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Bioactive Marine Natural Products
Byeng Wha Son 한국생약학회 1990 생약학회지 Vol.21 No.1
Marine organisms have proven to be rich sources of interesting organic molecules. A great number of compounds with diverse structural features and interesting biological activities have been isolated. Recent studies on secondary metabolites of marine organisms are discussed with a focus on a variety of biological activities and marine natural product literatures are also reviewed.
Byeng Wha Son,Dahai Zhang,Dedi Noviendri,Muhammad Nursid,Xiudong Yang 한국생약학회 2007 Natural Product Sciences Vol.13 No.3
Dioxopiperazine alkaloids, 12R,13S 1), fumitremorgin C (2), andbrevianamide F (3), were isolated from the marine-derived fungus Pseudallescheria, and the absolutestereostructures of compounds 1 -3 were elucidated on the basis of chemical and physicochemical evidence.Compounds 1 -3 showed an antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus,and multidrug-resistant . The MIC (minimum inhibitory concentration) values of compounds 1 -3 were125 g/mL for all strains. Keywords Marine-derived fungus, Pseudallescheria sp., 12,13-dihydroxyfumitremorgin C, fumitremorgin C,brevianamide F, antibacterial activity
Indolyl Alkaloid Derivatives, Nb-Acetyltryptamine and Oxaline from a Marine-Derived Fungus
YongLi,XiFengLi,DongSooKim,HongDaeChoi,ByengWhaSon 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.1
Indolyl alkaloids, Nb-acetyltryptamine (1) and the known oxaline (2) have been isolated from the organic extract of the broth of an unidentified fungus collected from the surface of the marine red alga Gracilaria verrucosa. The structure of Nb-acetyltryptamine (1) was assigned on the basis of comprehensive spectroscopic analyses.