standard Korean Language vs. different native words in Sinan regional vocabulary, ④ Metaphorical expressions in Sinan regional vocabulary, and ⑤ Onomatopoeia words in Sinan regional vocabulary.Secondly, there are the differences from stem extension and stem reduction: ① ‘i(으)’ vowel addition to the stem, ② the extension of ‘Xp(ㅂ)-’ into ‘Xup(웁)-’ when the allomorph ‘Xp (ㅂ)-’ and ‘Xu(우)-’ are unified ‘Xu(우)-’ in the so-called ‘p(ㅂ)’ irregular verbs stems. ③ derivational stems which are combined the suffixes. ④ assimilation or reduction on the reduction of the stems of some vocabulary in Sinan regional langauge.Finally, there are the difference in terms of euphonic changes, such as the changes of consonants ① ‘β(ㅸ)’ and ② ‘z(ㅿ)’, the noun stem final ③ ‘ch(ㅊ)’ and ‘kh(ㅋ)’, ④ vowel rouding and ⑤ the noun stem final ‘Vy’.