이온교환체로서 Polyphenylene Sulfide Sulfonic Acid에 관한 연구

전병광,손원근,서구원,맹학영,김동철,송해영 충남대학교 공업교육연구소 1994 論文集 Vol.17 No.1

Sulfonated poly(phenylene sulfide)(S-PPS) was prepared by the reaction of poly(phenylene sulfide)(PPS) with fuming sulfuric acid. The sulfonation was confirmed by the high intensity band of the SO_3H group at 1190 cm^-1. Thermally crosslinked S-PPS was used for a cation exchange polymer with high thermal stability. The ion exchange capacity of soluble S-PPS(H-form) and insoluble S-PPS(H-form) was 5.16meq/g and 3.50meq/g, respectively. The ion exchange capacity and IR absorbance at 1190cm^-1 of S-PPS were decreased as the curing temperature was increased.

한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

A Case of Pleural Paragonimiasis Confused with Tuberculous Pleurisy

( Jun Whi Song ),( Goo Hyeon Hong ),( Jae Uk Song ),( Woo Youl Kim ),( Seo Goo Han ),( You Sang Ko ),( Bok Soon Chang ),( Byeong Ho Jeong ),( Jung Seop Eom ),( Ji Hyun Lee ),( Byung Woo Jhun ),( Kyeon 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.76 No.4

Here, we report a case of pleural paragonimiasis that was confused with tuberculous pleurisy. A 38-year-old man complained of a mild febrile sensation and pleuritic chest pain. Radiologic findings showed right pleural effusion with pleural thickening and subpleural consolidation. Adenosine deaminase (ADA) activity in the pleural effusion was elevated (85.3 IU/L), whereas other examinations for tuberculosis were negative. At this time, the patient started empirical anti-tuberculous treatment. Despite 2 months of treatment, the pleural effusion persisted, and video-assisted thoracoscopic surgery was performed. Finally, the patient was diagnosed with pleural paragonimiasis based on the pathologic findings of chronic granulomatous inflammation containing Paragonimus eggs. This case suggested that pleural paragonimiasis should be considered when pleural effusion and elevated ADA levels are observed.

Prevention of Postendoscopic Retrograde Cholangiopancreatography Pancreatitis: The Endoscopic Technique

Byeong Jun Song,강대환 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.3

Pancreatitis is the most frequent and distressing complication of endoscopic retrograde cholangiopancreatography (ERCP). Many recentstudies have reported the use of pharmacological agents to reduce post-ERCP pancreatitis (PEP); however, the most effective agents havenot been established. Reduction in the incidence of PEP in high-risk patients has been reported through specific cannulation techniquessuch as guide wire-assisted cannulation and the use of pancreatic stents. The present review focuses on ERCP techniques for the preventionof PEP.

Functional Analysis of a Gene Encoding Endoglucanase that Belongs to Glycosyl Hydrolase Family 12 from the Brown-Rot Basidiomycete Fomitopsis palustris

( Byeong Cheol Song ),( Ki Yeon Kim ),( Jeong Jun Yoon ),( Se Hoon Sim ),( Kang Seok Lee ),( Yeong Suk Kim ),( Young Kyoon Kim ),( Chang Jun Cha ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.3

유럽연합의 고등교육 시스템

송병준(byeong jun Song) 숙명여자대학교 글로벌거버넌스연구소 2022 대학 연구 Vol.1 No.1

유럽에서 고등교육정책은 국가주권 영역에 깊숙이 위치하여 회원국의 단일화된 정책과 규제에 대한 거부감으로 인해 유럽연합 차원에서의 일관된 정책 실행이 제약되는 영역이다. 그러나 유럽 대학의 경쟁력 하락에 따른 위기감 고조로 1999년 유럽연합 밖에서 주요 유럽 국가들이 대학의 국제화를 위해 학위 및 자격증 시스템에 대한 상호인증과 조화를 목적으로 한 볼로냐 프로세스를 출범시켰다. 이에 자극받아 유럽연합 역시 2000년대 들어 고등교육 프로그램을 확대하고, 회원국 간 인적교류를 위한 여러 기술적 시스템을 구축하였다. 주목할 점은 유럽 46개국이 참여한 볼로냐 프로세스에는 유럽연합 27개 회원국이 모두 참여하면서 자연스럽게 양측 간 교류와 시스템 융합이 이루어지고 있다는 사실이다. 이 결과 유럽연합에서 고등교육정책의 경우 에라스무스(Erasmus)와 에라스무스 문두스(Erasmus Mundus) 등 대학의 국제화를 위한 프로그램이 확대되고, 유럽학점인증시스템(ECTS) 등 인적교류를 위한 시스템이 활성화되었다. 한편으로 볼로냐 프로세스에서도 역시 학위인증과 고등교육 기관의 질적 평가를 위한 자체 시스템을 구축하거나 유럽연합의 시스템을 차용하였다. 이에 따라 유럽연합의 고등교육정책은 볼로냐 프로세스와 병존하는 구조가 형성되었다. 이에 대학의 경쟁력이 사활적 사안으로 대두되는 한국도 학문 수준이 유사한 유럽연합과의 교류협력을 확대하기 위해 양측 간 양자 사업을 논의하고, 학점과 학위인증 및 교육의 질적 평가 등 고등교육 부분에서 국제적으로 통용되는 시스템 구축이 필요하다. Higher education policy is a policy area that is deeply located in the realm of national sovereignty, and member countries have objection to the unified policy of the European Union. Accordingly, higher education policy at the EU level was very limited. However, the Bologna Process was launched outside the European Union in 1999 to internationalize higher education due to the heightened sense of crisis caused by the decline in competitiveness of European universities. The Bologna Process aimed to establish a European Higher Education Area through mutual recognition and harmonization of degrees and certificates between European universities. European Union was also stimulated by the launch of the Bologna Process in the 2000s, expanding its higher education program and establishing several technical systems for student and faculty exchanges across borders. Specifically, the European Union expanded the Erasmus and Erasmus Mundus programs for the internationalization of universities. At the same time, the European Union actively implemented systems for human exchange, such as the European Credit Transfer and Accumulation System (ECTS). On the other hand, Bologna Process also built its own system such as Bologna Cycle for degree certificate and qualitative evaluation of higher education. The Bologna Process also introduced the European Credit Transfer and Accumulation System, already implemented by the European Union. It is noteworthy that the Bologna Process, which consists of 46 European countries, includes all 27 European Union member states. Accordingly, the European Union’s higher education policy coexists with the Bologna Process, and mutual exchange and system convergence are taking place. In Korea, internationalization of universities is also a major issue, and in order to promote exchanges and cooperation with the European Union, which has a similar academic level, it is necessary to discuss bilateral projects between the two sides. In addition, in order for Korean universities to promote international exchanges, it is necessary to establish a system for unified grades and degree certificates and qualitative evaluation of education among universities.

총담관에 발생한 원발성 점액표피양암종

송병준 ( Byeong Jun Song ),권정희 ( Jung Hee Kwon ),김진주 ( Jin Joo Kim ),이정원 ( Jung Won Lee ),민선영 ( Sun Young Min ),이경분 ( Kyoung Bun Lee ),장진영 ( Jin Young Jang ),류지곤 ( Ji Kon Ryu ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.5

Mucoepidermoid carcinoma of the bile duct is an extremely rare tumor. Seventeen cases originating from intrahepatic bile duct and 2 cases from common hepatic duct have been reported in the English literature. Mucoepidermoid carcinoma arising from the common bile duct has not been previously reported. A 68 year-old man was admitted due to obstructive jaundice. Computed tomography showed a malignant tumor of the common bile duct located in the intrapancreatic segment. Filling defects of the distal common bile duct was seen on endoscopic retrograde cholangiogram. Under the impression of bile duct cancer, pylorus-preserving pancreatoduodenectomy was performed. Histologic diagnosis of the resected specimen was mucoepidermoid carcinoma of the common bile duct. After surgery, the patient received concurrent chemoradiotherapy, and planned to receive additional chemotherapy. We herein report on a first case of primary mucoepidermoid carcinoma of the common bile duct, and review the literature. (Korean J Gastroenterol 2011;57:319-322)

소형제트엔진연료펌프의 무선제어방식을 적용한 임베디드시스템 고안

유규준(Kyu-Jun Yu),권병국(Byeong-Gook Kwon),송기훈(Gi Hun-Song),이준희(Jun-Hee Lee),오윤석(Yoon-Suk Oh),전형준(Hyeong-Jun Jeon) 한국컴퓨터정보학회 2023 한국컴퓨터정보학회 학술발표논문집 Vol.31 No.2

Cell Growth Inhibition and Induction of Apoptosis by Snake Venom Toxin in Ovarian Cancer Cell via Inactivation of Nuclear Factor κB and Signal Transducer and Activator of Transcription 3

Ju Kyoung Song,Jin Tae Hong,Mi Ran Jo,Mi Hee Park,Ho Sueb Song,Byeong Jun An,Min Jong Song,Sang Bae Han 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5

Snake venom toxin from Vipera lebetina turanica induces apoptosis in many cancer cell lines, but there is no study about the apoptotic effect of snake venom toxin on human ovarian cancer cells. In this study, we investigated the apoptotic effect of snake venom toxin in human ovarian cancer PA-1 and SK-OV3 cells. Snake venom toxin dose dependently (0~10 μg/mL) inhibited ovarian cancer cell growth with IC50 values 4.5 μg/mL in PA-1 cells, and 6.5 μg/mL in SKOV3 cells. Our results also showed that apoptotic cell death increased by snake venom toxin in a dose dependent manner (0~10 μg/mL). Consistent with increased cell death, snake venom toxin increased the expression of pro-apoptotic protein Bax and caspase-3, but down-regulated anti-apoptotic protein Bcl-2. Untreated ovarian cancer cells showed a high DNA binding activity of nuclear factor B (NF-κB), but it was inhibited by snake venom toxin accompanied by inhibition of p50 and p65 translocation into the nucleus as well as phosphorylation of inhibitory κB. Snake venom toxin also inhibited DNA binding activity of the signal transducer and activator of transcription 3 (STAT3). Moreover, the combination treatment of NF-κB (salicylic acid, 1 or 5 μM) and STAT3 (stattic, 1 μM) with snake venom toxin (1 μg/mL) further enhanced cell growth inhibitory effects of snake venom toxin. These results showed that snake venom toxin from Vipera lebetina turanica caused apoptotic cell death of ovarian cancer cells through the inhibition of NF-κB and STAT3 signal, and suggested that snake venom toxin may be applicable as an anticancer agent for ovarian cancer.

국내 염증성 장질환 환자들의 헬리코박터 파이로리 감염률에 관한 다기관 공동연구

송민준 ( Min Jun Song ),박동일 ( Dong Il Park ),황상준 ( Sang Jun Hwang ),김은란 ( Eun Ran Kim ),김영호 ( Young Ho Kim ),장병익 ( Byeong Ik Jang ),이석호 ( Suck Ho Lee ),지정선 ( Jeong Seon Ji ),신성재 ( Sung Jae Shin ) 대한소화기학회 2009 대한소화기학회지 Vol.53 No.6

목적: 국외 연구에서 염증성 장질환 환자에서 H. pylori 감염률은 일반인보다 낮다고 한다. 이에 국내 염증성 장질환 환자들에서 H. pylori 감염률을 알아보고, IBD 치료약제나 표현형과 관계가 있는지 조사하였다. 대상 및 방법: 2004년 11월부터 2006년 4월까지 국내 6개 의료기관의 외래를 방문한 169명의 궤양성대장염 환자와 147명의 크론병 환자들을 대상으로 전향 연구를 시행하였다. 염증성 장질환 환자들과 같은 날 상부위장관 및 대장내시경을 포함한 건강검진을 받은 수진자(염증성 장질환이 없는 것으로 확인된) 중 성별과 나이가 일치한 316명을 대조군으로 선정하였다. 결과: 염증성장질환 환자의 H. pylori 감염률은 25.3% (궤양성대장염 32.0%, 크론병 17.7%)로 대조군(52.5%)에 비해 통계적으로 유의하게 낮았다. 염증성 장질환 환자 중 특히 60세 미만, metronidazole이나 ciprofloxacin을 복용한 경우 H. pylori 감염률이 낮았지만, 항생제 복용력이 없는 경우에도 대조군에 비해 H. pylori 감염률이 낮았다. 크론병의 표현형에 따른 H. pylori 감염률의 차이는 없었다. 결론: 국내 염증성 장질환 환자들은 대조군에 비해 H. pylori 감염률이 낮았고 이러한 현상은 특히 60세 미만에서 두드러졌다. Background/Aims: The prevalence of Helicobacter pylori (H. pylori) infection has been reported to be lower in individuals with inflammatory bowel disease (IBD) in some Western countries. We investigated H. pylori infection in Korean patients with IBD and any possible associations of H. pylori infection with drug therapy for IBD and the phenotype of Crohn`s disease (CD). Methods: We studied 316 unselected patients with IBD, including 169 ulcerative colitis (UC) patients and 147 with CD, and the control group consisted of 316 age- and gender-matched healthy people who received a comprehensive medical examination for a regular checkup purpose. Infection rates of H. pylori as detected by the urea breath test were compared between the IBD patients and the controls. Results: A statistically significant difference in H. pylori infection rate was noticed between the IBD patients (25.3%) and the controls (52.5%; p<0.001), and between UC (32.0%) and CD patients (17.7%; p=0.04). Among the IBD patients, the age group of <60 and individuals with a history of taking metronidazole (13.0%; p=0.038) or ciprofloxacin (6.7%; p=0.001) were found to have a meaningfully lower infection rate, but those who did not take antibiotics still showed H. pylori infection rate significantly lower than the controls (CD 22.0% vs. UC 33.8% vs. Control 52.5%, p<0.001). With an exception of age, phenotypic characteristics showed no significant relations with H. pylori infection rate in CD patients. Conclusions: Korean patients with IBD, particularly CD, were found to have a significantly lower H. pylori infection rate than the controls. This association was more evident in those <60 years old, which suggested that H. pylori infection might be deemed to lower possible risks of IBD in younger adults. (Korean J Gastroenterol 2009;53:341-347)