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류진호,정경운,위준선,문정미,전병조,문원식,김용권,소정일,허탁,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4
Background: Although cardiopulmonary resuscitation(CPR) is a very effective therapy in cardiac arrest, it is hard to prove the true effectiveness of CPR. Several studies about out-of-hospital and emergency department CPR exist, but only a few reports about in-hospital CPR are available. This study was designed to investigate in-hospital cardiac arrest, to analyze the result of CPR, and to evaluate the problems associated with in-hospital CPR. Methods: A clinical analysis of 71 cases of in-hospital CPR announcement from January 2000 to August 2000 was performed. The initial rhythm on cardiac arrest, return of spontaneous circulation(ROSC), and the survivals were analyzed in the case of the 46 true cardiac arrest patients. Results: During 8 months, there were 71 cases of in-hospital CPR announcement. Among them, there were 46 cases of true cardiac arrest and 25 cases of non-cardiac arrest. Of the 46 true cardiac-arrest cases, 27(58.7%) experienced ROSC, 15(32.6) survived for over 24 hours, and 7(15.2%) survived to be discharged. The initial rhythms on cardiac arrest were 30 cases(65.2%) of asystole, 14(30.4%) of PEA(pulseless electrical activity), and 2(4.3%) of ventricular fibrillation, with ROSC being 17 cases(56.7%), 9(64.3%) and 1(50.0%) cases and discharged survivors being 4 cases(13.3%), 3(21.4%) and 0(0.0%) cases, respectively. Conclusion: Extraordinarily high proportions of asystole and PEA were seen in the initial rhythm of cardiac arrest, and those were associated with high survival rates. Although further study is needed to evaluate the course leading to this high proportion of asystole and PEA, this result suggests that if the EMS system in the hospital is activated promptly and systematically, a better outcome will be achieved in case of cardiac arrest with asystole and PEA.
( Byoung Hwan Lee ),( Na Young Kim ),( Sung Bum Kang ),( So Yeon Kim ),( Kyoung Ho Lee ),( Bo Youn Im ),( Jung Hee Jee ),( Jane C. Oh ),( Young Soo Park ),( Dong Ho Lee ) 대한소화기기능성질환·운동학회 2010 Journal of Neurogastroenterology and Motility (JNM Vol.16 No.2
Background/Aims: There has been a controversy regarding the usefulness of biofeedback therapy for functional constipation or fecal incontinence. This study was performed to investigate the Long-term clinical efficacy of biofeedback therapy. Methods: Sixty-four patients with constipation or fecal incontinence received biofeedback therapy for 4 weeks. Symptom improvements were evaluated immediately after the completion of biofeedback therapy and during the follow-up period of about 12 to 64 months. Results: Twenty-five patients in the constipation group [mean age of 52.1 years, 16 men (64.0%)] received 6.2 sessions of biofeedback therapy. Improvement of constipation after the completion of biofeedback therapy was as follows: major response (or improvement) in 3 patients (12.0%), fair in 6 (24.0%), minor in 11 (44.0%) and none in 5 (20.0%). Among 9 patients who showed major or fair improvement, 8 patients (88.9%) maintained the symptom improvement through the Long term follow-up periods. Thirty-nine patients in the fecal incontinence group [59.7 years old, 15 men (38.5%)] received 6.8 sessions of biofeedback therapy. Improvement of incontinence after the completion of biofeedback therapy was as follows: major improvement in 6 patients (15.4%), fair in 14 (35.9%), minor in 14 (35.9%), and none in 5 (12.8%). All 11 patients with major or fair improvement maintained the symptom improvement to the end of follow-up periods. Conclusions: Symptom improvements after biofeedback therapy were disappointing in both the constipation and incontinence group. However, when the symptom improvements were classified as major or fair, the improvements continued for at Least a year.(J Neurogastroenterol Motil 2010;16:177-185)
Echocardiogarphic Epicardial Fat Thickness on Long-Term Clinical Outcomes in Patients with STEMI
( So-Hee Lee ),( Jin-Sun Park ),( You-Hong Lee ),( Byoung-Joo Choi ),( So-Yeon Choi ),( Myeong-Ho Yoon ),( Gyo-Seung-Hwang ),( Seung-Jea Tahk ),( Joon-Han Shin ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: Epicardial adipose tissue (EAT) quantification has been demonstrated to correlate with the severity of coronary artery disease (CAD) and the CAD activity. Our previous study demonstrated that EAT thickness was closely related with short term clinical outcomes in patients with significant coronary artery disease. The aim of this study is to assess the relationship of EAT and long term clinical outcomes after percutaneous coronary intervention (PCI) in patients with ST elevation myocardial infarction (STEMI). Methods: We analyzed the data and clinical outcomes of 764 patients (616 males, 57 ± 12 year-old) STEMIpatients who underwent successful primary PCI from 2003 to 2009. Clinical outcome data was obtained and analyzed according to EAT thickness by echocardiography. Clinical outcome was defined as major adverse cardiac event (MACE; all cause of death, recurrent MI, target vessel revascularization). Results: Median and mean EAT of 764 patients were (median 3.3 mm) and 3.5±1.8 mm, respectively. Mean follow up month was 55±28 month. MACE was occurred in 142 patients (19%). Mean EAT was significantly increased in patients with MACE than those without MACE (3.5 ±1.7 vs. 3.9±2.0 mm, p=0.01. For all cause of death, age, killip classification and cerebrovascular disease were predictive. For TVR, age and EAT thickness were predictive variables. For recurrent MI, there was no predictive value. The MACE free survival of patients with thick EAT was significantly worse than patients with thin EAT (log-rank p=0.025). Conclusions: This study demonstrates that the EAT thickness is related with long term clinical outcome in patients with STEMI. The EAT thickness might provide additional information for future clinical outcome, especially TVR.
( So-hee Kim ),( Ho Jun Kim ),( Junghyun Son ),( Byoung Wook Jeon ),( Eun Sook Jeong ),( Eun Ju Cha ),( Jaeick Lee ) 한국질량분석학회 2012 Mass spectrometry letters Vol.3 No.2
After success of sildenafil for the treatment of erectile dysfunction, a large number of its analogues have been approved from FDA. Recently, the illegal dietary supplements which include sildenafil, vardenafil, tadalafil, or analogues of these drugs as ingredient have been widely distributed. Therefore, the determination of the residue of synthetic phosphodiesterase- 5 (PDE-5) inhibitors in dietary supplements is highly required due to indiscriminate and unintentional overdose caused nausea, chest pains, fainting and irregular heartbeat. In this paper, we report a rapid and sensitive analytical method for the simultaneous determination of nine phosphodiesterase-5 inhibitors by liquid chromatography-high resolution mass spectrometry. The present method was found to be accurate and reproducible with 40 μg/g of the limit of quantification for the nine PDE-5 inhibitors. The developed method can be successfully applied to the analysis of the seven illegal dietary supplements.
So Young Park,Min Byoung Chae,Yee Gyung Kwack,Moon Hee Lee,In Ho Kim,Young Soo Kim,Chul Soo Kim 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.3
Shwachman-Diamond syndrome (SDS) is a rare genetic disorder of unknown pathogenesis involving exocrine pancreatic insufficiency and hematological and skeletal abnormalities. About 25% of patients develop hematopoietic malignancies. We report on a case of a
Mycobacterium paraintracellulare sp. nov., for the genotype INT-1 of Mycobacterium intracellulare
Lee, So-Young,Kim, Byoung-Jun,Kim, Hong,Won, Yu-Seop,Jeon, Che Ok,Jeong, Joseph,Lee, Seon Ho,Lim, Ji-Hun,Lee, Seung-Heon,Kim, Chang Ki,Kook, Yoon-Hoh,Kim, Bum-Joon Microbiology Society 2016 International journal of systematic and evolutiona Vol.66 No.-
Huh, So-Young,Min, Ju-Hong,Kim, Woojun,Kim, Su-Hyun,Kim, Ho Jin,Kim, Byung-Jo,Kim, Byoung Joon,Lee, Kwang Ho SAGE Publications 2014 Multiple sclerosis journal: clinical and laborator Vol.20 No.6
<P><B>Background:</B></P><P>Although neuromyelitis optica (NMO) is a central nervous system (CNS) autoimmune disease distinct from multiple sclerosis (MS). NMO and NMO spectrum disorder (NMOSD) sometimes show asymptomatic lesions on brain magnetic resonance imaging (MRI) at onset, and even present with symptomatic brain involvement.</P><P><B>Objectives:</B></P><P>We investigated whether brain MRI at onset can be helpful for the differentiation of MS and NMOSD.</P><P><B>Methods:</B></P><P>We retrospectively analyzed initial brain MRIs, performed within three months of onset, in patients with MS (<I>n</I> = 51) and anti-aquaporin4-antibody-positive patients with NMOSD (<I>n</I> = 67).</P><P><B>Results:</B></P><P>NMOSD patients met the Paty (37%) and Barkhof (13%) criteria, and the criteria of the European Magnetic Imaging in MS (MAGNIMS) study group (9%), for MS. Ovoid lesions perpendicular to the lateral ventricle, isolated juxtacortical lesions in U-fibers and isolated ovoid/round cortical lesions were found only in MS patients, whereas longitudinal corticospinal tract lesions, extensive hemispheric lesions, periependymal lesions surrounding the lateral ventricle and cervicomedullary lesions were found only in NMOSD patients.</P><P><B>Conclusions:</B></P><P>Our study suggests that it is difficult to differentiate MS from NMOSD by the fulfillment of the MRI criteria for MS on brain MRI at onset; however, the characteristic morphology of brain lesions is highly useful for the early differentiation of the two disorders.</P>