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      • Future Trends in Multisensor Integration and Fusion

        Ren C. Luo,Michael G. Kay,W. Gary Lee 대한전자공학회 1992 대한전자공학회 학술대회 Vol.1992 No.10

        The need for intelligent systems that can operate in an unstructured, dynamic environment has created a growing demand for the use of multiple, distributed sensors. While most research in multisensor fusion has revolved around applications in object recognition-including military applications for automatic target recognition-developments in microsensor technology are encouraging more research in affordable, highly-redundant sensor networks. Three trends that are described at length are the increasing use of microsensors, the techniques that are used in the handling of partial or uncertain data, and the application of neural network techniques for sensor fusion.

      • Notch effect on creep damage for Hastelloy C276-BNi2 brazing joint

        Luo, Y.,Jiang, W.,Zhang, W.,Zhang, Y.C.,Woo, W.,Tu, S.T. Scientific and Technical Press ; Elsevier Science 2015 Materials & Design Vol.84 No.-

        The brazed structures have geometrical discontinuities like fillets working as notches. These notches have great effect on creep crack initiation and propagation. This paper studies the notch effect on creep damage for Hastelloy C276-BNi2 brazed joint, and the effects of notch type, notch radius and notch angle on creep damage have been investigated. The results show that the creep damage initiates in the filler metal. Different notch types bring different stress states, and generate different stress triaxialities and equivalent creep strains (CEEQs), leading to different creep damages. The maximum creep damage is generated in the notch tip for V-type notch, while the maximum creep damage is located at 0.4mm away from the notch tip for C-type notch. For U-type notch, the location of the maximum creep damage moves from the notch tip to the inside gradually as the notch radius increases. With the increase of notch radius and notch angle, the failure time of creep damage increases for U-type and V-type notches, while it decreases for C-type notch. The creep failure is prone to happen to V-type notch because it belongs to sharp notch.

      • c-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor

        Zuo, W.,Huang, F.,Chiang, Y.,Li, M.,Du, J.,Ding, Y.,Zhang, T.,Lee, H.,Jeong, L.,Chen, Y.,Deng, H.,Feng, X.H.,Luo, S.,Gao, C.,Chen, Y.G. Cell Press 2013 Molecular cell Vol.49 No.3

        Transforming growth factor β (TGF-β) is a potent antiproliferative factor in multiple types of cells. Deregulation of TGF-β signaling is associated with the development of many cancers, including leukemia, though the molecular mechanisms are largely unclear. Here, we show that Casitas B-lineage lymphoma (c-Cbl), a known proto-oncogene encoding an ubiquitin E3 ligase, promotes TGF-β signaling by neddylating and stabilizing the type II receptor (TβRII). Knockout of c-Cbl decreases the TβRII protein level and desensitizes hematopoietic stem or progenitor cells to TGF-β stimulation, while c-Cbl overexpression stabilizes TβRII and sensitizes leukemia cells to TGF-β. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TβRII at Lys556 and Lys567. Neddylation of TβRII promotes its endocytosis to EEA1-positive early endosomes while preventing its endocytosis to caveolin-positive compartments, therefore inhibiting TβRII ubiquitination and degradation. We have also identified a neddylation-activity-defective c-Cbl mutation from leukemia patients, implying a link between aberrant TβRII neddylation and leukemia development.

      • KCI우수등재

        체외수정 및 미세조작에 의한 가축배의 생산과 효율적 이용에 관한 연구 6. 소 핵이식배의 체외배양 , 동결보존 및 성판정에 관한 연구

        정영채,김창근,윤종택,나광빈,오성종,이종완,김흥률,김광식,박선애,유영아 ( Y . C . Chung,C . K . Kim,J . T . Yoon,G . B . Luo,S . J . Oh,J . W . Lee,H . R . Kim,K . S . Kim,S . A . Park,Y . A . You ) 한국축산학회 1997 한국축산학회지 Vol.39 No.3

        This study was carried out to establish an effective method for the improvement of subsequent development after nuclear transfer(NT) in bovine embryo, for the extension of utility through freezing and sexing of NT embryos. The rates of cleaved and developed embryos upto morula-blastocyst stages after the NT in in vitro produced embryos were 60.6 and 3.7%, respectively. Whereas, in in vivo embryos, slightly higher developments were obtained(70.8 and 5.6%), respectively. No difference was found in embryonic development upto morulablastocyst stages among the different levels of EGF added to the serum containing medium. The rates of cleaved and developed embryos upto morula-blastocyst were higher when electrostimulation was performed either before fusion or after addition at 21h IVM. The survival rate of frozen NT embryos was higher in late morula than that of earlier embryos. PCR-based sexing of NT embryo demonstrated that higher proportion of embryos was male(1.9:1), instead of normal ratio(1:1).

      • 전압, 공핵배 발생단계 및 체외배양액이 소의 제2세대 핵이식배 발생능에 미치는 영향

        정영채,김창근,나광빈,김광식,박세영,류재원,오신애,박진서 中央大學校 遺傳工學硏究所 1998 遺傳工學硏究論集 Vol.11 No.1

        소에서 체외에서 생산된 제1세대 핵이식배를 다시 공핵배로 사용하여 제2세대 핵이식배를 생산하기 위한 효과적인 방법을 개발하기 위하여 본 연구에서 세포융합시 전압, 제1세대 핵이식배의 발생단계 및 체외배양조건에 따라 제2세대 핵이식배의 발생결과를 조사한 결과는 다음과 같다. 1. 세포융합시 전압을 0.7kV/cm, 1.0kV/cm 및 1.2kV/cm로 하였을 때 세포융합율과 난할율에서 유의차는 없었으며 후기배의 발생율이 1.0kV/cm가 0.7kV/cm와 1.2kV/cm보다 다소 높게 나타났다. 2. 8-15, 16-23 및 25-32세포기의 제1세대 핵이식배를 공핵배로 이용한 제2세대 핵이식배의 융합율, 난할율 및 상실배까지의 발생율은 세포기에 따라 유의차가 없었다. 그러나 배반포배 발생율은 각각 3.4%, 6.9% 및 18.5%로서 16-23세포기와 25-32세포기간에는 유의차가 없었으나 25-32세포기는 8-15세포기보다 유의적으로 높았다(p<0.01). 3. 제2세대 핵이식배를 BOEC, BOEC-CM 및 10% FBS+BOEC-CM에서 배양한 결과 난할율과 상실배까지의 발생에서 큰 차이가 없었으나 배반포까지의 발생율은 각각 12.5%, 5.7% 및 9.6%로 BOEC 처리구에서 처리구가 가장 높은 것으로 나타났다. This study was carried out to investigate the effect of the electric pulses, donor embryo cell-stages and culture media on the 2nd generation nuclear transplant bovine embryos. Parent donor embryos were used at day 4 after IVF and 8 to 32 cell-stage embryos at day 3∼5 after the first cycle nuclear transfer were used as donor for 2nd generation. The recipient oocytes were enucleated 22 to 23 h after the onset of in vitro maturation(IVM) and preactivated 24 h after IVM. Electric fusion was performed 30 h after IVM. When a pulse of 0.7kV/cm, 1.0kV/cm or 1.2kV/cm direct current for 70μsec was applied, the fusion rates of the 2nd generation were 73.5%, 87.3% and 83.6%, respectively and the cleavage rates were 78.0%, 80.6% and 86.6%, respectively. The proportions of fusion and cleavage were lower in 0.7kV/cm than in 1.0kV/cm and 1.2kV/cm. The developmental rate to blastocyst in the 2nd generation nuclear transplant embryos was higher in 1.0kV/cm(12.9%) than in 0.7kV/cm(8.0%) and 1.2kV/cm(6.5%). The rate of fusion and cleavage and developmental rate to blastocyst in the 2nd generation embryos derived from 8 to 32 cell-stage donor embryos was 87.1%, 85.2% and 18.5%, respectively, from 25-32 cell-stage, 86.6%, 79.3% and 6.9%, respectively, from 16-23 cell-stage, and 84.1%, 77.6%, and 3.4%, respectively, from 8-15 cell-stage. These rates were not significantly different between 25-32 cell-stage and 16-23 cell-stage donor embryos, but the developmental rate was higher from 25-32 cell-stage donor embryos, than from 8-15 cell-stage. The developmental rate to blastocyst in the 2nd generation nuclear transplant embryos was higher in co-culture with bovine oviduct epithelial cells(12.5%) than in BOEC-conditioned medium with 10% FBS(9.6%) or without FBS(5.7%). The developmental rate in co-culture with BOEC was higher than in BOEC-conditioned medium.

      • KCI우수등재

        Optical properties of amorphous $Si_xC_yN_z$ ternary thin films prepared by plasma enhanced chemical vapor deposition

        Zhang, Z.H.,Fan, X.J.,Guo, H.X.,Zhang, W.,Zhang, C.Y.,Luo, F.Y. The Korean Vacuum Society 1998 Applied Science and Convergence Technology Vol.7 No.1

        Amorphous ternary $Si_xC_yN-z$ thin films were obtained by plasma enhanced chemical vapor deposition(PECVD) using $N_2, SiH_4 \;and \;C_2H_4$ as the reaction sources. The chemical state were characterized by x-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy(FTIR). The optical properties of the thin films were investigated by UV-visible spectrophotometer and ellipsometer, and the optical band gaps of thin films were determined from corresponding transmittance spectra following Tauc equation.

      • KCI등재

        Carrier Dynamics in Self-Assembled CdTe Stranski-Krastanow Quantum Dots Grown on ZnSe by Molecular Beam Epitaxy

        C. S. Yang,K. F. Chien,J. Y. Lai,C. W. Luo,W. C. Chou,Y. T. Shih,J. S. Wang,S. R. Jian 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5

        Self-assembled CdTe/ZnSe Stranski-Krastanow quantum-dot (QD) structures, which have a CdSe-like precursor-layer (PCL) between CdTe quantum dots and ZnSe matrix, were grown by molecular beam epitaxy. The carrier dynamics of the structures was studied by photoluminescence (PL) and time-resolved photoluminescence (TRPL) measurements. The temperature-dependent PL spectra revealed that there is a carrier transformation from small dots to larger dots via the precursor layer. Temperature-dependent PL measurements verify the existence of the QD excited excitonic state in 5.0 mono-layer (ML) coverage. In 0.6 ML coverage, the TRPL spectra exhibited a double-exponential decay process, as the detection energy at PCL emission energy. The faster decay time is corresponded to the carrier lifetime in PCL, the slower decay time exhibits the carrier in small QD. However, in 5.0 ML coverage, a faster and slower decay time represents the carrier lifetime in QD excited state for larger QD and the carrier lifetime in QD ground state for smaller QD.

      • Growth and residual stresses in the bonded compliant seal of planar solid oxide fuel cell: Thickness design of window frame

        Jiang, W.,Zhang, Y.C.,Zhang, W.Y.,Luo, Y.,Woo, W.,Tu, S.T. Elsevier Ltd 2016 Materials & Design Vol.93 No.-

        <P>Bonded compliant seal (BCS) is a new sealing method for planar solid oxide fuel cell. The BCS design uses a thin foil to bond the cell and window frame, which generates a multilayer structure. However, the high temperature bonding generates large residual stresses that greatly affect the fracture. This paper presents a numerical method and neutron diffraction measurement to study the residual stress, and effect of window frame thickness has been discussed. A grain boundary diffusion model incorporated with a power-law creep constitutive model is developed to calculate the growth stress in the oxide film. Then, the thermal elasto-plastic finite element method is applied to calculate the thermal stress. A neutron diffraction experiment is performed to measure the through thickness stresses. A good agreement is found between the calculation results and the neutron diffraction measurements. Compressive stress is generated in the oxide scale because of the substrate constraint. Furthermore, a competition exists between the generation of growth stress and the creep relaxation in the oxide layer. The residual stresses in the oxide layer decrease with the decrease in the substrate thickness. The thicknesses of the window frame and foil are designed to be 500 and 50 mu m, respectively. (C) 2015 Elsevier Ltd. All rights reserved.</P>

      • SCIESCOPUS

        Creep damage and crack initiation in P92-BNi2 brazed joint

        Jiang, W.,Zhang, W.,Zhang, G.,Luo, Y.,Zhang, Y.C.,Woo, W.,Tu, S.T. BUTTERWORTH - HEINEMANN 2015 MATERIALS AND DESIGN Vol.72 No.-

        Nickel-based brazed joints are widely used at high temperatures, and it is very important to ensure the creep strength. Using three-dimensional finite element method, this paper presents a study on the creep damage and creep crack initiation (CCI) in P92-BNi2 brazed compact tension (CT) joint specimen, and the effect of brazed residual stress on CCI has been investigated. Firstly, the as-brazed residual stress is simulated. Then the effect of residual stress on creep and damage is calculated by an uncoupled Norton equation and the ductility exhaustion approach. The results show that the CCI is a function of residual stress, load level, joint thickness and notch radius. The brazed residual stress has a great effect on creep damage, and it can lead to the initiation of creep crack lonely without any mechanical load. The combination of applied load not only accelerates the creep damage and decreases the CCI time, but also determines the creep crack propagation rate. The CCI time decreases with the increase of applied load and joint thickness. As the notch radius increases, the CCI time increases.

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