만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

DOF (Dissolved Ozone Flotation)를 이용한 부유물질과 총인의 제거와 소득의 동시효과에 관한 연구

이병호,김성혁,이상배,김미정 대한상하수도학회 2004 상하수도학회지 Vol.18 No.2

Effluent of wastewater treatment plant is to be disinfected to protect drinking water sources. DOF (Dissolved Ozone Flotation) was developed to meet this purpose. DOF was developed by combining DAF system with ozone. DAF system has good floating power with numerous microbubbles, and ozone has strong oxidation capability. And DOF system has good floating power and strong oxidation capability simultaneously. When DOF was applied to secondary wastewater effluent, color of 11CU in raw water which was secondary effluent was reduced to 1CU by the DOF system. Removal rate of other water quality parameters treated by DOF were also higher than that by DAF, which were proved the strength of oxidation capability of ozone. When ozone concentration of 3.3㎎/l were applied in DOF system, general aerobic bacteria were reduced to 5CFU/㎖ from TNTC (Too many Numbers To Count). With the same ozone concentration, total coliform were not detected at all. These figures are under the numbers of drinking water regulation. These microbes were the target parameters of DOF. It was proved that DOF was very effective in disinfection of wastewater treatment plant effluent as well as in removal of color, turbidity, and T-P.

공장폐수의 재활용에 관한 연구

이병호,김성혁 울산대학교 2000 공학연구논문집 Vol.31 No.1

본 연구는 공장폐수의 생물학적 처리에서 오존공정을 도입하여 보다 나은 처리효율을 얻고, 기타 공정의 추가 도입으로 최적의 수질을 얻을 수 있는 가능성을 검토하였다. S 공장의 생물학적처리장의 유입 원폐수를 대상시료로 하였으며 실험실내 Lab scale의 실험장치를 설치하였고, 유입수의 농도를 저농도에서 고농도로 점차적으로 미생물에 적응시켰다. 그리고 수질의 처리효율은 COD를 중시으로 분석하였다, 오존공정을 도입하지 않았을 경우 COD는 약 90%의 제거효율을 나타냈고, 오존의 주입농도를 변화시켰을 때 전오존주입농도 200㎎/ℓ에서 COD가 약 96%의 제거효율을 나타냈다. 또한 유입원수의 COD농도가 다양하게 변화하여도 오존공정을 도입함에 따라 처리되는 수질의 COD 는 안정된 값을 나타내었다. COD의 높은 처리효율을 얻기 위해서는 오존의 주입농도는 약 200㎎/ℓ 이상으로 고농도가 요구되며, 오존공정에 과산화수소를 첨가하였을 경우에는 COD의 처리효율이 낮게 나타났다. 오존공정과 함께 DAF(Dissolved Air Flotation) 및 활성탄 칼럼등의 추가도입으로 만족한 수질을 얻을 수 있었다. 본 연구결과가 실제현장에 도입되기 위해서는 각 공장별 발생 원폐수의 성상분석이 필요하고, 프로세스 시스템인 입장에서 개별적 전처리에 대한 경제성 검토가 필요하다. 그러나 공장폐수의 재활용을 위한 공정에서 오존의 도입 가능성은 매우 높았다. This paper investigated effectiveness ofhigh concentrations of ozone in activated sludge process as pretreatment for industrial wastewater. This research used S company wastewater for water reuse by COD reduction. Experiments have been performed in Lab scale. COD removal rate was about 90% without ozone application while about 96% with 200㎎/ℓof ozone. With ozone application effluent CID was very much stable as about 21∼28㎎/ℓ even though influent concentrstions were varied from 250∼550㎎/ℓ. Additional series of DAF(Dissolved Air Flotation) and Activated Carbon process even more improved the quality of effluent. Specific constituents of wastewater need to be analyzed for other industrial wastewater before employing ozone treatment. Economic aspects of ozione process also need to be analyzed.

선인장 양심실 보조장치의 설계 및 임상적용을 위한 평가

민병구,박찬영,최재순,이혁수,황창모,김삼성,윤걸중,김종원,선경,이경갑,정종태,김원곤 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.1

현재 개발되고 있는 맥동형 이식형 인공심장은 완전이식형 인공심장과 좌심실보조장치 뿐이다. 좌심실보조장치를 장착한 환자의 10~15%가 우심실의 보조를 필요로하고 완전이식형 인공심장의 장착을 위해서는 자연심장을 제거해야하는 상황에서 이식형 양심실보조장치에 대한 필요성이 대두되고 있다. 본 연구진은 완전이식형 인공심장으로 개발된 한국형 인공심장을 개선하여 양심 실 보조장치를 개발하였다. 양심실보조장치는 이동형 작동기식 미케니즘을 이용하고 있으며 에너지 변환장치와 감속기로 구성된 작동기와 혈액주머니, 그리고 내장형 제어기로 구성되어 있다. 선인장 펌프로 명명된 KAH350은 캐뉼라의 연결을 위한 커넥터를 포함하여 길이 177mm, 폭 164mm, 높이 67 이고 무게 780g이며 최대 심박출량은 5L/min 이다. 양심실보조장치로 개발된 선인장펌프는 좌심실보조장치로도 응용이 가능하다. 이식적합성과 생체적합성을 평가하기 위하여 좌심실보조장치로 5회, 양싱실보조장치로 6회의 동물실험을 수행하였다. 각각 최장 28일간 생존하였으며 11회의 동물실험중 장치의 결함에 의한 것이 3회 있었는데 이들은 모두 전자장치의 결함과 방수처리문제였다. 현재 이식적합성과 일박출량을 향상시킨 KAH400모델이 개발중이다. The types of pulsatile implantable artificial hearts that are on the way of development and have been developed are totally implantable artificial heart and implantable left ventricular assist device (LVAD). Approximately 10% to 15% of all patients Implanted with wearable VADs have required right heart support with another device. And it is reluctant to patient who should remove his or her own heart to be implanted with total artificial heart. These situations drive the development of implantable bi-ventricular assist device (BVAD). The Korean BVAD was develophed by modifying the moving actuator type Korean artificial heart. This electro-mechanical BVAD comprises actuator including energy converter and reduction gear train, blood sacs, and internal motor and energy controllers. The KAH350 which is named as 'Cactus Pump' is 177mm in length, 164mm in width, and 67mm in thickness including connectors and nuts. The weight and maximum cardiac output of Cactus Pump is 780g and 5L/min, respectively. The Cactus Pump that was developed as BVAD could be used as LVAD by attaching compliance caps on the 2 ports of one ventricle. The animal experiments were undergone 5 times for LVAD, and 6 times for BVAD. The best records were 28 days survival in both applications. There were 3 times of device failure and they were all associated with electrical connection and hermetic sealing. The KAH400 that has improved anatomical fitting characterisitcs and stroke volume is on development.

탄소강의 부식억제제로서 Amine Alcohol의 치환기에 의한 흡착 특성의 영향에 관한 연구

孫太源,閔丙喆,權東赫,金亨培 弘益大學校 科學技術硏究所 1991 科學技術硏究論文集 Vol.1 No.-

The inhibitive effect of monethanolamine, N-methylethanolamine and on carbon steel S.S.41 in the 3.5% NaCl solution has been studied using polarization test method. A significant retardation of corrosion rate was observed in the 3.5% NaCl solution containing the inhibitors. The adsorption characteristic of inhibitor was studied and the adsorption heat(???)was calculated by molecular interaction value f. The results obtained from polarization test method revealed that the efficiency of corrosion inhibition was effected by molecular interactions of adsorption complex on metal surface. Using Frumkin adsorption isotherm, which was most favorable isotherm to the experimental data, molecular interaction of adsorption(f) for MEA, and NMEA on carbon steel surface were calculated to be -8.77, and -8.25 Kcal/mole, respectively. From these results, the heat of adsorption were estimated to be 16.77 and 12.18Kcal/mole, respectively. From the activation energy values, it was known that mechanism of corrosion had been changed by the addition of corrosion inhibitors.

허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

Stable hybrid organic/inorganic multiple-read quantum-dot memory device based on a PVK/QDs solution

Kim, Sae-Wan,Kwon, Jin-Beom,Kim, Na-Ri,Lee, Jae-Sung,Lee, Sang-Won,Kang, Byoung-Ho,Kim, Ju-Seong,Xu, Binrui,Bae, Jin-Hyuk,Kang, Shin-Won Elsevier 2019 APPLIED SURFACE SCIENCE - Vol.481 No.-

<P><B>Abstract</B></P> <P>A thin-film memory device is proposed herein, based on quantum dots (QDs) with bi-stable characteristics under a positive voltage bias. The synthesized QDs had a CdSe/ZnS core/shell structure. The charge confinement effect within the QDs in the charge-storage layer was enhanced by adding (poly(9-vinylcarbazole)) (PVK). As the PVK concentration increases, the on/off ratio of the device increases. Noise was also reduced and stable I-V characteristics were demonstrated. Each thin film was fabricated by a spin-coating method, among solution process methods. The on/off ratio of the fabricated device was found to be maximum 378 × 10<SUP>3</SUP> at 1.5 wt% PVK concentration. The initial on/off state was maintained even when a negative voltage (commonly used for the “erase” function) was applied. In addition, the write voltage of the fabricated device using the conductive polymer poly-TPD was reduced from 2.8 to 1.7 V. By optimizing PVK concentration and forming the poly-TPD thin film, the fabricated memory device had an on/off ratio of about 4 × 10<SUP>3</SUP> at 0.5 V and the stored current maintained the initial value even after 200 h. Even with a single write process, the initially formed high state is maintained for more than 200 h, and it is possible to read repeatedly.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The multiple-read memory device based on quantum dots (QDs) and poly-vinyl carbazole (PVK) blended solutions was developed. </LI> <LI> The optimized concentration of PVK was 1.5 wt%, and then the on/off ratio was 378×10<SUP>3</SUP>, and the write voltage was 2.8 V. </LI> <LI> By using conductive polymer poly-TPD, write voltage can be reduced from 2.8 to 1.7 V. </LI> <LI> The stored current maintained the initial value even after 200 hours. </LI> </UL> </P>

Multicenter Prospective Comparative Study of Robotic Versus Laparoscopic Gastrectomy for Gastric Adenocarcinoma

Kim, Hyoung-Il,Han, Sang-Uk,Yang, Han-Kwang,Kim, Young-Woo,Lee, Hyuk-Joon,Ryu, Keun Won,Park, Joong-Min,An, Ji Yeong,Kim, Min-Chan,Park, Sungsoo,Song, Kyo Young,Oh, Sung Jin,Kong, Seong-Ho,Suh, Byoung Wolters Kluwer Health, Inc. All rights reserved. 2016 Annals of surgery Vol.263 No.1

<P>Objective:To compare short-term surgical outcomes including financial cost of robotic and laparoscopic gastrectomy.Background:Despite a lack of supporting evidence, robotic surgery has been increasingly adopted as a minimally invasive modality for the treatment of gastric cancer because of its assumed technical superiority over conventional laparoscopy.Methods:A prospective, multicenter comparative study was conducted. Patients were matched according to the surgeon, extent of gastric resection, and sex. The primary endpoint was morbidity and mortality. Outcomes were analyzed on an intention-to-treat and per-protocol basis.Results:A total of 434 patients were enrolled for treatment with either robotic (n=223) or laparoscopic (n=211) gastrectomy for intention-to-treat analysis, and a total of 370 patients (n=185 per treatment) were compared in per-protocol analysis. Results were similar between both analyses. In per-protocol analysis, both groups showed similar overall complication rates (robotic=11.9% vs laparoscopic=10.3%) and major complication rates (robotic=1.1% vs laparoscopic=1.1%) with no operative mortality in either group. Patients treated with robotic surgery showed significantly longer operative time (robotic=221 minutes vs laparoscopic=178 minutes; P<0.001) and significantly higher total costs (robotic=US$13,432 vs laparoscopic=US$8090; P<0.001), compared with those who underwent laparoscopic gastrectomy. No significant differences between groups were noted in estimated blood loss, rates of open conversion, diet build-up, or length of hospital stay.Conclusions:The use of robotic systems is assumed to provide a technically superior operative environment for minimally invasive surgery. However, our analysis of perioperative surgical outcomes indicated that robotic gastrectomy is not superior to laparoscopic gastrectomy. Clinical trials identification: NCT01309256.</P>

A description of Mycobacterium chelonae subsp. gwanakae subsp. nov., a rapidly growing mycobacterium with a smooth colony phenotype due to glycopeptidolipids

Kim, Byoung-Jun,Kim, Bo-Ram,Jeong, Joseph,Lim, Ji-Hun,Park, Sang Hyuk,Lee, Seung-Heon,Kim, Chang Ki,Kook, Yoon-Hoh,Kim, Bum-Joon Microbiology Society 2018 International journal of systematic and evolutiona Vol.68 No.12