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A dynamic performance management approach to support local strategic planning
Carmine Bianchi,Salvatore Tomaselli 한국행정학회 2015 International Review of Public Administration Vol.20 No.4
In spite of efforts devoted in the last decades to local strategic planning, such field of research and practice has been frequently characterized by a lack of implementation. We argue here that this phenomenon is due to the limitations of the static and linear approach to local strategic planning in fostering the development of common shared view among policy makers on the relevant system’s structure and behavior. By means of a case-study, we illustrate how an approach based on system dynamics modeling applied to Performance Management can be useful to overcome such weaknesses. The proposed approach enhances a better understanding of the causes and effects related to adopted policies, undertaken actions and targeted results. This helps key-players in an area to overcome possible barriers to collaboration, and therefore to adopt a combined “institutional and inter-institutional” perspective of performance.
Mehmet Yashin’s Decolonial Transcultural Proposal
Luigi Carmine Cazzato 부산외국어대학교 지중해지역원 2022 The Mediterranean Review Vol.15 No.2
Both Cypriot history and Yashin’s Turkish-Cypriot literary/cultural production are the tangible evidence of E. Said’s idea and take on culture. If the Mediterranean Sea can be understood as a history of crossings (I. Chambers), Cyprus is the quintessential product of this process and Yashin’s macrotext an aesthetic attempt at attesting it through a sort of deterritorialization of the subject and his/her language, or supposed mother-tongue, be it Greek, Turkish, Arabic or English. Starting from this ground, my attempt will be reading Yashin’s poems in a composite space historically dominated by Ottoman and British empires and other cultures, and so traversed by both colonial and imperial difference. Specifically, the main assumption is that Yashin’s stubborn “spectral” position of non-belonging and betweenness (“A Ghost”) is, at the several levels of identity positionality (ethnic, gender and genre), an implicit resistance to the colonial matrix of power (A. Quijano) informing Modernity, both in the space of colonial difference (P. Chatterjee), due to British colonialism, and in the space of imperial difference (W. Mignolo) due to Byzantine-Ottoman empires.
Lucia Tortorella,Cintoni Marco,Matteo Loverro,Conte Carmine,Nicolò Bizzarri,Costantini Barbara,Santullo Francesco,Nazario Foschi,Valerio Gallotta,Giacomo Avesani 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.1
Objective: To evaluate pre-operative predictors of early (<30 days) severe complications (gradeDindo 3+) in patients with gynecological malignancy submitted to pelvic exenteration (PE). Methods: We retrospectively analyzed 129 patients submitted to surger y at FondazionePoliclinico Gemelli between 2010 and 2019. We included patients affected by primar yor recurrent/persistent cer vical, endometrial, or vulvar/vaginal cancers. Post-operativecomplications were graded according to the Dindo classification. Logistic regression wasused to analyze potential predictors of complications. Results: We performed 63 anterior PE, 10 posterior PE, and 56 total PE. The incidence ofearly severe post-operative complications was 27.9% (n=36), and the early mortality rate was2.3% (n=3). More frequent complications were related to the urinar y diversion and intestinalsurger y. In univariable analysis, hemoglobin ≤10 g/dL (odds ratio [OR]=4.2; 95% confidenceinter val [CI]=1.65–10.7; p=0.003), low albumin levels (OR=3.9; 95% CI=1.27–12.11; p=0.025),diabetes (OR=4.15; 95% CI=1.22–14.1; p=0.022), 2+ comorbidities at presentation (OR=5.18;95% CI=1.49–17.93; p=0.012) were predictors of early severe complications. In multivariableanalysis, only low hemoglobin and comorbidities at presentation were independent predictors of complications. Conclusion: Pelvic exenteration is an aggressive surger y characterized by a high rate of post-operative complications. Pre-operative assessment of comorbidities and patient health statusare crucial to better select the right candidate for this type of surgery.
Duchi Serena,Francis Sam L.,Onofrillo Carmine,O’Connell Cathal D.,Choong Peter,Di Bella Claudia 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.1
BACKGROUND: Articular cartilage repair using implantable photocrosslinkable hydrogels laden with chondrogenic cells, represents a promising in situ cartilage engineering approach for surgical treatment. The development of a surgical procedure requires a minimal viable product optimized for the clinical scenario. In our previous work we demonstrated how gelatin based photocrosslinkable hydrogels in combination with infrapatellar derived stem cells allow the production of neocartilage in vitro. In this study, we aim to optimize the critical facets of the in situ cartilage engineering therapy: the cell source, the cell isolation methodology, the cell expansion protocol, the cell number, and the delivery approach. METHODS: We evaluated the impact of the critical facets of the cell-laden hydrogel therapy in vitro to define an optimized protocol that was then used in a rabbit model of cartilage repair. We performed cells counting and immunophenotype analyses, chondrogenic potential evaluation via immunostaining and gene expression, extrusion test analysis of the photocrosslinkable hydrogel, and clinical assessment of cartilage repair using macroscopic and microscopic scores. RESULTS: We identified the adipose derived stem cells as the most chondrogenic cells source within the knee joint. We then devised a minimally manipulated stem cell isolation procedure that allows a chondrogenic population to be obtained in only 85 minutes. We found that cell expansion prior to chondrogenesis can be reduced to 5 days after the isolation procedure. We characterized that at least 5 million of cells/ml is needed in the photocrosslinkable hydrogel to successfully trigger the production of neocartilage. The maximum repairable defect was calculated based on the correlation between the number of cells retrievable with the rapid isolation followed by 5-day non-passaged expansion phase, and the minimum chondrogenic concentration in photocrosslinkable hydrogel. We next optimized the delivery parameters of the cell-laden hydrogel therapy. Finally, using the optimized procedure for in situ tissue engineering, we scored superior cartilage repair when compared to the gold standard microfracture approach. CONCLUSION: This study demonstrates the possibility to repair a critical size articular cartilage defect by means of a surgical streamlined procedure with optimized conditions.
Giuseppina Tommonaro,Rocco De Prisco,Rita Pergamo,Carmine Iodice,Gennaro Roberto Abbamondi,Annalisa Spagnuolo,Barbara Nicolaus 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.10
The antioxidant capacity and the polyphenolic profile of fresh and processed cherry tomatoes were analyzed with the aim of investigating the effect of industrial processes on the nutritional qualities of fruits. The results exhibited a decrease of antioxidant activity mainly in the lipophilic fraction of processed tomatoes compared with fresh products. No great difference in the antioxidant capacity was detected in the hydrophilic and methanolic extracts of fresh tomatoes and processed tomato juices. Moreover, a decrease of polyphenolic content, estimated by means of high-performance liquid chromatography analysis and Folin–Ciocalteu method, was observed in all tomato juices. The overall polyphenolic profile of both fresh and processed tomatoes did not change significantly and, among all juices, a higher polyphenolic content was detected in juice containing peels and seeds in comparison to those without. From our data on antioxidant power and the bioactive metabolite content, tomato juice could be used as a valid and easily available source of antioxidants in everyday diet to preserve human health.