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A numerical investigation of hydrogen desorption phenomena in ZrCo based hydrogen storage beds
Yoo, H.,Ko, J.,Yun, S.h.,Chang, M.h.,Kang, H.g.,Kim, W.,Ju, H. Pergamon Press ; Elsevier Science Ltd 2013 INTERNATIONAL JOURNAL OF HYDROGEN ENERGY - Vol.38 No.14
In this paper, a three-dimensional (3D) hydrogen desorption model is applied to the thin double layered annulus ZrCo based hydrogen storage bed to precisely study the hydrogen desorption reaction and resultant heat and mass transport phenomena inside the bed. The 3D hydrogen desorption simulations are carried out and calculated results are compared with the experimental data measured by Kang et al. [1]. The present model reasonably captures the bed temperature evolution behavior and the hydrogen discharging time for 90% desorption. In addition, the thin double layered annulus metal hydride bed (MHB) design is numerically evaluated by comparing with a simple cylindrical MHB. More uniform distributions in the bed temperature and H/M atomic ratio and resultant superior hydrogen desorption performance are achieved with the thin double layered annulus bed owing to its high external surface to volume ratio and thus more efficient heating. This numerical study indicates that efficient design of the metal hydride bed is key to achieve rapid hydrogen discharging performance and the present 3D hydrogen desorption model is a useful tool for the optimization of bed design and operating conditions.
Carbon nanotube-based biosensor for detection of matrix metallopeptidase-9 and S-100B
Lee, H.S.,Oh, J.S.,Chang, Y.W.,Park, Y.J.,Shin, J.S.,Yoo, K.H. 한국물리학회 2009 Current Applied Physics Vol.9 No.4_SUP
We fabricated carbon nanotube (CNT)-based biosensor with field effect transistor structure for detection of matrix metallopeptidase-9 (MMP-9) and S-100B. To minimize contact effects, the metal electrodes were passivated with SiO<SUB>x</SUB> film, and anti-MMP-9 and S-100B antibody were immobilized on the CNT surface using a chemical linker. When MMP-9 or S-100B antigen was added to bind anti-MMP-9 or S-100B antibody, the decrease in electrical conductance was observed. We have also investigated the dependence of MMP-9 and S-100B concentration on the conductance change. A linear relationship was found between the conductance and the concentration in semi-logarithm scale.
宋孝源,金靜惠,柳浩濬,張基完,崔平和 中央醫學社 1965 中央醫學 Vol.8 No.1
The etiology of this anomaly is unknown, however, chief features of this condition are anomalous developments of clavicles and cranial bones due to disturbance in ossification of membranous bones. Many reporters have divided this anomaly into two types: those with a familial and hereditary history and those without. Probably more of the cases come under the head of those giving no familial or hereditary history. And anomalous development of one or both clavicles is the really characteristic defect. Therefore, Fitchet believed the term "hereditary cleidocranial dysostosis" should be discontinued and "congenital cleidal dysostosis" substituted instead. Authors have observed 3 patients with typical anomalies of cleidocranial dysostosis occurring in one family. Regarding family history, eight members Ln four generations were known to have defects in the clavicles. Case Ⅰ and Ⅱ: Daughters of case Ⅲ, aged 2 years and 9 months and 7 years each. Height, weight and mental development were considered normal for their age. The heads looked relatively large. X-ray examination of the skull, chest and pelvis revealed defects in the skull bones and clavicles, widening of the sutures and symphysis pubis. Situs inversus was noted in case Ⅰ. Case Ⅲ: Thirty-seven-year old male, 157cm in height, had normal mentality. On physical examination, brachycephaly and upward angulation of the clavicles were seen. Bony defects in the central portion of the frontal bone, parietal bosses, delay in closure of the sutures, anomalous dentition, persistent metopic suture and partial defects in the clavicles were identified on skull and chest x-rays.
소아 쭈쭈가무시병환자 28명의 임상상 및 유병기간에 따른 간접면역형광항체가의 변동상
박병규,오영균,윤희상,염명걸,유한욱,김재형,강환섭,김익상,장우현,김승환 대한감염학회 1993 감염 Vol.25 No.2
During the autumn of 1990 , we had investigated the clinical featuresw and followed the change in the direct immunofluorescent antibody(IFA) titers in 28 children with scrub typhus who resided in or near Chinju, Korea. All the children except one were diagnosed by the peak IFA titers of 1:160 or higher. The results were as follows: 1) The clinical features of our children were not different, to a large degree, from those of adults ever described in Korea literatures. But the frequence rates of skin rash, eschar and conjunctival injection were higher, those of proteinuria and hematuria were lower than those in adults and the characters of rash in our children were also quite different(faces were frequently the first site of eruption and even palms and soles were involved occasionally, initial bright red color of rash was changed into brown color during the acute phase). 2) IFA titers rose rapidly during the 2nd or 3rd week of illness and then formed plateau. When we suggest IFA titers of 1:180 or higher as the diagnostic criteria, the seropositivity of our children was 5/7(75%) in the 1st week and over 95% in the 2nd through 5th week of illness, and suggest IFA titers of 1:160 or higher,then the seropositivityin the 1st, 2nd and 3rd through 5th week were 3/7(43%), 23/31(74%) and over 95%,respectively. 3) IFA titers in 6-8 months after disease onset were 1:80(13 children) or 1:20( 7 children), and in one and half year (our longest follow-up period), 1:20 (3 children) showing that IFA lasts longer than one and half year after sickness. 4) From the above data (3) and the fact that majority of cases of scrub typhus occur in the autumn season in Korea, IFA titers of 1:40-1:160 should be used as the diagnostic criteria in order to distinguish between the present and past infections.
An exploration of the antioxidant effects of garlic saponins in mouse-derived C2C12 myoblasts
Kang, J. S.,Kim, S. O.,Kim, G.-Y.,Hwang, H. J.,Kim, B. W.,Chang, Y.-C.,Kim, W.-J.,Kim, C. M.,Yoo, Y. H.,Choi, Y. H. Spandidos Publications 2016 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.37 No.1
<P>In this study, we aimed to confirm the protective effects of garlic saponins against oxidative stress-induced cellular damage and to further elucidate the underlying mechanisms in mouse-derived C2C12 myoblasts. Relative cell viability was determined by 3-(4.5-dimethylthiazol-2-yl)-2.5 diphenyltetrazolium bromide assay. Comet assay was used to measure DNA damage and oxidative stress was determined using 2 ',7 '-dichlorofluorescein diacetate to measure intracellular reactive oxygen species (ROS) generation. Western blot analysis and small interfering RNA (siRNA)-based knockdown were used in order to investigate the possible molecular mechanisms. Our results revealed that garlic saponins prevented hydrogen peroxide (H2O2)-induced growth inhibition and exhibited scavenging activity against intracellular ROS. We also observed that garlic saponins prevented H2O2-induced comet tail formation and decreased the phosphorylation levels of gamma H2AX expression, suggesting that they can prevent H2O2-induced DNA damage. In addition, garlic saponins increased the levels of heme oxygenase-1 (HO-1), a potent antioxidant enzyme associated with the induction and phosphorylation of nuclear factor erythroid 2-related factor 2 (Nrf2) and the translocation of Nrf2 from the cytosol into the nucleus. However, the protective effects of garlic saponins on H2O2-induced ROS generation and growth inhibition were significantly reduced by zinc protoporphyrin IX, an HO-1 competitive inhibitor. In addition, the potential of garlic saponins to mediate HO-1 induction and protect against H2O2-mediated growth inhibition was adversely affected by transient transfection with Nrf2-specific siRNA. Garlic saponins activated extracellular signal-regulated kinase (ERK) signaling, whereas a specific ERK inhibitor was able to inhibit HO-1 upregulation, as well as Nrf2 induction and phosphorylation. Taken together, the findings of our study suggest that garlic saponins activate the Nrf2/HO-1 pathway by enabling ERK to contribute to the induction of phase II antioxidant and detoxifying enzymes, including HO-1 in C2C12 cells.</P>
장영록,정석원,김창수,전병찬,박용구,유태현,천태상,이화동 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.5
Mucocele is collection of mucus enclosed in a sac of lining sinus epithelium within an air sinus resulting from an obstruction to the outlet of the cavity which may cause an expansion of the bony walls. The condition commonly occurs in the frontal or anterior ethmoidal sinuses but, rare in sphenoid sinuses. Mucocele of the sinus is an uncommon cause of unilateral proptosis which may produce considerable difficulty in diagnosis. Ocular disturbances and headache are among the characteristic complaints and patients often first consult an ophyhalmologist or otolaryngologist. The authors experienced four cases of paranasal sinuse mucocele. There were 2 posterior ethmoid sinus mucoceles, 1 giant frontal sinus mucocele and 1 sphenoid sinus mucocele. These cases presented with exophthalmos, proptosis, headache or frontal mass. All cases removed by surgical procedures and good result was obstained.