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- 저자 : Namjoon Baek (검색결과 2 건)
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백소정(So-Jeong Baek),조남준(Namjoon Cho),조성진(Sung-Jin Cho),김은미(Eun-Mi Kim),김기광(Kee Kwang Kim) 한국생물공학회 2020 KSBB Journal Vol.35 No.2
Sulfonylurea treatment is used for diabetes mellitus, a metabolic disease caused by abnormal absorption of glucose in the body. But it is accompanied by side effects in vivo when taken for a long time. Therefore, there is a need for research on natural materials having similar effects to these therapeutic agents and having fewer side effects that can effectively regulate blood sugar. In this study, we investigated the antioxidative efficacy of Sparassis crispa (S. crispa) extract and the activity of ATP, glycolysis, and mitochondrial membrane potential using human hepatocyte HepG2 cells. As a result, S. crispa extract showed high antioxidant activity and induced a significant increase in HepG2 cell activity and ATP production. S. crispa extract also significantly accelerated the process and mitochondrial membrane potential. Taken together, these results suggest that S. crispa extract has the potential to be developed as a natural material for improving diabetic and diabetic complications by activating hepatic energy metabolism.
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New ethanol extraction improves the anti-obesity effects of black tea
Bongju Park,박현성,Sang-Jin Lee,Bonggyeong Lee,Ingyum Kim,Namjoon Baek,Tae Ho Lee,이석용,Miwon Son 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.3
Black tea has been reported to have anti-obesity effects in both rodents and humans. Gallic acid, an active component of black tea, decomposes quickly into pyrogallol in high-temperature solutions. This study introduced a new, aqueous ethanol extraction of black tea, which resulted in extracts with higher concentrations of gallic acid than conventional black tea extracts prepared by hot-water extraction or hot-ethanol extraction. We confirmed that, compared with the hot-water extract of black tea, the cold-ethanol extract of black tea (CE-BTE) had greater effects on reducing body weight and body fat, improving fatty liver, regulating blood glucose, and reducing blood cholesterol in the high-fat diet-induced obese mouse model. Nonetheless, although CE-BTE significantly reduced fat content, it did not reduce peroxisome proliferator-activated receptor (PPARc) protein in epididymal fat tissue of HFD mice. We also showed that CEBTE did not inhibit the function of PPARc protein to drive adipogenesis of mouse 3T3-L1 preadipocytes. Considering that PPARc is a master transcription factor not only for adipocyte differentiation, but also for adipose tissue function, such as glucose and lipid metabolism and insulin sensitivity, these results suggest that CE-BTE reduced fat mass and body weight without dampening fat cell homeostasis and insulin sensitivity.
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