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Seok-Hwan Choi,Se-Yeong Kim,Man-Ki Son,Hui-Seok Yang,Sun-Woo Lee,Jung-Il Kim,Kap-Yeol Jung 대한직업환경의학회 2013 대한직업환경의학회지 Vol.25 No.-
Background: We report a case of a spray painter who developed malignant fibrous histiocytoma (MFH) of the maxillary sinus following long-term exposure to chromium, nickel, and formaldehyde, implying that these agents are probable causal agents of MFH. Case report: The patient developed right-sided prosopalgia that began twenty months ago. The symptom persisted despite medical treatment. After two months, he was diagnosed with MFH through imaging studies, surgery, and pathological microscopic findings at a university hospital in Seoul. His social, medical, and family history was unremarkable. The patient had worked for about 18 years at an automobile repair shop as a spray painter. During this period, he had been exposed to various occupational agents, such as hexavalent chromium, nickel, and formaldehyde, without appropriate personal protective equipment. He painted 6 days a week and worked for about 8 hours a day. Investigation of the patient’s work environment detected hexavalent chromium, chromate, nickel, and formaldehyde. Conclusions: The study revealed that the patient had been exposed to hexavalent chromium, formaldehyde, and nickel compounds through sanding and spray painting. The association between paranasal cancer and exposure to the aforementioned occupational human carcinogens has been established. We suggest, in this case, the possibility that the paint spraying acted as a causal agent for paranasal cancer.
Detection of L-Xylosone and its Physiological Effects in Saccharomyces cerevisiae
Seok, Yeong-Jae,Yang, Kap-Seok,Kang, Ju-Gyeong,Kim, Seong-Tae,Huh, Won-Ki,Kang, Sa-Ouk The Microbiological Society of Korea 1996 The journal of microbiology Vol.34 No.2
L-Xylosone was detected as its quinoxaline derivative in the degradation solution of dehydro-L-ascorbic acid. The production rate of L-xylosone was much faster in aerated phosphate-cirate buffer (pH 5. 6) than in pure water. L-Xylosone and dehydro-L-ascorbic acid were identified in the crude extracts of Saccharomyces cerevisiae. The concentration of L-xylosone in the crude cell extracts was calculated to be about 0.2 nmol $(mg protein)^{-1}$. When L-xylosone was added to asynchronous culture of S. cerevisiae, it inhibited primarily the synthesis of protein and RNA. Examination of the effect of L- xylosone on synchronous culture of the yeast indicated that L-xylosone inhibited the initiation of DNA replication and that the cells were arrested at $G_1$, stage of cell division cycle. These results suggested a possibility that L-xylosone can act as an inhibitor of cell growth.
A Case of Complicated Silicosis with a Complex Clinical Course in a Glass Manufacturing Worker
Hee-Seok Yang,Jung-Il Kim,Byeong-Jin Ye,Tae-Jun Yoo,Sun-Woo Lee,Kap-Yeol Jung 대한직업환경의학회 2014 대한직업환경의학회지 Vol.26 No.-
We reported a case of complicated silicosis that occurred in a glass manufacturing plant worker who had presumably been exposed to low-concentration free silica for almost 20 years. To the best of our knowledge this report is the first in the Republic of Korea. The physician’s first impression was cancer since the enlargement of neck and supraclavicuar lymph nodes had clearly progressed and metastasis was suspected in ultrasonography. However, it turned out to be reactive hyperplasia and anthracosis. Although lung cancer was suspected and tests were performed in 2 hospitals due to repetitive cough and dyspnea, along with weight loss of approximately 10% over the course of 7 months, the patient was eventually diagnosed with complicated silicosis and pneumothorax occurred after 1 year. Herein, we report this case with a literature review.
단보 : 고농도 CO2노출에 의한 Aspergillus nidulans의 유성생식 촉진효과
한갑훈 ( Kap Hoon Han ),양영석 ( Yeong Seok Yang ),김종화 ( Jong Hwa Kim ) 한국균학회 2013 韓國菌學會誌 Vol.41 No.3
진균의 분화과정은 다양한 환경요인에 의하여 영향을 받는다. 모델 사상성 진균인 Aspergillus nidulans의 경우 빛이 존재하거나 높은 염 농도, 비 발효성 당에 의하여 무성분화가 촉진되며 반대로 빛이 없거나 발효성 당이 풍부할 때, 그리고 저산소 조건일 경우 유성분화를 촉진하게 된다. 또한 veA나 nsdD와 같은 유성생식 양성조절유전자들도 유성분화를 유도하는 것으로 알려져 있다. 본 연구에서는 A. nidulans에서 CO2의 농도와 분화패턴의 관계를 알아보고자 하였다. 정상적인 조건에서 veA+야생형 균주은 유성생식과 무성생식이 균형을 이룬 상태의 분화를 진행하게 된다. 그러나 5% 정도의 높은 CO2조건에서 배양하였을 경우 무성분화는 일어나지 않고 유성생식으로만 분화과정이 일어나게 된다. 뿐만 아니라 이러한 분화 양상은 veA와 nsdD에 의존적으로 일어나게 된다. 고농도의 CO2 조건이라 할지라도 veA-혹은 nsdD- 돌연변이 균주에서는 유성분화는 일어나지 않고 무성분화만이 일어나는 것을 관찰할 수 있었는데, 이는 CO2 농도가 높아져도 유성생식에 있어서 이들 유전자의 기능이 필요하다는 것을 시사한다. 또한 5% CO2조건은 인간 병원성 진균에게 있어서 사람의 신체 내에 살아남기 위하여 적응하여야 하는 대기 조건으로, 이러한 A nidulans의 CO2농도에 따른 분화양상의 변화는 A. fumigatus와 같은 인간 병원균의 생리, 분화적 변화에 대한 비교분석에 사용될 수 있다. Fungal development is largely affected by many environmental factors. In a model filamentous fungus Aspergillus nidulans, asexual development is promoted by exposure of light, presence of salt and non-fermentable sugars. In other hand, sexual development is largely induced by absence of light, fermentable sugars and hypoxic condition. Also, some important genes including veA and nsdD play positive roles in activating sexual development. Here, we reported that the effect of high concentration of CO2 on developmental decision in A. nidulans. When wild-type veA + strain was cultured in normal condition, sexual and asexual development occurred in balanced manner. However, high concentration of CO2 (~5%) strongly activated sexual development and inhibited asexual development. Furthermore, this CO2 effect was controlled by the veA(-) or nsdD(-) gene. High CO2 culture of veA or nsdD mutant didn`t activate sexual development, suggesting that the activation of sexual development induced by high CO2 cannot overcome the genetic requirement of sexual development such as veA(-) or nsdD(-). Since 5% CO2 is an important condition for human pathogenic fungi for surviving and adapting in human body, this developmental pattern of A. nidulans affected by CO2 concentration may provide interesting clues for comparative study with human fungal pathogens including Aspergillus fumigatus.