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( Bo Ram Youn ),( Kyung Hwan Kim ),( Wan Kim ),( Hyun Gee Moon ),( Won Yu Kang ),( Sang Cheol Cho ),( Sun Ho Hwang ),( Weon Kim ),( Eun Kyung Cho ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Endothelial dysfunction (ED) is well known to be associated with coronary artery disease (CAD). However, the effect of ED on clinical manifestation of CAD is not well established. This study is designed to assess the difference of endothelial dysfunction between acute coronary syndrome and stable angina pectoris (SAP). Method: Our study has enrolled 224 patients (182 SAP group and 42 ACS group) with chest pain consecutively and coronary angiography was performed for all patients. We used fi ow-medicated dilation (FMD) as detecting tool for endothelial dysfunction. Result: The average FMD value of was 9. 64±4. 10 for SAP group and 8. 17 ± 3. 96 for ACS group. The prevalence of some other medical conditions that are known to be associated with ED was similar between two groups. Although the difference of FMD value was meaningful when compared by t-test (p=0. 040), there was no signifi cant difference after adjusting other variables such as age, diabetes, hypertension, medications (p=0. 454). Age was only important contributing factor for ED in this study (p=0. 035). Conclusion: The severity of endothelial dysfunction was not different between ACS patients and SAP patients. From this result, we can propose that endothelial dysfunction cause coronary artery disease mainly by chronic pathological course such as atherosclerosis. The impact of endothelial dysfunction on plaque rupture or erosion may not be important in development of acute coronary syndrome.
( Bo Ram Youn ),( Kyung Hwan Kim ),( Wan Kim ),( Hyun Gee Moon ),( Won Yu Kang ),( Sang Cheol Cho ),( Sun Ho Hwang ),( Weon Kim ),( Myung Ho Jung ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Previous several studies revealed that everolimus-eluting (EES) and zotarolumus- eluting stent (ZES) had similar long-term clinical outcome. However, there were few studies that compared the efficacy of these stents in acute myocardial infarction (AMI) patients who treated by peri-procedual abciximab, a class of platelet glycoprotein IIb/IIIa inhibitor. Methods: 1698 AMI patients who treated by periprocedual abciximab were enrolled from KAMIR data. After propensity score matching, clinical outcome between 489 patients treated by EES (EES group) and 489 patients treated by ZES (ZES group) were compared. Primary end point was defi ned as composite of cardiac death, non-fatal myocardial infacrtion, and target-lesion revascularization (TLR) for 2 years. Secondary end point was cumulative incidence of respective clinical events. Results: For AMI patients who were not treated by abciximab, the composite outcome of EES group and ZES group were not signifi cantly different (p=0. 07). However, for AMI patients treated by abciximab, EES group revealed better composite outcome than ZES group after propensity score matching (p=0. 012). Although there were no signifi cant difference of cardiac death (p=0. 343), non-fatal MI (p=0. 146), EES group showed signifi cantly lower rate of TLR than ZES group (p=0. 003). Cox-regression analysis was performed to adjust compounding variables and the use of EES rather than ZES was independent contributor to improve composite outcome (p=0. 027). Conclusion: EES revealed better clinical outcome than ZES in AMI patients treated by periprocedual abciximab. However, it is not defi nite whether this result comes from the interaction of stent and abciximab or different effi cacy of two drug-eluting stents in AMI patients with large thrombotic burden.
전기방사한 나노섬유 웹 처리소재와 상용 투습방수소재의 역학적 특성 비교
윤보람 ( Bo Ram Youn ),이승신 ( Seung Sin Lee ) 한국감성과학회 2010 감성과학 Vol.13 No.2
전기방사한 나노섬유 웹은 가는 섬유직경과 수많은 미세공극 구조로 인해 우수한 투습성 및 차단 성능을 나타내며, 초박막·초경량의 특성을 갖는다. 이러한 특성 때문에 새로운 투습방수 소재로서 전기방사한 나노섬유 웹을 이용하고자 하는 시도가 이루어지고 있으며, 본 연구에서는 나노섬유 웹 처리소재의 역학적 특성을 측정하고 이를 기존 투습방수 소재와 비교함으로써 기능적 성능과 더불어 감성적 성능을 만족시키는 새로운 투습방수 소재 개발을 위한 기초자료를 제시하고자 하였다. 실험실 제작(lab-scale) 나노섬유 웹과 대량생산 (commercial) 나노섬유 웹을 이용하여 웹 밀도와 기반 직물, 적층 구조, 라미네이팅 여부 등에 차이를 두어 다양한 전기방사 나노섬유 웹 처리소재를 제작하였다. 이들 시료에 대해 KES-FB system을 이용하여 역학적 특성을 평가하고, 이를 기존 투습방수 소재인 고밀도 직물, PTFE 라미네이팅 직물, PU 코팅 직물의 역학적 특성치와 비교하였다. 연구 결과, 실험실에서 제작한 나노섬유 웹 처리소재는 부피감이 있으면서 유연하였고, 대량생산된 나노섬유 웹을 라미네이팅한 소재는 신장 변형이 적은, 치밀한 구조의 소재인 것으로 나타났다. 또한 고밀도 직물과 실험실 제작 나노섬유 웹 처리소재는 낮은 인장선형성과 굽힘강성, 전단강성으로 유사한 거동을 나타내어, 기존 PU 코팅이나 PTFE 라미네이팅 직물에 비해 뻣뻣함이 덜하면서 유연하고 부드러운 태를 가지는 것으로 해석되었다. 따라서 전기방사 나노섬유 웹 처리소재가 일정 수준의 방수성을 확보한다면 기능적 성능과 감성적 성능을 모두 충족시키는 새로운 투습방수 소재로 이용될 수 있을 것으로 사료된다. In this study, breathable waterproof materials were prepared by electrospinning. Five kinds of electrospun nanofiber web layered systems with different levels of nanofiber web density, as well as different substrates and layer structures were fabricated, and their mechanical properties (tensile, bending, shear, compression, surface, and thickness & weight) were measured by the KES-FB system and compared with those of conventional breathable waterproof fabrics (densely woven fabric, PTFE laminated fabric and PU coated fabric). The KES-FB measurements demonstrate that the lab-scale nanofiber web layered systems are more flexible and fuller than commercial nanofiber web layered systems, which have a more compact structure than the lab-scale nanofiber web layered systems. Densely woven fabrics and lab-scale nanofiber web layered systems showed lower values of tensile linearity (LT), bending stiffness (B), and shear stiffness (G) than those of PU coated and PTFE laminated fabric. These results indicate that they are more flexible and have less resistance to the shearing movement, corresponding to a more pliable material having a better drape, than PU coated fabrics and PTFE laminated fabrics.
Beneficial effect of agar mask against skin damages induced by UV exposure in SKH-1 hairless mice
Bo Ram Song,Ji Eun Kim,Woo Bin Yun,Mi Rim Lee,Jun Young Choi,Jin Ju Park,Dong Seob Kim,Chung Yeoul Lee,Hee Seob Lee,Yong Lim,Min Wook Jung,Bae Hwan Kim,Dae Youn Hwang 한국실험동물학회 2017 한국실험동물학회 학술발표대회 논문집 Vol.2017 No.8