Prevalence of Multiple Sclerosis in a Turkish City Bordering an Iron and Steel Factory

Ülkü Türk Börü,Adnan Burak Bilgiç,Cansu Köseoğlu Toksoy,Abdullah Yasir Yılmaz,Mustafa Tasdemir,Nilay Padir Sensöz,Özgür Öztop Çakmak,Arda Duman,Cem Bölük 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.2

Background and Purpose Multiple sclerosis (MS) is an autoimmune disease characterizedby inflammatory demyelination. Recent studies have shown that long-term exposure to air pollutants(including PM10 particulates) is potentially an environmental risk factor for MS. Weaimed to determine the prevalence rates of MS in two cities with different levels of air pollution. Methods This door-to-door population-based study was conducted between April 2014 andJune 2015. Two cities were screened for the prevalence rates of MS: 1) Karabük, which bordersan iron-and-steel factory, and 2) Akçakoca, which is a coastal city located in the same region. A validated survey form was used for screening MS. The 2010 McDonald Criteria were usedfor diagnosing MS. The patients were examined twice, first by a neurology assistant in the fieldand then by a senior neurologist in public health centers in the cities. Results The prevalence of MS was 95.9/100,000 in Karabük and 46.1/100,000 in Akçakoca. Intotal, 33 patients were diagnosed with clinically definite MS. The female/male ratio was 1.5, and21 patients were diagnosed with relapsing-remitting MS, 9 with secondary progressive MS, and3 with primary progressive MS. Conclusions We found that the prevalence of MS was more than two fold higher in Karabükthan in Akçakoca, which supports a link between air pollution and the pathogenesis of MS. However, larger etiological and epidemiological studies are needed to confirm this hypothesis.

Misoprostol alleviates paclitaxel-induced liver damage through its antioxidant and anti-apoptotic effects

Gür Fatih Mehmet,Aktaş İbrahim,Bilgiç Sedat,Pekince Merve 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.3

Backgrounds Anticancer drugs may damage non-target cells and tissues. One of the biggest reasons for changing or stopping chemotherapy regimens is these adverse effects. Objective This study aimed to investigate the therapeutic and protective efficacy of misoprostol (MP) against the harmful effects of paclitaxel (PAX), an anticancer drug, on normal liver tissue. Results Biochemical examinations revealed that activities of serum aspartate aminotransferase, alanine aminotransferase, and levels of triglyceride, and cholesterol and levels of tissue malondialdehyde increased significantly in the PAX group compared to the control group, and glutathione level decreased. The histological structure of the liver tissue of the control group rats was normal. Histopathological changes, such as focal microvesicular steatosis, sinusoidal dilatation, mononuclear cell infiltration, Councilman bodies, and an increase in apoptosis, were also observed in PAX group. The histopathological changes observed in the PAX group were greatly improved in the PAX + MP group. Conclusion When the obtained data were evaluated, it was concluded that the combined use of PAX with MP could reduce the cytotoxic effects of PAX on normal liver tissue, allowing cancer treatment to be continued uninterrupted and effectively.

No Adverse Outcomes of Video-Assisted Thoracoscopic Surgery Resection of cT2 Non-Small Cell Lung Cancer during the Learning Curve Period

Zeynep Bilgi,Hasan Fevzi Batırel,Bedrettin Yıldızeli,Korkut Bostancı,Tunç Laçin,Mustafa Yüksel 대한흉부외과학회 2017 Journal of Chest Surgery (J Chest Surg) Vol.50 No.4

Background: Video-assisted thoracoscopic surgery (VATS) anatomic lung resections are gradually becoming the standard surgical approach in early-stage non-small cell lung cancer (NSCLC). The technique is being applied in cases of larger tumors depending on the experience of the surgical team. The objective of this study was to compare early surgical and survival outcomes in patients undergoing anatomic pulmonary resections using VATS and thoracotomy techniques for clinical T2 NSCLC during the adaptation period of the surgical team to the VATS approach. Methods: The data of all patients who underwent anatomic pulmonary resection for NSCLC using VATS and open techniques since April 2012 were recorded to create a prospective lung cancer database. Clinical T2 NSCLC patients who underwent VATS anatomic lung resection were identified and compared with cT2 patients who underwent open resection. Results: Between April 2012 and August 2014, 269 anatomical resections for NSCLC were performed (80 VATS and 189 thoracotomy). Thirty-four VATS patients who had clinical T2 disease were identified and stage-matched to thoracotomy patients. The average tumor diameter was comparable (34.2±11.1×29.8±10.1 mm vs. 32.3±9.8×32.5±12.2 mm, p=0.4). Major complications were higher in the thoracotomy group (n=0 vs. n=5, p=0.053). There was no 30-day mortality, and the 2-year survival rate was 91% for VATS and 82% for thoracotomy patients (p=0.4). Conclusion: VATS anatomic resections in clinical T2 NSCLC tumors are safe and have perioperative and pathologic outcomes similar to those of thoracotomy, while remaining within the learning curve.

Impact of root canal curvature and instrument type on the amount of extruded debris during retreatment

Serefoglu Burcu,Kandemir Demirci Gözde,Miçooğulları Kurt Seniha,Kaşıkçı Bilgi İlknur,Çalışkan Mehmet Kemal 대한치과보존학회 2021 Restorative Dentistry & Endodontics Vol.46 No.1

Objectives: The aim of the current study was to assess whether the amount of extruded debris differs for straight and severely curved root canals during retreatment using H-files, R-Endo, Reciproc and ProTaper Universal Retreatment (PTU-R) files. Additionally, the area of residual filling material was evaluated. Materials and Methods: Severely curved (n = 104) and straight (n = 104) root canals of maxillary molar teeth were prepared with WaveOne Primary file and obturated with gutta-percha and AH Plus sealer. Root canal filling materials were removed with one of the preparation techniques: group 1: H-file; group 2: R-Endo; group 3: Reciproc; group 4: PTU-R (n = 26). The amount of extruded material and the area of the residual filling material was measured. The data were analyzed with 2-way analysis of variance (ANOVA) and 1-way ANOVA at the 0.05 significance level. Results: Except for Reciproc group (p > 0.05), PTU-R, R-Endo, and H-file systems extruded significantly more debris in severely curved canals (p < 0.05). Each file system caused more residual filling material in severely curved canals than in straight ones (p < 0.05). Conclusions: All instruments used in this study caused apical debris extrusion. Root canal curvature had an effect on extruded debris, except for Reciproc system. Clinicians should be aware that the difficult morphology of the severely curved root canals is a factor increasing the amount of extruded debris during the retreatment procedure.

Immunoregulatory Function of HLA-G in Gastric Cancer

Tuncel, Tolga,Karagoz, Bulent,Haholu, Aptullah,Ozgun, Alpaslan,Emirzeoglu, Levent,Bilgi, Oguz,Kandemir, Emin Gokhan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background: Human leukocyte antigen (HLA)-G-positive gastric cancers are associated with poor survival, but links with tumor escape mechanisms remain to be determined. Materials and Methods: We used immunohistochemistry to investigate HLA-G expression, tumor infiltrating CD8+ T lymphocytes, and Treg cells in 52 gastric cancer patients. Results: There were 29 cancer-related deaths during the follow-up period. Kaplan-Meier analysis indicated that patients with HLA-G-positive (n=16) primary tumors had a significantly poorer prognosis than patients with HLA-G-negative tumors (n=36, p=0.008). The median survival time was 14 months and 47 months, respectively. Patients with high numbers of Tregs and low numbers of CD8+T lymphocytes in the primary tumor had a poorer prognosis than those with low numbers of Tregs and high numbers of CD8+T lymphocytes (p=0.034, p=0.043). Multivariate Cox proportional hazard regression analysis showed that HLA-G expression (hazard ratio: 2.662; 95% confidence interval: 1.242-5.723; p=0.012) and stage (hazard ratio: 2.012;95% confidence interval: 1.112-3.715; p=0.041) were independent unfavorable factors for patient survival. Conclusions: We found a significant positive correlation between HLA-G expression and the number of tumor infiltrating Tregs (p=0.01) and a negative correlation with the number of CD8+T lymphocytes (p=0.041). HLA-G may protect gastric cancer cells from cytolysis by inducing Foxp3+Treg lymphocytes and suppressing CD8+T lymphocytes.

Clinicopathological Features and Survival of Young Turkish Patients with Testicular Germ Cell Tumors

Ozgun, Alpaslan,Karagoz, Bulent,Tuncel, Tolga,Emirzeoglu, Levent,Celik, Serkan,Bilgi, Oguz Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: Testicular germ cell tumors (TGCTs) are a relatively common malignancy in young men. The aim of this study was to investigate the clinicopathological features and survival of young Turkish patients with TGCT. Materials and Methods: In this retrospective study, the clinical and pathological characteristics of young Turkish patients with TGCT who were monitored by the Department of Medical Oncology of a military hospital between 2008 and 2013 were investigated. Overall survival data were analyzed. Results: Ninety-six patients were included in the study. The mean age was 26.4 years. Among the patients, 17.7% had seminoma and 43.8% had mixed non-seminomatous germ cell tumors. Some 46.9% were Stage I, 30.2% were Stage II, and 22.9 were Stage III. Of the patients, 83.3% received chemotherapy, 25% underwent retroperitoneal lymph node dissection (RPLND), 3.1% received radiotherapy, and 12.5% were followed-up without treatment. In addition, 18.8% of the patients were administered salvage chemotherapy due to relapse or progression. The 5-year overall survival rate was 90.2% for all patients. The 2-year overall survival rate was 100% for Stage I patients, 94% for Stage II patients, and 70.2% for Stage III patients. The difference between the survival curves of stages was statistically significant (p=0.029). Conclusions: In young Turkish patients with TGCT, good results were obtained with appropriate treatment, most receiving chemotherapy. The prognosis of the disease was good even in the advanced stage.

Mean Platelet Volume as a Prognostic Marker in Metastatic Colorectal Cancer Patients Treated with Bevacizumab-Combined Chemotherapy

Tunce, Tolga,Ozgun, Alpaslan,Emirzeoglu, Levent,Celik, Serkan,Bilgi, Oguz,Karagoz, Bulent Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Background: Recent studies have revealed a prognostic impact of the MPV (mean platelet volume)/platelet count ratio in terms of survival in advanced non-small cell lung cancer. However, there has been no direct analysis of the survival impact of MPV in patients with mCRC. The aim of the study is to evaluate the pretreatment MPV of patients with metastatic and non-metastatic colorectal cancer (non-mCRC) and also the prognostic significance of pretreatment MPV to progression in mCRC patients treated with bevacizumab-combined chemotherapy. Materials and Methods: Fifty-three metastatic and ninety-five non-metastatic colorectal cancer patients were included into the study. Data on sex, age, lymph node status, MPV, platelet and platecrit (PCT) levels were obtained retrospectively from the patient medical records. Results: The MPV was significantly higher in the patients with mCRC compared to those with non-mCRC ($7.895{\pm}1.060$ versus $7.322{\pm}1.136$, p=0.013). The benefit of bevacizumab on PFS was significantly greater among the patients with low MPV than those with high MPV. The hazard ratio (HR) of disease progression was 0.41 (95%CI, 0.174-0.986; p=0.04). In conclusion, despite the retrospective design and small sample size, MPV can be considered a prognostic factor for mCRC patients treated with bevacizumab-combined chemotherapy.

Ultrasound-guided femoral and sciatic nerve blocks combined with sedoanalgesia versus spinal anesthesia in total knee arthroplasty

Akcan Akkaya,Umit Yasar Tekelioglu,Abdullah Demirhan,Kutay Engin Ozturan,Hakan Bayir,Hasan Kocoglu,Murat Bilgi 대한마취통증의학회 2014 Korean Journal of Anesthesiology Vol.67 No.2

Background: Although regional anesthesia is the first choice for patients undergoing total knee arthroplasty (TKA), it may not be effective and the risk of complications is greater in patients who are obese or who have spinal deformities. We compared the success of ultrasound-guided femoral and sciatic nerve blocks with sedoanalgesia versus spinal anesthesia in unilateral TKA patients in whom spinal anesthesia was difficult. Methods: We enrolled 30 patients; 15 for whom spinal anesthesia was expected to be difficult were classified as the block group, and 15 received spinal anesthesia. Regional anesthesia was achieved with bupivacaine 62.5 mg and prilocaine 250 mg to the sciatic nerve, and bupivacaine 37.5 mg and prilocaine 150 mg to the femoral nerve. Bupivacaine 20 mg was administered to induce spinal anesthesia. Hemodynamic parameters, pain and sedation scores, and surgical and patient satisfaction were compared. Results: A sufficient block could not be obtained in three patients in the block group. The arterial pressure was significantly lower in the spinal group (P < 0.001), and the incidence of nausea was higher (P = 0.017) in this group. Saturation and patient satisfaction were lower in the block group (P < 0.028), while the numerical pain score (P < 0.046) and the Ramsay sedation score were higher (P = 0.007). Conclusions: Ultrasound-guided sciatic and femoral nerve blocks combined with sedoanalgesia were an alternative anesthesia method in selected TKA patients.

SDSS-V LVM-I Observation Control Software: SCP, ECP and NPS

Mingyeong Yang,Changgon Kim,Jos? S?nchez-Gallego,Florian Briegel,Felipe Besser,Pavan Bilgi,Hojae Ahn,Tae-Geun Ji,Nicholas P.Konidaris,Guillermo A.Blanc,Taeeun Kim,Mingyu Jeon,Hyun Chul Park,Hye-In Lee 한국천문학회 2022 天文學會報 Vol.47 No.1

Investigation of the Usability of Retrograded Flour in Meatball Production as A Structure Enhancer

Elif Aykin Dinç,er,Ö,zlem Kiliç,Bü,yü,kkurt,Cihadiye Candal,Bü,ş,ra Fatma Bilgiç,Mustafa Erbaş 한국축산식품학회 2018 한국축산식품학회지 Vol.38 No.1

This study aimed to research the possibilities of using retrograded flour produced in the laboratory environment in meatballs and the characteristics of these meatballs. In the use of retrograded flour to produce meatballs, it was ensured that the meatball properties, with respect to chemical, physical and sensorial aspects, were comparable to those of meatballs produced with bread (traditional) and rusk flour (commercial). The cooking loss of meatballs produced with using retrograded flour was similar to that of commercial meatballs. Doses of retrograded flour from 5% to 20% led to a significant decrease in cooking loss, from 21.95% to 6.19%, and in the diameter of meatballs, from 18.60% to 12.74%, but to an increase in the thickness of meatballs, from 28.82% to 41.39% compared to the control. The increase of a* and b* values was shown in that the meatballs were browned on cooking with increasing retrograded flour doses because of non-enzymatic reactions. The springiness of the traditional meatballs was significantly higher than that of the other meatballs. This might have been due to the bread crumbs having a naturally springy structure. Moreover, the addition of retrograded flour in the meatballs significantly (p<0.05) affected the hardness, springiness and cohesiveness of the meatballs with respect to textural properties. Accordingly, it is considered that the use of 10% retrograded flour is ideal to improve the sensorial values of meatballs and the properties of their structure.