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- 저자 : C-Y. Oliver Chen (검색결과 4 건)
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Hyperglycemia and Anthocyanin Inhibit Quercetin Metabolism in HepG2 Cells
Naoto Hashimoto,Jeffrey B. Blumberg,C-Y. Oliver Chen 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.2
A high glucose (Glu) milieu promotes generation of reactive oxygen species, which may not only cause cellular damage, but also modulate phase II enzymes that are responsible for the metabolism of flavonoids. Thus, we examined the effect of a high Glu milieu on quercetin (Q) metabolism in HepG2 cells. HepG2 cells were grown for 3 days in Glu ranging from 5.5 to 50 mmol/L and/or cyanidin-3-glucoside (C3G) ranging from 0 to 25 μmol/L. Subsequently, the capacity of HepG2 cells to metabolize Q was assessed for up to 16 h. Q metabolites were analyzed by high-performance liquid chromatography. Four major Q metabolites were observed in the culture medium and inside the HepG2 cells. Three of these metabolites appear to be sulfated forms of Q or methylated Q, and one was a methylated Q. These metabolites and Q itself were reduced or tended to be reduced in cells grown in a high Glu compared to a normal Glu medium. Addition of C3G or superoxide dismutase plus catalase did not prevent or enhance reduction of Q metabolites. In vitro, a hyperglycemic milieu decreases the production of the principal Q metabolites in HepG2 cells, mediated through mechanisms independent of oxidative stress.
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Shin-Kyo Chung,C.-Y. Oliver Chen,Jeffrey B. Blumberg 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6
To explore their bioactive fractions, Sageretia theezans leaves were extracted with 60% acetone and then fractionated sequentially with hexane, ethyl acetate, and water. Reactive oxygen radical species (ROS) (HOCl, ONOO−, and O2·−) scavenging activity, oxygen radical absorbance capacity (ORAC) value, and total phenolic content of each fraction were investigated. The ethyl acetate fraction had the largest total phenolic content and ORAC value and displayed the strongest ROS scavenging activity. The ethyl acetate fraction at 2μmol of gallic acid equivalents/L prolonged the lag time of low-density lipoprotein oxidation by 260% compared to the control. In the ethyl acetate fraction, 7-O-methylmearnsetin 3-O-rhamnoside and the other nine flavonols were characterized using high-performance liquid chromatography with electrochemical detection. The total flavonoid content in the ethyl acetate fraction was 460mg/g. 7-O-Methylmyricetin 3-O-rhamnoside and 7-O-methylmearnsetin 3-O-rhamnoside were the predominant flavonoids, making up 36% and 17% of the total flavonoid content, respectively.
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Bioavailability of plant pigment phytochemicals in Angelica keiskei in older adults
Camila R Correa,C-Y. Oliver Chen,Giancarlo Aldini,Helen Rasmussen,Carlos F Ronchi,Carolina Berchieri-Ronchi,Soo-Muk Cho,Jeffrey B Blumberg,Kyung-Jin Yeum 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.5
BACKGROUND/OBJECTIVES: Angelica keiskei is a green leafy vegetable rich in plant pigment phytochemicals such as flavonoids and carotenoids. This study examined bioavailability of flavonoids and carotenoids in Angelica keiskei and the alteration of the antioxidant performance in vivo. SUBJECTS AND MATERIALS: Absorption kinetics of phytochemicals in Angelica keiskei were determined in healthy older adults (> 60 y, n = 5) and subjects with metabolic syndrome (n = 5). Subjects consumed 5 g dry Angelica keiskei powder encapsulated in gelatin capsules with a low flavonoid and carotenoid liquid meal. Plasma samples were collected at baseline, 0.5, 1, 2, 3, 4, 5, 6, 7, and 8 h. Samples were analyzed for flavonoids and carotenoids using HPLC systems with electrochemical and UV detection, respectively, and for total antioxidant performance by fluorometry. RESULTS: After ingestion of Angelica keiskei increases in plasma quercetin concentrations were observed at 1-3 and 6-8 hr in the healthy group and at all time points in the metabolic syndrome group compared to baseline (P < 0.05). Plasma lutein concentrations were significantly elevated in both the healthy and metabolic syndrome groups at 8 hr (P < 0.05). Significant increases in total antioxidant performance were also observed in both the healthy and the metabolic syndrome groups compared to baseline (P < 0.05). CONCLUSIONS: Findings of this study clearly demonstrate the bioavailability of phytonutrients of Angelica keiskei and their ability to increase antioxidant status in humans.
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Carotenoids and total phenolic contents in plant foods commonly consumed in Korea
Gun-Ae Yoon,Kyung-Jin Yeum,Yoon-Suk Cho,C-Y. Oliver Chen,Guangwen Tang,Jeffrey B. Blumberg,Robert M. Russell,Sun Yoon,Yang Cha Lee-Kim 한국영양학회 2012 Nutrition Research and Practice Vol.6 No.6
Phytochemicals are reported to provide various biological functions leading to the promotion of health as well as the reduced risk of chronic diseases. Fat-soluble plant pigments, carotenoids, are extensively studied micronutrient phytochemicals for their potential health benefits. It is noteworthy that specific carotenoids may be responsible for different protective effects against certain diseases. In addition, each carotenoid can be obtained from different types of plant foods. Considering the fact that the phytochemical content in foods can vary according to, but not limited to, the varieties and culture conditions, it is important to establish a database of phytochemicals in locally produced plant foods. Currently, information on individual carotenoid content in plant foods commonly consumed in Korea is lacking. As the first step to support the production and consumption of sustainable local plant foods, carotenoids and total phenolic contents of plant foods commonly consumed in Korea are presented and their potential biological functions are discussed in this review.
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