Das Projekt einer Gesamtausgabe der Werke Eugen Finks

Cathrin Nielsen,Hans Rainer Sepp 한국현상학회 2005 철학과 현상학 연구 Vol.26 No.-

A Case Study of Bilingual and Monolingual Educators in Two Australian Early Childhood Settings

Larissa Hayes,Cathrine Neilsen-Hewett,Elisabeth Duursma 환태평양유아교육연구학회 2020 Asia-Pacific journal of research in early childhoo Vol.14 No.1

One quarter of the Australian population is born overseas and one in five Australians speak a language other than English (ABS, 2016). This has led to an increase in the number of bilingual children enrolled in early childhood settings. Despite this changing landscape there is a lack of support for bilingual children enrolled in early childhood settings as many children do not receive any assistance to maintain their home language. This study examined the understanding and perceptions of two monolingual and two bilingual early childhood educators in NSW on how to best support bilingual children. Four early childhood educators (two monolingual and two bilingual) from two different Early Childhood Centres in Australia were interviewed and asked about their knowledge and beliefs regarding bilingualism. Results showed bilingual educators to be more positive and knowledgeable about bilingualism. All educators acknowledged challenges of not being able to communicate with children and their families as they did not speak any English. Participants in this study appeared to have limited knowledge of the nature of bilingualism and had varying beliefs around how to best support bilingual children. The results showed an inherent lack of differentiation with respect to educators approach to pedagogy when teaching bilingual children. Implications for professional development and practice are discussed.

Individual and Contextual Factors Shaping Teachers’ Attitudes and Responses to Bullying among Young Children: Is Education Important?

Philippa Small,Cathrine Neilsen-Hewett,Naomi Sweller 환태평양유아교육연구학회 2013 Asia-Pacific journal of research in early childhoo Vol.7 No.3

This study examined how pre- and post-service early childhood teachers’ beliefs and responses to bullying among young children differ by level of qualification, type of bullying and whether or not it was witnessed. Results showed 1st and 4th-year student- and diploma-qualified teachers perceived acts of physical bullying to be more serious than verbal or relational bullying to a greater extent than did degree-qualified teachers. Degree-qualified teachers were less susceptible to bullying type and indicated they would be more likely to intervene than the other three groups. Results are discussed in relation to their implication for teaching practice and the content of pre-service education.

The Role of Professional Development in Improving Quality and Supporting Child Outcomes in Early Education and Care

Iram Siraj,Denise Kingston,Cathrine Neilsen-Hewett 환태평양유아교육연구학회 2019 Asia-Pacific journal of research in early childhoo Vol.13 No.2

A skilled workforce that understands the needs of children and can deliver high quality curricula to children with diverse needs, is required in order to realise the wide-ranging benefits that could follow from public investment in ECEC provision (such as in-service Professional Development (PD)). It is well established in the literature that high quality ECEC is important for children’s outcomes, and that variations in quality can be explained, to a large extent, by variations in educator pedagogy and practice. We argue for a better understanding of how ECEC educators and services can achieve (and be supported to optimise) children’s development and learning outcomes. This paper argues for more rigorous PD designs, considered evidence-based content and delivery that are embedded within a rich evidence-base of practice, and that focus on educator effectiveness, practice change, and also on the benefits to children’s learning and development. The paper draws upon effective PD literature and describes lessons learnt, focussing on the ‘who’, ‘what’ and ‘how’ of evaluation of effective in-service PD design and delivery.

Genetic diversity of Sesame (Sesamum indicum L) using high throughput diversity array technology

Tesfaye Tewodros,Tesfaye Kassahun,Keneni Gemechu,Ziyomo Cathrine,Alemu Tesfahun 한국작물학회 2022 Journal of crop science and biotechnology Vol.25 No.4

Sesame is an important oil crop widely cultivated in Africa and Asia. Characterization of genetic diversity and population structure of sesame genotypes in these continents can be used to designing breeding methods. In the present study, 300 genotypes comprising 209 Ethiopian landraces, and 75 exotic collections from diferent African and Asia countries, and 16 varieties were used. The panel was genotyped using two high-throughput diversity array technology markers. A total of 6115 silicoDArT and 6474 SNP markers were reported, of which 5065 silicoDArT and 5821 SNP markers were aligned with the reference sesame genome. For further analysis, it was fltered with an allele frequency for each SNP site and left 2997 highquality SNPs. All genotypes used in this study were descended from eight geographical origins. The average diversity of the panel was 0.14. Considering the genotypes based on their geographical origin, Africa collections (0.21) without Ethiopian collection was more diverse, when further portioned Africa, North Africa (0.23) collection was more diverse than others, but at the continent level, Asia (0.17) was more diverse than Africa (0.14). The genetic distance among the populations was ranged from 0.015 to 0.394. The populations were clustered into four groups. The structure analysis was divided into four hypothetical ancestral populations and 21 genotypes were an admixture. This indicate genotypes from the same origin didn’t classify on the country of origin. The genetic diversity and population structure guide future research work to design association studies and the systematic utilization of genetic resource.

Cervical cancer in the screening era: who fell victim in spite of successful screening programs?

B. Folke Pettersson,Kristina Hellman,Roxane Vaziri,Sonla Andersson,Ann-Cathrin Hellström 대한부인종양학회 2011 Journal of Gynecologic Oncology Vol.22 No.2

Objective: To compare profiles of a prescreening and screening cohort of women with cervical cancer regarding histopathology and clinical variables in order to identify those remaining at risk despite successful screening programs. By analyzing these profiles we hope to improve future screening methods. Methods: The prescreening and screening cohorts consisted of 5,046 and 1,174 women, respectively, treated for cervical cancer at the Department of Gynecological Oncology at Radiumhemmet, Karolinska University Hospital, during the periods 1944-1957 and 1990-2004. Results: Mean age increased from 48.9 years to 55.3 years in the cohorts treated 1944-1957 and 1990-2004, respectively. The percentage of patients older than 69 years was 5.4% and 27.3% in the prescreening and screening period, respectively. A shift towards earlier stages at diagnosis, a reduction of squamous cervical cancer and an increase of adenocarcinoma were observed in the screening cohort. The percentage of adenocarcinoma was about 6 times higher among younger patients. Cases of stump cancer and cervical cancer associated with pregnancy have declined. Eighty-seven women in the screening cohort had a history of treatment for in situ carcinoma by conization; 28% of these cases developed cervical cancer within one year after conization. Conclusion: The profile changed in the screening era indicating a need to refine screening for improved detection of in older women. This study, one of the largest clinical series of cervical cancer, provides an important baseline with which later studies can be compared to evaluate the effects of human papillomavirus vaccine and other important changes in this field. Objective: To compare profiles of a prescreening and screening cohort of women with cervical cancer regarding histopathology and clinical variables in order to identify those remaining at risk despite successful screening programs. By analyzing these profiles we hope to improve future screening methods. Methods: The prescreening and screening cohorts consisted of 5,046 and 1,174 women, respectively, treated for cervical cancer at the Department of Gynecological Oncology at Radiumhemmet, Karolinska University Hospital, during the periods 1944-1957 and 1990-2004. Results: Mean age increased from 48.9 years to 55.3 years in the cohorts treated 1944-1957 and 1990-2004, respectively. The percentage of patients older than 69 years was 5.4% and 27.3% in the prescreening and screening period, respectively. A shift towards earlier stages at diagnosis, a reduction of squamous cervical cancer and an increase of adenocarcinoma were observed in the screening cohort. The percentage of adenocarcinoma was about 6 times higher among younger patients. Cases of stump cancer and cervical cancer associated with pregnancy have declined. Eighty-seven women in the screening cohort had a history of treatment for in situ carcinoma by conization; 28% of these cases developed cervical cancer within one year after conization. Conclusion: The profile changed in the screening era indicating a need to refine screening for improved detection of in older women. This study, one of the largest clinical series of cervical cancer, provides an important baseline with which later studies can be compared to evaluate the effects of human papillomavirus vaccine and other important changes in this field.

Bhargavaea indica sp. nov., a Member of the Phylum Firmicutes, Isolated from Arabian Sea Sediment

Pankaj Verma,성치남,Prashant Kumar Pandey,Ramesh Ramchandra Bhonde,Cathrin Spröer,Manfred Rohde,Yogesh Shreepad Shouche 한국미생물학회 2013 The journal of microbiology Vol.51 No.1

A Gram-positive, aerobic, coccoid-rod shaped, non-motile, catalase- and oxidase-positive bacterium, designated strain KJW98T, was isolated from the marine sediment of Karwar jetty, west coast of India. The strain was β-haemolytic, nonendospore-forming and grew with 0–8.5% (w/v) NaCl, at 15–48°C and at pH 6.5–9.0, with optimum growth with 0.5% (w/v) NaCl, at 42°C and at pH 7.0–8.0. Phylogenetic analyses based on 16S rRNA and gyrB gene sequences showed that strain KJW98T forms a lineage within the genus Bhargavaea. The G+C content of the genomic DNA was 55 mol%. The DNA–DNA relatedness values of strain KJW98T with B. beijingensis DSM 19037T, B. cecembensis LMG 24411T and B. ginsengi DSM 19038T were 43.2, 39 and 26.5%, respectively. The major fatty acids were anteiso-C15:0 (37.7%), iso-C15:0 (19.7%), anteiso-C17:0 (17.0%) and iso-C16:0 (11.1%). The predominant menaquinone was MK-8 and the cell-wall peptidoglycan was of A4α type with L-lysine as the diagnostic diamino acid. The major polar lipids were diphosphatidylglycerol and phosphatidylglycerol. The phenotypic, genotypic and DNA–DNA relatedness data indicate that strain KJW98T should be distinguished from the members of the genus Bhargavaea, for which the name Bhargavaea indica sp. nov. is proposed with the type strain KJW98T (=KCTC 13583T=LMG 25219T).

TNS1 and NRXN1 Genes Interacting With Early-Life Smoking Exposure in Asthma-Plus-Eczema Susceptibility

Margaritte-Jeannin Patricia,Vernet Raphaël,Budu-Aggrey Ashley,Ege Markus,Madore Anne-Marie,Linhard Christophe,Mohamdi Hamida,von Mutius Erika,Granell Raquell,Demenais Florence,Laprise Cathrine,Bouzigo 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.6

Purpose: Numerous genes have been associated with allergic diseases (asthma, allergic rhinitis, and eczema), but they explain only part of their heritability. This is partly because most previous studies ignored complex mechanisms such as gene-environment (G-E) interactions and complex phenotypes such as co-morbidity. However, it was recently evidenced that the co-morbidity of asthma-plus-eczema appears as a sub-entity depending on specific genetic factors. Besides, evidence also suggest that gene-by-early life environmental tobacco smoke (ETS) exposure interactions play a role in asthma, but were never investigated for asthma-plus-eczema. To identify genetic variants interacting with ETS exposure that influence asthma-plus-eczema susceptibility. Methods: To conduct a genome-wide interaction study (GWIS) of asthma-plus-eczema according to ETS exposure, we applied a 2-stage strategy with a first selection of single nucleotide polymorphisms (SNPs) from genome-wide association meta-analysis to be tested at a second stage by interaction meta-analysis. All meta-analyses were conducted across 4 studies including a total of 5,516 European-ancestry individuals, of whom 1,164 had both asthma and eczema. Results: Two SNPs showed significant interactions with ETS exposure. They were located in 2 genes, NRXN1 (2p16) and TNS1 (2q35), never reported associated and/or interacting with ETS exposure for asthma, eczema or more generally for allergic diseases. TNS1 is a promising candidate gene because of its link to lung and skin diseases with possible interactive effect with tobacco smoke exposure. Conclusions: This first GWIS of asthma-plus-eczema with ETS exposure underlines the importance of studying sub-phenotypes such as co-morbidities as well as G-E interactions to detect new susceptibility genes.