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Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells
Cha Kyung Youn,Seon Joo Park,Mei Hong Li,Min Young Lee,Kun Yeong Lee,Man Jin Cha,Ok Hyeun Kim,Ho Jin You,In Youp Chang,Sang Pil Yoon,Young Jin Jeon 대한생리학회-대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.4
Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-Ձ, IFN-Ճ, and IL-1Ղ). Treatment of MIN6N8a cells with radicicol inhibited CM-stimulated activation of NF-ՊB/Rel, which plays a critical role in iNOS transcription, in a dose-related manner. Nitrite production in the presence of PD98059, a specific inhibitor of the extracellular signal-regulated protein kinase-1 and 2 (ERK1/2) pathway, was dramatically diminished, suggesting that the ERK1/2 pathway is involved in CM-induced iNOS expression. In contrast, SB203580, a specific inhibitor of p38, had no effect on nitrite generation. Collectively, this series of experiments indicates that radicicol inhibits iNOS gene expression by blocking ERK1/2 signaling. Due to the critical role that NO release plays in mediating destruction of pancreatic beta cells, the inhibitory effects of radicicol on iNOS expression suggest that radicicol may represent a useful anti-diabetic activity.
Cha, Min Suc,Jo, Sang Woo,Han, Seung Hui,Hong, Soo Hyun,So, Soonyong,Kim, Tae-Ho,Oh, Seong-Geun,Hong, Young Taik,Lee, Jang Yong Elsevier 2019 Journal of Power Sources Vol.413 No.-
<P><B>Abstract</B></P> <P>Ether-free poly(<I>p</I>-phenylene)-based anion exchange membrane materials with outstanding vanadium ion blocking properties are reported. The synthesized ionomers with a rigid backbone structure show small dimensional variations despite the high ion exchange capacities. Among the synthesized membranes, the QPPP-2 membrane with ion exchange capacity of 2.1 meq·g<SUP>−1</SUP> exhibits high anion (OH<SUP>−</SUP>, SO<SUB>4</SUB> <SUP>2−</SUP>, and Cl<SUP>−</SUP>) conductivity. The QPPP-2 membrane shows an extremely low diffusion coefficient (2.12 × 10<SUP>−9</SUP> cm<SUP>2</SUP> min<SUP>−1</SUP>) for VO<SUP>2+</SUP>, which is much lower than that of Nafion 115 (2.88 × 10<SUP>−6</SUP> cm<SUP>2</SUP> min<SUP>−1</SUP>), indicating the vanadium ion blocking property of QPPP-2. Moreover, the chemical and operational stabilities of the membranes are investigated <I>via</I> ex situ soaking tests in 0.1 M VO<SUB>2</SUB> <SUP>+</SUP> solution and in situ operation tests for 100 cycles, respectively. The vanadium redox flow battery single cell assembled with the QPPP-2 membrane exhibits a coulombic efficiency of 99%, voltage efficiency of 87%, and energy efficiency of 86% during 100 cycles at 80 mA cm<SUP>−2</SUP>. The excellent chemical, morphological, and electrochemical properties of the QPPP-2 membrane make it suitable for use in vanadium redox flow battery.</P> <P><B>Highlights</B></P> <P> <UL> <LI> AEMs are fabricated by a Ni(0)-catalyzed cross-coupling reaction. </LI> <LI> The synthesized ionomers indicated excellent dimensional and chemical stability. </LI> <LI> Ether-free polymeric AEMs showed extremely low vanadium ion cross over. </LI> <LI> The performance of developed AEM showed high EE (87%) with high capacity retention. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells
Youn, Cha Kyung,Park, Seon Joo,Li, Mei Hong,Lee, Min Young,Lee, Kun Yeong,Cha, Man Jin,Kim, Ok Hyeun,You, Ho Jin,Chang, In Youp,Yoon, Sang Pil,Jeon, Young Jin The Korean Society of Pharmacology 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.4
Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-${\alpha}$, IFN-${\gamma}$, and IL-$1{\beta}$). Treatment of MIN6N8a cells with radicicol inhibited CM-stimulated activation of NF-${\kappa}B$/Rel, which plays a critical role in iNOS transcription, in a dose-related manner. Nitrite production in the presence of PD98059, a specific inhibitor of the extracellular signal-regulated protein kinase-1 and 2 (ERK1/2) pathway, was dramatically diminished, suggesting that the ERK1/2 pathway is involved in CM-induced iNOS expression. In contrast, SB203580, a specific inhibitor of p38, had no effect on nitrite generation. Collectively, this series of experiments indicates that radicicol inhibits iNOS gene expression by blocking ERK1/2 signaling. Due to the critical role that NO release plays in mediating destruction of pancreatic beta cells, the inhibitory effects of radicicol on iNOS expression suggest that radicicol may represent a useful anti-diabetic activity.
Hong, Seok Bok,Jeong, Jae-Min,Kang, Heon Gyu,Seo, Donghyuk,Cha, Younghyun,Jeon, Hyeonyeol,Lee, Geun Young,Irshad, Mobina,Kim, Do Hyun,Hwang, Sung Yeon,Kim, Jung Won,Choi, Bong Gill American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.41
<P>The integration of metal oxides and carbon materials provides a great potential for enhancing the high energy and power densities of supercapacitors, but the rational design and scalable fabrication of such composite materials still remain a challenge. Herein, we report a fast, scalable, and one-pot hydrodynamic synthesis for preparing ion conductive and defect-free graphene from graphite and MnO<SUB>2</SUB>/graphene nanocomposites. The use of this hydrodynamic method using Taylor-Couette flow allows us to efficiently fast shear-exfoliate graphite into large quantities of high-quality graphene sheets. Deposition of MnO<SUB>2</SUB> on graphene is subsequently performed in a fluidic reactor within 10 min. The prepared MnO<SUB>2</SUB>/graphene nanocomposite shows outstanding electrochemical performances, such as a high specific capacitance of 679 F/g at 25 mV/s, a high rate capability of 74.7% retention at an extremely high rate of 1000 mV/s, and an excellent cycling characteristic (∼94.7% retention over 20 000 cycles). An asymmetric supercapacitor device is fabricated by assembling an anode of graphene and a cathode of MnO<SUB>2</SUB>/graphene, which resulted in high energy (35.2 W h/kg) and power (7.4 kW/kg) densities (accounting for the mass of both electrodes and the electrolyte) with a high rate capability and long cycle life.</P> [FIG OMISSION]</BR>
( Shun Ji Jin ),( Won Kyung Cho ),( Hee Jun Park ),( Kwang Ho Cha ),( Jun Sung Park ),( Ja Seong Koo ),( Hun Sik Wang ),( Jeong Soo Kim ),( Min Soo Kim ),( Sung Joo Hwang ) 한국약제학회 2011 Journal of Pharmaceutical Investigation Vol.41 No.2
The objective of the study was to prepare self-microeulsifying drug delivery system (SMEDDS) incorporating atorvastatin calcium and evaluate its properties and oral bioavailability. Solubility of atorvastatin in various vehicles was determined. Pseudo-ternary phase diagrams were constructed to identify the good self-emulsification region. The droplet size distributions of the resultant emulsions were determined by dynamic light scattering measurement. The mean droplet size of chosen formulation (20% ethyl oleate, 40% tween-80, 40% Carbitol(R)) was 23.4±1.3 nm. The SMEDDS incorporating atorvastatin calcium appeared to be associated with better performance in dissolution and pharmacokinetic studies, compared with raw atorvastatin calcium. In dissolution test, the release percentage of atorvastatin from SMEDDS mixture could rapidly reach more than 95% within 3 min. Oral AUC0→8(hr)values in SD rats was 1994±335 ng·hr/mL, which significantly increased (P<0.05) compared with raw atorvastatin calcium. The SMEDDS formulation was relatively stable when stored at 4˚C during 3 months. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds, such as atorvastatin, by the oral route.
Min, Dong Eun,Kim, Do Hee,Han, Mi Young,Cha, Sung Ho,Yoon, Kyung Lim The Korean Pediatric Society 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.6
Purpose: In Kawasaki disease (KD) patients, coronary artery complications, incomplete and refractory types occur more frequently in patients with streptococcal or other bacterial/viral infections. Recently, we observed a higher incidence of coronary lesions in KD patients with high anti-streptolysin O (ASO) titer. Therefore, we hypothesized that KD patients diagnosed with concurrent streptococcal infection have poor prognosis, with respect to treatment response and development of coronary artery lesions. Methods: A retrospective review was performed in 723 patients with KD who were admitted to 2 major hospitals between June 2010 and September 2017. Results: Among 723 patients with KD, 11 initially showed an elevated ASO titer (>320 IU/mL) or elevated follow-up ASO titer after treatment. Of these patients, 5 showed no response to the first intravenous immunoglobulin treatment, 3 had abnormalities of the coronary arteries. This is a significantly higher proportion of patients with a high ASO titer (n=3,27.3%) than those with a normal ASO titer (n=53 [7.4%], P=0.047). A severe clinical course was seen in 81.8% of patients in the high ASO group versus 14.5% of patients in the normal ASO group. Conclusion: It is not certain whether acute streptococcal infection may cause KD, but this study revealed that KD with high ASO titers showed higher rates of severe clinical course. It may be helpful to analyze concurrent streptococcal infection in patients with a severe clinical course.
( Sang Hyeok Im ),( Dong Hwan Kim ),( Young Hoon La ),( Nam Jin Kim ),( Cha Won Hwang ),( Jae Min Cha ),( Bong Ki Ryu ) 대한금속재료학회 ( 구 대한금속학회 ) 2010 재료마당 Vol.23 No.3
This study looks at crystallization and sintering behavior in B2O3 containing Li2O-Al2O3-SiO2 glass powder. The sintered sample was produced with glass powders measuring 44 μm. The relative density and transmittance of the sintered samples showed the highest value at the temperature of 650°C. At temperatures higher than 650°C, crystal growth occurred to decrease the densification of B2O3-Li2O-Al2O3-SiO2 (BLAS) glass powder. The main crystalline phase in the glass powder was a-spodumene. From non-isothermal differential thermal analysis, the crystallization of particles (Φ=44 μm) was observed at 640°C to 684°C with respect to the heating rate. The activation energy of crystallization (E(C)) and the Avrami constant (n) calculated by Kissinger and Ozawa equations indicated that the surface and the bulk crystallization occurred simultaneously in the glass. The optimum sintering temperature of this glass powder was 650°C without crystal growth of β-spodumene, although nucleation or nano-crystal growth occurred.
( Min Young Baek ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang-woo Cha ),( Young Seok Kim ),( Young Deok Cho ),( Hong Soo Kim ),( Boo Sung Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Background: Transarterial chemoembolization (TACE) is an alternative treatment for small-sized single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We aimed to investigate the clinical outcomes of patients with a single HCC less than 5cm treated with TACE. Methods: From August 2003 to October 2014, 361 patients were treated with TACE as a first treatment. Among these, 74 patients had a single HCC less than 5cm. We analyzed complete response (CR) after TACE and predictive factors for overall survival (OS) in these patients. Results: Sixty-five patients (87.8%) had liver cirrhosis (Child A/B/C, 40/23/2). Forty-five patients (58.1%) had modified UICC stage I, 30 patients (40.5%) had stage II, and one patient (1.4%) had stage III. Median tumor size was 1.9cm (range, 1.0-4.6cm). Median alphafetoprotein (AFP) was 9.1 ng/ml (range, 1.3-10268 ng/ml). Thirty nine patients (52.7%) achieved CR after TACE and seventeen patients (43.6%) recurred after CR (local recurrence/distant recurrence, 15/2). The 1-, 3-, 5-year OS rates were 86.2%, 65.4%, and 30.3%, respectively. Median OS was 30.6 months (95% CI, 24.5-36.7) for non-CR group and 78.1 months (95% CI, 44.1-112.2) for CR group (p=0.003). In multivariate analysis, CR (p=0.011), modified UICC stage I (p=0.043) were positive predictive factors, and ascites (p=0.011) was negative predictive factor for OS. Conclusions: TACE is a valid treatment option in patients with a single HCC not suitable for curative treatment. CR, modified UICC stage, and ascites were predictive factors for OS.
Renal Precursor Cell Transplantation Using Biodegradable Polymer Scaffolds
( Sang Soo Kim ),( Heung Jae Park ),( Joung Ho Han ),( Min Sun Park ),( Moon Hyang Park ),( Kang Won Song ),( Kwan Joong Joo ),( Cha Yong Choi ),( Byung Soo Kim ) 한국미생물생명공학회 2005 Journal of microbiology and biotechnology Vol.15 No.1
( Sang Soo Lee ),( Ra Ri Cha ),( Chang Min Lee ),( Wan Soo Kim ),( Hyun Chin Cho ),( Jin Joo Kim ),( Jae Min Lee ),( Hong Jun Kim ),( Chang Yoon Ha ),( Hyun Jin Kim ),( Tae Hyo Kim ),( Woon Tae Jung ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims:HepaticCvirus(HCV)genotype3infectionisthemostdifficultformofHCVtotreat,withamorerapidprogressiontofibrosisandcirrhosiscomparedwithothergenotypes.Theaimsofthisretrospectiveobservationalstudyweretoelucidatetheimpactofgenotype3infectiononhepatocellularcarcinoma(HCC)developmentandoverallmortalityinpatientswithHCV-relatedcirrhosis,comparedtoHCVgenotype1and2intheGyeongnamProvince,locatedonthesoutheastcoastofKorea.Methods:Atotal153patientswithHCV-relatedcirrhosiswereincludedbetweenJanuary2005andDecember2014.Amongthese,74hadgenotype1,55genotype2,and24patientshadgenotype3infection.Results:Theprevalenceofgenotype3inHCV-relatedcirrhosiswas16%.Individualsatriskforgenotype3infectionwereyoung,malegender,andpeoplewhoinjectdrugs.Duringmedianamedianfollow-up40.1months,38patientsdevelopedHCC,and23patientsdied.TheincidenceofHCCdevelopmentandoverallmortalitywassignificanthigherinpatientswithgenotype3comparedtopatientswithgenotype1and2inthelogranktest.Despitebeingyounger,HCVgenotype3wasaindependentriskfactorforHCCdevelopment(adjustedhazardratio[HR〕=2.55)andoverallmortality(adjustedHR=3.69)onmultivariateanlalysis.Afterexclusionofpatientswithachievedsustainedvirologicresponse,theincidenceofHCCdevelopmentandoverallmortalitywassignificanthigherinpatientswithgenotype3comparedtopatientswithnogenotype3.Conclusions:HCVgenotype3infectionisassociatedwithanincreasedriskofHCCandoverallmortalityinpatientswithcirrhosisafteradjustingwithconfoundingfactors.