Inorganic-organic hybrid nanoporous materials as adsorbent to remove VOCs

Jae Hoon Kim,Jin Hee An,Young Soo La,Jin Su Jung,Suck Man Kim,Nam Gu Moon,Byung Wha Lee,Young Ho Yoon,Young Il Choi,정한모 한국공업화학회 2008 Journal of Industrial and Engineering Chemistry Vol.14 No.2

Inorganic–organic hybrid nanoporous materials were prepared by the co-condensation of 1,2-bis(triethoxysilyl)ethane (BTSE) with 1,3- bis(triethoxysilyl)benzene (BTSB) or 4,4'-bis(triethoxysilyl)-1,1'-biphenyl (BTSP). The nanoporous materials had broad pore-size distribution in the range of mesopore and macropore. The nanoporous materials prepared by co-condensation of BTSE with more than 30 wt% of BTSP showed an enhanced removal capability of volatile organic compounds (VOCs) from air compared to that prepared with BTSE only, probably due to the affirmative interaction between VOCs and aromatic ring in the nanoporous materials. The VOC generation from polypropylene/talc composite (PPF) was reduced to around half when three part of these inorganic–organic hybrid nanoporous material was added per 100 part of PPF during the melt compounding process as an additive, which suggests a new application of nanoporous material.

Development of the Composite Biologic Scoring as a Predictor of Longterm Prognosis of Lung Transplantation

( Ji Yeon Choi ),( Song Lee Kim ),( Sang Hoon Lee ),( A La Woo ),( Young Mok Park ),( Seung Hyun Young ),( Ah Young Leem ),( Su Hwan Lee ),( Eun Young Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background Survival after lung transplantation (LT) has steadily improved but its prognosis is still lower than other solid organ transplantation. It is important to predict prognosis in patients who underwent LT but currently there is no specific tool for prediction. Methods In the single-center retrospective study, we reviewed data from patients who underwent LT at Severance Hospital in South Korea from October 2012 to September 2020. Patients who underwent multi-organ transplantation (n=5), re-transplantation (n=5), age ≤18 years old (n=4) and early acute-phase patients within 3 months after LT (n=31) were excluded. A total of 249 LT patients were included for constructing the prediction model for prognosis called the Composite Biologic Scoring (CBS), using the numeric biologic markers around 3 months as a reference which were highest among observation period. Cox proportional hazards model was used to calculate the weight of each criterion included in the CBS, and the predictive accuracy and discriminative ability were measured by concordance index (C-index) and Kaplan Meier survival curve. Results Among 249 patients, mean age was 54.5±11.6 years, and 161 (64.7%) were men. Eight independent prognostic factors were identified and points were assigned to each variable based on Cox proportional hazards regression analysis including white blood cells, hemoglobin, platelet, ferritin, fibrinogen, aspartate aminotransferase, triglyceride, and lactate dehydrogenase (Fig. 1). The C-index for cox proportional hazards model was 0.809 and the calibration curves for the probability of 2, 3, and 5-year overall survival showed close approximation between nomogram prediction and actual observation. Three stratified risk groups according to CBS in post LT patients demonstrated significant distinction between Kaplan-Meier survival curves (Fig. 2 & 3; p-value<0.001). Conclusion The CBS is a useful prediction model for long-term prognosis of LT patients. Further validation study is needed to confirm.

Factors Related to Diagnostic Yield of Lung Biopsy Using both Radial EBUS and Fluoroscopy

( Seung Hyun Yong ),( Soojoung Yu ),( Young Mok Park ),( A La Woo ),( Ah Young Leem ),( Su Hwan Lee ),( Sang Hoon Lee ),( Kyung Soo Chung ),( Song Yee Kim ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background Transbronchial lung biopsy (TBLB) is a key modality in the diagnosis of peripheral lung lesions. Radial EBUS is new diagnostic technology which can apply to enhance the accuracy of peripheral lung biopsy during bronchoscopy. The purpose of this study was to investigate factors related to diagnostic yield of TBLB with radial EBUS Method A retrospective analysis on the diagnostic yield of TBLB under fluoroscopy consist with radial EBUS, with or without guide sheath (GS) was conducted. Data included TBB that was performed from 2020 to 2021 at a single center by a single operator Results 294 patients with confirmed final diagnoses were included in this study. Definitive diagnosis was established by TBLB in 117/155 (75.48%) patients using radial EBUS without GS, 55/69 (79.71%) patients using EBUS with GS, and 54/70 (77.14%) patients whose tissues were obtained partly without GS and partly with GS. We compared diagnostic yield by type pulmonary lesion which was inconsistent between the diagnostic modalities, but overall, solid lesions had highest diagnostic yield (77.05%) compared to pure ground glass opacities (75%) and part-solid lesions (76.09%). Lung cancer patients that underwent rebiopsy were analyzed in this study which showed diagnostic yield of 68.29%. Diagnostic yield showed improvement over time in radial EBUS assisted TBLB cases that did not use GS with yield of 59.62% in 2020 and 83.5% in 2021. Conclusion For many decades there has not been another diagnostic method to enhance the TBLB in diagnosis of peripheral pulmonary lesions until radial EBUS is introduced. This investigation reviewed current diagnostic usage of TBLB accompanied by radial EBUS and compared diagnostic yields not only by size and targeting, but solid components and exam period as well. Further studies on re-biopsy by TBLB will be needed to learn more about its significance in clinical application.

Clinical Implication of Candida Score in Multidrug-Resistant Pneumonia with Airway Candida Colonization

La Yeonju,Kwon Da Eun,Jeon Soyoung,Lee Sujee,Lee Kyoung Hwa,Han Sang Hoon,Song Young Goo 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.2

Background The growth of Candida in respiratory secretions is usually considered colonization, and antifungal therapy is rarely required. The role of Candida colonization in the progression of bacterial pneumonia remains controversial. The aim of this study was to identify the clinical implication of Candida score by analyzinge the relationship with multidrug-resistant (MDR) pneumonia and prognosis in patients with airway Candida colonization. Materials and Methods This study was a retrospective review of patients with airway Candida colonization by bronchial washing or bronchoalveolar lavage. The Candida score was calculated according to the four factors (severe sepsis, surgery at baseline, total parenteral nutrition, and multifocal Candida colonization). Pneumonia related mortality or hopeless discharge expecting death was defined as a poor outcome. Results A total of 148 patients were enrolled in the study. In a multivariate analysis model, Candida score was identified as an independent predictor of poor outcomes (odds ratio 2.23; 95% confidential interval 1.57 – 3.17; P <0.001) in pneumonia patients with airway Candida colonization. With a Candida score of three or higher compared with low score group, it was associated with bacterial pneumonia, especially methicillin-resistant Staphylococcus aureus (MRSA) infection (0.0% vs. 15.2%, P = 0.004). In addition, patients with a high Candida score had a longer hospital stay (13 vs. 38 days, P <0.001), longer duration of intensive care (7 vs. 18 days, P <0.001), and higher pneumonia-related mortality (0.0% vs. 45.5%, P <0.001) as compared to the low Candida score group. The Candida score showed a positive correlation with other pneumonia severity scales such as CURB-65 (Confusion, Urea, Respiratory rate, Blood pressure, and age ≥65 years) (r = 0.461, P <0.001), Pneumonia Severity Index (r = 0.397, P <0.001), and predisposition, insult, response, and organ dysfunction (PIRO) score (r = 0.425, P <0.001). Conclusion This study revealed that Candida is no longer a bystander of airway colonization, and that it affects the progression of bacterial pneumonia, including multidrug-resistant pathogens, particularly MRSA infection. Also Candida score can be used to predict the prognosis of patients with pneumonia. Background The growth of Candida in respiratory secretions is usually considered colonization, and antifungal therapy is rarely required. The role of Candida colonization in the progression of bacterial pneumonia remains controversial. The aim of this study was to identify the clinical implication of Candida score by analyzinge the relationship with multidrug-resistant (MDR) pneumonia and prognosis in patients with airway Candida colonization. Materials and Methods This study was a retrospective review of patients with airway Candida colonization by bronchial washing or bronchoalveolar lavage. The Candida score was calculated according to the four factors (severe sepsis, surgery at baseline, total parenteral nutrition, and multifocal Candida colonization). Pneumonia related mortality or hopeless discharge expecting death was defined as a poor outcome. Results A total of 148 patients were enrolled in the study. In a multivariate analysis model, Candida score was identified as an independent predictor of poor outcomes (odds ratio 2.23; 95% confidential interval 1.57 – 3.17; P <0.001) in pneumonia patients with airway Candida colonization. With a Candida score of three or higher compared with low score group, it was associated with bacterial pneumonia, especially methicillin-resistant Staphylococcus aureus (MRSA) infection (0.0% vs. 15.2%, P = 0.004). In addition, patients with a high Candida score had a longer hospital stay (13 vs. 38 days, P <0.001), longer duration of intensive care (7 vs. 18 days, P <0.001), and higher pneumonia-related mortality (0.0% vs. 45.5%, P <0.001) as compared to the low Candida score group. The Candida score showed a positive correlation with other pneumonia severity scales such as CURB-65 (Confusion, Urea, Respiratory rate, Blood pressure, and age ≥65 years) (r = 0.461, P <0.001), Pneumonia Severity Index (r = 0.397, P <0.001), and predisposition, insult, response, and organ dysfunction (PIRO) score (r = 0.425, P <0.001). Conclusion This study revealed that Candida is no longer a bystander of airway colonization, and that it affects the progression of bacterial pneumonia, including multidrug-resistant pathogens, particularly MRSA infection. Also Candida score can be used to predict the prognosis of patients with pneumonia.

온실 환경에서 엽면적 지수에 의한 엽온 및 열유속 예측 모델 개발

전영광 ( Young Kwang Jeon ),조라훈 ( La Hoon Cho ),박선용 ( Sun Yong Park ),김석준 ( Seok Jun Kim ),이충건 ( Chung Geon Lee ),오광철 ( Kwang Cheol Oh ),김대현 ( Dae Hyun Kim ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.1

다층 작물의 정확한 물리적 분류 해석은 온실 환경에서 각 캐노피의 상호 작용을 이해하고, 조사, 캐노피 온도, 증산 및 엽면적 지수에 의한 열유속을 기반으로 하는 식물 모델을 설계 하는데 있어서 매우 중요하다. 본 연구에서는 실제 운영중인 온실의 측정값을 기반으로 각 엽면적 지수에 대한 작물 모델을 논의한다. 식물과 공기 사이의 열유속에 대해 엽면적 지수을 이용한 식물 모델을 통해 정확하게 예측할 수 있다면, 작물이 밀식된 다양한 가상 온실의 냉난방 부하를 예측할 수 있을 것이다. 측정 정확도를 높이기 위해 흡기 차폐가 있는 온습도 센서, 적외선 캐노피 센서 및 이산화탄소 센서를 설치했다. 작물 환경은 휴대용 일사계, 기공전도계, 엽면적지수계, 풍속계로 측정되었다. 측정값을 작물 모델식에 입력하고 캐노피 모델 온도를 계산하였다. 작물 모델의 캐노피 온도를 현장 측정값과 비교하였고, R2=0.98, RMSE=0.46으로 신뢰성이 평가 되었다. 연구 결과, 큰 잎 작물 모델은 공기 순환층이 캐노피 크기보다 클 때 적합하지만, 온실에서 작물의 물리적 특성이 엽면적 지수에 의해 영향을 받을 때, 작물 모델은 다층 해석을 통해 고려되어야 할 것이다.

Synthesis and Evaluation of Multifunctional Fluorescent Inhibitors with Synergistic Interaction of Prostate-Specific Membrane Antigen and Hypoxia for Prostate Cancer

Kwon, Young-Do,Oh, Jung-Mi,La, Minh Thanh,Chung, Hea-Jong,Lee, Sun Joo,Chun, Sungkun,Lee, Sun-Hwa,Jeong, Byung-Hoon,Kim, Hee-Kwon American Chemical Society 2019 Bioconjugate chemistry Vol.30 No.1

<P>Prostate cancer is one of the most common cancers in the world. It is widely known that prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and hypoxia is a common characteristic of many solid tumors, including prostate cancer. In this study, we designed multifunctional fluorescent inhibitors to target PSMA and tumor hypoxia in order to increase the tumor uptake of inhibitors. Novel PSMA inhibitors were prepared using lysine as the backbone to connect three different functional groups: the glutamate-urea-lysine (GUL) structure for inhibiting PSMA, 2-nitroimidazole for the hypoxia-sensitive moiety, and a near-infrared fluorophore (sulfo-Cyanine 5.5). According to the <I>in vitro</I> PSMA binding assay, novel fluorescent inhibitors were demonstrated to have nanomolar binding affinities. Multifunctional inhibitor <B>2</B> with one 2-nitroimidazole had a similar inhibitory activity to inhibitor <B>1</B> that did not contain the hypoxia targeting moiety, but multifunctional inhibitor <B>3</B> with two 2-nitroimidazoles showed lower inhibitory activity than inhibitor <B>1</B> due to the bulky structure of the hypoxia-sensitive group. However, <I>in vivo</I> optical imaging and <I>ex vivo</I> biodistribution studies indicated that both multifunctional inhibitors <B>2</B> and <B>3</B> had higher accumulation in tumors than inhibitor <B>1</B> due to a synergistic combination of PSMA and hypoxia targeting moieties. These observations suggest that this novel multifunctional strategy might be a promising approach to improve the diagnosis and therapy of prostate cancer.</P> [FIG OMISSION]</BR>

Effect of Calcium Extracted from Salt-fermented Anchovy Engraulis japonicus on Osteoporosis in Ovariectomized SD‐Rats

Ji Young Moon,Bo La Choi,Myeong Jin Lee,Seung Hyun Lee,Chae Eun Kim,Se Young Oh,Hyeon Ji Jeong,Han Na Lee,Eun Ji CHO,Jung Ha Park,Tea Hoon Kim,Eun Woo Lee 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.8

IL-15에 의한 류마티스관절염 환자 활막 섬유모세포에서의 SDF-1 유도

박영은 ( Young Eun Park ),김성일 ( Sung Il Kim ),박성후 ( Seong Hu Park ),백승훈 ( Seung Hoon Baek ),오혜좌 ( Hye Jwa Oh ),허양미 ( Yang Mi Heo ),조미라 ( Mi La Cho ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.3

Objective: Interleukin-15 (IL-15) recruits and activates synovial T cells, and IL-15 plays an important role in amplifying and perpetuating inflammation in the pathogenesis of rheumatoid arthritis (RA). Stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant for memory T cells in the inflamed RA synovium. This study investigated the effect of IL-15 on SDF-1 production in RA fibroblast-like synoviocytes (FLS). Methods: The expressions of IL-15 and SDF-1 were determined from the synovium of patients with RA and osteoarthritis (OA) by performing immunohistochemistry. The expressions of SDF-1 was measured from the RA FLS that were cultured with IL-15 and IL-17 by real-time RT-PCR and ELISA. The SDF-1 expression was also measured, via ELISA, from the RA FLS stimulated by IL-15 together with the inhibitors of such intracellular signal molecules as phosphatidylinositol 3-kinase (PI 3-kinase, LY294002), STAT3 (AG490), MAP Kinase (PD98059), NF-κB (parthenolide) and activator protein 1 (AP-1, curcumin). Results: IL-15 and SDF-1 were mainly expressed in the RA synovium compared to that of the OA synovium. IL-15 increased the SDF-1 expressions and it, and had an additive effect with IL-17 on the SDF-1 expressions in the cultured RA FLS. The IL-15 induced increase of the SDF-1 expression in the cultured RA FLS was blocked by the inhibitors of PI 3-kinase, NF-κB and AP-1. Conclusion: The SDF-1 expression was increased in the RA synovium and it was up-regulated by IL-15 in the RA FLS through the PI 3-kinase, NF-κB, and AP-1 pathways. These results imply that the IL-15 induced increase of the SDF-1 expressions may be involved in the immunopathogenesis of RA.

A transgenic mouse showing sustained hyperactivity; a possible animal model of ADHD

DE LA PEÑ,A June Bryan,DELA PEÑ,A Irene Joy,KIM Hee Jin,SHIN Chan Young,CHEONG Jae Hoon 한국특수교육학회 2014 한국특수교육학회 학술대회 Vol.2014 No.-

Antimicrobial Activity of Siegesbeckia pubescens Extracts against the Fish Pathogens

Bo la Choi,Eun ji Cho,Seung hyun Lee,Myeong jin Lee,Chae eun Kim,Se young Oh,Tae Hoon Kim,Eun-Woo Lee 한국수산과학회 양식분과 2015 한국수산과학회 양식분과 학술대회 Vol.2015 No.10