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Prevalence of Multiple Sclerosis in a Turkish City Bordering an Iron and Steel Factory
Ülkü Türk Börü,Adnan Burak Bilgiç,Cansu Köseoğlu Toksoy,Abdullah Yasir Yılmaz,Mustafa Tasdemir,Nilay Padir Sensöz,Özgür Öztop Çakmak,Arda Duman,Cem Bölük 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.2
Background and Purpose Multiple sclerosis (MS) is an autoimmune disease characterizedby inflammatory demyelination. Recent studies have shown that long-term exposure to air pollutants(including PM10 particulates) is potentially an environmental risk factor for MS. Weaimed to determine the prevalence rates of MS in two cities with different levels of air pollution. Methods This door-to-door population-based study was conducted between April 2014 andJune 2015. Two cities were screened for the prevalence rates of MS: 1) Karabük, which bordersan iron-and-steel factory, and 2) Akçakoca, which is a coastal city located in the same region. A validated survey form was used for screening MS. The 2010 McDonald Criteria were usedfor diagnosing MS. The patients were examined twice, first by a neurology assistant in the fieldand then by a senior neurologist in public health centers in the cities. Results The prevalence of MS was 95.9/100,000 in Karabük and 46.1/100,000 in Akçakoca. Intotal, 33 patients were diagnosed with clinically definite MS. The female/male ratio was 1.5, and21 patients were diagnosed with relapsing-remitting MS, 9 with secondary progressive MS, and3 with primary progressive MS. Conclusions We found that the prevalence of MS was more than two fold higher in Karabükthan in Akçakoca, which supports a link between air pollution and the pathogenesis of MS. However, larger etiological and epidemiological studies are needed to confirm this hypothesis.