BCC-DPSO Algorithm for Task Scheduling on NOC

Wei Gao,Yubai Li,Song Chai,Jian Wang 보안공학연구지원센터 2014 International Journal of Grid and Distributed Comp Vol.7 No.5

In this paper, a BCC-DPSO scheduling algorithm is proposed to solve multi-objective optimization problem for task scheduling on Network-on-Chip (NoC). In our proposal, the relative advantage of the solution is evaluated by calculating its efficiency using BCC model in Data Envelopment Analysis (DEA), and the referred-time method is introduced to rank the BCC-efficient solution. Moreover, a sub-swarm strategy is adopted to reduce the high computational requirement introduced by the DEA. There are four sub-swarms, each of which optimizes one of four observed metrics, namely makespan, energy, link load and workload balance. Meanwhile, the speed vector updating formulation is modified to comply with the sub-swarm strategy. By conducting comparative simulations, the results show that our proposal produces more efficient schedule solution than other multi-objective Particle Swarm Optimization (PSO).

Optimization of membrane fouling process for mustard tuber wastewater treatment in an anoxic-oxic biofilm-membrane bioreactor

Hongxiang Chai,Liang Li,Yinghua Wei,Jian Zhou,Wei Kang,Zhiyu Shao,Qiang He 대한환경공학회 2016 Environmental Engineering Research Vol.21 No.2

Membrane bioreactor (MBR) technology has previously been used by water industry to treat high salinity wastewater. In this study, an anoxic-oxic biofilm-membrane bioreactor (AOB-MBR) system has been developed to treat mustard tuber wastewater of 10% salinity (calculated as NaCl). To figure out the effects of operating conditions of the AOB-MBR on membrane fouling rate (KV), response surface methodology was used to evaluate the interaction effect of the three key operational parameters, namely time interval for pump (t), aeration intensity (UGr) and transmembrane pressure (TMP). The optimal condition for lowest membrane fouling rate (KV) was obtained: time interval was 4.0 min, aeration intensity was 14.6 m3/(m2￥h) and transmembrane pressure was 19.0 kPa. And under this condition, the treatment efficiency with different influent loads, i.e. 1.0, 1.9 and 3.3 kg COD m-3d-1 was researched. When the reactor influent load was less than 1.9 kg COD m-3d-1, the effluent could meet the third discharge standard of “Integrated Wastewater Discharge Standard”. This study suggests that the model fitted by response surface methodology can predict accurately membrane fouling rate within the specified design space. And it is feasible to apply the AOB-MBR in the pickled mustard tuber factory, achieving satisfying effluent quality.

Triptolide Inhibits Histone Methyltransferase EZH2 and Modulates the Expression of Its Target Genes in Prostate Cancer Cells

Tamgue, Ousman,Chai, Cheng-Sen,Hao, Lin,Zambe, John-Clotaire Daguia,Huang, Wei-Wei,Zhang, Bin,Lei, Ming,Wei, Yan-Ming Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

The histone methyltransferase EZH2 (enhancer of zeste homolog 2) plays critical roles in prostate cancer (PCa) development and is a potential target for PCa treatment. Triptolide possesses anti-tumor activity, but it is unknown whether its therapeutic effect relates with EZH2 in PCa. Here we described EZH2 as a target for Triptolide in PCa cells. Our data showed that Triptolide suppressed PCa cell growth and reduced the expression of EZH2. Overexpression of EZH2 attenuated the Triptolide induced cell growth inhibition. Moreover, Triptolide treatment of PC-3 cells resulted in elevated mRNA levels of target genes (ADRB2, CDH1, CDKN2A and DAB2IP) negatively regulated by EZH2 as well as reduced mRNA levelsan of EZH2 positively regulated gene (cyclin D1). Our findings suggest the PCa cell growth inhibition mediated by Triptolide might be associated with downregulation of EZH2 expression and the subsequent modulation of target genes.

Synthesis and characterization of graphene and carbon nanotubes: A review on the past and recent developments

Wei-Wen Liu,Siang-Piao Chai,Abdul Rahman Mohamed,U. Hashim 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4

Carbon nanotubes (CNTs) and graphene have built broad interest in most areas of science and engineering because of their extraordinary physical, mechanical, thermal and optical properties. Graphene is a two-dimensional one-atom-thick planar sheet of sp2-bonded carbon atoms while CNTs are a cylindrical nanostructure which composed entirely of sp2-bonded carbon atoms as well. This review presents and discusses the past and current advancement of synthesis and characterization of graphene and CNTs. The review also concludes with a brief summary and an outlook on the challenges and future prospects in the growth of graphene and CNTs.

Poster Session:PS 0479 ; Nephrology : Hypotonic Versus Isotonic Fluid Maintenance Therapy on Biochemical Outcomes after Major Surgery

( Wei Ying Jen ),( Margaret L Teng ),( Wee Chuan Hing ),( Valerie Ma ),( Shridhar Ganpathi Iyer ),( Chung Cheen Chai ),( Horng Ruey Chua ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Premixed hypotonic solutions of 0.33% saline + 5% dextrose + 10mmol/ L potassium-chloride (0.33S, tonicity 133mEq/L) and 0.9% saline ±dextrose (NS, tonicity 308mEq/L) are common peri-operative maintenance fiuids, but their effects on serum biochemistry are unclear. Methods: Using a single-centre, prospectively-maintained electronic database, we retrospectively examined post-operative biochemistry in adults maintained on exclusively 0.33S or NS peri-operatively, from March 2012 to September 2013. Outcomes included new-onset post-operative hyponatremia, hypokalaemia, hypoglycaemia, and acute kidney injury (AKI, =1.5x increase in serum creatinine); multivariate analyses were adjusted for demographics, comorbidities, surgery-types/duration, infusion time/ volumes, and hospital length-of-stay. Results: We studied 279 patients given 0.33S, and 279 NS controls matched for cumulative infusion volume. Mean age was 59(±18) years. More NS patients had diabetes mellitus, ischemic heart disease and chronic kidney disease (p<0.05). Surgery types included gastrointestinal/hepatobiliary (43%), orthopaedic (30%) and nephrectomy (3%). Mean fi uid volumes administered were 6.9(±3.3)L of 0.33S and 7.1(±5.6)L of NS (p=0.57), with 100% versus 52% of drips containing dextrose, respectively. More 0.33S patients (versus NS) developed hyponatremia (30% versus 17%, p<0.001); this difference was signifi cant for gastrointestinal/hepatobiliary (p=0.001) but not orthopaedic (p=0.74) surgeries. Less 0.33S patients (versus NS) had hypokalaemia (1% versus 10%, p<0.001), hypoglycaemia (1% versus 4%, p=0.01), and AKI (3% versus 8%, p=0.007). On multivariate analyses, 0.33S, gastrointestinal/hepatobiliary surgeries and nephrectomy were independently associated with hyponatremia; while NS, hypertension, longer infusion hours, and nephrectomy were independently associated with AKI (p<0.05). Conclusions: 0.33S infusion in post-surgical patients, especially post-gastrointestinal/ hepatobiliary surgeries, is strongly associated with hyponatremia, but with less hypokalaemia or hypoglycaemia, compared with NS. The association between NS administration and AKI is heavily confounded by baseline comorbidities and requires further prospective evaluation. Both fi uid types are not appropriate for isolated use, and more balanced maintenance fi uids are desired.

Variation of sexual dimorphism and asymmetry in disease expression of inflammatory arthritis among laboratory mouse models with different genomic backgrounds

Wei Dong,Cheng Tian,Z. Galvin Li,David Brand,Yanhong Cao,Xiaoyun Liu,Jiamin Ma,Andy Chai,LindaK.myers,Jian Yan,Karen Hasty,John Stuart,Yan Jiao,Weikuan Gu,Xiaojun Cai 한국실험동물학회 2023 Laboratory Animal Research Vol.39 No.4

Sex difference has shown in the arthritis diseases in human population and animal models. We investigate how the sex and symmetry vary among mouse models with different genomic backgrounds. Disease data of sex and limbs accumulated in the past more than two decades from four unique populations of murine arthritis models were analyzed. They are (1) interleukin-1 receptor antagonist (IL-1ra) deficient mice under Balb/c background (Balb/c KO); (2) Mice with collagen II induced arthritis under DBA/1 background; (3) Mice with collagen II induced arthritis under C57BL/6 (B6) background and (4) A F2 generation population created by Balb/c KO X DBA/1 KO. Our data shows that there is a great variation in sexual dimorphism for arthritis incidence and severity of arthritis in mice harboring specific genetic modifications. For a F2 population, the incidence of arthritis was 57.1% in female mice and 75.6% in male mice. There was a difference in severity related to sex in two populations: B6.DR1/ B6.DR4 (P < 0.001) and F2 (P = 0.023) There was no difference Balb/c parental strain or in collagen-induced arthritis (CIA) in DBA/1 mice. Among these populations, the right hindlimbs are significantly higher than the scores for the left hindlimbs in males (P < 0.05). However, when examining disease expression using the collagen induced arthritis model with DBA/1 mice, sex-dimorphism did not reach statistical significance, while left hindlimbs showed a tendency toward greater disease expression over the right. Sexual dimorphism in disease expression in mouse models is strain and genomic background dependent. It sets an alarm that potential variation in sexual dimorphism among different racial and ethnic groups in human populations may exist. It is important to not only include both sexes and but also pay attention to possible variations caused by disease expression and response to treatment in all the studies of arthritis in animal models and human populations.

Circ_0068655 Promotes Cardiomyocyte Apoptosis via miR-498/PAWR Axis

Chai Qiaoying,Zheng Mingqi,Wang Le,Wei Mei,Yin Yajuan,Ma Fangfang,Li Xinping,Zhang Haijun,Liu Gang 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.5

Background: The cardiomyocyte apoptosis is considered as one of major contributions to cardiac remodeling after myocardial infarction (MI). Numerous studies find that circular RNAs (circRNAs) play pivotal roles in a variety of biological functions. However, the role of circ_0068655 in MI and human induced pluripotent stem-derived cardiomyocytes (HCMs) remains unknown. Methods: The expression of circ_0068655, miR-498, and PRKC apoptosis WT1 regulator (PAWR) in human MI heart tissues and hypoxia subjected HCMs was evaluated with qRT-PCR and Western blot. The effects of circ_0068655 on hypoxia-induced apoptotic death and cell migration in HCMs were evaluated with qRT-PCR, cell viability, cell death ELISA (POD), and Caspase-3 activity assay, and Trans-well assay, respectively. Furthermore, luciferase assay, qRT-PCR, biotin-labeled miRNA pulldown assay, and Western blot were employed in the functional studies. Results: We found that the expression of circ_0068655 and PAWR was enhanced in MI patients and hypoxia subjected HCMs; by contrast, the expression of miR-498 decreased. Inhibited expression of circ_0068655 in HMCs counteracted hypoxia-induced apoptotic death and impaired cell migration, in sharp contrast to circ_0068655 knockdown. We identified that circ_0068655 sponged an endogenous miR-498 to sequester and inhibit its activity, leading to the increased PAWR expression. Conclusions: Our findings reveal that the expression of circ_0068655 can promote cardiomyocyte apoptosis through the modulation of miR-498-PAWR axis in vitro, which highlights the diagnostic and therapeutic value of circ_0068655 in patients with MI.

LB energy-saving high temperature shift catalyst and its adsorption thermodynamics

Lingchao Wei,Fu’An Wang,Yi Liu,Yongli Chai 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.1

This study prepared an LB energy-saving high temperature shift catalyst by optimizing its prepare parameters with artificial neural network, and measured its catalytic activities at various steam-gas ratios. It shows that the LB catalyst performs well at a lower steam-gas ratio. The chromatographic retention parameters of CO, CO2, and H2O on LB catalyst were experimentally determined by means of inverse gas chromatography (IGC). Adsorption enthalpies, Gibbs adsorption free energies and adsorption entropies of different gases were estimated by their retention volumes in infinite dilution region. The interaction parameters ( χ) between absorbate gases and LB catalyst were calculated according to Flory-Huggins theory, and were inversely linear with temperature. The thermodynamics mechanism of the adsorption process was discussed from the view of the microcosmic factors of molecular structure and thermodynamic properties.

Cloning and different expression of ATP synthase genes between propargite resistant and susceptible strains of Tetranychus cinnabarinus (Acarina: Tetranychidae)

Shu-Jun Wei,Jing Ni,Kuanyu Zheng,Zhenguo Yang,Daoyan Xie,Aisi Da,Jianping Chai,Xiujun Jiang,Shaoxiang Li 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.1

The carmine spider mite, Tetranychus cinnabarinus (Boisduval), is a serious phytophagous mite damaging importantcrops and can rapidly develop resistance to acaricides. Mitochondrial ATP synthase (F1F0 ATP synthase)is an important target site of acaricides. The role of ATP synthase in acaricide resistance remains unclear at themolecular level. In this study, twelve full-length cDNAs of ATP synthase genes were cloned and characterizedfrom T. cinnabarinus and their expression levels were determined for both progargite-resistant and susceptiblestrains. The effect of propargite exposure on gene expression was also evaluated. Analyses of gene expressionrevealed that TcATPsynU-2, TcATPsynF0-2 and TcATPsynF0-4 were significantly down-regulated in the progargite-resistant strain. TcATPsynF0-2 and TcATPsynF0-4 had a strong response to progargite exposure. Theresults suggest that lower levels of TcATPsynU-2, TcATPsynF0-2 and TcATPsynF0-4 expression might be related topropargite-resistance observed in the resistant T. cinnabarinus. This is the first attempt to identify specific ATPasegenes involved in propargite resistance in T. cinnabarinus.

Acid-hydrolyzed agricultural residue: A potential adsorbent for the decontamination of naphthalene from water bodies

Mijia Zhu,Wei Tian,Hankui Chai,Jun Yao 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.4

Development and application of low-cost and effective adsorbents to remove polycyclic aromatic hydrocarbons from effluents has become a research focus in recent years. We selected reed stem, ginkgo nut shell and hazelnut shell as adsorbents, and used acid hydrolysis as a simple modification technology. The adsorption isotherms of naphthalene to raw and modified adsorbents were controlled by partitioning. The adsorption capability of the hydrolysed hazelnut shell was notably enhanced at a higher level compared with that of other adsorbents. Results showed that the adsorption capacity (17250.42 μg/g) of modified hazelnut shell was observed for an initial naphthalene concentration of 25mg/L, with a contact time of 72 h, adsorbent dosage of 1 g/L and initial pH of 7.0. Furthermore, the regeneration capability of hydrolyzed hazelnut shell indicated that it was a promising adsorbent for naphthalene removal in wastewater treatment.