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CHOI OK-JA,HONG YOUNG-DON,GWON HUI-JEONG,CHOI SANG-MU,CHOI SUN-JU Korean Nuclear Society 2005 Nuclear Engineering and Technology Vol.37 No.4
N-(3-bromo-2,4,6-trimethylacetanilide)iminodiacetic acid (BrTIDA) was synthesized using nitrilotriacetic anhydride prepared in situ, and lyophilized vials were prepared which contained 20 mg of BrTIDA and 0.4 mg of $SnCl_2$. To evaluate the clinical efficacy of the in-house prepared lyophilized kit, a technetium-99m complex of BrTIDA was prepared; its in vivo pharmacokinetic behavior was evaluated via animal studies to assess the hepatocytic function and the functional status of the cystic duct and the gallbladder. Serial static image scans of rabbits and the biodistribution in mice injected with $^{99m}Tc-BrTIDA$ revealed that none of the tissues except for the hepatobiliary system showed radioactivity concentrations, and a rapid clearance from the organs was observed. In conclusion, a lyophilized kit and its prepared $^{99m}Tc-BrTIDA$ can be applied as a hepatobiliary imaging agent for the evaluation of the functional status of the hepatocytes and the patency of the biliary duct.
Choi, Kang-hyuk,Hong, Young-Don,Choi, Ok-Ja,Choi, Sun-Ju Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.8
In order to develop radiopharmaceuticals for targeting a serotonin receptor such as $5-HT_{1A}$, histidine-$C_n$-arylpiperazines (AP) (C = alkyl, n = 2, 3, 4) were prepared in five steps with yields of 25%, 37% and 51%, respectively, and radiolabeled with the $[^{99m}Tc(CO)_3(H_2O)+3]^+$. The $^{99m}Tc(CO)_3$-Histidine-Cn-APs were prepared with a high yield (>99%) and characterized as a tridentate complex with a neutral charge to pass through the blood-brain barrier (BBB). The rhenium complexes with $Re(CO)_3$ were also synthesised and comparative experiments were achieved to evaluate the nature of the $^{99m}Tc$ complexes.
Neuro-Behçet disease presented diplopia with hemiparesis following minor head trauma
Choi, Ja-Yun,Park, Sun-Young,Hwang, In-Ok,Lee, Young-Hwan The Korean Pediatric Society 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.9
Behçet disease (BD) is rare in childhood. We report a 9-year-old boy with neuro-Behçet disease who presented diplopia and weakness on the left side after a cerebral concussion. Brain magnetic resonance imaging (MRI) revealed hyperintensity of the right mesodiencephalic junction on T2-weighted and fluid attenuated inversion recovery images. Prednisolone administration resulted in complete remission and normalization of abnormal MRI finding. Brain MRI is a useful diagnostic tool when the neurological sign is the first symptom of subclinical BD.
Basic : A case of genotype 4 hepatitis E after ingestion of roe deer in Gyeongnam province (초)
( Ja Yoon Choi ),( Sang Soo Lee ),( Hong Jun Kim ),( Chang Yoon Ha ),( Hyun Ju Min ),( Hyun Jin Kim ),( Tae Hyo Kim ),( Woon Tae Jung ),( Ok Jae Lee ),( Hae Sun Yun ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)
Ja Pung Koo,Ho Jung An,Hee Seo Koo,Ji Hwan Park,Suhn Yeop Kim,Yong Kwon Kim,Jung Hyun Choi,Soon Hee Kim,Kyung Ok Min 국제물리치료학회 2010 Journal of International Academy of Physical Ther Vol.1 No.1
2 week study was conducted to investigate the effects of Interferential Current(IC) and Kaltenborn-Evjenth Orthopedic Manual Therapy(KEOMT) on functional constipation. Interventions were applied to spinal segments between T9-L2 which provides innerva˗ tions to the gastrointestinal tract. Subjects(n=24) were randomly allo˗ cated to two treatment groups: the IC group or the KEOMT group. Results for the IC therapy demonstrated significant decrease with the colonic transit time(CTT) as well as scores on the constipation assessment scale(CAS). The frequency of defecations per week had increased significantly(p<0.05). The KEOMT displayed decreased CTT in the left colon region. The scores on the CAS were reduced and frequency of defecations per week had increased significantly (p<0.05). This study not only showed that both modes of therapy improved symptoms of constipation, but also optimized gastrointesti˗ nal content movement, eventuating in a more normalized CTT. In conclusion, both the IC therapy and the Kaltenborn-Evjenth Orthopedic Manual Therapy have shown to be effective interventions for improving functional constipation.
Neuro-Behçet disease presented diplopia with hemiparesis following minor head trauma
Ja Yun Choi,Sun Young Park,In Ok Hwang,Young Hwang Lee 대한소아청소년과학회 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.9
Behçet disease (BD) is rare in childhood. We report a 9-year-old boy with neuro-Behçet disease who presented diplopia and weakness on the left side after a cerebral concussion. Brain magnetic resonance imaging (MRI) revealed hyperintensity of the right mesodiencephalic junction on T2-weighted and fluid attenuated inversion recovery images. Prednisolone administration resulted in complete remission and normalization of abnormal MRI finding. Brain MRI is a useful diagnostic tool when the neurological sign is the first symptom of subclinical BD.
Case Report : Genotype-4 hepatitis E in a human after ingesting roe deer meat in South Korea
( Ja Yoon Choi ),( Jeong Mi Lee ),( Yun Won Jo ),( Hyun Ju Min ),( Hyun Jin Kim ),( Woon Tae Jung ),( Ok Jae Lee ),( Hae Sun Yun ),( Yeong Sil Yoon ) 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.3
The recent increase in the number of cases of indigenous hepatitis E virus (HEV) infection highlights the importance of identifying the transmission routes for the prevention of such infections. Presented herein is the first case of acute HEV infection after ingesting wild roe deer meat in South Korea. A 43-year-old male presented with abdominal discomfort and jaundice. He had not recently traveled abroad, but had eaten raw roe-deer meat 6-8 weeks before the presentation. On the 7th day of hospitalization the patient was diagnosed with acute viral hepatitis E. Phylogenetic analysis of his serum revealed genotype-4 HEV. This case supports the possibility of zoonotic transmission of HEV because the patient appears to have been infected with genotype-4 HEV after ingesting raw deer meat. ((Iin Mol HepatoI2013;19:309¬314)
Accumulation and Toxicity of Germanium in Cucumber under Different Types of Germaniums
Choi, Ik Won,Seo, Dong Cheol,Han, Myung Ja,DeLaune, R. D.,Ok, Yong Sik,Jeon, Weon Tai,Lim, Byung Jin,Cheong, Yong Hwa,Kang, Hang Won,Cho, Ju Sik Taylor Francis 2013 Communications in soil science and plant analysis Vol.44 No.20