VARIATION OF 24-HOUR INTRAOCULAR PRESSURE IN SILICONE OIL–FILLED EYES

Chang, Joo Hyun,Shin, Jae Pil,Kim, In Taek,Park, Dong Ho Lippincott 2016 Retina Vol.36 No.1

<P>Purpose:To evaluate the variation of 24-hour intraocular pressure (IOP) in silicone oil (SO)-filled eyes.Methods:Prospective, nonrandomized comparative case series of 42 eyes of 21 patients, each with an SO-filled eye after vitrectomy. The fellow eyes served as controls. Each subject slept the usual 8 hours, and IOPs were measured at 4-hour intervals over 24 hours, twice before sleep (5:30 and 9:30 pm), twice during sleep (1:30 and 5:30 am), and twice after sleep (9.30 am and 1:30 pm). Intraocular pressure was measured in the sitting position using a Goldmann applanation tonometer. The SO-filled eyes and fellow eyes were compared with respect to diurnal-to-nocturnal and nocturnal-to-diurnal IOP changes.Results:At all 6 time points, SO-filled eyes had higher mean IOPs than fellow eyes (all P < 0.05). For both groups, mean nocturnal IOP was higher than mean diurnal IOP (both P < 0.001). Changes in diurnal-to-nocturnal IOP and nocturnal-to-diurnal IOP between SO-filled eyes and fellow eyes did not differ significantly (P > 0.05, respectively). The peak IOP occurred in the nocturnal period for all fellow eyes and for 94.7% of SO-filled eyes.Conclusion:The IOP of SO-filled eyes varied over a 24-hour period, peaking largely in the nocturnal period, as observed for the IOP of fellow eyes.</P>

오리고기에 關한 硏究(Ⅱ) : 오리고기 통조림의 貯藏中 罐內變化 Various Changes in the Canned Duck-meat during the Storage Period

조덕봉,김동필,성하진,장인애 광주보건대학 1978 論文集 Vol.4 No.-

Various changes, especially leaching of heavy metals, in .the canned dock-meat during the 10 months storage period were investigated. Detinning reached to 57.28 ppm level, and the leaching of Pb and Fe levels were equivalent to 3.88 and 60.00 ppm respectively in the stored 10 months cans. The changes of pH and vacuum degrees were not significant and swelled cans were not observed. . Corrosion of tin-plate was increased as the during storage period in each sample.

중증 고혈압증의 임상적 관찰

육동민(Dong Min Yook),곽시영(Si Young Kwak),김성식(Seong Sik Kim),이성숙(Seong Sook Lee),홍관표(Kwan Pyo Hong),최창필(Chang Pil Choi),이재우(Jae Woo Lee),이시래(Si Rhae Lee) 대한내과학회 1987 대한내과학회지 Vol.33 No.2

N/A Clinical studies were carried out in the 110 cases of severe hypertension who had been admitted from January 1979 to August 1985 and the following results were obtained: 1) Underlying diseases of severe hypertension were essential hypertension in 67 cases, renal parenchymal hypertension in 36 cases, and renovascular hypertension in 7 cases. 2) Plasma renin activity was the highest in the group of renovascular hypertension which was 22.07±9.20 ng/ ml/hr, and as a whole, the higher diastolic blood pressure, the higher plasma renin activity was. Plasma renin activity in the group of K-W grade IV retinopathy was higher than those of the other groups. 3) The incidence of ventricular hypertrophy fullfilling voltage criteria and with accompanying ST-T changes on electrocardiolgram was 81.5% in the group of essential hypertension and there was no difference in relation to the level of pressure or fundoscopic changes. 4) The serum creatinine level was the highest in the group of renal parenchymal hypertension (7.93±2.98 mg/dl), and in the group of K-W grade IV retinopathy (6.86±3.50mg/dl), but there was no significant difference in relation to the level of diastolic blood pressure, 5) There were no significant difference in cardiothoracic ratio on chest X-ray in relation to underlying diseases, diastolic blood pressure or fundoscopic changes. 6) The major complications were congestive heart failure (49.1%), hypertensive encephalopathy (17.3%), and cerebrovascular accident (8.2%). 7) In the group of essential hypertension blood pressure was controlled by conservative treatment in 81.0% but in 35.7% in the group of renal hypertension. The patients of chronic renal failure who were treated with dialysis blood pressure was controlled in 87.0%. In all 6 cases with renal transplantation, nephrectomy or renal angioplasty blood pressure was well controlled. 8) In cases refractory to triple antihypertensive regimen blood pressure was controlled by minoxidil in 66.7% and by captopril in 75.0%. 9) In 45 cases who were followed up for more than 6 months diastolic blood pressure was controlled under 100mmHg in 77.8% and there were improvement of renal function, fundoscopic findings and electrocardiographic findings in 20.0%, 33.3% and 16.7%, respectively.

補中益氣湯이 납中毒된 흰쥐의 臟器重量에 미치는 影響

임종필,남궁동,강창수,강태욱 又石大學校 1994 論文集 Vol.16 No.-

Lead acetate and Bojungiki-tang extract, a herbal restorative were treated p. o. 40㎎/㎏ and 500㎎/㎏ respectively and concurrently to mouse, and examined variation of body weigh, accumulation of lead in organs of rats. The results obtained in this study are as follows: 1. Bojungiki-tang extract(BIT) resulted increase of body weight and the increase ratio of body weight in lead-treated group was dropped but the group of concurrent administration with BIT showed significant recovery. 2. The accumulation of lead in liver of lead-treated group increased but the group of concurrent administration with BIT showed significant decrease. 3. The ratio of liver weight/body weight of lead-treated group increased but the group of concurrent administration with BIT showed significant decrease. These results on the whole indicated that concurrent administration with BIT sowed significant recovery from the toxicity of lead-treated group.

RF DIN Connector의 Passive IMD 개선에 관한 연구

고윤선,정재필,오창헌,신동욱 한국항행학회 2002 韓國航行學會論文誌 Vol.6 No.3

최근 이동통신 서비스가 확대됨에 따라 인접 기지국간의 간섭문제가 증가하게 되었으며, 그에 따라 CDMA시스템의 active IMD 뿐만 아니라 PIMD (Passive Inter Modulation Distortion)에 대한 문제도 시스템 설계 시 고려되어야 한다. 본 논문에서는 RF connector 중 대표적 connector인 7/16“ DIN connector를 통하여 동촉선에서의 PIMD발생 정도를 분석하였고, PIME 개선 방안을 제안하였다. 첫째, 대부분의 전류가 통과하는 경로에는 표면조도가 좋은 금속이 전도율이 좋아 유리하며, 둘째 RF에너지가 충분ㅎ히 한 매질에서 통과할 수 있도록 최소 5m 이상으로 도금을 해야 함을 알수 있었다. 셋째, 도금 재료의 노화현상 방지를 위해 비열이 높고 전도율이 높은 금속 선택이 필수적이며, 비용절감 면에서는 삼원합금 등 대체 도금 재질 개발이 요구됨을 알 수 있었다. 현재 국내 PIMD 규격인 KTF-150dBc를 만족시키기 위해서는 7/16“ DIN connector 의 경우 도금재질에 관계없이 표면조도 6s, 도금두께 5m일때 KTF의 PIMD 규정을 만족시킬 수 있음을 알 수 있었다. Recently, as the range of mobile communication services is extended, the interference between adjacent base-stations is increased. Nowdays, on of the important factors causing interference is IMD(Inter-Modulation Distortion) problems. Not only active IMD but also passive IMD effects must be considered to design a CDMA system. In this study, we design and implement 7/16'' DIN connectors which have a various intensity of surface illumination, thickness and quality of plating material to analyze the effects of PIMD. And propose the methods for improving the PIMD characteristics: First, it is more profitable to use the metal which has good intensity of surface illumination where most of all electric currents passes through it. Secondly, we should plate metals more than 5 μm for RF energy enough to propagate in a medium. Thirdly, it is necessary to select a metal having high conductivity and specific heat to protect the aging phenomenon of plate material. And it is required to develop a new plating material to replace the current materials, such as the alloy of three components for cost reduction. We have to know that the plate which has intensity of surface illumination 6 S and the thickness of plating material 5 μm satisfy domestic PIMD specification (KTF) - 150 dBc, regardless of the plate material in case of 7/16'' DIN connector.

Necrotizing soft tissue infection

Sung Jin Park,Dong Heon Kim,Chang In Choi,Sung Pil Yun,Jae Hun Kim,Hyung Il Seo,Hong Jae Jo,Tae Yong Jun 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.91 No.1

Purpose: Necrotizing soft tissue infection is the infection of the soft tissue with necrotic changes. It is rare, but results in high mortality. We analyzed the characteristics of patients, prognosis, and mortality factors after reviewing 30 cases of a single hospital for 5 years. Methods: From January 2009 to December 2013, 30 patients diagnosed with necrotizing fasciitis or Fournier’s gangrene in Pusan National University Hospital were enrolled for this study. The following parameters were analyzed retrospectively: demographics, infection site, initial laboratory finding, initial antibiotics, isolated microorganisms, number of surgeries, time to first operation, length of intensive care unit, and total hospital stays. Results: The overall mortality rate was 23.3%. Mean body mass index (BMI) of the survival group (24.7 ± 5.0 kg/㎡) was significantly higher than the nonsurvival group (22.0 ± 1.4 kg/㎡, P = 0.029). When BMI was less than 23 kg/㎡, the mortality rate was significantly higher (P = 0.025). Two patients (6.7%) with chronic kidney disease requiring hemodialysis died (P = 0.048). Initial WBC count (>13×10<SUP>3</SUP>/μL), CRP (>26.5 mg/dL), and platelet (PLT) count (<148×10<SUP>3</SUP>/μL) were found to have negative impact on the prognosis of necrotizing soft tissue infection. Factors such as potassium level, blood urea nitrogen (>27.6 mg/dL), serum creatinine (>1.2 mg/dL) that reflected kidney function were significant mortality factors. Conclusion: Patients with low BMI or abnormal values of WBC count, CRP, and PLT count reflecting the degree of infection or abnormal renal function will need more intensive care.

자궁내막기질인 Type I Collagen을 이용한 생쥐 배아의 착상에 관한 연구

김정훈(Chung Hoon Kim),채희동(Hee Dong Chae),강병문(Byung Moon Kang),장윤석(Yoon Seok Chang),강은희(Eun Hee Kang),전용필(Yong Pil Cheon),박견(Kyun Park) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.1

목적: Type I collagen을 이용하여 3차원적 배양체계와 유사한 구조적인 환경을 조성하여 생쥐 배아의 착상전후의 상태를 보기 위한 연구를 중심으로 하였다. 연구방법: 포배단계의 배를 획득하기 위해서 자궁과 수란관의 일부를 적출하고 배양액으로 관류하여 배를 획득한 후 실험에 사용하였다. 멸균된 centrifuge용 시험관에 collagen이 polymerization되게 하였다. 배아는 착상과정의 비교를 위하여 type I collagen군(실험군)과 대조군으로 나누었으며, 대조군에서는 type I collagen 없이 배양액만 사용하여 배아를 배양하였다. 배의 성장과 분화는 24시간 단위로 해부현미경하에서 관찰하였다. 결과: 배양 제 3일에 배아의 부착율은 차이가 없었으나, 배아의 크기는 대조군에 비하여 실험군에서 뚜렸하게 컸다. 배아의 성장이 대조군에서 배양용기의 표면을 따라 수평적으로 진행되는 것과는 달리 실험군에서는 구형을 이루며 입체적으로 성장하기 때문에 색깔이 훨씬 진하게 나타났다. 배아의 발달단계를 관찰한 결과 배양 제 4일과 5일에는 실험군에서 대조군에 비하여 유의하게 발달단계가 높았다. 결론: Type I collagen을 사용한 본 연구는 착상연구의 모델로서 실험적으로 원하는 환경을 설정할 수 있고 관찰이 용이한 장점을 보여주었으나, 생체의 자궁내막세포와 같은 dynamic milieu가 결여되어 있어, 실제의 자궁내막과 유사한 체계를 이루는 배양체계를 어느 정도 수준까지 완성하려면 지속적인 연구가 필요할 것으로 사료된다. Objectives: To examine the in vitro interactions of blastocyst attachment using type I collagen. Materials and methods: ICR mice were used and follicular growth was stimulated by pregnant mare serum gonadotropin and human chorionic gonadotropin. On day 4 of pregnancy, the uteri were removed and blastocysts were flushed. Mixtures of 1mL sterile water, 0.5mL DMEM, 2mL type collagen solution and 0.5mL 0.1M NaOH were prepared and transferred to an incubator where the collagen solution polymerized. Blastocysts were transferred to dishes previously coated with type I collagen. CMRL 1066 was used as the basic culture medium. It was supplemented with 1mM glutamine and 1mM sodium pyruvate plus 50 IU/ml penicillin and 50 mg/ml streptomycin. During the first 4 days the culture medium was supplemented with 20% fetal calf serum and thereafter with 20% heat inactivated human cord serum. All blastocysts were initially cultured for 2 days without media change. After 2 days, fresh medium was renewed daily. The stages of embryo growth were examined and recorded everyday under a dissecting microscope and classified according to the standard in vivo criteria set forth by Witschi. Results: By 48h, nearly all blastocysts had attached to the surface of collagen pad. Following adhesion to the collagen pad, the blastocysts maintained their 3-dimensional integrity in contrast to control. The embryos in collagen pad were not flattening and kept polarity and spherical shape during culture. The polar trophoblast invaded the type I collagen downward unlike the horizontal growth in control. In the developmental stage of mouse blastocyst, there were significant differences between control and type I collagen group during day 4 and 5 culture. Conclusion: Blastocyst development was better in type I collagen group than control. Therefore, in vitro culture study using type I collagen could provide improved model for the establishment of blastocyst implantation study.

Cronkhite-Canada 증후군 1예

이수걸,문창형,김무영,최성호,여동승,강필중,송철수,조몽,양웅석,허윤,문한규 대한내과학회 1992 대한내과학회지 Vol.42 No.2

저자들은 Cronkhite-Canada 증후군 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Cronkhite-Canada syndrome is a disease entity, including such characteristics as gastrointestinal polyposis associated with ectodermal changes-alopecia, hyperpigmentation of the skin and atrophy of the nails. But it has no familial tendency. In 1955, a report of 2 patients by Cronkhite and Canada established this entity as clinically distinct from any of the other known forms of gastrointestinal polyposis. Since that time, at least 53 similar casas has been described in the world literature, but no case has been reported in Korea.

반복작업에 의해 발생한 척골관 증후군 1례

김정원,박인선,이영준,김유창,김필자,강동묵,이채언 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : To report cubital tunnel syndrome due to repetitive motions. Methods : A worker complaining muscle weakness and atrophy of the right hand intrinsic muscles admitted to a hospital. We evaluated him with blood tests, neurophysio-logic studies (NCV & EMG), plain X-ray and US at the both elbows. We investigated his occupational history, and videotaped his work motions based on the work cycle at his previous work site. Finally, an ergonomics expert analyzed the motions using rapid upper limb assessment (RULA). Results : NCV & EMG studies reveals slow conduction velocity on both ulnar nerve across the elbow, more severely in the right side. US shows us compatible finding with diffuse neuritis of both ulnar nerves at both elbows. RULA score is 7. Conclusion : We confirmed that the worker's symptoms were related to his previous jobs demanding repetitive motions using the elbow joints. It is necessary that we should prepare appropriate measures to evaluate, prevent, rehabilitate, and help injured workers to return to work.

우유와 두유를 혼합한 이유보충음료의 개발

손경희,윤선,이민준,김순영,김용태,장동훈,강석필 연세대학교 생활과학연구소 2001 生活科學論集 Vol.10 No.1

The purpose of this study is to develop an infant supplement composed of cow and soy milk which has acceptable taste and digestability and meets nutritional needs of the infants. Even though soy milk is and excellent source of protein for infants who are allergic to dairy products, its protein quality is still lower than that of regular milk. Therefore in the present study the development of sow-soy milk infant formula was attempted. To make the formula equal amount of cow and soy milk were mixed and supplemented with vitamins and minerals to meet the nutritional standards of breast milk, CODEX and recommended dietary allowances for Korean infants. In animal experimental study, the weight gain rate of weaning rats was highest in the order of 100% milk, cow-soy milk, control, soy milk, commercial soy infant milk group. Feed efficiency ratio(FER) were not significantly different among control, 100% milk and cow-soy milk groups. However, commercialized soy infant milk group showed significantly lower FER than other groups. When the cow-soy milk formula was fed to infant in the age of 5 month to 25 months, it did not show any unsatisfactory results in acceptability and bowel movements of the subjects. Since the cow-soy milk formula has not only all the nutrients for the physical growth of infants but also contains valuable physiological functional ingredients, it is expected to be a good choice of supplements for infants.