Nâmık Kemal and His Utopian Dream About Freedom

( Timucin Bugra Edman ),( Hacer Gozen ) 한국영어영문학회 2021 영어 영문학 Vol.67 No.2

Born in 1840, Nâmık Kemal left his mark on Turkish and world literature. He was one of the pioneers of the Ottoman Reform era. Due to Nâmık Kemal’s pioneering endeavors and his writings that purported to enlighten the society and expostulate on the political descension occurring during his time under the rule of Abdulaziz, the 32nd Sultan of the Ottoman Empire, Kemal was twice sent into exile. During these exiles, he deepened his knowledge and academic background further, explored new worlds, and wrote Dream. This study deduces how, in contrast to its apparent meaning, Nâmık Kemal’s choice of title for his “utopia” was meant to suggest a sarcastic condition, indeed one that he might have intentionally created while he was ostracized in Famagusta, Cyprus. Nâmık Kemal’s utopia, Dream, consists of a “dream” that he claims to have had while in a mansion overlooking Bosphorus in Istanbul. Dream, in an ironic way, is actually Nâmık Kemal’s collection of thoughts designed to agitate the Ottoman nation. This study subsumes Dream as a euchronia or a homotopical utopia that portrays a better society created in the same place in Istanbul and the Ottoman Empire. The study also reveals how Nâmık Kemal posited the social and local environments in Dream with the intent to influence future political, cultural, and social connotations and reasoning in his contemporary world. Through a comparative study of history and literature, this essay thus propounds how Nâmık Kemal actually intended to “shake” the people to awaken them from their long-lasting irresponsible sleep.

Apium graveolens Extract Inhibits Cell Proliferation and Expression of Vascular Endothelial Growth Factor and Induces Apoptosis in the Human Prostatic Carcinoma Cell Line LNCaP

Tulay Koken,Bugra Koca,Mete Ozkurt,Nilufer Erkasap,Gokhan Kusx,Mustafa Karalar 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.12

Apium graveolens has been shown to inhibit the growth of a variety of cancer tissues. In this study, we investigated the anticancer effect of A. graveolens on the human prostatic carcinoma cell line LNCaP. LNCaP cells were treated with increasing concentrations of an ethanolic extract of A. graveolens ranging from 1000 to 3000 μg/mL, and viability was determined after 24 and 48 h using the XTT cell proliferation assay. The levels of cleaved poly (ADP-ribose) polymerase (PARP), one of the best biomarkers of apoptosis, were analyzed. Finally, quantitative gene expression analysis of vascular endothelial growth factor (VEGF), a critical mediator of angiogenesis, was performed using real-time reverse transcription–polymerase chain reaction. A. graveolens extract inhibited cell viability in both a time- and dose-dependent manner. Data from cleaved PARP assays suggested that A. graveolens caused induction of apoptosis in these cells. Treatment of cells with A. graveolens also resulted in downregulation of VEGF expression. This study showed that the antiproliferative effect exerted by an ethanolic extract of A. graveolens is triggered by induction of apoptosis. We also demonstrated that VEGF expression was downregulated by treatment with A. graveolens extract.

The Effect of Preoperative Three Dimensional Modeling and Simulation on Outcome of Intracranial Aneursym Surgery

Erkin Ozgıray,Bugra Husemoglu,Celal Cınar,Elif Bolat,Nevhis Akınturk,Huseyin Bıceroglu,Ceren Kızmazoglu 대한신경외과학회 2024 Journal of Korean neurosurgical society Vol.67 No.2

Objective : Three-dimensional (3D) printing in vascular surgery is trending and is useful for the visualisation of intracranial aneurysms for both surgeons and trainees. The 3D models give the surgeon time to practice before hand and plan the surgery accordingly. The aim of this study was to examine the effect of preoperative planning with 3D printing models of aneurysms in terms of surgical time and patient outcomes. Methods : Forty patients were prospectively enrolled in this study and divided into two groups : groups I and II. In group I, only the angiograms were studied before surgery. Solid 3D modelling was performed only for group II before the operation and was studied accordingly. All surgeries were performed by the same senior vascular neurosurgeon. Demographic data, surgical data, both preoperative and postoperative modified Rankin scale (mRS) scores, and Glasgow outcome scores (GOS) were evaluated. Results : The average time of surgery was shorter in group II, and the difference was statistically significant between the two groups (p<0.001). However, no major differences were found for the GOS, hospitalisation time, or mRS. Conclusion : This study is the first prospective study of the utility of 3D aneurysm models. We show that 3D models are useful in surgery preparation. In the near future, these models will be used widely to educate trainees and pre-plan surgical options for senior surgeons.

Concrete Properties Containing Fine Aggregate Marble Powder

Kürsat Esat Alyamaç,Alp Bugra Aydin 대한토목학회 2015 KSCE Journal of Civil Engineering Vol.19 No.7

The rapid growth of the marble industry introduces concerns regarding the negative impact of marble quarrying on the environment, because the cutting of marble creates sludge. The incorporation of marble sludge (powder) into concrete and cementbased products would make significant environmental and economic contributions. This study aims to develop a concrete mixture with maximum marble content that has strength properties comparable to that of the non-marble reference concrete (without marble powder), as opposed to developing a marble powder concrete with maximum compressive strength. The main purpose is to replace sand with marble powder in concrete because such a mixture will be environmentally friendly and economically feasible. The concrete samples are produced by replacing sand with marble powder at 10%, 20%, 30%, 40%, 50% and 90% by volume. The compressive strength values are determined after 7, 28 and 90 days with splitting tensile strength values at 28-th day including water absorption and abrasion resistance values. A feasibility evaluation is performed using parameters such as fresh concrete, compressive strength, sorptivity, abrasion resistance, and estimated cost. Based on the feasibility evaluation it is shown that using up to 40% marble powder in concrete is suitable in accordance with the requirements.

Highly durable spray-coated superhydrophobic surface: Pre-anodizing and fatty acid chain length effect

Aras Omur,Enver Baydir,Bugra Akman 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.3

In the study, aluminum plates were first anodized and then coated with ZnO by spray-pyrolysis method. By modification with long chain fatty acid, these surfaces demonstrate superior hydrophobicity and durability. After optimizing the anodizing time for each fatty acid, several runs were conducted by varying concentration and spray solution quantity. Comparison was made by optimizing the process parameters in which each acid showed maximum hydrophobicity. Anodized, spray coated and modified surfaces were characterized by FT-IR, XRD, SEM and topography analysis. The chemical and mechanical strength of the surfaces were explored under various extreme conditions. The highest contact angle of 164o was obtained by coating 10 minutes anodized surface with 0.4M and 15 ml ZnNO3 solution and modifying it with stearic acid. In the performed tests, it has been observed that this surface is much more durable than surfaces modified with other fatty acids.

Three-Dimensional Printing Assisted Preoperative Surgical Planning for Cerebral Arteriovenous Malformation

Uzunoglu, Inan,Kizmazoglu, Ceren,Husemoglu, Resit Bugra,Gurkan, Gokhan,Uzunoglu, Cansu,Atar, Murat,Cakir, Volkan,Aydin, Hasan Emre,Sayin, Murat,Yuceer, Nurullah The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.6

Objective : The aim of this study to investigate the benefits of patient-based 3-dimensional (3D) cerebral arteriovenous malformation (AVM) models for preoperative surgical planning and education. Methods : Fifteen patients were operated on for AVMs between 2015 and 2019 with patient-based 3D models. Ten patients' preoperative cranial angiogram screenings were evaluated preoperatively or perioperatively via patient-based 3D models. Two patients needed emergent surgical intervention; their models were solely designed based on their AVMs and used during the operation. However, the other patients who underwent elective surgery had the modeling starting from the skull base. These models were used both preoperatively and perioperatively. The benefits of patients arising from treatment with these models were evaluated via patient files and radiological data. Results : Fifteen patients (10 males and five females) between 16 and 66 years underwent surgery. The mean age of the patients was 40.0±14.72. The most frequent symptom patients observed were headaches. Four patients had intracranial bleeding; the symptom of admission was a loss of consciousness. Two patients (13.3%) belonged to Spetzler-Martin (SM) grade I, four (26.7%) belonged to SM grade II, eight (53.3%) belonged to SM grade III, and one (6.7%) belonged to SM grade IV. The mean operation duration was 3.44±0.47 hours. Three patients (20%) developed transient neurologic deficits postoperatively, whereas three other patients died (20%). Conclusion : Several technological innovations have emerged in recent years to reduce undesired outcomes and support the surgical team. For example, 3D models have been employed in various surgical procedures in the last decade. The routine usage of patient-based 3D models will not only support better surgical planning and practice, but it will also be useful in educating assistants and explaining the situation to the patient as well.

PPAR-Gamma Pro12Ala Polymorphism and Gastric Cancer Risk in a Turkish Population

Canbay, Emel,Kurnaz, Ozlem,Canbay, Bahar,Bugra, Dursun,Cakmakoglu, Bedia,Bulut, Turker,Yamaner, Sumer,Sokucu, Necmettin,Buyukuncu, Yilmaz,Yilmaz-Aydogan, Hulya Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Background: Peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$) is a ligand dependent transcription factor involved in various processes, including carcinogenesis. We aimed to investigate any possible association of the $PPAR{\gamma}$ Pro12Ala (rs1801282) polymorphism with risk of developing gastric cancer (GC). Patients and Methods: A hospital based case control study was designed covering 50 patients with GC and 120 healthy controls. The frequencies of $PPAR{\gamma}$ Pro12Ala (rs1801282) were determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results: The Ala12 allele of the $PPAR{\gamma}$ Pro12Ala G gene was associated with a 1.95 fold increased risk of GC development (p: 0.022; 95% CI: 1.58-2.40). Subgroup analyses showed that the same allele was also associated with metastasis (p: 0.000; OR:4.09; 95%CI:2.273-7.368) and differentiation (p: 0.004; OR:1.95; 95%CI:1.335-2.875) in patients with GC. Conclusion: This study suggests that the $PPAR{\gamma}$ Pro12Ala G (Ala12) allele might be associated with development, differentiation and metastatic process of GC in the Turkish population. Further studies conducted in larger study groups and in different ethnic populations will be needed to clarify the exact role of the $PPAR{\gamma}$ Pro12Ala polymorphism in GC.

Asymptomatic Accessory Mitral Valve Tissue Diagnosed by Echocardiography

Onur Kadir Uysal,Mustafa Duran,Bugra Ozkan,Kamuran Tekin,Zafer Elbasan 대한심장학회 2012 Korean Circulation Journal Vol.42 No.11

Is platelet-rich plasma improves the anastomotic healing in hyperthermic intraperitoneal chemotherapy with oxaliplatin: an experimental rat study

Omer Faruk Buk,Sonmez Ocak,Bugra Genc,Bahattin Avcı,Hatice Olger Uzuner 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.98 No.2

Purpose: Hyperthermic intraperitoneal chemotherapy (HIPEC) is a novel treatment option for peritoneal surface malignancies. Due to cytotoxic effects of chemotherapeutic agents, anastomosis healing can be impaired and lead to leakage rates higher than conventional intestinal surgery. In this experimental study, we aimed to investigate the effects of platelet-rich plasma (PRP) on colonic anastomosis in rats that received HIPEC with oxaliplatin. Methods: Thirty rats were divided into 3 groups. Group 1 was determined as control group and hyperthermic saline perfusion was performed after colon anastomosis. In group 2, colon anastomosis then hyperthermic oxaliplatin perfusion was performed. In the last group, the colonic anastomosis was enhanced by PRP gel and then hyperthermic oxaliplatin perfusion was performed. All the rats were reoperated on postoperative day 7 and anastomotic bursting pressure values were recorded. Tissue samples were taken for hydroxyproline assay and histopathological examination. Results: Control group had higher anastomotic bursting pressure value than group 2 and group 3 (P < 0.001). There were significant differences in anastomotic bursting pressure between groups 2 and 3 (P < 0.001). Group 2 had significantly lower hydroxyproline levels than group 3 and control group (P < 0.001). Histopathological examination revealed that PRP application reduced inflammatory response. Conclusion: PRP application on colonic anastomosis improves anastomotic healing and can reduce anastomosis related complications and stoma creation; though further clinical studies are needed.

Utility of Peripheral Blood Parameters in Predicting Breast Cancer Risk

Okuturlar, Yildiz,Gunaldi, Meral,Tiken, Elif Eda,Oztosun, Bugra,Inan, Yesim Ozdem,Ercan, Tarik,Tuna, Savas,Kaya, Ali Osman,Harmankaya, Ozlem,Kumbasar, Abdulbaki Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Purpose: We aimed to study the inflammatory parameters of complete blood count in breast cancer cases. Materials and Methods: This retrospective study covered 178 breast cancer patients and 107 age and body mass index matched healthy women. Complete blood count parameters, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and MPV/platelet were analyzed. Results: The leukocyte, neutrophil and neutrophil/lymphocyte ratio were higher in the patient group (p values 0.001, 0.0001 and 0.0001, respectively) while haemoglobin and hematocrit were higher in the control group (p=0.0001 for both). Logistic regression analysis showed that elevated neutrophils and platelet distribution width (PDW) (OR: 0.627, 95%CI: 0.508-0.774, p=0.001 and OR: 1.191 95%CI: 1.057-1.342 p=0.003) were independent variables for predicting breast cancer. The cut-off value for the neutrophil/lymphocyte ratio was 2.56. Conclusions: According to our study results, neutrophil levels as part of complete blood count may be used as an independent predictor of breast cancer risk.