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Kim Min Jung,Ryu Borim,Park Eun-Gee,Yi Siyeon,Kim Kwangsoo,Park Jun Won,Shin Kichul 대한의학회 2024 Journal of Korean medical science Vol.39 No.4
This retrospective cohort study aimed to compare coronavirus disease 2019 (COVID-19)- related clinical outcomes between patients with and without gout. Electronic health recordbased data from two centers (Seoul National University Hospital [SNUH] and Boramae Medical Center [BMC]), from January 2021 to April 2022, were mapped to a common data model. Patients with and without gout were matched using a large-scale propensityscore algorithm based on population-level estimation methods. At the SNUH, the risk for COVID-19 diagnosis was not significantly different between patients with and without gout (hazard ratio [HR], 1.07; 95% confidence interval [CI], 0.59–1.84). Within 30 days after COVID-19 diagnosis, no significant difference was observed in terms of hospitalization (HR, 0.57; 95% CI, 0.03–3.90), severe outcomes (HR, 2.90; 95% CI, 0.54–13.71), or mortality (HR, 1.35; 95% CI, 0.06–16.24). Similar results were obtained from the BMC database, suggesting that gout does not increase the risk for COVID-19 diagnosis or severe outcomes.
Kim, Eunbi,Na, Sunghun,An, Borim,Yang, Se-Ran,Kim, Woo Jin,Ha, Kwon-Soo,Han, Eun-Taek,Park, Won Sun,Lee, Chang-Min,Lee, Ji Yoon,Lee, Seung-Joon,Hong, Seok-Ho The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.2
Understanding the crosstalk mechanisms between perivascular cells (PVCs) and cancer cells might be beneficial in preventing cancer development and metastasis. In this study, we investigated the paracrine influence of PVCs derived from human umbilical cords on the proliferation of lung adenocarcinoma epithelial cells (A549) and erythroleukemia cells (TF-$1{\alpha}$ and K562) in vitro using $Transwell^{(R)}$ co-culture systems. PVCs promoted the proliferation of A549 cells without inducing morphological changes, but had no effect on the proliferation of TF-$1{\alpha}$ and K562 cells. To identify the factors secreted from PVCs, conditioned media harvested from PVC cultures were analyzed by antibody arrays. We identified a set of cytokines, including persephin (PSPN), a neurotrophic factor, and a key regulator of oral squamous cell carcinoma progression. Supplementation with PSPN significantly increased the proliferation of A549 cells. These results suggested that PVCs produced a differential effect on the proliferation of cancer cells in a cell-type dependent manner. Further, secretome analyses of PVCs and the elucidation of the molecular mechanisms could facilitate the discovery of therapeutic target(s) for lung cancer.
Ryu, Borim,Kim, Nari,Heo, Eunyoung,Yoo, Sooyoung,Lee, Keehyuck,Hwang, Hee,Kim, Jeong-Whun,Kim, Yoojung,Lee, Joongseek,Jung, Se Young JMIR Publications 2017 Journal of medical Internet research Vol.19 No.12
<P><B>Background</B></P><P>Personal health record (PHR)–based health care management systems can improve patient engagement and data-driven medical diagnosis in a clinical setting.</P><P><B>Objective</B></P><P>The purpose of this study was (1) to demonstrate the development of an electronic health record (EHR)–tethered PHR app named MyHealthKeeper, which can retrieve data from a wearable device and deliver these data to a hospital EHR system, and (2) to study the effectiveness of a PHR data-driven clinical intervention with clinical trial results.</P><P><B>Methods</B></P><P>To improve the conventional EHR-tethered PHR, we ascertained clinicians’ unmet needs regarding PHR functionality and the data frequently used in the field through a cocreation workshop. We incorporated the requirements into the system design and architecture of the MyHealthKeeper PHR module. We constructed the app and validated the effectiveness of the PHR module by conducting a 4-week clinical trial. We used a commercially available activity tracker (Misfit) to collect individual physical activity data, and developed the MyHealthKeeper mobile phone app to record participants’ patterns of daily food intake and activity logs. We randomly assigned 80 participants to either the PHR-based intervention group (n=51) or the control group (n=29). All of the study participants completed a paper-based survey, a laboratory test, a physical examination, and an opinion interview. During the 4-week study period, we collected health-related mobile data, and study participants visited the outpatient clinic twice and received PHR-based clinical diagnosis and recommendations.</P><P><B>Results</B></P><P>A total of 68 participants (44 in the intervention group and 24 in the control group) completed the study. The PHR intervention group showed significantly higher weight loss than the control group (mean 1.4 kg, 95% CI 0.9-1.9; <I>P</I><.001) at the final week (week 4). In addition, triglyceride levels were significantly lower by the end of the study period (mean 2.59 mmol/L, 95% CI 17.6-75.8; <I>P</I>=.002).</P><P><B>Conclusions</B></P><P>We developed an innovative EHR-tethered PHR system that allowed clinicians and patients to share lifelog data. This study shows the effectiveness of a patient-managed and clinician-guided health tracker system and its potential to improve patient clinical profiles.</P><P><B>Trial Registration</B></P><P>ClinicalTrials.gov NCT03200119; https://clinicaltrials.gov/ct2/show/NCT03200119 (Archived by WebCite at http://www.webcitation.org/6v01HaCdd)</P>
김연수(Kim, Yonsoo),이보림(Lee, Borim),김태균(Kim, Taegyun) 한국방재학회 2019 한국방재학회논문집 Vol.19 No.7
태풍피해는 호우로 인한 홍수, 강풍, 풍랑 등 3가지 피해가 동시에 발생하는 재해로, 지난 10년간 피해액 기준으로 가장 큰 피해를 일으켰다. 본 연구에서는 전국 229개 시군구를 대상으로 1994년 이후 발생한 태풍피해자료를 이용하여 태풍위험지수(TRI)를 개발하였다. 태풍위험지수는 PSR 구조체계를 이용하여 시군구별로 개발하였다. 압력지수(PI)는 수문기상, 지역특성, 사회경제적 지표 등 10개 지표를, 상태지수(SI)는 피해 관련 3개 지표를, 대책지수(RI)는 재정상태, 방재관련 사업, 시설 등 6개 지표를 이용하였다. 지수산정을 위한 각 지표의 가중치는 엔트로피 방법을 이용하였다. 압력지수는 수도권과 남해안 지역이 높게 나타났고, 상태지수는 남해안과 동해안 지역이 높게 나타났으나, 대책지수는 지역적 경향성을 찾기 어려웠다. 태풍위험지수는 남해안과 동해안 및 지리산, 덕유산 인근 지역이 높게 나타났으며, 이는 태풍피해 다발지역과 일치하는 것을 알 수 있다. 개발된 태풍위험지수는 태풍에 위한 피해를 감소하기 위한 대비와 방재 관련 사업의 우선순위를 결정하는데 이용될 수 있을 것이다. Typhoon cause damage through simultaneous flooding, strong winds, and storms; they have been one of the most damaging disasters of the last decade. In this study, we develop a typhoon risk index (TRI) based on records of typhoon damage that occurred in 229 municipalities across South Korea since 1994. The TRI employs a pressure-state-response (PSR) framework system. For the pressure index (PI), we use ten indicators that represent hydro-meteorological, regional, and socio-economic characteristics. The state index (SI) includes three indicators related to typhoons and the response index (RI) comprises six indicators including financial status and disaster mitigation-related projects and facilities. The weighting of each indicator for the TRI was calculated using an entropy method. The PIs are higher in the Seoul metropolitan and southern coast areas of the Korean peninsula. The SIs are higher for the southern and eastern coastal areas. It is not easy to determine a regional trend for the RIs. The TRI is higher for the southern and eastern coasts and the Jirisan and Deogyusan areas. These regions are consistent with the areas where typhoons have frequently caused damage. The TRI developed in this research will contribute to decision-making about the priority of disaster prevention projects to mitigate typhoon damage.
Eunbi Kim,Sunghun Na,Borim An,Se-Ran Yang,Woo Jin Kim,Kwon-Soo Ha,Eun-Taek Han,Won Sun Park,Chang-Min Lee,Ji Yoon Lee,Seung-Joon Lee,Seok-Ho Hong 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.2
Understanding the crosstalk mechanisms between perivascular cells (PVCs) and cancer cells might be beneficial in preventing cancer development and metastasis. In this study, we investigated the paracrine influence of PVCs derived from human umbilical cords on the proliferation of lung adenocarcinoma epithelial cells (A549) and erythroleukemia cells (TF-1α and K562)<i> in vitro</i> using Transwell<sup>Ⓡ</sup> co-culture systems. PVCs promoted the proliferation of A549 cells without inducing morphological changes, but had no effect on the proliferation of TF-1α and K562 cells. To identify the factors secreted from PVCs, conditioned media harvested from PVC cultures were analyzed by antibody arrays. We identified a set of cytokines, including persephin (PSPN), a neurotrophic factor, and a key regulator of oral squamous cell carcinoma progression. Supplementation with PSPN significantly increased the proliferation of A549 cells. These results suggested that PVCs produced a differential effect on the proliferation of cancer cells in a cell-type dependent manner. Further, secretome analyses of PVCs and the elucidation of the molecular mechanisms could facilitate the discovery of therapeutic target(s) for lung cancer.