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내당능장애군 및 새로 진단된 제2형 당뇨병 환자에서 혈장 프로인슐린의 분비양상
공병호,최승진,김재택,오연상,신순현 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.4
연구배경:제2형 당뇨병의 병인은 크게 췌장베타세포의 인슐린분비장애와 말초조직에서의 인슐린저항성으로 설명되며 현재 이들 중에 어느 것이 더 중요한지는 명확히 증명되어지고 있지 않으며 민족에 따라 차이가 있는 것으로 알려져 있다. 저자 등은 제2형 당뇨병의 병인에서 베타세포의 기능이상의 역할을 알아보기 위하여 새로 진단된 제2형 당뇨병 환자, 내당능장애군과 정상인에 있어서 경구 당부하검사시 인슐린, C펩타이드와 프로인슐린의 분비이상을 측정 비교하였다. 방법:새로 진단 받은 제2형 당뇨병 환자군 47명과 내당능장애군 9명, 정상 대조군 13명을 대상으로 75g 경구당부하검사를 실시하여 혈당, 혈장 인슐린, C펩타이드 및 프로인슐린 농도를 측정하였다. 결과:1)내당능장애군에서 경구당부하검사 후 인슐린, C펩타이드와 프로인슐린의 현격한 증가를 보인 반면, 제2형 당뇨병 환자군에서는 그 분비양상이 둔화되어 거의 증가되지 않았다. 2)공복시 프로인슐린 농도는 정상대조균에서 7.7±4.4poml/L였으며, 내당능 장애군은 15.2±6.9poml/L(p=0.005), 제2형 당뇨병 환자군은16.9±8.4poml/L(p<0.005)로 두군 모두 정상대조군에 비해 의미있게 높았으며 경구당부하후 60분, 90분, 120분에는 내당능장애군에서 의미있게 높았다. 3)혈장 공복시 프로인슐린/인슐린비는 내당능장애군에서 공복시와 경구당부하후 30분에 그리고 제2형 당뇨병 환자군에서는 공복시, 경구당부하구검사 후 30분, 60분과 90분에 정상대조군에 비해 의미있는 증가를 보였다. 4)프로인슐린 반응면적은 내당능장애군에서 110.7±13.1poml/L/hr로 정상대조군의 73.6±5.1poml/L/hr 및 제2형 당뇨병 환자군의 80.5±5.9poml/L/hr에 비해 의미있게(p=0.048)증가되었다. 결론:내당능장애군에서 이미 베타세포의 프로인슐린의 분비능에 이상이 있으며 인슐린 분비양상의 변화가 제2형 당뇨병의 병인에 관여함을 알 수 있었다. Background : Type 2 diabetes mellitus is characterized beta cell dysfunction and insulin resistance but the relative roles of the two factors are different in various ethnic groups. The changes in plasma proinsulin levels is thought to be a market for the beta-cell dysfunction. To study the role of beta cell dysfunction in the pathogenesis of type 2 diabetes mellitus we compared the concentrations of plasma insulin, C-peptide and proinsulin among the control group, impaired glucose to lerance (IGT) group and newly diagnosed Type 2 Diabetes Mellitus (DM) group during the oral glucose to lerance test. Methods : In 47 newly diagnosed patients with type 2 DM, 9 IGT and 13 controls the 75g oral glucose to lerance test (OGTI) were performed and samples were analyzed for glucose, insulin, C-peptide and proinsulin. Results : 1) In IGT group plasma insulin, C-peptide and proinsulin concentrations were increased markedly during OGTT but were blunted i type 2 diabetes group. 2) The basal plasma proinsulin level was 7.7±4.4 pmol/L in control group, 15.2±6.9 pmol/L (p<0.005) in IGT group, amd 16.9±8.3 pmol/L (p<0.005) in type 2 DM group, and the proinsulin levels at 60 min, 90 min, 120 min during OGTT were significantly elevated in IGT group than those of control group. 3) The plasma proinsulin/ insulin ratio were significantly increased in IGT group and type 2 DM group at basal and 30 min during OGTT> 4) The proinsulin response areas were significantly increased in IGT group (110.7±13.1 pmol/L/hr, p=0.048) than those of control group (73.6±5.1 pmol/L/hr) and type 2 DM group (80.5±5.9 pmol/L/hr). Conclusion : Beta cell secretory defects such as proinsulin secretion were present in impaired glucose to lerance and changes of insulin secretory function might have a role in the pathogenesis of type 2 DM (J Kor Diabetes Asso 467~475, 2000).
Postprandial Glucose and Insulin Responses to Processed Rice Products in Normal Subjects
Kim, Jae-Cherl,Kim, Jung-In,Kong, Byoung-Wook,Jung, Suk-Heui,Park, Su-Jin,Kwon, Tae-Wan The Korean Society of Food Science and Nutrition 2002 Preventive Nutrition and Food Science Vol.7 No.2
The influence of physical forms of gelatinized rice products on enzymatic hydrolysis in vitro and glycemic and insulinemic responses in normal subjects were studied. Densities of garaedu, bagsulgi, and cooked rice were 1.20, 1.18 and 1.11 g/mL, respectively, while moisture contents of garaeduk, bagsulgi, and cooked rice were 47.5, 43.1 and 66.0% (wt.), respectively. The highest initial rate of in vitro hydrolysis by porcine pancreatic $\alpha$-amylase was observed in bagsulgi followed by cooked rice and garaeduk. However, time for complete hydrolysis seemed to reach a plateau value. Postprandial glucose and insulin responses and satiety of rice products were studied in 12 normal subjects (mean age 23.2 $\pm$ 2.4 years, 6 men and 6 women). Postprandial serum glucose and insulin levels, after consumption of the rice products, reached a peak at 30 min. Garaeduk showed significantly less incremental responses for glucose (1627.5$\pm$134.9 mg.min/dL) and insulin (2041$\pm$287.0 uU.min/mL) than did bagsulgi for glucose (2407.4$\pm$208.3 mg.min/dL) and insulin (3582$\pm$264.4 uU.min/mL). Satiety responses to the rice products were not significantly different. Therefore, it can be concluded that garaeduk may be more beneficial in controlling postprandial hyperglycemia and hyperinsulinemia than bagsulgi. These results also suggest that physical properties of starch products, acquired by the specific processing methods, affect postprandial metabolism of carbohydrate foods.
Kim, Byoung Soo,Kwon, Yang Woo,Kong, Jeong-Sik,Park, Gyu Tae,Gao, Ge,Han, Wonil,Kim, Moon-Bum,Lee, Hyungseok,Kim, Jae Ho,Cho, Dong-Woo Elsevier 2018 Biomaterials Vol.168 No.-
<P><B>Abstract</B></P> <P>3D cell-printing technique has been under spotlight as an appealing biofabrication platform due to its ability to precisely pattern living cells in pre-defined spatial locations. In skin tissue engineering, a major remaining challenge is to seek for a suitable source of bioink capable of supporting and stimulating printed cells for tissue development. However, current bioinks for skin printing rely on homogeneous biomaterials, which has several shortcomings such as insufficient mechanical properties and recapitulation of microenvironment. In this study, we investigated the capability of skin-derived extracellular matrix (S-dECM) bioink for 3D cell printing-based skin tissue engineering. S-dECM was for the first time formulated as a printable material and retained the major ECM compositions of skin as well as favorable growth factors and cytokines. This bioink was used to print a full thickness 3D human skin model. The matured 3D cell-printed skin tissue using S-dECM bioink was stabilized with minimal shrinkage, whereas the collagen-based skin tissue was significantly contracted during <I>in vitro</I> tissue culture. This physical stabilization and the tissue-specific microenvironment from our bioink improved epidermal organization, dermal ECM secretion, and barrier function. We further used this bioink to print 3D pre-vascularized skin patch able to promote <I>in vivo</I> wound healing. <I>In vivo</I> results revealed that endothelial progenitor cells (EPCs)-laden 3D-printed skin patch together with adipose-derived stem cells (ASCs) accelerates wound closure, re-epithelization, and neovascularization as well as blood flow. We envision that the results of this paper can provide an insightful step towards the next generation source for bioink manufacturing.</P>
추나요법을 포함한 수기치료의 효과 및 안전성에 관한 문헌고찰
김기병 ( Ki Byoung Kim ),박태용 ( Tae Yong Park ),이정한 ( Jeong Han Lee ),공재철 ( Jae Cheol Kong ),이수경 ( Su Kyung Lee ),신병철 ( Byung Cheul Shin ),권영달 ( Young Dal Kwon ),송용선 ( Yung Sun Song ) 한방재활의학과학회 2008 한방재활의학과학회지 Vol.18 No.4
Objectives : This study aims to educate clinical doctors of the valuable practice of Manipulative Therapy(MT) as an opportunity for evidence-based medicine. Consequently it also serves to review the effectiveness and safety of MT. Methods : The literature studies of overseas were done by Cochrane Library and Medline website; those of domestic researches were completed by utilizing the sources which are gained from KERIS, KISS, DBpia, Kisti, and domestic institutes related with MT. Results : Eight papers related to the effectiveness of MT were published in South Korea, which concluded with the positive effects of MT. None of them are, however, well-designed randomized controlled trials(RCT). On the other hand, fifteen cases of nine articles indicate the adverse reaction of MT, and numbers of the researches in overseas revealed the side effects of MT in order of cervical, lumbar, and thoracic vertebrae. A vascular adverse reaction such as vertebral and carotid artery dissection was a highly reported cervical adverse reaction; in the thoracic and lumbar regions, neurological adverse reaction in terms of disc herniation was frequently discovered. Conclusions : Henceforth, highly qualitative studies are required developing the effective outcomes and preventing any possible complications of MT. Therefore, systemic curriculums in institutions and sufficient clinical training in the filed are strongly recommended.