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Park, Sung Wook,Kim, Jin Hyoung,Kim, Ko-Eun,Jeong, Moon Hee,Park, Hyunsung,Park, Bongju,Suh, Young-Ger,Park, Woo Jin,Kim, Jeong Hun BlackWell Publishing Ltd 2014 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol.18 No.5
<P>Retinal neovascularization in retinopathy of prematurity (ROP) is the most common cause of blindness for children. Despite evidence that hypoxia inducible factor (HIF)-1α -VEGF axis is associated with the pathogenesis of ROP, the inhibitors of HIF-1α have not been established as a therapeutic target in the control of ROP pathophysiology. We investigated the hypothesis that degradation of HIF-1α as a master regulator of angiogenesis in hypoxic condition, using β-lapachone, would confer protection against hypoxia-induced retinopathy without affecting physiological vascular development in mice with oxygen-induced retinopathy (OIR), an animal model of ROP. The effects of β-lapachone were examined after intraocular injection in mice with OIR. Intraocular administration of β-lapachone resulted in significant reduction in hypoxia-induced retinal neovascularization without retinal toxicity or perturbation of developmental retinal angiogenesis. Our results demonstrate that HIF-1α–mediated VEGF expression in OIR is associated with pathological neovascularization, not physiological angiogenesis. Thus, strategies blocking HIF-1α in the developing eye in the pathological hypoxia could serve as a novel therapeutic target for ROP.</P>
도시공원을 활용한 산림치유프로그램이 고령노인의 우울과 기억감퇴에 미치는 영향 -곤지암 도자공원을 사례로
이은진 ( Eunjin Lee ),박봉주 ( Bongju Park ),왕금옥 ( Geumok Wang ),이현홍 ( Hyunhong Lee ) 사단법인 아시아문화학술원 2020 인문사회 21 Vol.11 No.6
본 연구는 생활권내 도시공원을 활용한 산림치유프로그램이 고령노인의 우울과 주관적 기억감퇴에 미치는 영향을 알아보고자 하였다. 연구대상자는 경기도 K시에 거주중인 75세 이상의 여성 고령노인 10명이었으며 주1회 2시간씩 총 7회의 산림치유 프로그램을 실시하였다. 본 프로그램의 효과를 검증하기 위해 단축형 노인우울 척도(GDSSF-K)와 주관적 기억감퇴 설문지(SMCQ)를 프로그램 전후에 평가하였다. 자료 분석에는 SPSS ver 18.0을 사용하였으며 Shapiro-Wilk test로 정규성을, Wilcoxon signed rank test로 통계검증을 실시하였다. 분석결과 도시공원에서 산림치유프로그램이 고령노인의 우울 완화에 긍정적인 효과가 있음을 확인했다. 이는 지역사회 노인을 위한 복지 서비스에 유용하게 이용될 수 있을 것으로 사료된다. The purpose of study was to find out the effects of forest healing programs using urban parks in the living area on depression and subjective memory loss in older old people. The subjects of this study were 10 elderly women aged 75 or older living in K city, Gyeonggi-do, and a total of seven times forest healing programs were conducted once a week for two hours. In order to verify the effectiveness of this program, the Geriartric Depress Scale Short Form-Korea Version (GDSSF-K) and the Subjective Memory Complaints Questionnaire (SMCQ) were used to evaluate before and after the program. SPSS ver 18.0 was used for data analysis, normality was performed with the Shapiro-Wilk test, and statistical verification was performed with the Wilcoxon signed rank test. Forest healing programs at urban parks in the living area have been confirmed to have a positive effect on depression relief for older old people. It is thought that this can be usefully used for welfare services for the elderly in the community.
Hypoxia-inducible Factor-2α-dependent Hypoxic Induction of Wnt10b Expression in Adipogenic Cells
Park, Young-Kwon,Park, Bongju,Lee, Seongyeol,Choi, Kang,Moon, Yunwon,Park, Hyunsung American Society for Biochemistry and Molecular Bi 2013 The Journal of biological chemistry Vol.288 No.36
<P>Adipocyte hyperplasia and hypertrophy in obesity can lead to many changes in adipose tissue, such as hypoxia, metabolic dysregulation, and enhanced secretion of cytokines. In this study, hypoxia increased the expression of Wnt10b in both human and mouse adipogenic cells, but not in hypoxia-inducible factor (HIF)-2α-deficient adipogenic cells. Chromatin immunoprecipitation analysis revealed that HIF-2α, but not HIF-1α, bound to the <I>Wnt10b</I> enhancer region as well as upstream of the <I>Wnt1</I> gene, which is encoded by an antisense strand of the <I>Wnt10b</I> gene. Hypoxia-conditioned medium (H-CM) induced phosphorylation of lipoprotein-receptor-related protein 6 as well as β-catenin-dependent gene expression in normoxic cells, which suggests that H-CM contains canonical Wnt signals. Furthermore, adipogenesis of both human mesenchymal stem cells and mouse preadipocytes was inhibited by H-CM even under normoxic conditions. These results suggest that O<SUB>2</SUB> concentration gradients influence the formation of Wnt ligand gradients, which are involved in the regulation of pluripotency, cell proliferation, and cell differentiation.</P>
New ethanol extraction improves the anti-obesity effects of black tea
Bongju Park,박현성,Sang-Jin Lee,Bonggyeong Lee,Ingyum Kim,Namjoon Baek,Tae Ho Lee,이석용,Miwon Son 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.3
Black tea has been reported to have anti-obesity effects in both rodents and humans. Gallic acid, an active component of black tea, decomposes quickly into pyrogallol in high-temperature solutions. This study introduced a new, aqueous ethanol extraction of black tea, which resulted in extracts with higher concentrations of gallic acid than conventional black tea extracts prepared by hot-water extraction or hot-ethanol extraction. We confirmed that, compared with the hot-water extract of black tea, the cold-ethanol extract of black tea (CE-BTE) had greater effects on reducing body weight and body fat, improving fatty liver, regulating blood glucose, and reducing blood cholesterol in the high-fat diet-induced obese mouse model. Nonetheless, although CE-BTE significantly reduced fat content, it did not reduce peroxisome proliferator-activated receptor (PPARc) protein in epididymal fat tissue of HFD mice. We also showed that CEBTE did not inhibit the function of PPARc protein to drive adipogenesis of mouse 3T3-L1 preadipocytes. Considering that PPARc is a master transcription factor not only for adipocyte differentiation, but also for adipose tissue function, such as glucose and lipid metabolism and insulin sensitivity, these results suggest that CE-BTE reduced fat mass and body weight without dampening fat cell homeostasis and insulin sensitivity.
Online Learning Control of Hydraulic Excavators Based on Echo-State Networks
Park, Jaemann,Lee, Bongju,Kang, Seonhyeok,Kim, Pan Young,Kim, H. Jin IEEE 2017 IEEE transactions on automation science and engine Vol.14 No.1
<P>Note to Practitioners-Motivated by the fact that obtaining useful mathematical models of hydraulic excavators may be impractical or too costly, this paper proposes an online learning control technique for the position control of hydraulic excavators. The proposed control technique uses remote control valve (RCV) signals and measurements of the joint angles to learn the dynamics of the excavator in an online manner, and the RCV inputs required to track the desired trajectory are generated simultaneously. As a result of online learning, the controller compensates for the changes in the plant dynamics over time, caused by factors, such as fluid temperature change or component wear. In this paper, we have implemented and validated the proposed controller on a 21-ton class hydraulic excavator. The proposed online learning control framework can also be applied to a wide range of control applications, where a mathematical model of the plant is absent or impractical to obtain.</P>
Jaemann Park,Bongju Lee,H. Jin Kim 한국산업응용수학회 2013 한국산업응용수학회 학술대회 논문집 Vol.8 No.1
Control of nonlinear systems require some explicit representation of the nominal plant dynamics. However, for highly complex systems obtaining such mathematical form may not be possible. In these situations, researchers have applied online learning techniques in order to achieve the control objective. Echo state networks (ESN), that are a class of recurrent neural networks, have provided promising results in this online learning area. However, the online learning of ESNs has been restricted to using recursive least squares (RLS) which has its own drawbacks such as numerical instability due to round-off errors, slow tracking capability for time-varying parameters, and high sensitivity to initial conditions of the algorithm. In this work, we investigate various algorithms that can be used for the online training of ESNs. The algorithms are evaluated numerically based on the tracking performance for a given reference trajectory and their computational complexity.
BMB Reports : Hypoxic repression of CYP7A1 through a HIF-1α-and SHP-independent mechanism
( Yunwon Moon ),( Bongju Park ),( Hyunsung Park ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.3
Liver cells experience hypoxic stress when drug-metabolizing enzymes excessively consume O2 for hydroxylation. Hypoxic stress changes the transcription of several genes by activating a heterodimeric transcription factor called hypoxia-inducible factor- 1α/β (HIF-1α/β). We found that hypoxic stress (0.1% O2) decreased the expression of cytochrome P450 7A1 (CYP7A1), a rate-limiting enzyme involved in bile acid biosynthesis. Chenodeoxycholic acid (CDCA), a major component of bile acids, represses CYP7A1 by activating a transcriptional repressor named small heterodimer partner (SHP). We observed that hypoxia decreased the levels of both CDCA and SHP, suggesting that hypoxia repressed CYP7A1 without inducing SHP. The finding that overexpression of HIF-1α increased the activity of the CYP7A1 promoter suggested that hypoxia decreased the expression of CYP7A1 in a HIF-1-independent manner. Thus, the results of this study suggested that hypoxia decreased the activity of CYP7A1 by limiting its substrate O2, and by decreasing the transcription of CYP7A1. [BMB Reports 2016; 49(3): 173-178]